CN1135346A - Chinese medicinal preparation for treatment of psoriasis and preparation method thereof - Google Patents

Abstract

The Chinese medicinal preparation is prepared from ginseng, dark plum, glossy ganoderma, leech, the root of membranous milk vetch and pilose antler etc., which has the function of tonifying kidney, invigorating blood-circulation and relieaving internal heat, removing obstruction in channels and inducing sweat, and promoting imunity of humanbody. It is indicated for treatment of psorasis, and its effective rate is up to above 90%, curative rate is up to 86%.

Description

Psoriatic Chinese medicine preparation of a kind of treatment and preparation method thereof

The present invention relates to a kind of Chinese medicine preparation, the psoriatic medicament of particularly a kind of treatment.

The people knows that all psoriasis (formal name used at school psoriasis) is a kind of very painful refractory skin, and the lighter produces pimple, takes off white scales, play is itched unbearably; The decortication of weight person's whole body, it is rotten to the corn to suppurate, and LOM is until threat to life.According to reports, sickness rate is all very high all over the world for this disease at present, and bright from China's census paper, the psoriatic is up to ten million people.

Psoriasis can be divided into clinically: homeliness type, pustule type, arthrosis type, four types of erythrodermic, and its clinical manifestation is summarized as follows:

1., psoriasis vulgaris:

The skin lesion of psoriasis vulgaris is from the beginning of being circular, with pimple or the Semen Glycines size or the bigger maculopapule of needle point size.Its pimple exceeds skin surface, clear-cut margin, drying, touch sense, pale red or the redness of infiltration arranged.Big or several skin lesion of skin lesion flaring merge in flakes mutually, it shows canescence or white squama along with the development of skin lesion, and the more multilamellar that is of squama, the squama of grabbing gently very easily comes off and falls in flakes cloudlike lamellar, as scrape and get the visible translucent thin film phenomenon of squama, rescud thin film then red color visible basal surface and the petechia phenomenon of needle point size is arranged.Thin film phenomenon and petechial hemorrhage phenomenon are the psoriatic lesion features.Patient's subjective symptoms is mainly scratches where it itches, if the thick then movable position of skin lesion breach pain, the big person of skin lesion scope area has the uncomfortable phenomenon of the slight heating and the whole body.Lab testing is except existing with struvite focus and leukocyte increases, generally the Non Apparent Abnormality phenomenon.

2., psoriasis pustulosa:

The many transformation by homeliness type of psoriasis pustulosa forms, and also just time-out is pustule, and this kind of morbidity is anxious, with heating, and leukocyte raises, arthralgia, symptoms such as general malaise.Skin ulcer liquid muddiness is cultivated no bacterial growth, and pustule can merge mutually in flakes.Form large stretch of pus crusts, this type is long than the homeliness type course of disease, easily repeatedly.

3., psoriasis arthropathica:

This type except having the homeliness type skin lesion, with typical arthritis, can show as congestion and swelling pain clinically, and the joint deformity dysfunction has simultaneously that leukocyte increases, erythrocyte sedimentation rate speeds, the class pathogenic wind-warm factor positive, but also the bone mutation forms so that ankylosis.The skin lesion symptom changes with the joint symptom variation.

4., erythrodermic psoriasis:

Erythrodermic psoriasis number extremely greatly is that the reason of generation has owing to the patients with psoriasis vulgaris malpractice produces: A, for oral administration, injection corticosteroid drug, as prednisone, gently change cortisone, dexamethasone, meticortelone etc., after the drug withdrawal suddenly; B, the stronger external used medicine of stimulation also can cause as medicines such as mustard gas ointment, arsenic and mercurial classes.C, the stronger ultraviolet of irradiation, high temperature bath, a large amount of infection of drinking, generate heat, spirit hypertonicity and anxiety etc. also can cause, this type of patient's skin lesion symptom is the general erubescence, and the erythema squama of popularity is generated heat with fear of cold, fervescence does not fall, the limited General Symptoms that waits of mobility, the unusual and anemia of the had hepatic and renal function that has is the most serious type of psoriasis.

How can effectively prevent and treat this persistent ailment, to become a problem of medical circle person of noble aspirations tackling key problem already.

The purpose of this invention is to provide the psoriatic Chinese medicine preparation of a kind of treatment, this medicament has excellent curative.

The inventor has had unique opinion and understanding in that original more than 100 prescriptions and up to ten thousand parts of medical records have been carried out classification, conclusion, screening from the cause of disease, pathology, pharmacology theoretically to psoriasis.Finding the cause of disease accurately is the prerequisite of doing well to prevent and treat.Psoriasis though heritability is arranged, is not principal element from cause of disease aspect.The inventor thinks that this disease has the cause of disease of two aspects.The one, theory of infection because the infectious fever human body is in stress state or because the antigenicity of metainfective metabolite changes the human body immune state, activates body troubles ospc gene, causes the damage of epidermis and produces this disease; The 2nd, environmental factors, when being in, human body surpasses under the condition own, as moist, cold, drench with rain, violent direct stimulation, scaring or long-term spirit depressing all can be brought out primary disease, this is because the predisposing factor that certain human body itself exists, under certain condition, human body is subjected to the stimulation of certain inducement, impels the interior potential ill gene of body to be exposed to clinical and the generation primary disease.And therefrom the psoriatic pathological essence of hospital's face is: heat in blood is an illusion, and blood stasis is an essence.Why produce psoriatic lesion, its basic reason is the human body microcirculation disturbance, and the capillary of skin blood stasis is obstructed, causes metabolism not normal, and cell growth cycle shortens and generation desquamation phenomenon.The present invention just is based on above-mentioned cognition, has taked and the general traditional Chinese medical science " clearing away heat and cooling blood method " reverse therapy commonly used, i.e. " warming YANG kidney tonifying, blood circulation promoting and blood stasis dispelling ".Under above-mentioned thought guidance, the inventor has succeeded in developing a kind of Chinese medicine preparation that psoriasis is had obvious curative effects.

Medicament of the present invention contains Radix Ginseng, Fructus Mume, Ganoderma, Hirudo, the Radix Astragali and Cornu Cervi Pantotrichum.Also can further contain Herba Schizonepetae.

The preferred weight umber proportioning of described composition is:

Radix Ginseng 2-4 part, Fructus Mume 58-62 part, Ganoderma 5-7 part, Hirudo 8-10 part, Radix Astragali 28-32 part, Cornu Cervi Pantotrichum 2-4 part.Herba Schizonepetae can be 8-10 part.

The main effect of each composition is as follows among the we:

Radix Ginseng: sweet in flavor and warm in property, little hardship.The function strongly invigorating primordial QI, heart tonifying takes off admittedly, calms the nerves to promote the production of body fluid.Modern scientific research, Radix Ginseng has excitation to maincenter N, can make reticuloendothelial system superfunction, and the enhancing human body immunity ability improves body resist the disease ability.

Fructus Mume: nature and flavor are sour and astringent, warm.The function astringing intestine to stop diarrhea of astringing the lung, promoting the production of body fluid to quench thirst drives the ascarid dysentery relieving.Treating psoriasis, enteritis, dysentery etc.Modern scientific research, Fructus Mume have antagonism protein allergy and histamine shock's effect.In the treatment psoriasis, there is the psoriatic lesions of promotion to organize regressive effect.

Cornu Cervi Pantotrichum: sweet in flavor and warm in property, function kidney-replenishing, benefiting essence-blood bone and muscle strengthening.Cure mainly and suffer from a deficiency of the kidney, asthenia of essence and blood, the erosion of vulva.Modern scientific research, Cornu Cervi Pantotrichum can enhancing human body immunity ability, improve the effect of its carbohydrate metabolism selectively by spinal cord N.Promote the regenerative process of skin trauma and ulcer, can make damaged tissue recover normal.

Ganoderma: the light temperature of nature and flavor, function is overflow foster strong.Cure mainly dizzy insomnia, N is weak.Modern scientific research, Ganoderma can make leukocyte early recover, and improve the liver detoxification ability, recover body damaged cell.

Radix Astragali: sweet in flavor and warm in property, function invigorating QI to consolidate the body surface resistance, holder skin ulcer granulation promoting.Modern scientific research, Radix Astragali can make the skin blood circulation freely contain, and by expansion coronary vasodilator and renal blood vessels, promote the circulation of whole body essence and blood liquid, eliminate the dermatosis pathological tissues.

Hirudo: the salty hardship of nature and flavor is flat, and function is invigorated blood circulation, and dissipating blood stasis stimulates the menstrual flow.Cure mainly the wound blood stasis, the blood stasis amenorrhea.Modern scientific research, Hirudo have the effect that prevents blood coagulation, promote the skin microcirculation metabolic function.

The comprehensive function of above-mentioned Chinese medicine is: warming YANG kidney tonifying, promoting blood circulation and detoxication, collateral dredging induce sweat.Have the human body of raising immunocompetence, strengthen body metabolism, eliminate the psoriasis tinea by the metabolic capacity of human body own and become tissue.

Medicaments preparation method of the present invention means is routinely made honeyed pill.

Medicament of the present invention has the warming YANG kidney tonifying, the effect that promoting blood circulation and detoxication, collateral dredging induce sweat.Have the raising human body immunity, can strengthen body metabolism, eliminate the psoriatic lesions tissue by the metabolic capacity of human body own.

The inventor uses medicament of the present invention, and recent two decades has been treated people surplus the patient 30,000, spreads all over the two nineteen provinces and cities of the whole nation except that Tibet, and effective percentage reaches more than 90%, and cure rate reaches more than 86%.

Further specify the present invention below by embodiment and case.Embodiment

Get Radix Ginseng 3g, Fructus Mume 60g, Ganoderma 6g, Hirudo 9g, Radix Astragali 30g and Cornu Cervi Pantotrichum 3g, after concocting, be ground into 120 order fine powders, mixing, sterilization; Per 100 gram powder add refined honey 80-110 gram, stir, and become stone roller, and shaping is made big honeyed pills, every ball 9 grams, and sterilization, packing is promptly.Finished product is a pitchy, and is mellow and full glossy, mildly bitter flavor and sour-sweet.

This oral drug, one time two ball, three times on the one, 63 days is a course of treatment.Airtight, moistureproof storage.Zest stimulating food such as fasting meat, drinks, the anemia of pregnant woman prohibits clothes.

Case:

1, clinical data:

Male's 68 examples in 100 cases for the treatment of between year July in March, 1984 to 1994, women's 32 examples, age 9-46 year, stadium 3 week-3 year, the overwhelming majority is a homeliness type.Erythra is drop shape person 74 examples, irregular and map shape 26 examples.By humid environment is inducement person's 68 examples, and focal infection person's 13 examples, emotional distress are inducement person's 17 examples, and family history 32 examples are arranged.Wherein western medicines such as 82 example ethyliminums, aminopterin, meticorten invalid or effectively after i.e. recurrence, the laboratory routine inspection except anti-" 0 " and leukocyte in various degree unusually, blood, routine urinalysis and liver function routine are all normal.

2, criterion of therapeutical effect and result

Recovery from illness: erythra all disappears, and leaves pigmentation spots or the class of going down.Produce effects: deflorescence is more than 75%.Invalid: deflorescence less than 50% also has newborn erythra.Obeyed for 9 weeks at most, minimum three weeks of clothes, on average obeyed 37 days, 92 examples of fully recovering (92%), produce effects 4 examples, invalid 4 examples are wherein lacked, were not used hormone medicine preferable with the course of disease.Visit recurrence 14 examples in the 3-5, recurrence 29 examples in the 5-7, recurrence 18 examples do not recur 39 examples in the 7-10 more than 10 years, and recurrence back this pharmaceutical treatment of reuse still has good effect.

3, model case

(1) Liu, man, 29 years old, peasant, first visit on April 18th, 1984, patient's identification number 84-118, readme is had sore throat because of the back headache of drenching with rain, and the whole body is aching and tired, it is not good to press common cold treatment in certain hospital, and after about two weeks, the whole body goes out red pimple from top to bottom, finds then that the mound examines to enlarge to take off white scales.Look into: slippery and rapid pulse, the body of the tongue red drop, yellow thick fur, T:38 ℃, general is dispersed in drop shape and lamellar macule, goes up attached argyraemia color phosphorus bits, possesses typical petechial hemorrhage and thin film phenomenon, and family history is arranged.Rash is disconnected to be psoriasis vulgaris.Laboratory report, anti-" 0 " 1500U is from blood cell 14000mm ², surplus no abnormal.Obey this honeyed pill after three weeks, erythra begins to disappear, and erythra all disappears after six weeks, and routine test is all normal, continues clothes again and three weeks consolidates curative effect., nineteen ninety in 1987, visit for 1994 three times and reach no any rebound phenomenon more than 10 years.

(2) Zhan, the man, people from Linyi County, Shanxi, in year surplus the trouble psoriasis ten, developed into serious Folium Styracis Suberifoliae psoriasis pustulosa by 1981, once in how tame hospitalize times more than 3 years such as Xi'an, Beijing, go bankrupt or broke and spent medical fee more than 20,000, not only do not feel any better, and the state of an illness is more and more heavy, finishes at last and has descended the notice of being critically ill.Have no alternative come back home after, hear that Jing Xiamin doctor just can control this disease in the county, the mood of just having had thought in arms allows relatives with ambulance he be delivered to this institute.After having taken the honeyed pill of the present invention of three courses of treatment, the whole mattings of the phenoclasts on the skin have recovered health again with coming back to life.This old man is more than 70 year old now, goes to work in the fields every day, finds time also to go out to make business, and does not recur during the last ten years again.

Claims (6)

1, a kind of Chinese medicine preparation is characterized in that containing Radix Ginseng, Fructus Mume, Ganoderma, Hirudo, the Radix Astragali and Cornu Cervi Pantotrichum.

2, Chinese medicine preparation as claimed in claim 1 is characterized in that further containing Herba Schizonepetae.

3, Chinese medicine preparation as claimed in claim 1 is characterized in that the parts by weight proportioning is: Radix Ginseng 2-4 part, Fructus Mume 58-62 part, Ganoderma 5-7 part, Hirudo 8-10 part, Radix Astragali 28-32 part, Cornu Cervi Pantotrichum 2-4 part.

4, Chinese medicine preparation as claimed in claim 3 is characterized in that the parts by weight proportioning is:

3 parts of Radix Ginsengs, 60 parts of Fructus Mumes, 6 parts of Ganodermas, 9 parts of Hirudos, 30 parts of the Radixs Astragali, 3 parts in Cornu Cervi Pantotrichum.

5, the preparation method of the described Chinese medicine preparation of one of a kind of claim 1-4 is characterized in that getting Radix Ginseng, Fructus Mume, Ganoderma, Hirudo, the Radix Astragali, Cornu Cervi Pantotrichum, is ground into 120 order fine powders after the process of preparing Chinese medicine, mixing, sterilization; Per 100 gram powder add refined honey 80-110 gram, stir, and become stone roller, and shaping is made honeyed pill, then sterilization.

6, the purposes of the described Chinese medicine preparation of one of a kind of claim 1-4 is characterized in that being used for the treatment of psoriasis.