CN113648367A - Traditional Chinese medicine micro powder granules for assisting in reducing blood sugar - Google Patents
Traditional Chinese medicine micro powder granules for assisting in reducing blood sugar Download PDFInfo
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- CN113648367A CN113648367A CN202010395253.9A CN202010395253A CN113648367A CN 113648367 A CN113648367 A CN 113648367A CN 202010395253 A CN202010395253 A CN 202010395253A CN 113648367 A CN113648367 A CN 113648367A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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Abstract
The invention discloses a traditional Chinese medicine micro powder granule for assisting in reducing blood sugar, which comprises main medicines: rhizoma Dioscoreae, rhizoma Polygonati Odorati, fructus Lycii, and Poria; auxiliary materials: dextrin, soluble starch, and soybean dietary fiber by steaming and processing main materials, mixing, and pulverizing with air flow guide pulverizer at a speed of 1.3/m3·min‑1Mixing with classification turbine at 6000r/min to obtain fine powder with particle diameter of about 75 μm, mixing with adjuvants, granulating by wet method, and oven drying to obtain granule. The traditional Chinese medicine micro powder granules for assisting in reducing blood sugar are prepared by mixing a plurality of traditional Chinese medicinesThe traditional Chinese medicines are mixed according to a certain ratio, so that the multiple traditional Chinese medicines can act synergistically to assist in improving the physical condition, the original medicine is micronized and is easier to absorb by the human body, and the traditional Chinese medicine is prepared into granules which are easy to store and take, has strong practicability and is worthy of popularization.
Description
Technical Field
The invention relates to a granule, in particular to a granule which is used for assisting in reducing blood sugar and is prepared from a plurality of traditional Chinese medicine micro-powders.
Background
With the continuous improvement of the living standard of people, the change of the dietary structure and the coming of the aging society in recent years, the incidence of diabetes mellitus is on the increasing trend in multiple age groups. Clinically, the blood sugar reducing western medicines have various types and definite blood sugar reducing curative effect, but most of the medicines have toxic and side effects, are easy to cause discomfort of a digestive system and systemic adverse reaction, and are likely to fail secondarily. The traditional Chinese medicine has mild and lasting effect, high safety, capability of regulating blood sugar in two directions and great advantage in preventing and treating diabetes and complications thereof, so that the traditional Chinese medicine can be selected by healthy people for health care and prevention in addition to the fact that a plurality of diabetes patients can select the traditional Chinese medicine to enhance the curative effect of western medicines and reduce the toxic and side effects of the western medicines. However, the processing method of the traditional Chinese medicine is complex, and the effect of the traditional Chinese medicine is difficult to ensure due to a plurality of factors such as intake amount, intake channels, compliance and the like when the traditional Chinese medicine is used by a user.
Disclosure of Invention
The invention aims to solve the technical problems that the dosage of a plurality of commonly used traditional Chinese medicines for assisting in reducing blood sugar is uncontrollable due to self-medication, the absorption effect is poor, the compliance is poor and the like, and the invention provides granules prepared from a plurality of traditional Chinese medicine component micro-powders for assisting in reducing blood sugar.
The technical scheme adopted by the invention for solving the problems is as follows: a traditional Chinese medicine micro powder granule for assisting in reducing blood sugar is characterized in that the mass ratio of main medicines to auxiliary materials is 2:3, the main medicines are steamed and processed Chinese yam: fragrant solomonseal rhizome: medlar: adding Poria =2:2:1:1 at equal ratio, mixing, and controlling air speed at 1.3/m with air flow guiding type pulverizer3•min-1And the rotation speed of a grading turbine is 6000r/min, fine powder with the particle size of about 75 mu m is prepared, the fine powder is fully mixed, and simultaneously, dextrin is added as an auxiliary material: dry starch: weighing soybean dietary fiber =27:17:30 in proportion, and controlling the wind speed to be 1.3/m by adopting an airflow guide type pulverizer3•min-1And a grading turbine with the rotating speed of 6000r/min, preparing fine powder with the particle size of about 75 mu m, and fully mixing.
The granulation method adopts wet granulation, the adhesive is 16% starch slurry, the starch slurry and the powder are fully mixed, then the mixture is granulated by a 10-mesh or 18-mesh screen, the mixture is placed into a blast oven with the drying temperature of 50 ℃ for drying for 2h, and a 24-mesh screen is used for finishing granules.
The content of the main drug in the granules is more than 40 percent, and the content of the crude polysaccharide is not less than 90 percent of the marked amount; the sum of the sieve which can not pass through the first sieve (2000um) and the sieve which can pass through the fifth sieve (180um) is not more than 15 percent; the water content measured by a drying method is not more than 8%; in the solubility test, the test sample should be completely dissolved or slightly turbid with no coke powder or foreign matter after being stirred with hot water for 5 minutes.
The granules can be packaged into small bags after being prepared into granules, so that the granules are easier to carry and take, and the compliance is greatly improved.
By adopting the technical scheme, the invention has the beneficial effects that: the main drugs are all common traditional Chinese medicines which are proved to be effective in regulating blood sugar through traditional Chinese medicine and pharmacology, and the formula is verified through animal gavage experiments: a hyperglycemic model is manufactured by taking an aged rat as an experimental object through intraperitoneal injection of alloxan, the administration-free blank pure water and a fine powder solution which is steamed and prepared into a size of 75 mu m are used for gastric lavage treatment for 30 days, and the rat tail vein blood sugar is detected, so that the blood sugar of the rat subjected to administration treatment is averagely reduced to a normal interval (about 5 mmol/L), the blood sugar of the blank group not administered is still too high (about 10 mmol/L), and the formula is known to have a regulating effect on the hyperglycemia indeed.
The same medicinal materials are steamed, processed and prepared into 75 mu m fine powder, which is more beneficial to the absorption of effective substances than simple hot water brewing, and the gavage experiment of animals also proves that: the rat of the right age is taken as an experimental object, a hyperglycemia model is manufactured by intraperitoneal injection of alloxan, pure water without any medicinal material, a hot water brewing decoction of the formula and a fully mixed fine powder solution which is steamed and prepared into 75 mu m are respectively used for performing intragastric administration for 30 days, the rat tail vein blood sugar is detected to know that both have a certain blood sugar reducing effect, but the hot water brewing decoction has lower influence on the blood sugar than the micronized granule solution, and the granules prepared by micronization and full mixing of the medicaments are more conductive to absorption and play effects.
The same medicinal materials can be used for searching the optimal intake amount through different concentration gastric lavage experiments of animals: taking an aged rat as an experimental object, manufacturing a hyperglycemia model by intraperitoneal injection of alloxan, respectively steaming the formula, preparing fully mixed fine powder with the particle size of 75 mu m into solutions with different concentrations, and carrying out intragastric administration treatment for 30 days, wherein the medicine intake of each mouse per day of a low-concentration group is 0.3g/kg, the medicine intake of each mouse per day of a medium-concentration group is 0.4g/kg, the medicine intake of each mouse per day of a high-concentration group is 0.5g/kg, the medium-concentration auxiliary blood glucose reduction effect is best obtained by detecting the tail vein blood glucose of the rat, and the recommended intake of a person per day is calculated to be about 4g according to the equivalent dose ratio of 6.3 calculated according to the body surface area between the person and the rat.
Therefore, the medicine is packaged in 10 g/bag, each bag contains 4g of medicine components, and the recommended intake can be achieved by respectively taking one bag with warm water in the morning and evening, 2 times a day and 1 bag each time, and two months are a treatment course.
The traditional Chinese medicine micro powder granule for assisting in reducing blood sugar, disclosed by the invention, can be used for fully mixing a plurality of traditional Chinese medicines with effects according to a ratio, so that the plurality of traditional Chinese medicines can be in synergistic effect, the original medicine micronization is easier to absorb by a human body, and the traditional Chinese medicine micro powder granule is prepared into granules which are easy to store and take, is convenient to use, has a remarkable effect, has very strong practicability and is worthy of popularization.
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The invention is described in detail below with reference to the figures and examples.
Fig. 1 is a process flow diagram of the preparation of the granules.
Detailed Description
The foregoing is illustrative of the preferred embodiments of the present invention and is not to be construed as limiting thereof in any way. Any simple modification, variation and modification of the above embodiments according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.
Example 1:
the traditional Chinese medicine micro powder granule for assisting in reducing blood sugar comprises a main medicine and an auxiliary material, and the mass ratio of the main medicine to the auxiliary material is 2: 3. Accurately weighing main medicine yam according to the ratio: fragrant solomonseal rhizome: medlar: steaming Poria =2:2:1:1, pulverizing, and controlling air speed at 1.3/m3•min-1And the rotation speed of a grading turbine is 6000r/min, the mixture is prepared into fine powder with the particle size of about 75 microns, and the fine powder is fully mixed, refrigerated at low temperature and taken at present.
Weighing the auxiliary materials as dextrin according to the proportion: dry starch: weighing soybean dietary fiber =27:17:30 in proportion, mixing, and controlling air speed to be 1.3/m by adopting an air flow guide type pulverizer3•min-1And a grading turbine with the rotating speed of 6000r/min, preparing fine powder with the particle size of about 75 mu m, fully mixing, and fully and uniformly mixing with the main medicine powder for later use.
The granulation method adopts wet granulation, the adhesive is 16% starch slurry, the starch slurry and the powder are fully mixed, then the mixture is granulated by a 10-mesh or 18-mesh screen, the mixture is placed into a blast oven with the drying temperature of 50 ℃ for drying for 2h, and a 24-mesh screen is used for finishing granules.
Packaging with 12 g/bag, wherein each bag contains 4.8g of medicinal components, and the recommended intake can be achieved by taking the medicine with warm water in the morning and evening respectively, 2 times a day, 1 bag each time, and two months are one treatment course.
Example 2:
10 packs of the granules produced in example 1 were randomly sampled, and the crude polysaccharide content in each pack of granules was measured by the phenol-sulfuric acid method.
The reagents used were: concentrated sulfuric acid (analytically pure, 95.5%); 80% phenol: 80 g phenol (analytically pure redistilled reagent) was dissolved with 20 g water; 6% of phenol: preparing 80% phenol before use; standard dextran or analytically pure glucose; 15% trichloroacetic acid (15% TCA): 15 g TCA was dissolved in 85 g water; 5% trichloroacetic acid (5% TCA): 25 g TCA was dissolved in 475 g water; 6mol/L sodium hydroxide: 120 g of analytically pure sodium hydroxide is dissolved in 500ml of water; 6mol/L hydrochloric acid.
Table 1: determination of crude polysaccharide content in granules
As can be seen from the table above, the crude polysaccharide content of the granule is qualified.
Example 3
The granules produced in example 1 were randomly sampled for 5 packs and the particle size acceptability was determined by a manual double sieving method.
Weighing, placing in a specified upper layer first sieve (2000 μm), lower layer fifth sieve (180 μm) (with a sealed receiving container under the lower layer sieve), sieving while maintaining horizontal state, reciprocating left and right, and beating for 3 min while sieving. Weighing the particles and powder which can not pass through the upper layer sieve and can pass through the lower layer sieve, and calculating the proportion (%) of the particles and powder to be qualified if the proportion is not more than 15%.
Table 2: determination of particle size of granules
As can be seen from the above table, the granule was found to be acceptable in terms of particle size measurement.
Example 4
The granules produced in example 1 were randomly sampled for 2 packs and the water content (%) of the granules was measured by the baking method.
Taking 2-5 g of a test article, paving the test article in a flat weighing bottle which is dried to constant weight, precisely weighing the test article until the thickness is not more than 5mn, opening a bottle cap, drying the test article for 5 hours at 100-105 ℃, covering the bottle cap, moving the test article in a drying container, cooling the test article for 30 minutes, precisely weighing the test article, drying the test article for one hour at the temperature, cooling and weighing the test article until the difference between two successive weighing processes is not more than 5 mg. And calculating the water content (%) according to the weight loss, and determining that the water content is not higher than 8 percent to be qualified.
Table 3: determination of water content of granules
As can be seen from the above table, the granule has a qualified water content.
Example 5
10 packs of granules produced in case 1 were randomly drawn and their effect on blood glucose was determined by animal experiments.
Taking an aged rat as an experimental object, manufacturing a hyperglycemia model by intraperitoneal injection of alloxan, respectively steaming the formula, preparing fully mixed fine powder with the particle size of 75 mu m, preparing the fully mixed fine powder into solutions with different concentrations, and carrying out intragastric administration treatment for 30 days, wherein the dosage of the low-concentration group per mouse per day is 0.3g/kg, the dosage of the medium-concentration group per mouse per day is 0.4g/kg, the dosage of the high-concentration group per mouse per day is 0.5g/kg, and the blood glucose reduction ratio is calculated by detecting the tail vein blood glucose of the rat.
The table shows that the medium concentration auxiliary blood sugar reduction effect is best, and the recommended daily intake of people is calculated to be about 4g according to the equivalent dose ratio of 6.3 converted according to the body surface area between people and rats. Therefore, the medicine is packaged in 10 g/bag, each bag contains 4g of medicine components, and the recommended intake can be achieved by respectively taking one bag with warm water in the morning and evening, 2 times a day and 1 bag each time, and two months are a treatment course.
Claims (5)
1. A traditional Chinese medicine micro powder granule for assisting in reducing blood sugar is characterized in that a certain medicine and auxiliary materials are mixed according to a ratio of 2:3 and are prepared into the granule through wet granulation.
2. The traditional Chinese medicine micro powder granule for assisting in reducing blood glucose according to claim 1, wherein the main drug is composed of a plurality of traditional Chinese medicines, namely steamed and processed Chinese yam: fragrant solomonseal rhizome: medlar: weighing Poria =2:2:1:1, mixing thoroughly, and controlling wind speed to 1.3/m with air flow guiding type pulverizer3•min-1And the rotation speed of a grading turbine is 6000r/min, and the fine powder with the particle size of about 75 mu m is prepared and refrigerated at low temperature.
3. The traditional Chinese medicine micro powder granule for assisting in reducing blood glucose according to claim 1, which is characterized in that the auxiliary materials are dextrin: dry starch: weighing soybean dietary fiber =27:17:30 in proportion, mixing thoroughly, and controlling air speed to 1.3/m by air flow guiding type pulverizer3•min-1And the rotation speed of the grading turbine is 6000r/min, and the fine powder with the grain diameter of about 75 mu m is prepared.
4. The traditional Chinese medicine micro powder granule for assisting in reducing the blood sugar according to claim 2, which is characterized in that a binding agent used in a wet granulation method is 16% starch slurry, the drying condition is that the starch slurry is dried for 2 hours at 50 ℃, a 10 or 18 mesh screen is used for granulation, and a 24 mesh screen is used for granule finishing.
5. The traditional Chinese medicine micro powder granule for assisting in reducing blood glucose as claimed in claim 1, wherein the granule is prepared into a specification of 10 g/bag, is matched with a packaging bag with a corresponding specification, is taken with boiled water 2 times a day and 1 bag at a time, and two months are a treatment course.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010395253.9A CN113648367A (en) | 2020-05-12 | 2020-05-12 | Traditional Chinese medicine micro powder granules for assisting in reducing blood sugar |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114766628A (en) * | 2022-05-21 | 2022-07-22 | 温州岁安健康食品有限公司 | Meal replacement powder for diabetics to eat and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417846A (en) * | 2013-04-19 | 2013-12-04 | 陕西步长高新制药有限公司 | Hypoglycemic traditional Chinese medicine composition and preparation method thereof |
| CN106666312A (en) * | 2017-01-11 | 2017-05-17 | 大连雅威特生物技术股份有限公司 | Health-care food for assisting blood glucose decreasing and preparation method of granule and capsule thereof |
| CN108835521A (en) * | 2018-07-26 | 2018-11-20 | 刘建孚 | A kind of auxiliary glycosuria crowd adjusts the special diet formula and preparation method of blood glucose |
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- 2020-05-12 CN CN202010395253.9A patent/CN113648367A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417846A (en) * | 2013-04-19 | 2013-12-04 | 陕西步长高新制药有限公司 | Hypoglycemic traditional Chinese medicine composition and preparation method thereof |
| CN106666312A (en) * | 2017-01-11 | 2017-05-17 | 大连雅威特生物技术股份有限公司 | Health-care food for assisting blood glucose decreasing and preparation method of granule and capsule thereof |
| CN108835521A (en) * | 2018-07-26 | 2018-11-20 | 刘建孚 | A kind of auxiliary glycosuria crowd adjusts the special diet formula and preparation method of blood glucose |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114766628A (en) * | 2022-05-21 | 2022-07-22 | 温州岁安健康食品有限公司 | Meal replacement powder for diabetics to eat and preparation method thereof |
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