CN113575948B - Lycopene soft capsule and preparation method and application thereof - Google Patents

Lycopene soft capsule and preparation method and application thereof Download PDF

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CN113575948B
CN113575948B CN202110889600.8A CN202110889600A CN113575948B CN 113575948 B CN113575948 B CN 113575948B CN 202110889600 A CN202110889600 A CN 202110889600A CN 113575948 B CN113575948 B CN 113575948B
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lycopene
soft capsule
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preparation
content
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CN113575948A (en
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那立欣
张静怡
曲春波
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Shanghai University of Medicine and Health Sciences
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3481—Organic compounds containing oxygen
    • A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation

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Abstract

The invention relates to the technical field of health products, in particular to a lycopene soft capsule, a preparation method and application thereof, wherein the lycopene soft capsule comprises lycopene, vegetable oil and suspending agent as raw materials, and glycerol, gelatin, polyethylene glycol and preservative as raw materials of a soft capsule shell. According to the invention, the vegetable oil is used as a dispersion medium of lycopene and is used as a content to prepare the lycopene soft capsule, so that lycopene is prevented from contacting with the external environment in the storage process, the lycopene is prevented from being oxidized and decomposed, the stability of the lycopene is improved, a certain slow release effect is achieved after the lycopene is taken, and the lycopene is prevented from being decomposed and invalid in the gastric acid environment after the lycopene is taken.

Description

Lycopene soft capsule and preparation method and application thereof
Technical Field
The invention relates to the technical field of health products, in particular to a lycopene soft capsule and a preparation method and application thereof.
Background
Lycopene (lycopene) is a fat-soluble unsaturated hydrocarbon, is a carotenoid, and has a molecular formula of C 40 H 56 The relative molecular mass is 536.85, the melting point is 174 ℃ (trans), and the beta-carotene is an isomer. Lycopene is an intermediate in the biosynthesis of many carotenoids, which can form other carotenoids upon cyclization, but cannot be synthesized in animals and can only be taken up from food. Lycopene is an open chain unsaturated carotenoid, has various physiological functions of resisting oxidation, resisting cancer, enhancing human immunity, preventing cardiovascular diseases, preventing osteoporosis, protecting liver, resisting ultraviolet radiation, promoting intercellular communication, inhibiting LDL-cholesterol oxide formation, reducing damage to lymphocyte DNA in vivo caused by peroxidation, regulating and controlling tumor proliferation, activating immune cells and the like, so that the commercial value of lycopene is more and more paid attention to.
The capacity of the antioxidant activity of lycopene is attributed to the fact that lycopene has a plurality of conjugated double bond structures on the same plane, but lycopene is easily oxidized and decomposed due to the existence of unsaturated double bonds, is very sensitive to light, oxygen, heat, acid and the like in the storage processing process, and meanwhile, the lycopene is a fat-soluble substance, is poor in solubility in water, so that the commercial application of lycopene is greatly limited.
Disclosure of Invention
In order to solve the problems, the invention provides a lycopene soft capsule, and a preparation method and application thereof. Lycopene is used as the content of the soft capsule, and the shell material is coated to isolate the lycopene from the external environment, so that the lycopene is prevented from being influenced by light, oxygen, heat, acid and other environments, and the stability of the lycopene is improved.
According to one of the technical schemes of the invention, the lycopene soft capsule comprises, by mass, 10-15 parts of lycopene, 50-75 parts of vegetable oil and 0.2-0.5 part of suspending agent, and the soft capsule shell comprises 5-10 parts of glycerin, 10-20 parts of gelatin, 1-3 parts of polyethylene glycol and 0.01-0.03 part of preservative.
Lycopene is a fat-soluble substance and is insoluble in water, so that the raw material of the soft capsule content takes vegetable oil as a dispersion medium of lycopene, on one hand, the digestion and the absorption of a human body are facilitated, and on the other hand, the fluidity and the uniformity of lycopene are improved, and meanwhile, in order to ensure the problems of sinking and uneven distribution of the material in the filling preparation process, a proper amount of suspending agent is required to be added to improve the dispersity of lycopene in the capsule content.
Further, the vegetable oil is a vegetable oil containing medium chain fatty acid, the suspending agent is beeswax, and the preservative is ethylparaben.
The vegetable oil containing the medium-chain fatty acid is selected, the medium-chain fatty acid molecules are smaller than the long-chain fatty molecules of other foods, the medium-chain fatty acid is easy to digest and absorb by human bodies, and the liver is more prone to using the medium-chain fatty acid as a fuel source for energy production, so that the metabolism efficiency is improved, and the vegetable oil containing the medium-chain fatty acid can promote the absorption effect of lycopene and synergistically promote the lycopene to exert the antioxidant activity. The soft capsule shell raw material contains a proper amount of preservative, so that the antibacterial and antiseptic effects can be very good, and the storage stability of the soft capsule is improved.
Further, the vegetable oil is coconut oil; coconut oil is the only fat composed of medium-chain fatty acid in our daily food, and saturated fatty acid which is rich in the coconut oil also plays a role of an antioxidant, and the coconut oil synergistically promotes lycopene to exert the health-care effect.
Further, the lycopene is prepared by adopting a supercritical fluid extraction technology, and the specific method comprises the following steps: mixing the crude tomato red powder with hexane (mass volume ratio of 1g:2 mL) to form a homogeneous mixed system, dissolving pigment in the raw materials from hexane, performing supercritical carbon dioxide extraction at 35-50deg.C under 10-15MPa and carbon dioxide flow rate of 10-15L/h, and recovering pigment by decompression method to obtain refined lycopene. The method can obtain lycopene with a content of more than 90%, and the lycopene subjected to supercritical extraction has no odor and solvent residue, and can retain lycopene activity to the maximum extent.
The invention also provides a preparation method of the lycopene soft capsule, which comprises the following steps:
preparation of the soft capsule contents: placing lycopene in vegetable oil, dispersing uniformly, adding suspending agent, homogenizing under high pressure to obtain soft capsule content;
preparation of a soft capsule shell: sequentially adding glycerol, gelatin and polyethylene glycol into hot water, mixing, adding antiseptic, mixing, and vacuum degassing to obtain latex;
and pressing and shaping the soft capsule content and the latex, and drying to obtain the lycopene soft capsule.
Further, in the lycopene soft capsule, the content raw materials of the soft capsule also comprise 50-75 parts of vegetable protein and 1-3 parts of emulsifying agent.
Further, the vegetable protein is selected from soy protein isolate and/or walnut protein isolate; the emulsifier is one or more selected from soybean phospholipid, tween 20, poloxamer 188, span 80, tween 80, glyceryl monostearate, glyceryl distearate, polyoxyethylene castor oil, span 20 and polyglyceryl fatty acid ester.
The preparation method of the lycopene soft capsule comprises the following steps:
preparation of the soft capsule contents:
adding water into vegetable protein, mixing to obtain vegetable protein solution, adjusting pH to 9-10, adding emulsifier, and homogenizing to obtain emulsion;
placing lycopene in vegetable oil, dispersing uniformly, adding suspending agent, homogenizing under high pressure to obtain homogeneous solution;
adding the homogeneous liquid drop into the emulsion under high-speed stirring to obtain soft capsule content;
preparation of a soft capsule shell: sequentially adding glycerol, gelatin and polyethylene glycol into hot water, mixing, adding antiseptic, mixing, and vacuum degassing to obtain latex;
and pressing and shaping the soft capsule content and the latex, and drying to obtain the lycopene soft capsule.
The illumination is a key factor affecting the stability of lycopene, even if the lycopene is prepared into a soft capsule, the lycopene is inevitably influenced by the illumination, in order to further improve the stability of the lycopene soft capsule, vegetable protein is added into the soft capsule content as a raw material, water and an emulsifying agent are added into the soft capsule content to prepare a uniform aqueous emulsion, and then the oil phase homogeneous liquid containing lycopene obtained through high-pressure homogenization is dripped into the aqueous emulsion under the condition of high-speed stirring, so that an oil-in-water solution system of the vegetable protein aqueous phase for coating the lycopene oil phase is formed, and the oil phase is taken as the soft capsule content to prepare a soft capsule product.
On the other hand, in the soft capsule content, although the phenomenon of sedimentation and uneven distribution of materials can be avoided, the technical problems of unsmooth discharging and unstable filling amount are caused by the increase of the viscosity of the content, and the technical problems of adverse encapsulation due to the increase of the viscosity of the content are well solved by adding vegetable protein and emulsifying agent into the raw materials to prepare the soft capsule content of an oil-in-water system, so that the uniformity of the content of active ingredients in the soft capsule is improved.
Further, in the preparation method of the lycopene soft capsule, the preparation process of the content of the soft capsule is carried out at 50-60 ℃.
Further, in the preparation method of the lycopene soft capsule, in the preparation process of the soft capsule shell: the temperature of the hot water is 60-70 ℃, the degassing time is 20-30min, and the mass ratio of the hot water to the gelatin is 1-1.5:1.
The temperature of hot water is too low, so that capsule shell components such as glycerol and the like can not be well fused together, the gelatin components can be destroyed when the temperature is too high, the final film forming performance is affected, the latex water content is reduced due to the same overlong degassing time, the shell making effect is affected, the time is too short, and bubbles are not completely removed, so that micropore defects are generated in the soft capsule.
Further, in the preparation method of the lycopene soft capsule, the mass fraction of the vegetable protein in the vegetable protein solution is 20-35%.
The mass fraction of vegetable proteins in the vegetable protein solution is a key factor affecting the oil-in-water system, and too high or too low is detrimental to the formation of an oil-in-water stabilizing system, thereby affecting the stability of the final soft capsule.
The invention also provides application of the lycopene soft capsule in preparing an anti-aging health care product, an immunity-improving health care product or a cardiovascular health care product.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the vegetable oil is used as a dispersion medium of lycopene and is used as a content to prepare the lycopene soft capsule, so that lycopene is prevented from contacting with the external environment in the storage process, the lycopene is prevented from being oxidized and decomposed, the stability of the lycopene is improved, a certain slow release effect is achieved after the lycopene is taken, and the lycopene is prevented from being decomposed and invalid in the gastric acid environment after the lycopene is taken.
Detailed Description
Various exemplary embodiments of the invention will now be described in detail, which should not be considered as limiting the invention, but rather as more detailed descriptions of certain aspects, features and embodiments of the invention.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. In addition, for numerical ranges in this disclosure, it is understood that each intermediate value between the upper and lower limits of the ranges is also specifically disclosed. Every smaller range between any stated value or stated range, and any other stated value or intermediate value within the stated range, is also encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference for the purpose of disclosing and describing the methods and/or materials associated with the documents. In case of conflict with any incorporated document, the present specification will control.
It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the invention described herein without departing from the scope or spirit of the invention. Other embodiments will be apparent to those skilled in the art from consideration of the specification of the present invention. The specification and examples of the present invention are exemplary only.
As used herein, the terms "comprising," "including," "having," "containing," and the like are intended to be inclusive and mean an inclusion, but not limited to.
In the following embodiments of the present invention, the lycopene is prepared by using a supercritical fluid extraction technology, and the specific method comprises: mixing the crude red tomato powder with hexane (mass volume ratio of 1g:2 mL) to form a homogeneous mixture, dissolving pigment in the raw material from hexane, performing supercritical carbon dioxide extraction at 45deg.C under 10MPa and carbon dioxide flow rate of 10L/h, and recovering pigment by decompression method to obtain refined lycopene (content 13.7%). The preservative is ethyl hydroxy benzoate.
Example 1
(1) The soft capsule comprises the following raw materials: 15 parts of lycopene, 50 parts of coconut oil and 0.5 part of beeswax; soft capsule shell raw material: 10 parts of glycerin, 20 parts of gelatin, 2 parts of polyethylene glycol and 0.02 part of preservative.
(2) Preparation of the soft capsule contents: dispersing lycopene in oleum Cocois (55deg.C), adding Cera flava, and homogenizing under high pressure to obtain soft capsule content;
preparation of a soft capsule shell: sequentially adding glycerol, gelatin and polyethylene glycol into hot water (20 parts) at 70 ℃ to mix uniformly, adding preservative to mix uniformly, and vacuum degassing for 30min to obtain latex;
transferring the soft capsule content and latex into a pressing machine, pressing and shaping (ambient temperature 20+ -2deg.C, humidity 45+ -5%), drying (ambient temperature 25+ -2deg.C, humidity less than 40%, air supply humidity 20%, air supply volume 10 m) 3 And (3) drying to obtain capsule shells with the water content of 8-9% by mass, and picking up pills (removing abnormal capsules) to obtain lycopene soft capsules (the specification is that each capsule contains 500mg of content).
Example 2
(1) The soft capsule comprises the following raw materials: lycopene 10 parts, coconut oil 75 parts and beeswax 0.2 parts, and the soft capsule shell raw materials are as follows: 5 parts of glycerin, 10 parts of gelatin, 1 part of polyethylene glycol and 0.01 part of preservative.
(2) Preparation of the soft capsule contents: dispersing lycopene in oleum Cocois (60 deg.C), adding Cera flava, and homogenizing under high pressure to obtain soft capsule content;
preparation of a soft capsule shell: sequentially adding glycerin, gelatin and polyethylene glycol into hot water (15 parts) at 60 ℃ to uniformly mix, adding a preservative to uniformly mix, and vacuum degassing for 30min to obtain latex;
transferring the soft capsule content and latex into a pressing machine, pressing and shaping (ambient temperature 20+ -2deg.C, humidity 45+ -5%), drying (ambient temperature 25+ -2deg.C, humidity less than 40%, air supply humidity 20%, air supply volume 10 m) 3 And (3) drying to obtain capsule shell with water content of 8-9% and picking up pill (removing abnormal capsule) to obtain the final productSoft capsule of lycopene (specification is that each soft capsule contains 500mg of content).
Example 3
(1) The soft capsule comprises the following raw materials: 12 parts of lycopene, 60 parts of coconut oil and 0.4 part of beeswax, and the shell material of the soft capsule: 8 parts of glycerin, 15 parts of gelatin, 1 part of polyethylene glycol and 0.03 part of preservative.
(2) Preparation of the soft capsule contents: dispersing lycopene in oleum Cocois (50deg.C), adding Cera flava, and homogenizing under high pressure to obtain soft capsule content;
preparation of a soft capsule shell: sequentially adding glycerol, gelatin and polyethylene glycol into hot water (15 parts) at 65 ℃ to mix uniformly, adding preservative to mix uniformly, and vacuum degassing for 30min to obtain latex;
transferring the soft capsule content and latex into a pressing machine, pressing and shaping (ambient temperature 20+ -2deg.C, humidity 45+ -5%), drying (ambient temperature 25+ -2deg.C, humidity less than 40%, air supply humidity 20%, air supply volume 10 m) 3 And (3) drying to obtain capsule shells with the water content of 8-9% by mass, and picking up pills (removing abnormal capsules) to obtain lycopene soft capsules (the specification is that each capsule contains 500mg of content).
Example 4
(1) The soft capsule comprises the following raw materials: 15 parts of lycopene, 50 parts of coconut oil, 0.5 part of beeswax, 50 parts of soy protein isolate, 2 parts of emulsifier (glycerol monostearate) and raw materials of soft capsule shells: 10 parts of glycerin, 20 parts of gelatin, 2 parts of polyethylene glycol and 0.02 part of preservative.
(2) Preparation of the soft capsule contents: at 50 ℃, adding water into the soy protein isolate, uniformly mixing to prepare a soy protein isolate solution with the mass fraction of 30%, adding ammonia water to adjust the pH value to 10, adding glycerol monostearate, and homogenizing to obtain an emulsion; dispersing lycopene in oleum Cocois (55deg.C), adding Cera flava, and homogenizing under high pressure to obtain homogeneous solution; dropwise adding the homogeneous solution into the emulsion under high-speed stirring at 1500rpm, and stirring at 1000rpm for 30min to obtain soft capsule content;
preparation of a soft capsule shell: sequentially adding glycerol, gelatin and polyethylene glycol into hot water (20 parts) at 70 ℃ to mix uniformly, adding preservative to mix uniformly, and vacuum degassing for 30min to obtain latex;
transferring the soft capsule content and latex into a pressing machine, pressing and shaping (ambient temperature 20+ -2deg.C, humidity 45+ -5%), drying (ambient temperature 25+ -2deg.C, humidity less than 40%, air supply humidity 20%, air supply volume 10 m) 3 And (3) drying to obtain capsule shells with the water content of 8-9% by mass, and picking up pills (removing abnormal capsules) to obtain lycopene soft capsules (the specification is that each capsule contains 500mg of content).
Example 5
(1) The soft capsule comprises the following raw materials: 15 parts of lycopene, 50 parts of coconut oil, 0.5 part of beeswax, 75 parts of walnut protein isolate, 3 parts of emulsifier (glycerol monostearate) and raw materials of soft capsule shells: 10 parts of glycerin, 20 parts of gelatin, 2 parts of polyethylene glycol and 0.02 part of preservative.
(2) Preparation of the soft capsule contents: at 50 ℃, adding water into the walnut protein isolate, uniformly mixing to prepare a walnut protein isolate solution with the mass fraction of 25%, adding ammonia water to adjust the pH value to 10, adding glycerol monostearate, and homogenizing to obtain emulsion; dispersing lycopene in oleum Cocois (55deg.C), adding Cera flava, and homogenizing under high pressure to obtain homogeneous solution; dropwise adding the homogeneous solution into the emulsion under high-speed stirring at 1800rpm, and stirring at 1200rpm for 30min after the completion of dropwise adding to obtain soft capsule content;
preparation of a soft capsule shell: sequentially adding glycerol, gelatin and polyethylene glycol into hot water (20 parts) at 70 ℃ to mix uniformly, adding preservative to mix uniformly, and vacuum degassing for 30min to obtain latex;
transferring the soft capsule content and latex into a pressing machine, pressing and shaping (ambient temperature 20+ -2deg.C, humidity 45+ -5%), drying (ambient temperature 25+ -2deg.C, humidity less than 40%, air supply humidity 20%, air supply volume 10 m) 3 And (3) drying to obtain capsule shells with the water content of 8-9% by mass, and picking up pills (removing abnormal capsules) to obtain lycopene soft capsules (the specification is that each capsule contains 500mg of content).
Effect verification example 1
The soft capsules prepared in examples 1 to 5 were randomly selected for 50 capsules, and the content quality was measured, and the results are shown in Table 1;
TABLE 1
Example 1 Example 2 Example 3 Example 4 Example 5
500±10mg 33 granules 25 granules 29 granules 45 granules 44 granules
500±20mg 9 granules 10 granules 8 granules of 1 granule 1 granule
500±30mg 3 granules 7 grains 5 granules 1 granule 2 granules
500±40mg 4 granules 6 granules 5 granules 2 granules 1 granule
500±50mg 1 granule 2 granules 3 granules 1 granule 2 granules
As can be seen from the data in Table 1, the deviation rates of the soft capsules prepared in examples 4-5 were significantly lower than those of examples 1-3, indicating that the preparation of the oil-in-water emulsion soft capsule contents greatly improved the uniformity of the soft capsule packaging.
Effect verification example 2
The lycopene tablets sold on the market and the lycopene soft capsules prepared in the examples 1-5 of the invention are respectively evaluated on the color and the stability after being placed for 3 months under the light-shielding condition of 30+/-2 ℃ and 40+/-5% of relative humidity, wherein the color and the stability are the visual index results shown in Table 2;
TABLE 2
Tablet formulation Example 1 Example 2 Example 3 Example 4 Example 5
Color Obvious fading Unchanged Unchanged Unchanged Unchanged Unchanged
Layering —— Non-layering Non-layering Non-layering Non-layering Non-layering
The results in Table 2 show that lycopene can be prepared into soft capsule preparation to avoid lycopene decomposition failure caused by influence of ambient temperature, humidity and oxygen, and improve lycopene stability.
Effect verification example 3
(1) Influence of light on stability of lycopene soft capsules:
the lycopene tablet sold in the market with equal quality and the lycopene soft capsule prepared in the embodiment 1-5 of the invention are respectively weighed, placed in a polyethylene bag, vacuum-packed, placed in a place where sunlight is directly irradiated for 28d, and then measured for lycopene content by using high performance liquid chromatography (related contents are not described in detail in the prior art), and the lycopene preservation rate is calculated according to a lycopene preservation rate calculation formula:
lycopene retention w=c 1 /C 0 ×100％；
Wherein C is 0 C for lycopene content (μg/mL) in the starting sample 1 The lycopene content (μg/mL) in the sample at the end of the storage time.
The measurement results are shown in Table 3;
TABLE 3 Table 3
Tablet formulation Example 1 Example 2 Example 3 Example 4 Example 5
W 52％ 75％ 77％ 72％ 88％ 85％
As can be seen from the data in Table 3, the soft capsules treated in examples 4-5 were best in light stability.
(2) Influence of oxygen on stability of lycopene soft capsules:
the lycopene tablet sold in the market with equal quality and the lycopene soft capsule prepared in the embodiment 1-5 of the invention are respectively weighed, the lycopene soft capsule is protected from light at normal temperature, the lycopene content is measured by using high performance liquid chromatography after being sampled after being exposed to the air for 28 days (the related content is the prior art and is not repeated here), and the lycopene preservation rate is calculated according to a lycopene preservation rate calculation formula:
lycopene retention w=c 1 /C 0 ×100％；
Wherein C is 0 C for lycopene content (μg/mL) in the starting sample 1 The lycopene content (μg/mL) in the sample at the end of the storage time.
The measurement results are shown in Table 4;
TABLE 4 Table 4
Tablet formulation Example 1 Example 2 Example 3 Example 4 Example 5
W 62％ 85％ 82％ 84％ 88％ 90％
(3) Influence of temperature on stability of lycopene soft capsules:
respectively weighing lycopene tablets sold in the market with equal quality and lycopene soft capsules prepared in the embodiments 1-5 of the invention, placing the lycopene tablets and the lycopene soft capsules in an aluminum foil bag, vacuum-packing, respectively placing the lycopene soft capsules in a temperature of-4 ℃ and a temperature of 30 ℃ and a temperature of 60 ℃ for 28 days, measuring the content of lycopene by using high performance liquid chromatography (related content is not repeated in the prior art), and calculating the lycopene preservation rate according to a lycopene preservation rate calculation formula:
lycopene retention w=c 1 /C 0 ×100％；
Wherein C is 0 C for lycopene content (μg/mL) in the starting sample 1 The lycopene content (μg/mL) in the sample at the end of the storage time.
The measurement results are shown in Table 5;
TABLE 5
Tablet formulation Example 1 Example 2 Example 3 Example 4 Example 5
W(-4℃) 78％ 85％ 88％ 86％ 92％ 93％
W(30℃) 65％ 82％ 81％ 80％ 85％ 86％
W(60℃) 58％ 72％ 74％ 71％ 76％ 78％
The foregoing description of the preferred embodiments of the invention is not intended to limit the invention to the particular embodiments disclosed, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.

Claims (2)

1. A preparation method of lycopene soft capsules is characterized in that,
the soft capsule comprises the following raw materials in parts by weight: 10-15 parts of lycopene, 50-75 parts of vegetable oil, 0.2-0.5 part of suspending agent, 50-75 parts of vegetable protein and 1-3 parts of emulsifying agent; the soft capsule shell comprises the following raw materials: 5-10 parts of glycerol, 10-20 parts of gelatin, 1-3 parts of polyethylene glycol and 0.01-0.03 part of preservative;
the vegetable oil is vegetable oil containing medium-chain fatty acid, the suspending agent is beeswax, and the preservative is ethylparaben;
the plant protein is selected from soybean protein isolate and/or walnut protein isolate; the emulsifier is one or more selected from soybean phospholipid, tween 20, poloxamer 188, span 80, tween 80, glyceryl monostearate, glyceryl distearate, polyoxyethylene castor oil, span 20 and polyglyceryl fatty acid ester;
the preparation of the soft capsule content comprises the following steps:
adding water into vegetable protein, mixing to obtain vegetable protein solution, adjusting pH to 9-10, adding emulsifier, and homogenizing to obtain emulsion;
placing lycopene in vegetable oil, dispersing uniformly, adding suspending agent, homogenizing under high pressure to obtain homogeneous solution;
adding the homogeneous liquid drop into the emulsion under high-speed stirring to obtain soft capsule content;
preparation of a soft capsule shell: sequentially adding glycerol, gelatin and polyethylene glycol into hot water, mixing, adding antiseptic, mixing, and vacuum degassing to obtain latex;
pressing and shaping the soft capsule content and latex, and drying to obtain lycopene soft capsule;
the mass fraction of the vegetable protein in the vegetable protein solution is 20-35%;
in the preparation process of the soft capsule content, the temperature of the solvent is 50-60 ℃;
the preparation process of the soft capsule shell comprises the following steps: the temperature of the hot water is 60-70 ℃, the degassing time is 20-30min, and the mass ratio of the hot water to the gelatin is 1-1.5:1.
2. An application of lycopene soft capsules prepared by the preparation method of claim 1 in preparing anti-aging health care products, immunity-improving health care products or cardiovascular health care products.
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