CN1695697A - Medication for treating ache of rheumatoid arthritis - Google Patents

Abstract

A Chinese medicine for treating the pain caused by rheumatic arthritis, cervical spondylopathy, periomethritis, bumbar intervertebral disk protrusion, hyperosteogeny, etc is prepared from 15 Chinese-medicinal materials including safflower, Chuan-xiong rhizome, notoginseng, liquorice root, etc.

Description

A kind of medicine for the treatment of ache of rheumatoid arthritis

Technical field:

The present invention discloses a kind of medicine for the treatment of ache of rheumatoid arthritis, can treat at the pain that diseases such as rheumatic arthritis cause, belongs to the Chinese medicine technical field.

Background technology:

Rheumatism, the rheumatoid disease traditional Chinese medical science are commonly called as " arthromyodynia ", be by wind, cold, wet three gas and assist into it, cause blood vessels obstructed, show as muscle muscles and bones joint aches, numb, swelling, even red and swollen distortion, weight person can cause the destruction of joint sclerotin, cause joint deformity, pain seriously perplexs human beings'health unbearably.In the Drug therapy process, the problem that runs into is: the state of an illness twines stupid, and Jing Jiu Bu More makes pathogen go deep into muscles and bones, and coagulation of QI-blood is not all right, and it is turbid to become the living phlegm-damp stasis of blood, and the meridians obturation is obstructed, and these product of non-vegetation can be led to, and must borrow worm Serpentis and so on search to pick and penetrate, and can open and coagulate.Medicine commonly used " controlling numbness looses ", " indometacin " etc., but easily recur after all existing drug withdrawal to some extent, grow and can lead to complications the course of treatment, and have than serious adverse.

Summary of the invention:

The present invention discloses a kind of medicine for the treatment of ache of rheumatoid arthritis, have evident in efficacy, treating both the principal and secondary aspects of a disease characteristics, and cure the no rebound phenomena in back.

The present invention is according to pathogeny and the Therapeutic Principle of China's traditional medicine to rheumatism, the pain cause that causes at this disease, with reference to the modern medicine achievement, in the medical treasure-house of motherland, choose and have wind-expelling and dispelling dampness, activating blood circulation to dissipate blood stasis, the pure Chinese herb medicine of anti-inflammatory analgetic is made Chinese medicine preparation through science.

The present invention is made of by weight following medicine:

Radix Angelicae Pubescentis 13-20 part, Radix Saposhnikoviae 10-18 part, black-snake 18-25 part, Cortex Eucommiae 13-18 part, Rhizoma Gastrodiae 15-20 part, Flos Carthami 8-15 part, Rhizoma Chuanxiong 8-15 part, Rhizoma Cibotii 8-15 part, Radix Notoginseng 15-20 part, Radix Cyathulae 15-22 part, Radix Clematidis 18-25 part, Radix Glycyrrhizae 12-15 part, Radix Tripterygii Wilfordii 8-12 part, Rhizoma Atractylodis 18-25 part, Herba Ephedrae 3-8 part.

Above-mentioned prescription optimum ratio is:

15 parts of Radix Angelicae Pubescentiss, 15 parts of Radix Saposhnikoviaes, 20 parts of black-snakes, 15 parts of the Cortexs Eucommiae, 15 parts in Rhizoma Gastrodiae, 10 parts on Flos Carthami, 8 parts of Rhizoma Chuanxiongs, 12 parts of Rhizoma Cibotii, 20 parts of Radix Notoginseng, 20 parts of Radix Cyathulaes, 20 parts of Radix Clematidis, 10 parts in Radix Glycyrrhizae, 10 parts of Radix Tripterygii Wilfordiis, 18 parts of Rhizoma Atractylodis, 3 parts in Herba Ephedrae.

The said medicine pulverize separately is become 80～110 order fine powders, behind the mix homogeneously, under 100 ℃～110 ℃, carried out the ripening sterilization treatment 10～30 minutes, promptly get powder medicine of the present invention.

Above-mentioned prescription of the present invention also can be made into other dosage forms pharmaceutically.

Usage and consumption: oral.

Formulation rate of the present invention can be according to variations such as route of administration, patient age, body weight, disease type and the orders of severity, and daily dose is 0.01～20mg/kg.Each 2～5g, secondary took with eliminating cold for resuscitation water or yellow wine and to take after mixing it with water every day.

Attention: be not taken by pregnant women the careful usefulness of hyperpietic.

Indication: the pain that sciatic neuritis, fracture sequelae, scapulohumeral periarthritis, cervical spondylosis, hypertrophic spondylitis cause.

Be monarch with Rhizoma Atractylodis among the present invention, the key medicine of the spleen strengthening and damp drying, it is wet to rise the water that should change of loosing with hot using warming therapy abnormal smells from the patient, and temper rises and belongs to lung, the strong then humidifying of spleen, solid these Rhizoma Atractylodis liter of spleen again reach eliminating pathogenic factor for supporting vital QI as the principal agent of square medicine by dampness.Herba Ephedrae, Radix Tripterygii Wilfordii, black-snake, Radix Notoginseng is a minister, insufficiency of the spleen wet long-pending, lung also can not solely be good for, and must lose defeated merit, Rhizoma Atractylodis is joined Corchorus olitorius L., sweating can be arranged, and you are from changing Radix Tripterygii Wilfordii for following water delivery diseases, black-snake, Radix Notoginseng can be dredged active a surname's inducing QI blood, with dehumidifying resistance middle-jiao yang, function of the spleen and stomach, the Cortex Eucommiae, Rhizoma Cibotii, Radix Cyathulae, Radix Clematidis, Rhizoma Gastrodiae dispels the wind strong muscles and bones for assistant with dehumidifying, warm waist kidney and gasified water is wet, to go the gasification function of strengthening rising the spleen lung qi dispersing, with Radix Saposhnikoviae, Flos Carthami, Rhizoma Chuanxiong, Radix Glycyrrhizae is for making activating blood circulation to dissipate blood stasis, the meridian dredging is with dehumidifying, in sum, profoundness of the present invention is Rhizoma Atractylodis and the Herba Ephedrae part that matches, and equivalent is to sending out its antiperspirant, damp is from antiperspirantization, during Rhizoma Atractylodis times Herba Ephedrae, spleen transmitting and distributing the fluids and declare its lung, damp and disappearing certainly.

Characteristics of the present invention are: pure Chinese herbal medicine is made, toxic and side effects is little, treating both the principal and secondary aspects of a disease, evident in efficacy, pain symptom disappears rapidly, cure the no rebound phenomena in back, be adapted to the pain therapy that various rheumatic and rheumatoid arthritis aches, cervical spondylosis, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, sciatica, hyperosteogeny diseases cause.

For showing the therapeutic effect of medicine of the present invention, through system's clinical observation: selected case history is divided into 2 groups at random, treatment group (A group) 147 examples, and male's 63 examples, the women 84; Age 19-68 year, average 51 years old; Rheumatic arthritis 49 examples wherein, rheumatoid arthritis 62 examples, other (as cervical spondylosis, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, sciatica, hyperosteogeny etc.) 36 examples.Matched group 128 examples are male's 59 examples wherein, and the women 69; Age 18-65 year, 48 years old mean age, rheumatic arthritis 36 examples wherein, rheumatoid arthritis 62 examples, other (as cervical spondylosis, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, sciatica, hyperosteogeny etc.) 30 examples.2 groups of cases are checked through t at aspects such as age, sex, the courses of disease, and difference does not have the significance meaning.Wherein smelting treatment group selects for use ointment of the present invention to stick, and matched group is selected " the deep ball of Jin wind " of vegetable garden board for use.

Criterion of therapeutical effect: (diagnostic criteria) carried out with reference to " the clinical research guideline of new Chinese medicine treatment numbness disease ".

Clinical cure: symptom all disappears, and it is normal that functional activity recovers; Main doctor trained in Western medicine physico-chemical examination is normal.

Produce effects: symptomatology disappears or main disease is eliminated, and function of joint is recovered substantially, can participate in normal work or physical labor; The physico-chemical examination index is normal substantially.

Effectively: cardinal symptom disappears substantially, and main function of joint is recovered substantially or had made marked progress, and can't take care of oneself transfers to and can take care of oneself, or loses the job and work and can state recover to some extent; Main physical and chemical index makes moderate progress.

Invalid: with the treatment before compare, each side does not all have progress.

Therapeutic outcome:

147 examples are organized in clinical total effects treatment, clinical cure 68 examples (46.3%), produce effects 42 examples (%28.6), effective 21 examples (14.3), invalid 16 examples (10.8), total effective rate 89.2%.Matched group 128 examples, clinical cure 31 examples (24.2%), produce effects 26 examples (20.3%), effective 19 examples (14.8%), invalid 52 examples (40.7%), total effective rate 59.3%.Two groups relatively, and the treatment group significantly is better than matched group.See the following form:

Group	Clinical cure	Produce effects	Effectively	Invalid	Total effective rate (%)
						Treatment group 147	????68(46.3)	??42(28.6)	??21(14.3)	??16(10.8)	??89.2
Matched group 128	????31(24.2)	??26(20.3)	??19(14.8)	??52(40.7)	??59.3

Case 1

Xu certain, sex: man, age: 55 years old;

The main suit: suffered from rheumatoid 30 years, moist ill because of being subjected in one's early years, weight when light during the state of an illness was once sought medical advice in inside and outside the province how tame hospital, and poor effect, the state of an illness but increase the weight of so far day by day, can't take care of oneself.

Symptom: duplex can not stretch two wrist moderates tetanic (the light activity degree is arranged), both shoulders pain, both arms can not go up act, two hip, two swelling and pain in knee, can not squat down, two ankle swells and ache, can only move and walk.

Chemical examination: RF (+) ESR:85mm/h resists " 0 ":＜500u

Diagnosis: rheumatoid arthritis, functional classification IV;

Adopt Drug therapy of the present invention, through three courses of treatment, two wrists, duplex, both shoulders activity freely, two knee joints can be squatted down, the disappearance of swelling and ache is advised it to continue to take medicine of the present invention and is consolidated two courses of treatment, follows up a case by regular visits to so far recurrence.

Case 2:

Record certain, sex: woman, age: 42 years old;

The main suit: because of puerperal careless, suffered from rheumatoid 12 years, the state of an illness is very serious, shows effect repeatedly by the multi-treatment state of an illness, causes and can't work.

Symptom: left finesse feels pain, gradually swelling, the distortion of left hand middle finger is at local hospital admission, the chemical examination rheumatoid factor positive, erythrocyte sedimentation rate 90mm/n, anti-" 0 ":＜480u begins with the treatment of Western medicine diclofenac, the state of an illness alleviates often bounce-back of back, after use Chinese herbal medicine decoction treatment instead, but poor effect, low thermal phenomenon is persistent.

Use this patent Drug therapy after course of treatment the left finesse pain disappear, swelling is progressively gone down, it is normal that the distortion of left hand middle finger slowly recovers, and follows the doctor's advice and continue to use medicine of the present invention to return to one's perfect health after two courses of treatment, and return to duty, follows up a case by regular visits to so far recurrence.

The specific embodiment:

Further specify the present invention below in conjunction with embodiment:

Embodiment 1

Take by weighing raw material by following proportioning: Radix Angelicae Pubescentis 15kg, Radix Saposhnikoviae 15kg, black-snake 20kg, Cortex Eucommiae 15kg, Rhizoma Gastrodiae 15kg, Flos Carthami 10kg, Rhizoma Chuanxiong 8kg, Rhizoma Cibotii 12kg, Radix Notoginseng 20kg, Radix Cyathulae 20kg, Radix Clematidis 20kg, Radix Glycyrrhizae 10kg, Radix Tripterygii Wilfordii 10kg, Rhizoma Atractylodis 18kg, Herba Ephedrae 3kg, the said medicine pulverize separately is become 80～110 order fine powders, behind the mix homogeneously, under 100 ℃～110 ℃, carry out the ripening sterilization treatment 10～30 minutes, promptly get powder medicine of the present invention.

Embodiment 2

Take by weighing raw material by following proportioning: Radix Angelicae Pubescentis 20kg, Radix Saposhnikoviae 12kg, black-snake 18kg, Cortex Eucommiae 18kg, Rhizoma Gastrodiae 20kg, Flos Carthami 8kg, Rhizoma Chuanxiong 10kg, Rhizoma Cibotii 8kg, Radix Notoginseng 15kg, Radix Cyathulae 18kg, Radix Clematidis 18kg, Radix Glycyrrhizae 15kg, Radix Tripterygii Wilfordii 10kg, Rhizoma Atractylodis 20kg, Herba Ephedrae 5kg, the said medicine pulverize separately is become 80～110 order fine powders, behind the mix homogeneously, under 100 ℃～110 ℃, carry out the ripening sterilization treatment 10～30 minutes, promptly get powder medicine of the present invention.

Claims (2)

1, a kind of medicine for the treatment of ache of rheumatoid arthritis, form by weight by following medicine:

Radix Angelicae Pubescentis 13-20 part, Radix Saposhnikoviae 10-18 part, black-snake 18-25 part, Cortex Eucommiae 13-18 part, Rhizoma Gastrodiae 15-20 part, Flos Carthami 8-15 part, Rhizoma Chuanxiong 8-15 part, Rhizoma Cibotii 8-15 part, Radix Notoginseng 15-20 part, Radix Cyathulae 15-22 part, Radix Clematidis 18-25 part, Radix Glycyrrhizae 12-15 part, Radix Tripterygii Wilfordii 8-12 part, Rhizoma Atractylodis 18-25 part, Herba Ephedrae 3-8 part.

2, medicine according to claim 1 is characterized in that it being the medicament of being made by the following weight proportion raw material:

15 parts of Radix Angelicae Pubescentiss, 15 parts of Radix Saposhnikoviaes, 20 parts of black-snakes, 15 parts of the Cortexs Eucommiae, 15 parts in Rhizoma Gastrodiae, 10 parts on Flos Carthami, 8 parts of Rhizoma Chuanxiongs, 12 parts of Rhizoma Cibotii, 20 parts of Radix Notoginseng, 20 parts of Radix Cyathulaes, 20 parts of Radix Clematidis, 10 parts in Radix Glycyrrhizae, 10 parts of Radix Tripterygii Wilfordiis, 18 parts of Rhizoma Atractylodis, 3 parts in Herba Ephedrae.