CN1135350A - Method for preparation of medicine good for memory - Google Patents
Method for preparation of medicine good for memory Download PDFInfo
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- CN1135350A CN1135350A CN96103426A CN96103426A CN1135350A CN 1135350 A CN1135350 A CN 1135350A CN 96103426 A CN96103426 A CN 96103426A CN 96103426 A CN96103426 A CN 96103426A CN 1135350 A CN1135350 A CN 1135350A
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- radix
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- radix rehmanniae
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Abstract
About twenty-four traditional Chinese medicines of radix rehmanniae recen, prepared rehmannia root, Chinese yam, cornel, Chinese angelica, the fruit of Chinese magnoliavine, asparagus fern, the tuber of dwarf lily turf, polygala root, wild jujube kernel etc. are ground into fine powder, the other fifteen medicines are added with alcohol to conduct twice reflux extraction and concentrated and cleared, then mixed with said fine powder and passed through processes of drying, dis integrating, screening, making pill by alcohol, coating with shengditan to make concentrated water bindered pill, secondary drying, polishing and pakaging.
Description
The invention belongs to a kind of preparation method of medicine, particularly a kind of preparation method of remembering pellet.
Research on Memory is key subjects in the scientific research, and Chinese medicine thinks that human intelligence is directly relevant with the heart, brain, kidney, splenic organs.The heart controlling mental and emotional activities, the spirit with human body, consciousness, thinking activities are relevant; Kidney controlling essence storage, the smart marrow of giving birth to fill brain, brain for " mansion of strange perseverance ", are again the places of marrow and gods high concentration, and all thinking activitiess of people are all arranged by brain; The spleen has the function to transport and transform nutrients, is source of generating QI and blood.Existing brain-strengthening peace piracetam mainly has the cardiopalmus of preventing and treating, dizziness, fatigue, weak, insomnia, forgetful function, but it does not particularly have facilitation to improving memory to preventing and treating forgetful function and not obvious yet.Record ancient prescription (the original name bank is from ball) in Chinese medicine " Longevity and Life Preservation ", it is made by Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Radix Angelicae Sinensis, Fructus Schisandrae Chinensis, armored, Radix Ginseng, Radix Asparagi, Radix Ophiopogonis, Radix Polygalae, Semen Ziziphi Spinosae, Rhizoma Acori Graminei, Semen Platycladi, Os Draconis, Poria, Cortex Phellodendri, the Rhizoma Anemarrhenae and Fructus Lycii, cure mainly that " lamp window reading is arduous; knowledge is easily forgotten, and spirit dusk is tired.Function with nourishing kidney replenishing essence, invigorating the heart and spleen, nourishing the brain and improving intelligence, but it is a honeyed pill, every ball 9 grams of commercial weight/time, every day one, the ball secondary 18 restrained totally, and as seen, the honeyed pill volume is big, consumption is big; Former side according to dosage takes one week of needs onset time, and taking three months continuously is a course of treatment, and dose is big, the time is big, take effect slow, and has bitter cold to hinder the side effect of stomach.
The object of the present invention is to provide and a kind ofly have nourishing kidney replenishing essence, invigorating the heart and spleen, nourishing the brain and improving intelligence and improve memory function and volume is little, bioavailability is high, curative effect is fast, the preparation method of the memory pellet that has no side effect
This invention utilizes the modernism effective component extracting to make concentrated watered pill, and its concrete technical solution is:
Get Radix Rehmanniae 8～15% (weight ratio), Radix Rehmanniae Preparata 8～15%, Rhizoma Dioscoreae, Fructus Corni, Radix Angelicae Sinensis, Fructus Schisandrae Chinensis, Radix Asparagi, Radix Ophiopogonis, Radix Polygalae, Semen Ziziphi Spinosae, Semen Platycladi, Cortex Phellodendri, the Rhizoma Anemarrhenae, Fructus Lycii each 2.5～8.0%, Radix Ginseng, Carapax Et Plastrum Testudinis, Os Draconis each 1～3%, Rhizoma Acori Graminei 1.25～4%, Poria 2～6%:
Carapax Et Plastrum Testudinis, Radix Ginseng, Os Draconis, Poria powder are broken into fine powder, and 25～75% and all the other ten four Chinese medicines of getting above-mentioned Radix Rehmanniae total amount add 50～95% alcohol reflux secondaries, and alcohol adding amount is 6～10 times for the first time, extracts 1～4 hour; Add for the second time 4～8 times of alcohol, extracted 0.5～2 hour, and under 40～65 ℃, be concentrated into relative density 1.25～1.40 clear paste, add above-mentioned fine powder, mixing, dry under 40～65 ℃, pulverize, sieve, with the general ball of ethanol, with remaining Radix Rehmanniae charcoal processing coating, make concentrated watered pill, again 40～65 ℃ down dry, beat earlier, pack, get final product.
The red preparation method of this memory keeps the Chinese medicine conventional dosage forms watered pill, makes concentrated watered pill in conjunction with the modernism effective component extracting again and the honeyed pill contrast has following advantage:
But 1 reduced volume, reduce consumption, now measure 3 grams/time, secondary every day totally 6 grams;
2, improve bioavailability, heighten the effect of a treatment, reduce side effect, former side according to dosage takes one week of needs onset time, and taking needs continuously was a course of treatment in three months, and this memory got final product onset in red one day, one month is a course of treatment, and does not have the side effect that former side's bitter cold hinders stomach;
3, have nourishing kidney replenishing essence, invigorating the heart and spleen, nourishing the brain and improving intelligence, improving memory function, be used to prevent and treat forgetful, cardiopalmus, dizziness, tired weak, insomnia and dreamful sleep, disease such as absent minded.
Embodiments of the invention are provided below:
Get Radix Rehmanniae 300g, Radix Rehmanniae Preparata 500g, Rhizoma Dioscoreae 110g, Fructus Corni 290g, Radix Angelicae Sinensis 110g, Fructus Schisandrae Chinensis 280g, Carapax Et Plastrum Testudinis 50g, Radix Ginseng 100g, Radix Asparagi 290g, Radix Ophiopogonis 120g, Radix Polygalae 290g, Semen Ziziphi Spinosae 110g, Rhizoma Acori Graminei 60g, Semen Platycladi 290g, Os Draconis 55g, Poria 220g, Cortex Phellodendri 110g, Rhizoma Anemarrhenae 280g, Fructus Lycii 110g.
Carapax Et Plastrum Testudinis, Radix Ginseng, Os Draconis, Poria powder are broken into fine powder, standby; 908 Radix Rehmanniae and all the other ten four Chinese medicines are added 60% alcohol reflux 2 times, add 6 times of ethanol for the first time, extracted 3.5 hours, add for the second time 8 times of alcohol, extracted 0.5 hour, so that extracts active ingredients is more complete, merge extractive liquid,, filtered and recycled ethanol, and to be concentrated into relative density under 40～45 ℃ be 1.25～1.35 clear paste, (temperature is low excessively, will make concentration time long), add above-mentioned fine powder, mixing, dry under 40～45 ℃, pulverize, cross sieve No. six, with the general ball of ethanol, all the other Radix Rehmanniae system carbon coatings are made concentrated watered pill, dry again, baking temperature is controlled between 60～65 ℃, and (temperature is too high, and its polysaccharide component will be changed, and the watered pill is become sticky), polishing, packing, get final product.
Embodiment 2:
Get Radix Rehmanniae 500g, Radix Rehmanniae Preparata 200g, Rhizoma Dioscoreae 290g, Fructus Corni 110g, Radix Angelicae Sinensis 280g, Fructus Schisandrae Chinensis l10g, Carapax Et Plastrum Testudinis 100g, Radix Ginseng 50g, Radix Asparagi 120g, Radix Ophiopogonis 290g, Radix Polygalae 110g, Semen Ziziphi Spinosae 290g, Rhizoma Acori Graminei 140g, Semen Platycladi 120g, Os Draconis 95g, Poria 100g, Cortex Phellodendri 280g, Rhizoma Anemarrhenae 110g, Fructus Lycii 280g.
With Carapax Et Plastrum Testudinis, Radix Ginseng, Os Draconis, Poria powder is broken into fine powder, and is standby, and 70% and all the other ten four Chinese medicines of getting above-mentioned Radix Rehmanniae total amount add 90% alcohol reflux 2 times, add for the first time 9 times of ethanol, extracted 1.5 hours, and added 4.5 times of alcohol for the second time, extracted 1.5 hours, with effective component extracting more fully, merge extractive liquid,, filtered and recycled ethanol, and to be concentrated into relative density be 1.30～1.40 (60～65 ℃) clear paste, add above-mentioned fine powder, mixing, dry under 60～65 ℃, pulverize, cross sieve No. six, with the general ball of ethanol, the fresh rehmannia charcoal coating is made concentrated watered pill, and is dry again, baking temperature is controlled between 40～45 ℃, beats earlier, packing, get final product.Embodiment 3
Get Radix Rehmanniae 400g, Radix Rehmanniae Preparata 400g, Rhizoma Dioscoreae 200g, Fructus Corni 200g, Radix Angelicae Sinensis 200g, Fructus Schisandrae Chinensis 200g, Carapax Et Plastrum Testudinis 75g, Radix Ginseng 75g, Radix Asparagi 200g, Radix Ophiopogonis 200g, Radix Polygalae 200g, Semen Ziziphi Spinosae 200g, Rhizoma Acori Graminei 100g, Semen Platycladi 200g, Os Draconis 75g, Poria 150g, Cortex Phellodendri 200g, Rhizoma Anemarrhenae 200g, Fructus Lycii 200g.
With Carapax Et Plastrum Testudinis, Radix Ginseng, Os Draconis, Poria powder is broken into fine powder, and is standby, and 200 gram Radix Rehmanniae and all the other ten four Chinese medicines are added 70% alcohol reflux 2 times, add for the first time 8 times of ethanol, extracted 2 hours, and added 6 times of alcohol for the second time, extracted 1 hour, merge extractive liquid,, filtered and recycled ethanol, and to be concentrated into relative density be 1.30～1.35 (50～55 ℃) clear paste, adds above-mentioned fine powder, mixing, dry under 40～50 ℃, pulverize, cross sieve No. six, with the general ball of ethanol, Radix Rehmanniae charcoal processing coating is made concentrated watered pill, and is dry again, baking temperature is controlled between 40～50 ℃, beats earlier, packing, get final product.
Claims (1)
1, a kind of preparation method of remembering pellet, it is characterized in that, get Radix Rehmanniae 8～15% (weight ratio), Radix Rehmanniae Preparata 8～15%, Rhizoma Dioscoreae, Fructus Corni, Radix Angelicae Sinensis, Fructus Schisandrae Chinensis, Radix Asparagi, Radix Ophiopogonis, Radix Polygalae, Semen Ziziphi Spinosae, Semen Platycladi, Cortex Phellodendri, as female, Fructus Lycii each 2.5～8.0%, Radix Ginseng, Os Draconis, Carapax Et Plastrum Testudinis each 1～3%, Rhizoma Acori Graminei 1.25～4%, Poria 2～6% are broken into fine powder with Carapax Et Plastrum Testudinis, Radix Ginseng, Os Draconis, Poria powder; 25～75% and all the other ten four Chinese medicines of Radix Rehmanniae total amount are added 50～95% alcohol reflux secondaries, and alcohol adding amount is 6～10 times for the first time, extracts 1～4 hour; Add for the second time 4～8 times of alcohol, extracted 0.5～2 hour, under 40～65 ℃, be concentrated into relative density 1.25～1.40 clear paste; Add above-mentioned fine powder, mixing; Dry under 40～65 ℃, pulverize, sieve, with the general ball of ethanol,, make concentrated watered pill with remaining Radix Rehmanniae charcoal processing coating; Dry under 40～65 ℃ again, beat earlier, pack, get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96103426A CN1053370C (en) | 1996-03-25 | 1996-03-25 | Method for preparation of medicine good for memory |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96103426A CN1053370C (en) | 1996-03-25 | 1996-03-25 | Method for preparation of medicine good for memory |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1135350A true CN1135350A (en) | 1996-11-13 |
| CN1053370C CN1053370C (en) | 2000-06-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96103426A Expired - Fee Related CN1053370C (en) | 1996-03-25 | 1996-03-25 | Method for preparation of medicine good for memory |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1059817C (en) * | 1997-10-16 | 2000-12-27 | 沈广兴 | Traditional Chinese medicine preparation for reinforcing the kidney and enhancing fitness of old age people |
| WO2003059367A1 (en) * | 2002-01-15 | 2003-07-24 | Chuanzheng Sun | A healthful chinese traditional medicinal preparation optimizing the brain |
| CN100402018C (en) * | 2004-11-11 | 2008-07-16 | 内蒙古蒙药股份有限公司 | Process and apparatus for preparing water bolus of Mongolian medicine |
| CN101152531B (en) * | 2007-09-28 | 2010-05-19 | 郭淑梅 | Heart-nourishing brain-nourishing traditional Chinese medicine preparation for treating amnesia |
| CN109568588A (en) * | 2018-12-20 | 2019-04-05 | 韦德举 | A kind of selenium-rich ginseng pressed candy of intelligence promoting and tranquilization and preparation method thereof |
| CN111388579A (en) * | 2020-04-27 | 2020-07-10 | 董建国 | Medicine for enhancing memory |
-
1996
- 1996-03-25 CN CN96103426A patent/CN1053370C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1059817C (en) * | 1997-10-16 | 2000-12-27 | 沈广兴 | Traditional Chinese medicine preparation for reinforcing the kidney and enhancing fitness of old age people |
| WO2003059367A1 (en) * | 2002-01-15 | 2003-07-24 | Chuanzheng Sun | A healthful chinese traditional medicinal preparation optimizing the brain |
| CN100402018C (en) * | 2004-11-11 | 2008-07-16 | 内蒙古蒙药股份有限公司 | Process and apparatus for preparing water bolus of Mongolian medicine |
| CN101152531B (en) * | 2007-09-28 | 2010-05-19 | 郭淑梅 | Heart-nourishing brain-nourishing traditional Chinese medicine preparation for treating amnesia |
| CN109568588A (en) * | 2018-12-20 | 2019-04-05 | 韦德举 | A kind of selenium-rich ginseng pressed candy of intelligence promoting and tranquilization and preparation method thereof |
| CN111388579A (en) * | 2020-04-27 | 2020-07-10 | 董建国 | Medicine for enhancing memory |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1053370C (en) | 2000-06-14 |
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