CN113633641A - 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 - Google Patents
用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 Download PDFInfo
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- CN113633641A CN113633641A CN202110874748.4A CN202110874748A CN113633641A CN 113633641 A CN113633641 A CN 113633641A CN 202110874748 A CN202110874748 A CN 202110874748A CN 113633641 A CN113633641 A CN 113633641A
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- tetrahydro
- thioxo
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- purin
- pyrimidin
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| CN200880111701A CN101873857A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
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| CN201310681047.4A Pending CN103638029A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
| CN201610055826.7A Pending CN105687199A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
| CN200880111701A Pending CN101873857A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
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| CN201610055826.7A Pending CN105687199A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
| CN200880111701A Pending CN101873857A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
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| US8927559B2 (en) | 2010-10-11 | 2015-01-06 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as CRTH2 antagonists |
| AU2012335220B2 (en) | 2011-11-11 | 2017-06-01 | Pfizer Inc. | 2-thiopyrimidinones |
| US9422280B2 (en) * | 2012-03-29 | 2016-08-23 | Basf Se | N-substituted hetero-bicyclic compounds and derivatives for combating animal pests II |
| US9616063B2 (en) | 2014-12-01 | 2017-04-11 | Astrazeneca Ab | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase |
| SG11201708407TA (en) | 2015-05-05 | 2017-11-29 | Pfizer | 2-thiopyrimidinones |
| CN111182898B (zh) * | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| SG11202000086PA (en) * | 2017-07-17 | 2020-02-27 | Astrazeneca Ab | Mpo inhibitors for use in medicine |
| KR20220080133A (ko) * | 2019-10-10 | 2022-06-14 | 바이오하벤 테라퓨틱스 리미티드 | 골수퍼옥시다제 저해제의 전구약물 |
| MX2022010902A (es) * | 2020-03-05 | 2022-10-07 | Biohaven Therapeutics Ltd | Metodo para tratar la esclerosis lateral amiotrofica con un inhibidor de la mieloperoxidasa. |
| CA3181917A1 (en) * | 2020-05-06 | 2021-11-11 | Biohaven Therapeutics Ltd. | Process for the preparation of verdiperstat |
| CN115403584B (zh) * | 2021-05-26 | 2024-04-02 | 长春金赛药业有限责任公司 | 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用 |
| TW202426450A (zh) | 2022-08-18 | 2024-07-01 | 瑞典商阿斯特捷利康公司 | 髓過氧化物酶抑制劑 |
| CN119789849A (zh) * | 2022-08-31 | 2025-04-08 | 阿斯利康(瑞典)有限公司 | 药物制剂 |
| CN120265633A (zh) * | 2022-12-09 | 2025-07-04 | 深圳信立泰药业股份有限公司 | 一种吡咯并[3,2-d]嘧啶-4-酮类衍生物及其制备方法和医药用途 |
| WO2024163892A1 (en) * | 2023-02-02 | 2024-08-08 | University Of Virginia Patent Foundation | Myeloperoxidase (mpo) inhibition as a treatment target for delayed cerebral injury (dci) in aneurysmal subarachnoid hemorrhage (sah) |
| WO2025172474A1 (en) | 2024-02-15 | 2025-08-21 | Astrazeneca Ab | Inhibitors of myeloperoxidase |
| WO2025190901A1 (en) | 2024-03-13 | 2025-09-18 | Institut National de la Santé et de la Recherche Médicale | Use of myeloperoxidase (mpo) inhibitors for promoting cd8+ t cell responses |
| CN121378265B (zh) * | 2025-10-30 | 2026-07-24 | 乐平市康鑫医药化工有限公司 | 一种吡唑类化合物及其制备方法和用途 |
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| ES2716404T3 (es) * | 2002-01-28 | 2019-06-12 | Kyowa Hakko Kogyo Kk | Antagonistas de receptores A2A para su uso en el tratamiento de trastornos del movimiento |
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| AR066936A1 (es) * | 2007-06-13 | 2009-09-23 | Astrazeneca Ab | 3 - (2r - tetrahidrofuril - metil) - 2 - tioxantina. composiciones farmaceuticas. |
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| WO2006062465A1 (en) * | 2004-12-06 | 2006-06-15 | Astrazeneca Ab | Novel pyrrolo [3, 2-d] pyrimidin-4-one derivatives and their use in therapy |
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| DONG-KUG CHOI: "Ablation of the Inflammatory Enzyme Myeloperoxidase Mitigates mitigates Features of Parkinson’s Disease in Mice", THE JOURNAL OF NEUROSCIENCE, vol. 25, no. 28, 13 July 2005 (2005-07-13), pages 6594, XP002596179, DOI: 10.1523/JNEUROSCI.0970-05-2005 * |
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