CN113615785A - Polygala japonica apple juice beverage formula capable of improving sleep quality and preparation method thereof - Google Patents
Polygala japonica apple juice beverage formula capable of improving sleep quality and preparation method thereof Download PDFInfo
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- 241001638289 Polygala japonica Species 0.000 title description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims abstract description 28
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- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
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- A23L2/52—Adding ingredients
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract
The invention relates to a beverage formula of forgetful apple juice for improving sleep quality and a preparation method thereof, wherein the beverage formula comprises the following raw materials in parts by weight: 80-120 parts of gamma-aminobutyric acid, 400-600 parts of spina date seed, 150-250 parts of poria cocos, 400-600 parts of nepenthes, 30-60 parts of mimosa pudica and 800-1200 parts of apple concentrated juice.
Description
Technical Field
The invention relates to the technical field of apple juice beverage preparation, and particularly relates to a forgetfulness apple juice beverage formula for improving sleep quality and a preparation method thereof.
Background
1/3 hours of life are spent in sleep, which is a necessary process for life, is an important link for body recovery, integration and memory consolidation, and is an indispensable component for health. According to the world health organization survey, over 27% of people have sleep problems. With the continuous development of society, the pressure of people on work and life is gradually increased, and a large number of insomnia people appear, which are manifested by insomnia, dreaminess, amnesia, headache and the like. A questionnaire survey of ten thousand people on a world sleeping day shows that 45% of the nations have varying degrees of sleep disturbance.
With the increasing of various pressures of the modern society, the number of insomnia patients is on the rise. Has become a refractory disease of more global concern. Modern medicine for treating insomnia generally adopts sedative hypnotic drugs for treatment, but because the drugs have a plurality of adverse reactions, the drugs are easy to generate drug resistance and dependence after long-term administration, and the liver and kidney functions are damaged.
According to the traditional Chinese medicine, insomnia mostly occurs due to disharmony of viscera, qi-blood disharmony is caused, the viscera is regulated, qi-blood harmonization and yin-yang balance are realized, the viscera functions are normally treated as the treatment principle of the disease, and insomnia mostly occurs due to emotional damage, improper diet, work and rest disorder, weak constitution caused by long-term illness and the like, so that viscera dysfunction, nutrition and defense disharmony, yin-yang disharmony and yang failing to enter yin are caused. The location of the disease is mainly in the heart and is usually related to the liver, spleen, stomach, kidney and other viscera. The normal operation of yin and yang of ying and wei is the basis for ensuring the heart spirit to regulate the normal sleep of human body. The location of insomnia is in the heart, but is related to the normal functional activities of the liver, spleen, stomach and kidney. Therefore, the key to the physical and mental health of people is to correct sleep disorders in time and ensure normal and high-quality sleep of modern people.
Disclosure of Invention
The invention aims to provide a forgetfulness apple juice beverage formula for improving sleep quality and a preparation method thereof, which are used for improving sleep quality.
In order to achieve the purpose, the invention adopts the following technical scheme: the beverage formula of the forgetful apple juice for improving sleep quality comprises the following raw materials in parts by weight: 80-120 parts of gamma-aminobutyric acid, 400-600 parts of spina date seeds, 150-250 parts of poria cocos, 400-600 parts of nepenthes, 30-60 parts of mimosa and 800-1200 parts of apple concentrated juice.
Further preferably, the formula of the forgetful apple juice beverage for improving sleep quality comprises the following raw materials in parts by weight: 100 parts of gamma-aminobutyric acid, 500 parts of spina date seeds, 200 parts of poria cocos, 500 parts of forgetmenot-go, 50 parts of mimosa pudica and 1000 parts of apple condensed juice.
A preparation method of an apple juice beverage for improving sleep quality comprises the following steps:
s1: preparing raw materials: drying and pulverizing herba Ecliptae, herba Mimosae Pudicae, semen Ziziphi Spinosae and Poria respectively; and stir-frying the crushed spina date seeds for 3-5 minutes by slow fire for later use;
s2: water extraction: decocting the forgetfule roots, the sensitive plants, the spina date seeds and the poria cocos prepared in the step S1 for two times respectively, and then mixing all the residues for the third time; filtering the solution obtained by the three times of decoction and mixing;
s3: ultrasonic centrifugation: carrying out ultrasonic treatment on the mixed liquor in the S2, then filtering, and centrifuging the clear liquor;
s4: concentration: concentrating the centrifuged supernatant in S3 to obtain a water extract;
s5: alcohol precipitation: adding ethanol into the water extract in the S4, standing, and filtering the supernatant after standing;
s6: and (3) concentrating under reduced pressure: concentrating the filtrate obtained in the step S5 to obtain a concentrated solution;
s7: preparing materials: adding gamma-aminobutyric acid and concentrated apple juice into the concentrated solution obtained in the step S6, and then adding water to fix the volume;
s8: filling: subpackaging the mixed solution obtained in S7, sterilizing at high temperature, and packaging.
Further preferably, the first decoction time is 1-3 hours, the second decoction time is 2-3 hours, and the third decoction time is 0.5-2 hours.
Further preferably, the volume of the water added for the second decoction and the third decoction is 20-25 times of the volume of the corresponding filtration dregs.
More preferably, a 180-200 mesh filter screen is adopted for filtering in S3.
More preferably, the ultrasonic frequency in S3 is 20kHz, and the time is 22-26 hours.
More preferably, the concentration temperature in S4 is 70-95 ℃, the pressure is-0.04-0.09 MPa, and the relative density of the water extract is 1.05-1.15 g/L.
Preferably, in the step S5, 65-95% of ethanol is adopted for alcohol precipitation, and the volume ratio of the ethanol to the water extract is 1-6: 1, the alcohol precipitation temperature is 1-35 ℃; and then standing for 72-96 hours at 6-10 ℃.
More preferably, the temperature of the concentration under reduced pressure in S6 is 55 to 85 ℃ and the pressure is 0.04 to 0.09 MPa.
Has the advantages that: the formula of the invention takes the spina date seed, the tuckahoe, the nepenthes (day lily) and the sensitive plant as main raw materials, can nourish heart and liver, calm nerves and arrest sweating, improves the anxiety state of people and improves the sleep quality of people by adding the gamma-aminobutyric acid; meanwhile, the apple condensed juice is added, so that the taste of the product can be improved, various vitamins can be provided, nerves can be relieved, and the sleep can be improved.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below.
Example 1: the beverage formula of the forgetful apple juice for improving sleep quality comprises the following raw materials in parts by weight: 100 parts of gamma-aminobutyric acid, 500 parts of spina date seeds, 200 parts of poria cocos, 500 parts of forgetmenot-go, 50 parts of mimosa pudica and 1000 parts of apple condensed juice.
A preparation method of an apple juice beverage for improving sleep quality comprises the following steps:
s1: preparing raw materials: drying and pulverizing herba Ecliptae, herba Mimosae Pudicae, semen Ziziphi Spinosae and Poria respectively; parching pulverized semen Ziziphi Spinosae with slow fire for 4 min;
s2: decocting: respectively adding water into the nepenthes, the sensitive plants, the spina date seeds and the poria cocos prepared in the step S1 for first decoction, wherein the ratio of the added water to the raw materials is 25:1, and the decoction time is 2 hours; then filtering the mixture, and collecting filtrate; continuously adding water into the residues for second decoction, wherein the ratio of the water to the residues is 15:1, the decoction time is 2.5 hours, then filtering, and collecting the filtrate; and continuously adding water into the dregs for carrying out third decoction, wherein the ratio of the added water to the dregs is 23:1, and the decoction time is 1 hour.
S3: ultrasonic centrifugation: carrying out ultrasonic treatment on the mixed solution in the step S2, wherein the ultrasonic frequency is 20kHz, the ultrasonic time is 24 hours, then filtering by adopting a 190-mesh filter screen, and centrifuging the clear solution;
s4: concentration: concentrating the centrifuged supernatant in S3 at 80 deg.C under 0.02MPa to obtain water extractive solution with relative density of 1.1 g/L;
s5: alcohol precipitation: adding 75% ethanol into the water extract in the S4 for alcohol precipitation, wherein the volume ratio of the ethanol to the water extract is 5:1, the alcohol precipitation temperature is 30 ℃; standing at 8 deg.C for 82 hr, and filtering the supernatant;
s6: and (3) concentrating under reduced pressure: concentrating the filtrate obtained in the step S5 to obtain a concentrated solution, wherein the concentration temperature is 70 ℃, and the pressure is 0.02 MPa;
s7: preparing materials: adding gamma-aminobutyric acid and concentrated apple juice into the concentrated solution obtained in the step S6, adding water to a constant volume of 30000 parts, and properly adding a flavoring agent such as glycerol, sorbitol, mannitol and the like to improve the taste of the beverage;
s8: filling: and (4) subpackaging the mixed solution obtained in the step (S7) into glass bottles with 30ml each, carrying out damp-heat sterilization at 115 ℃ for 30 minutes, and finally packaging.
Example 2: the beverage formula of the forgetful apple juice for improving sleep quality comprises the following raw materials in parts by weight: 80 parts of gamma-aminobutyric acid, 400 parts of spina date seeds, 150 parts of poria cocos, 400 parts of forgetmenot-go, 30 parts of mimosa pudica and 800 parts of apple condensed juice.
A preparation method of an apple juice beverage for improving sleep quality comprises the following steps:
s1: preparing raw materials: drying and pulverizing herba Ecliptae, herba Mimosae Pudicae, semen Ziziphi Spinosae and Poria respectively; parching pulverized semen Ziziphi Spinosae with slow fire for 3 min;
s2: decocting: respectively adding water into the nepenthes, the sensitive plants, the spina date seeds and the poria cocos prepared in the step S1 for first decoction, wherein the ratio of the added water to the raw materials is 20:1, and the decoction time is 1 hour; then filtering the mixture, and collecting filtrate; continuously adding water into the dregs for second decoction, wherein the ratio of the added water to the dregs is 10:1, the decoction time is 2 hours, then filtering, and collecting the filtrate; and continuously adding water into the dregs for carrying out third decoction, wherein the ratio of the added water to the dregs is 20:1, and the decoction time is 0.5 hour.
S3: ultrasonic centrifugation: carrying out ultrasonic treatment on the mixed solution in the step S2, wherein the ultrasonic frequency is 20kHz, the ultrasonic time is 22 hours, then filtering by adopting a 180-mesh filter screen, and centrifuging the clear solution;
s4: concentration: concentrating the centrifuged supernatant in S3 at 70 deg.C under-0.04 MPa to obtain water extractive solution with relative density of 1.05 g/L;
s5: alcohol precipitation: adding 65% ethanol into the water extract in the S4 for alcohol precipitation, wherein the volume ratio of the ethanol to the water extract is 3:1, the alcohol precipitation temperature is 20 ℃; standing at 6 deg.C for 72 hr, and filtering the supernatant;
s6: and (3) concentrating under reduced pressure: concentrating the filtrate obtained in the step S5 to obtain a concentrated solution, wherein the concentration temperature is 55 ℃, and the pressure is 0.04 MPa;
s7: preparing materials: adding gamma-aminobutyric acid and concentrated apple juice into the concentrated solution obtained in the step S6, adding water to a constant volume of 30000 parts, and properly adding a flavoring agent such as glycerol, sorbitol, mannitol and the like to improve the taste of the beverage;
s8: filling: and (4) subpackaging the mixed solution obtained in the step (S7) into glass bottles with 30ml each, carrying out damp-heat sterilization at 115 ℃ for 30 minutes, and finally packaging.
Example 3: the beverage formula of the forgetful apple juice for improving sleep quality comprises the following raw materials in parts by weight: 120 parts of gamma-aminobutyric acid, 600 parts of spina date seeds, 250 parts of poria cocos, 600 parts of forgetmenot-go, 60 parts of mimosa pudica and 1200 parts of apple condensed juice.
A preparation method of an apple juice beverage for improving sleep quality comprises the following steps:
s1: preparing raw materials: drying and pulverizing herba Ecliptae, herba Mimosae Pudicae, semen Ziziphi Spinosae and Poria respectively; and stir-frying the crushed spina date seeds for 3-5 minutes by slow fire for later use;
s2: decocting: respectively adding water into the nepenthes, the sensitive plant, the spina date seed and the poria cocos prepared in the step S1 for first decoction, wherein the ratio of the added water to the raw materials is 30:1, and the decoction time is 03 hours; then filtering the mixture, and collecting filtrate; continuously adding water into the dregs of a decoction for second decoction, wherein the ratio of the added water to the dregs of a decoction is 25:1, the decoction time is 3 hours, then filtering, and collecting the filtrate; and continuously adding water into the dregs of a decoction for carrying out third decoction, wherein the ratio of the added water to the dregs of a decoction is 25:1, and the decoction time is 2 hours.
S3: ultrasonic centrifugation: carrying out ultrasonic treatment on the mixed solution in the step S2, wherein the ultrasonic frequency is 20kHz, the ultrasonic time is 26 hours, then filtering by adopting a 200-mesh filter screen, and centrifuging the clear solution;
s4: concentration: concentrating the centrifuged supernatant in S3 at 95 ℃ and 0.09MPa to obtain a water extract with a relative density of 1.15 g/L;
s5: alcohol precipitation: adding 95% ethanol into the water extract in the S4 for alcohol precipitation, wherein the volume ratio of the ethanol to the water extract is 6: 1, the alcohol precipitation temperature is 35 ℃; standing at 10 deg.C for 96 hr, and filtering the supernatant;
s6: and (3) concentrating under reduced pressure: concentrating the filtrate obtained in the step S5 to obtain a concentrated solution, wherein the concentration temperature is 85 ℃ and the pressure is 0.09 MPa;
s7: preparing materials: adding gamma-aminobutyric acid and concentrated apple juice into the concentrated solution obtained in the step S6, adding water to a constant volume of 30000 parts, and properly adding a flavoring agent such as glycerol, sorbitol, mannitol and the like to improve the taste of the beverage;
s8: filling: and (4) subpackaging the mixed solution obtained in the step (S7) into glass bottles with 30ml each, carrying out damp-heat sterilization at 115 ℃ for 30 minutes, and finally packaging.
Test eating test: 70 patients with primary insomnia who met the inclusion criteria were randomized into 35 cases in the experimental group and 35 cases in the control group according to a simple randomized cohort approach. The traditional Chinese medicine diagnosis standard is implemented according to the traditional Chinese medicine disease diagnosis curative effect standard issued by the State administration of traditional Chinese medicine. The Western diagnosis standard refers to the diagnosis standard of insomnia in 3 rd edition ((CCMD232R) of Chinese mental disease classification scheme and diagnosis standard.1 piece (30ml) of the beverage prepared in the example 1 is orally taken by a treatment group, the beverage is taken twice a day and is taken one hour before noon nap and night nap for 2 weeks, the eszolam tablet is orally taken by a control group for 30 minutes before sleep for 30 minutes each time lmg, and is taken 1 time every night, and the observation index is the Pittsburgh Sleep Quality Index (PSQI) scale.
Pittsburgh Sleep Quality Index (PSQI) scale study results: the comparison difference of the total score before treatment of the two groups has no statistical significance (P0.05), and the two groups have comparability. The difference between the total scores before and after treatment of the two groups has significant statistical significance (P0.01), and the two treatment methods are prompted to obviously reduce the score of the PSQI scale. The comparison between the total components of the two groups after treatment also has no statistical significance (P0.05), which indicates that the effects of the two groups are basically equivalent.
The difference in the scores of the two groups before treatment was not statistically significant (P-0.2186), suggesting comparability between the groups; the scores before and after treatment in the two groups are compared, the difference has statistical significance (P0.05), and the two treatment methods are suggested to improve the sleep quality. The scores of the two groups after treatment are counted, and the difference has statistical significance (P is 0.0135), so that the treatment group is prompted to have better sleep quality improving effect.
The difference in scores between the first two groups was not statistically significant (P-0.0507) in terms of time to sleep score, suggesting comparability between groups; the scores before and after treatment in the two groups are compared, and the difference has statistical significance (P0.01), so that the two treatment methods can improve the time for falling asleep. The score difference between the two groups after treatment has significant statistical significance (P is 0.0052), and the treatment group is prompted to have better effect of improving the sleep quality.
The difference in the scores of the two groups before treatment was not statistically significant (P-0.7230), suggesting comparability between the groups; the scores before and after treatment in the two groups are compared, and the difference has statistical significance (P0.01), so that the sleep time can be improved by the two treatment methods. The difference in scores between the two groups after treatment was not statistically significant (P-0.6750), suggesting that the score improved sleep quality was comparable between the two groups.
The difference in the scores of the two groups before treatment was not statistically significant (P-0.5909), suggesting comparability between the groups; the scores before and after treatment in the two groups are compared, and the difference has statistical significance (P0.01), so that the two treatment methods can improve the sleep efficiency. The difference in scores between the two groups after treatment was not statistically significant (P-0.5631), suggesting that the two groups were equally effective.
In terms of sleep disorder scores, the difference in scores between the two groups before treatment was not statistically significant (P ═ 0.0630), suggesting comparability between groups; the scores before and after treatment in the two groups are compared, and the difference has statistical significance (P0.01), so that the two treatment methods can improve the sleep disorder. The difference in scores between the two groups after treatment was not statistically significant (P-0.6326), suggesting that the two groups had comparable sleep disorder-improving effects.
The difference in scores between the first two groups was not statistically significant (P-0.5579) in daytime dysfunction scores, suggesting comparability between groups; the scores before and after treatment in the two groups are compared, and the difference has statistical significance (P0.01), so that the two treatment methods can improve the daytime dysfunction. The difference in scores between the two groups after treatment was not statistically significant (P ═ 0.0182), suggesting that the treatment group had a better effect in improving daytime dysfunction.
As can be seen from the above, the difference of each score of the sleep quality, the sleep time, the sleep efficiency, the sleep disorder, the daytime dysfunction and the like before the treatment of the two groups has no statistical significance. After the two groups of treatment, scores of sleep quality, sleep time, sleep efficiency, sleep disorder, daytime dysfunction and the like are reduced, and the difference has statistical significance, so that the two treatment schemes can improve the sleep condition of patients, and the effects are basically the same. The comparison among the groups shows that the treatment group is superior to the control group in the aspects of sleep quality, sleep time and daytime dysfunction score, and compared with the oral eszolam tablet, the drink of the invention has obvious effect on improving the sleep quality.
The apple juice drinks prepared in the embodiments 2 and 3 have similar effects to the apple juice drink prepared in the embodiment 1, and have significant effects on improving sleep, and the details are not repeated here.
The present invention is not limited to the above-mentioned preferred embodiments, and any other products in various forms can be obtained by anyone in the light of the present invention, but any changes in the shape or structure thereof, which have the same or similar technical solutions as those of the present application, fall within the protection scope of the present invention.
Claims (10)
1. The beverage formula of the forgetful apple juice for improving sleep quality is characterized in that: the material comprises the following raw materials in parts by weight: 80-120 parts of gamma-aminobutyric acid, 400-600 parts of spina date seeds, 150-250 parts of poria cocos, 400-600 parts of nepenthes, 30-60 parts of mimosa and 800-1200 parts of apple concentrated juice.
2. The beverage formula of forgetfulness apple juice for improving sleep quality as claimed in claim 1, is characterized in that: the material comprises the following raw materials in parts by weight: 100 parts of gamma-aminobutyric acid, 500 parts of spina date seeds, 200 parts of poria cocos, 500 parts of forgetmenot-go, 50 parts of mimosa pudica and 1000 parts of apple condensed juice.
3. A preparation method of a forgetful apple juice beverage for improving sleep quality is characterized by comprising the following steps: the method comprises the following steps:
s1: preparing raw materials: drying and pulverizing herba Ecliptae, herba Mimosae Pudicae, semen Ziziphi Spinosae and Poria respectively; and stir-frying the crushed spina date seeds for 3-5 minutes by slow fire for later use;
s2: water extraction: decocting the forgetfule roots, the sensitive plants, the spina date seeds and the poria cocos prepared in the step S1 for two times respectively, and then mixing all the residues for the third time; filtering the solution obtained by the three times of decoction and mixing;
s3: ultrasonic centrifugation: carrying out ultrasonic treatment on the mixed liquor in the S2, then filtering, and centrifuging the clear liquor;
s4: concentration: concentrating the centrifuged supernatant in S3 to obtain a water extract;
s5: alcohol precipitation: adding ethanol into the water extract in the S4, standing, and filtering the supernatant after standing;
s6: and (3) concentrating under reduced pressure: concentrating the filtrate obtained in the step S5 to obtain a concentrated solution;
s7: preparing materials: adding gamma-aminobutyric acid and concentrated apple juice into the concentrated solution obtained in the step S6, and then adding water to fix the volume;
s8: filling: subpackaging the mixed solution obtained in S7, performing moist heat sterilization, and finally packaging.
4. The preparation method of the forgetfulness apple juice beverage for improving sleep quality as claimed in claim 3, is characterized in that: the first decoction time is 1-3 hours, the second decoction time is 2-3 hours, and the third decoction time is 0.5-2 hours.
5. The preparation method of the forgetfulness apple juice beverage for improving sleep quality as claimed in claim 4, is characterized in that: the volume of water added for the first decoction is 20-30 times of the volume of the corresponding raw materials; the volume of water added for the second decoction is 10-20 times of the volume of the corresponding filtered decoction dregs; the volume of water added for the third decoction is 20-25 times of the volume of the corresponding filtered decoction dregs.
6. The preparation method of the forgetfulness apple juice beverage for improving sleep quality as claimed in claim 3, is characterized in that: in S3, the ultrasonic frequency is 20kHz, and the ultrasonic time is 22-26 hours.
7. The preparation method of the forgetfulness apple juice beverage for improving sleep quality as claimed in claim 3, is characterized in that: in S3, a 180-200 mesh filter screen is adopted for filtering.
8. The preparation method of the forgetfulness apple juice beverage for improving sleep quality as claimed in claim 3, is characterized in that: in the S4, the concentration temperature is 70-95 ℃, the pressure is-0.04-0.09 MPa, and the relative density of the water extract is 1.05-1.15 g/L.
9. The preparation method of the forgetfulness apple juice beverage for improving sleep quality as claimed in claim 3, is characterized in that: s5, ethanol precipitation is carried out by adopting 65-95% ethanol, and the volume ratio of ethanol to water extract is 3-6: 1, the alcohol precipitation temperature is 20-35 ℃; and then standing for 72-96 hours at 6-10 ℃.
10. The preparation method of the forgetfulness apple juice beverage for improving sleep quality as claimed in claim 3, is characterized in that: the temperature of the reduced pressure concentration in S6 is 55-85 ℃, and the pressure is-0.04-0.09 MPa.
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| CN114304448A (en) * | 2022-01-28 | 2022-04-12 | 广州市诺品健康科技有限公司 | Sleep-aiding beverage and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109430866A (en) * | 2018-10-31 | 2019-03-08 | 吉林省恒实传食品科技发展有限公司 | A kind of tranquilizing and allaying excitement improves health care's food formula and preparation method thereof of sleep quality |
| CN112167476A (en) * | 2020-09-30 | 2021-01-05 | 黑龙江北草堂中药材有限责任公司 | Composition and beverage for improving sleep and preparation method |
| CN113017093A (en) * | 2021-04-13 | 2021-06-25 | 上海同济生物制品有限公司 | Composition with functions of maintaining beauty, keeping young and helping sleep and preparation method thereof |
-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109430866A (en) * | 2018-10-31 | 2019-03-08 | 吉林省恒实传食品科技发展有限公司 | A kind of tranquilizing and allaying excitement improves health care's food formula and preparation method thereof of sleep quality |
| CN112167476A (en) * | 2020-09-30 | 2021-01-05 | 黑龙江北草堂中药材有限责任公司 | Composition and beverage for improving sleep and preparation method |
| CN113017093A (en) * | 2021-04-13 | 2021-06-25 | 上海同济生物制品有限公司 | Composition with functions of maintaining beauty, keeping young and helping sleep and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 刘艳骄;刘征宇;: "睡眠食物与保健食品中调整睡眠产品研发概述" * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114304448A (en) * | 2022-01-28 | 2022-04-12 | 广州市诺品健康科技有限公司 | Sleep-aiding beverage and preparation method thereof |
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