CN113546290A - Nasal cavity drug delivery device - Google Patents

Nasal cavity drug delivery device Download PDF

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Publication number
CN113546290A
CN113546290A CN202110958261.4A CN202110958261A CN113546290A CN 113546290 A CN113546290 A CN 113546290A CN 202110958261 A CN202110958261 A CN 202110958261A CN 113546290 A CN113546290 A CN 113546290A
Authority
CN
China
Prior art keywords
strip
drug
rotating shaft
bin
shaft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202110958261.4A
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Chinese (zh)
Inventor
郭刚
张亚
佟振博
秦旭
郑奇军
焦璐璐
谭震
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aitshenbo Suzhou Pharmaceutical Technology Co ltd
Original Assignee
Xinbosi Nanjing Intelligent Technology Co ltd
Nanjing Aobo Industrial Intelligent Technology Research Institute Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xinbosi Nanjing Intelligent Technology Co ltd, Nanjing Aobo Industrial Intelligent Technology Research Institute Co ltd filed Critical Xinbosi Nanjing Intelligent Technology Co ltd
Publication of CN113546290A publication Critical patent/CN113546290A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body

Abstract

The invention discloses a nasal cavity drug delivery device, which comprises a shell, wherein a bubble cap strip is arranged in the shell and comprises a drug bin strip and sealing paper, and the sealing paper covers the drug bin strip and seals the drug bin; a driving shaft, a left rotating shaft and a right rotating shaft are rotatably arranged in the shell, the driving shaft is used for rotatably transmitting the blister strip, sealing paper of the blister strip transmitted to the top of the driving shaft is stripped from the medicine bin strip, the stripped sealing paper is wound on the right rotating shaft, the stripped medicine bin strip is wound on the left rotating shaft, and the rotating directions of the left rotating shaft and the right rotating shaft are opposite; an air bin is arranged above the top of the driving shaft, an opening correspondingly matched with the medicine bin on the stripped medicine bin strip is formed at the bottom of the air bin, a blowing nozzle communicated with the air bin is arranged on one side of the shell, and a nose opening communicated with the air bin is arranged at the top of the shell; the invention realizes the continuous drug delivery to the nasal cavity, improves the delivery efficiency of the nasal cavity, has good effect of the nasal cavity and improves the bioavailability of the drug.

Description

Nasal cavity drug delivery device
Technical Field
The invention relates to a nasal cavity drug delivery device, and belongs to the technical field of nasal cavity drug delivery.
Background
The nasal administration is a mode of administration that the medicine is directly delivered into the nasal cavity through the nostrils, the medicine particles are firstly deposited on a certain specific area on the inner surface of the nasal cavity and then reach the action part of the medicine through a mucous layer and a mucous epithelial cell layer so as to treat local diseases of the nasal cavity and brain and systemic diseases; the traditional nasal administration is generally used for treating nasal cavity local diseases (rhinitis, nasal polyp, nasosinusitis and the like) and after nasal cavity operation, and directly delivers the medicine to the nasal cavity focus, so that the medicine can not only play a better drug effect, but also reduce the toxic and side effects caused by the medicine reaching the tissues of the whole body through blood circulation; in recent years, novel nasal administration has also been used for the treatment of brain and systemic diseases; for brain diseases, due to the existence of blood brain barrier, the conventional administration routes (intravenous injection, oral administration, intramuscular injection and the like) cause that drug molecules are difficult to enter the brain through blood circulation, and limit the treatment effect of the brain diseases (Alzheimer disease, Parkinson disease, epilepsy and the like); a large number of researches show that the nasal mucosa and the brain have direct nose-brain access, and the medicine can directly reach the brain through the nose-brain access, so that the limitation of a blood brain barrier is avoided, and a new method is provided for treating brain diseases; because the lower layer of epithelial cells of the nasal mucosa has rich capillaries and rich blood flow, drug molecules can be absorbed by the nasal mucosa to enter the capillaries and then enter the blood circulation to treat systemic diseases, such as the nasal cavity delivering insulin to treat diabetes and the like; nasal administration has the advantages of avoiding the first pass effect of the liver, improving the effectiveness of the medicine entering the brain, improving the bioavailability and the like, and is concerned by more and more researchers; the nasal cavity drug delivery device plays a crucial role in drug bioavailability, particularly delivery to the olfactory region for brain disease treatment, but at present, no nasal cavity drug delivery device capable of being connected with drug delivery is available, continuous drug delivery to the nasal cavity cannot be achieved, and in order to solve the problem, the invention provides the nasal cavity drug delivery device which is used for achieving continuous drug delivery to the nasal cavity.
Disclosure of Invention
The invention aims to solve the problems in the prior art, and provides a nasal administration device which is used for realizing continuous administration and delivery to a nasal cavity, improving the delivery efficiency of nasal administration, achieving a good nasal administration effect and improving the bioavailability of a medicament.
In order to achieve the above object, the present invention adopts the following technical solutions:
a nasal cavity drug delivery device comprises a shell, wherein a bubble cap strip is placed in the shell and comprises a drug bin strip and sealing paper, a plurality of drug bins are arranged on the drug bin strip at equal intervals, drug particles are placed in the drug bins, and the sealing paper covers the drug bin strip and seals the drug bins; a driving shaft, a left rotating shaft and a right rotating shaft are rotatably arranged in the shell, the driving shaft is used for rotatably transmitting the blister strip, sealing paper of the blister strip transmitted to the top of the driving shaft is stripped from the medicine bin strip, the stripped sealing paper is wound on the right rotating shaft, the stripped medicine bin strip is wound on the left rotating shaft, and the rotating directions of the left rotating shaft and the right rotating shaft are opposite; set up the gas storehouse in the top of driving shaft, the bottom in gas storehouse is formed with the medicine storehouse on the medicine storehouse strip after peeling off and corresponds the complex opening, wherein one side sets up the blow gun with the gas storehouse intercommunication in the casing, sets up the nose mouth with the gas storehouse intercommunication at the top of casing.
As a further preferred aspect of the present invention, the driving shaft is provided with a driving gear, the left rotating shaft is provided with a left driven gear, the right rotating shaft is provided with a right driven gear, the driving gear is in meshing transmission connection with the right driven gear, and the driving gear is in meshing transmission connection with the left driven gear through an intermediate gear; when the driving shaft is rotated, the driving shaft drives the right driven gear and the middle gear to rotate through the driving gear, and the middle gear drives the left driven gear to rotate, so that the driving shaft is utilized to drive the left rotating shaft and the right rotating shaft to rotate.
As a further preferred aspect of the present invention, a groove correspondingly matched with the medicine bin on the medicine bin strip is formed on the outer circumferential surface of the driving shaft, and the blister strip is clamped on the outer circumferential surface of the driving shaft through the medicine bin on the medicine bin strip; the recess on the driving shaft just is used for holding the medicine storehouse on the medicine storehouse strip, and the driving shaft of being convenient for is better rotates the transmission to the bubble cap strip, and the recess on the driving shaft can carry on spacingly to the medicine storehouse on the medicine storehouse strip simultaneously, makes the medicine storehouse on the medicine storehouse strip after peeling off more stable under the air current effect.
As a further preferred aspect of the present invention, a knob for rotating the driving shaft is connected to the driving shaft, the knob extending to the outside of the housing; the driving shaft can be conveniently and manually rotated.
As a further preferred aspect of the present invention, a driving device for driving the rotation of the driving shaft is provided outside the housing; the driving shaft is used for realizing rotation of the driving shaft by utilizing a mechanical component or an electric component.
As a further preferred aspect of the invention, a driven shaft is rotatably provided inside the housing, and the blister strip to be used is wound around the driven shaft; when the driving shaft rotates to transmit the blister strip, the blister strip to be used wound on the driven shaft starts to be unwound, so that the blister strip to be used is better matched with the driving shaft to rotate for transmission, and disorder of the blister strip to be used is avoided.
The invention has the advantages that:
in an initial state, the sealing paper of the blister strip positioned at the top of the driving shaft is peeled off from the medicine bin strip, the peeled sealing paper is wound on the right rotating shaft, the peeled medicine bin strip is wound on the left rotating shaft, and medicine particles do not exist in the medicine bin on the medicine bin strip at the front end of the blister strip; when the electric wrench is used, firstly, the driving shaft is rotated through the knob, so that the driving shaft rotates anticlockwise, the driving shaft drives the right driven gear and the middle gear to rotate clockwise through the driving gear, and the middle gear drives the left driven gear to rotate anticlockwise; the right driven gear drives the right rotating shaft to rotate clockwise, and the left driven gear drives the left rotating shaft to rotate anticlockwise; in the rotating process, because the rotating directions of the left rotating shaft and the right rotating shaft are opposite, the sealing paper of the blister strip transmitted to the top of the driving shaft and the medicine bin strip are continuously peeled; when the driving shaft rotates once, a medicine bin on a peeled medicine bin strip corresponds to an opening at the bottom of the air bin, at the moment, a nose opening is placed into the nasal cavity, the mouth holds the blow nozzle to start blowing, the air flow enters the air bin to drive medicine particles in the medicine bin to flow into the nasal cavity through the nose opening together, the blowing is repeated until all the medicine particles in the medicine bin are blown away, the driving shaft rotates once again, and the continuous nasal cavity administration can be completed by repeated operation; the invention realizes the continuous drug delivery to the nasal cavity, improves the delivery efficiency of the nasal cavity, has good effect of the nasal cavity and improves the bioavailability of the drug.
Drawings
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic side view of the present invention;
FIG. 3 is a first schematic diagram of the internal structure of the present invention;
FIG. 4 is a second schematic diagram of the internal structure of the present invention;
FIG. 5 is a third schematic view of the internal structure of the present invention;
FIG. 6 is a schematic view of the structure of the cartridge of FIG. 5 corresponding to the opening at the bottom of the cartridge;
FIG. 7 is a schematic view showing the construction of the driving shaft of the present invention;
fig. 8 is a partial schematic view of the blister strip of the present invention;
the meaning of the reference symbols in the figures:
1-shell, 2-blister strip, 3-medicine bin strip, 4-sealing paper, 5-medicine bin, 6-air bin, 7-blowing nozzle, 8-nose, 9-groove, 10-knob, 11-driving shaft, 12-left rotating shaft, 13-right rotating shaft, 21-driving gear, 22-left driven gear, 23-right driven gear and 24-intermediate gear.
Detailed Description
The invention is described in detail below with reference to the figures and the embodiments.
As shown in fig. 1-8, the present embodiment is a nasal cavity drug delivery device, which includes a casing 1, a blister strip 2 is placed inside the casing 1, the blister strip 2 includes a drug bin strip 3 and a sealing paper 4, a plurality of drug bins 5 are arranged on the drug bin strip 3 at equal intervals, drug particles are placed in the drug bins 5, and the sealing paper 4 covers the drug bin strip 3 and seals the drug bins 5; a driving shaft 11, a left rotating shaft 12 and a right rotating shaft 13 are rotatably arranged in the shell 1, the driving shaft 11 is used for rotatably transmitting the blister strip 2, the sealing paper 4 transmitted to the blister strip 2 at the top of the driving shaft 11 is stripped from the medicine bin strip 3, the stripped sealing paper 4 is wound on the right rotating shaft 13, the stripped medicine bin strip 3 is wound on the left rotating shaft 12, and the rotating directions of the left rotating shaft 12 and the right rotating shaft 13 are opposite; set up gas storehouse 6 in the top of driving shaft 11, the bottom of gas storehouse 6 is formed with the opening that corresponds the complex with the medicine storehouse 5 on the medicine storehouse strip 3 after peeling off, sets up the blow gun 7 with gas storehouse 6 intercommunication in casing 1 one of them side, sets up the nose mouth 8 with gas storehouse 6 intercommunication at casing 1's top.
In the embodiment, a driving gear 21 is arranged on the driving shaft 11, a left driven gear 22 is arranged on the left rotating shaft 12, a right driven gear 23 is arranged on the right rotating shaft 13, the driving gear 21 is in meshing transmission connection with the right driven gear 23, and the driving gear 21 is in meshing transmission connection with the left driven gear 22 through an intermediate gear 24; when the driving shaft 11 is rotated, the driving shaft 11 drives the right driven gear 23 and the middle gear 24 to rotate through the driving gear 21, and the middle gear 24 drives the left driven gear 22 to rotate, so that the left rotating shaft 12 and the right rotating shaft 13 are driven to rotate by the driving shaft 11.
In the embodiment, a groove 9 correspondingly matched with the medicine bin 5 on the medicine bin strip 3 is formed on the outer circumferential surface of the driving shaft 11, and the blister strip 2 is clamped on the outer circumferential surface of the driving shaft 11 through the medicine bin 5 on the medicine bin strip 3; recess 9 on the driving shaft 11 just is used for holding the medicine storehouse 5 on the medicine storehouse strip 3, and the driving shaft 11 of being convenient for is better rotates the transmission to blister strip 2, and recess 9 on the driving shaft 11 simultaneously can carry on spacingly to medicine storehouse 5 on the medicine storehouse strip 3, makes the medicine storehouse 5 on the medicine storehouse strip 3 after peeling off more stable under the air current effect.
In the embodiment, a knob 10 for rotating the driving shaft 11 is connected to the driving shaft 11, and the knob 10 extends to the outer side of the shell 1; the driving shaft 11 is conveniently rotated manually.
In practical application, a driving device for driving the driving shaft to rotate can be arranged on the outer side of the shell; the driving shaft is used for realizing rotation of the driving shaft by utilizing a mechanical component or an electric component.
In practical application, a driven shaft can be rotatably arranged in the shell, and the blister strip to be used is wound on the driven shaft; when the driving shaft rotates to transmit the blister strip, the blister strip to be used wound on the driven shaft starts to be unwound, so that the blister strip to be used is better matched with the driving shaft to rotate for transmission, and disorder of the blister strip to be used is avoided.
The application process of this embodiment is as follows:
in an initial state, the sealing paper 4 of the blister strip 2 positioned at the top of the driving shaft 11 is peeled off from the medicine bin strip 3, the peeled sealing paper 4 is wound on the right rotating shaft 13, the peeled medicine bin strip 3 is wound on the left rotating shaft 12, and medicine particles do not exist in the medicine bin 5 on one section of the medicine bin strip 3 at the front end of the blister strip 2;
when the electric wrench is used, firstly, the driving shaft 11 is rotated through the knob 10, so that the driving shaft 11 rotates anticlockwise, the driving shaft 11 drives the right driven gear 23 and the middle gear 24 to rotate clockwise through the driving gear 21, and the middle gear 24 drives the left driven gear 22 to rotate anticlockwise; the right driven gear 23 drives the right rotating shaft 13 to rotate clockwise, and the left driven gear 22 drives the left rotating shaft 12 to rotate anticlockwise; in the rotating process, because the rotating directions of the left rotating shaft 12 and the right rotating shaft 13 are opposite, the sealing paper 4 of the blister strip 2 transferred to the top of the driving shaft 11 is continuously peeled off from the medicine bin strip 3;
when the driving shaft 11 rotates once, the medicine bin 5 on one peeled medicine bin strip 3 corresponds to the opening at the bottom of the air bin 6, at the moment, the nose opening 8 is placed in the nasal cavity, the mouth holds the blowing nozzle 7 to start blowing, the air flow enters the air bin 6 to drive the medicine particles in the medicine bin 5 to flow into the nasal cavity through the nose opening 8 together, the blowing is repeated until all the medicine particles in the medicine bin 5 are blown away, the driving shaft 11 rotates once again, and the continuous nasal cavity administration can be completed by repeated operation; the invention realizes the continuous drug delivery to the nasal cavity, improves the delivery efficiency of the nasal cavity, has good effect of the nasal cavity and improves the bioavailability of the drug.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.
In the description of the present invention, it should be noted that the terms "mounted," "connected," and "disposed" are to be construed broadly and may be, for example, fixedly connected, disposed, detachably connected, disposed, or integrally connected and disposed unless otherwise explicitly stated or limited; can be mechanically or electrically connected; the two elements can be directly connected, indirectly connected through an intermediate medium, or communicated with each other inside; the specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
The foregoing shows and describes the general principles, principal features and advantages of the invention; it should be understood by those skilled in the art that the above embodiments do not limit the present invention in any way, and all technical solutions obtained by using equivalent alternatives or equivalent variations fall within the scope of the present invention.

Claims (6)

1. A nasal cavity drug delivery device is characterized by comprising a shell, wherein a bubble cap strip is placed in the shell and comprises a drug bin strip and sealing paper, a plurality of drug bins are arranged on the drug bin strip at equal intervals, drug particles are placed in the drug bins, and the sealing paper covers the drug bin strip and seals the drug bins; a driving shaft, a left rotating shaft and a right rotating shaft are rotatably arranged in the shell, the driving shaft is used for rotatably transmitting the blister strip, sealing paper of the blister strip transmitted to the top of the driving shaft is stripped from the medicine bin strip, the stripped sealing paper is wound on the right rotating shaft, the stripped medicine bin strip is wound on the left rotating shaft, and the rotating directions of the left rotating shaft and the right rotating shaft are opposite; set up the gas storehouse in the top of driving shaft, the bottom in gas storehouse is formed with the medicine storehouse on the medicine storehouse strip after peeling off and corresponds the complex opening, wherein one side sets up the blow gun with the gas storehouse intercommunication in the casing, sets up the nose mouth with the gas storehouse intercommunication at the top of casing.
2. The nasal cavity drug delivery device according to claim 1, wherein the driving shaft is provided with a driving gear, the left rotating shaft is provided with a left driven gear, the right rotating shaft is provided with a right driven gear, the driving gear is in meshing transmission connection with the right driven gear, and the driving gear is in meshing transmission connection with the left driven gear through an intermediate gear.
3. The nasal cavity drug delivery device according to claim 1 or 2, wherein the outer circumference of the driving shaft is formed with a groove corresponding to the drug cartridge on the drug cartridge strip, and the blister strip is engaged around the outer circumference of the driving shaft through the drug cartridge on the drug cartridge strip.
4. A nasal delivery device according to claim 2, wherein a knob is attached to the drive shaft for rotating the drive shaft, the knob extending outside the housing.
5. A nasal delivery device as claimed in claim 2, wherein the housing is provided with drive means on the outside thereof for driving rotation of the drive shaft.
6. A nasal delivery device as claimed in claim 1, wherein a driven shaft is rotatably provided within the housing, the blister strip to be used being wound around the driven shaft.
CN202110958261.4A 2021-08-19 2021-08-20 Nasal cavity drug delivery device Pending CN113546290A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2021109541417 2021-08-19
CN202110954141 2021-08-19

Publications (1)

Publication Number Publication Date
CN113546290A true CN113546290A (en) 2021-10-26

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ID=78105846

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110958261.4A Pending CN113546290A (en) 2021-08-19 2021-08-20 Nasal cavity drug delivery device

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CN (1) CN113546290A (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1736502A (en) * 1999-03-03 2006-02-22 奥普蒂诺斯公司 Nasal delivery method
CN101056666A (en) * 2004-09-15 2007-10-17 奥普蒂诺斯公司 Nasal delivery devices
CN201182811Y (en) * 2007-12-28 2009-01-21 国家纳米技术与工程研究院 Dry powder inhaler convenient for carrying
CN107735134A (en) * 2015-04-10 2018-02-23 微剂量治疗公司 Blister strips propulsive mechanism
CN209827853U (en) * 2019-04-03 2019-12-24 成都市温江区人民医院 Multifunctional storage device
CN209900344U (en) * 2018-10-30 2020-01-07 成都市温江区人民医院 Powder medicine inhalation device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1736502A (en) * 1999-03-03 2006-02-22 奥普蒂诺斯公司 Nasal delivery method
CN101056666A (en) * 2004-09-15 2007-10-17 奥普蒂诺斯公司 Nasal delivery devices
CN201182811Y (en) * 2007-12-28 2009-01-21 国家纳米技术与工程研究院 Dry powder inhaler convenient for carrying
CN107735134A (en) * 2015-04-10 2018-02-23 微剂量治疗公司 Blister strips propulsive mechanism
CN209900344U (en) * 2018-10-30 2020-01-07 成都市温江区人民医院 Powder medicine inhalation device
CN209827853U (en) * 2019-04-03 2019-12-24 成都市温江区人民医院 Multifunctional storage device

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Effective date of registration: 20221111

Address after: Room B1006, No. 388 Ruoshui Road, Suzhou Industrial Park, Suzhou Area, China (Jiangsu) Pilot Free Trade Zone, Suzhou City, Jiangsu Province, 215000

Applicant after: Aitshenbo (Suzhou) Pharmaceutical Technology Co.,Ltd.

Address before: 211899 floor 11, tower a, Jiangbei International wisdom Valley, No. 1, Xinbei Road, Pukou District, Nanjing, Jiangsu Province

Applicant before: Nanjing Aobo Industrial Intelligent Technology Research Institute Co.,Ltd.

Applicant before: Xinbosi (Nanjing) Intelligent Technology Co.,Ltd.

CB02 Change of applicant information
CB02 Change of applicant information

Address after: 215151 1st Floor, 2nd Floor, 5th Floor, 3rd Floor and 4th Floor, 5th Floor, Yangshan Science and Technology Industrial Park, No. 8, Jinyan Road, High-tech Zone, Suzhou, Jiangsu Province

Applicant after: Aitshenbo (Suzhou) Pharmaceutical Technology Co.,Ltd.

Address before: Room B1006, No. 388 Ruoshui Road, Suzhou Industrial Park, Suzhou Area, China (Jiangsu) Pilot Free Trade Zone, Suzhou City, Jiangsu Province, 215000

Applicant before: Aitshenbo (Suzhou) Pharmaceutical Technology Co.,Ltd.

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20211026