CN113677789A - 免疫调节性间充质干细胞 - Google Patents

免疫调节性间充质干细胞 Download PDF

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Publication number
CN113677789A
CN113677789A CN202080018981.6A CN202080018981A CN113677789A CN 113677789 A CN113677789 A CN 113677789A CN 202080018981 A CN202080018981 A CN 202080018981A CN 113677789 A CN113677789 A CN 113677789A
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mscs
cell
cells
isolated
pbmcs
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J·斯帕斯
S·布鲁克斯
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Global Stem Cell Technologies
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Global Stem Cell Technologies
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0668Mesenchymal stem cells from other natural sources
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/02Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/03Compounds acting on the NO pathway, e.g. nitrososarginine
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/15Transforming growth factor beta (TGF-β)
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/231Interleukin-10 (IL-10)
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    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells

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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202080018981.6A 2019-03-12 2020-03-12 免疫调节性间充质干细胞 Pending CN113677789A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19162270.3 2019-03-12
EP19162270 2019-03-12
PCT/EP2020/056625 WO2020182935A1 (en) 2019-03-12 2020-03-12 Immunomodulating mesenchymal stem cells

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CN113677789A true CN113677789A (zh) 2021-11-19

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CN202080018981.6A Pending CN113677789A (zh) 2019-03-12 2020-03-12 免疫调节性间充质干细胞

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US (1) US20220154147A1 (US07342112-20080311-C00072.png)
EP (1) EP3938494A1 (US07342112-20080311-C00072.png)
JP (1) JP2022524764A (US07342112-20080311-C00072.png)
KR (1) KR20210139259A (US07342112-20080311-C00072.png)
CN (1) CN113677789A (US07342112-20080311-C00072.png)
AU (1) AU2020235912A1 (US07342112-20080311-C00072.png)
BR (1) BR112021017738A8 (US07342112-20080311-C00072.png)
CA (1) CA3132414A1 (US07342112-20080311-C00072.png)
MX (1) MX2021010739A (US07342112-20080311-C00072.png)
WO (1) WO2020182935A1 (US07342112-20080311-C00072.png)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202320819A (zh) 2021-07-08 2023-06-01 比利時商比利時百靈佳殷格翰動物醫藥公司 用於治療慢性齦口炎之間葉幹細胞
TW202319059A (zh) 2021-07-08 2023-05-16 比利時商比利時百靈佳殷格翰動物醫藥公司 用於治療動物之骨關節炎之間葉幹細胞
WO2023280834A1 (en) 2021-07-08 2023-01-12 Boehringer Ingelheim Veterinary Medicine Belgium Mesenchymal stem cells for use in the treatment of atopic dermatitis
CN117915924A (zh) 2021-07-08 2024-04-19 勃林格殷格翰比利时兽医公司 间充质干细胞用于治疗慢性肾病
WO2024033462A1 (en) 2022-08-11 2024-02-15 Boehringer Ingelheim Vetmedica Gmbh Mesenchymal stem cells for use in the treatment of insect-bite hypersensitivity in equines

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080095749A1 (en) * 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
US20140017787A1 (en) * 2010-10-11 2014-01-16 Aline M. Betancourt Mesenchymal stem cells and related therapies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047163A2 (en) 1998-03-18 1999-09-23 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
EP2298862B1 (en) 2004-03-22 2017-08-30 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
AU2017235446A1 (en) 2016-03-16 2018-11-08 Cell Medicine, Inc. Mesenchymal stem cells with enhanced efficacy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080095749A1 (en) * 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
US20140017787A1 (en) * 2010-10-11 2014-01-16 Aline M. Betancourt Mesenchymal stem cells and related therapies

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WO2020182935A1 (en) 2020-09-17
JP2022524764A (ja) 2022-05-10
MX2021010739A (es) 2021-12-15
BR112021017738A2 (US07342112-20080311-C00072.png) 2021-11-16
BR112021017738A8 (pt) 2022-08-02
CA3132414A1 (en) 2020-09-17
AU2020235912A1 (en) 2021-10-07
US20220154147A1 (en) 2022-05-19
KR20210139259A (ko) 2021-11-22
EP3938494A1 (en) 2022-01-19

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