CN113532980B

CN113532980B - Automatic matrix solid-phase dispersion extraction device

Info

Publication number: CN113532980B
Application number: CN202110643466.3A
Authority: CN
Inventors: 吴友谊; 张占恩; 高仕谦; 李勇
Original assignee: Foshan Nanhai Suke Environmental Research Institute; Suzhou University of Science and Technology
Current assignee: Foshan Nanhai Suke Environmental Research Institute; Suzhou University of Science and Technology
Priority date: 2021-06-09
Filing date: 2021-06-09
Publication date: 2024-03-19
Anticipated expiration: 2041-06-09
Also published as: CN113532980A

Abstract

The invention discloses an automatic matrix solid-phase dispersion extraction device which automatically completes grinding, compaction and elution. In the three-dimensional grinding unit, one side of a grinder with a grinding cavity is provided with a screw rod, the other side of the grinder is provided with a rotating shaft, the screw rod and the rotating shaft are both connected with the grinder, the rotating shaft and the screw rod are both connected with a frame and can axially move along the frame, and a first driving device can drive the screw rod to rotate; in the column loading unit, the solid phase extraction tube and the collecting bottle are both arranged on the movable seat, the collecting bottle is positioned below the solid phase extraction tube, and the movable seat can move linearly; in the unloading unit, one end of the supporting plate is provided with a funnel with a filter screen and a valve, and the other end of the supporting plate can rotate along a vertical axis to drive the funnel to rotate below the grinder or above the solid-phase extraction tube; in the compacting unit, the fourth driving device can drive the pressing plug to descend into the solid-phase extraction tube; in the elution unit, one end of the infusion tube is connected with the sealing plug, the other end of the infusion tube is connected with the pump, and the fifth driving device can drive the sealing plug to descend and plug the solid-phase extraction tube.

Description

Automatic matrix solid-phase dispersion extraction device

Technical Field

The invention relates to the technical field of sample treatment, in particular to an automatic matrix solid-phase dispersion extraction device.

Background

It is well known that sample pretreatment is an important step prior to sample measurement. The sample pretreatment link occupies about 40% of the analysis and measurement time, and the quality of the sample pretreatment directly influences the accuracy of the analysis and measurement and even the analysis result, so that the selection of a stable and reliable sample pretreatment technology is extremely important.

Matrix solid-phase dispersion (MSPD) is an environmental sample pretreatment technology integrating sample crushing, dispersing, purifying and extracting steps, simplifies the sample pretreatment process, and is suitable for solid, semisolid and viscous samples. However, each link of MSPD, including weighing, mixing, grinding, column loading, and rinsing (eluting), is manual, which is time-consuming and labor-consuming, and the pretreatment results often vary with the strength and skill of the operator, even when the same operator is handling the MSPD, and the batch-to-batch results also vary widely. Meanwhile, MSPD work is completed manually, and the problems of low sample processing speed and small sample flux exist.

Disclosure of Invention

The invention aims to provide an automatic matrix solid-phase dispersion extraction device, which solves one or more technical problems in the prior art and at least provides a beneficial selection or creation condition.

The technical scheme adopted for solving the technical problems is as follows:

the invention provides an automatic matrix solid-phase dispersion extraction device, which comprises:

the three-dimensional grinding unit comprises a grinder, a frame and a first driving device; the grinder is provided with a grinding cavity, one side of the grinder is provided with a screw rod, the other side of the grinder is provided with a rotating shaft, the screw rod is connected with the grinder, the rotating shaft is connected with the grinder, the axis of the screw rod is coincident with that of the rotating shaft, the rotating shaft is connected with the frame and can axially move along the frame, the screw rod is connected with the frame and can axially move along the frame, and the first driving device is connected with the screw rod to drive the screw rod to axially rotate around the screw rod;

the column loading unit comprises a movable seat, a solid phase extraction tube and a collecting bottle, wherein the solid phase extraction tube is arranged on the movable seat, the collecting bottle is arranged on the movable seat and positioned below the solid phase extraction tube, and the movable seat can linearly move;

the discharging unit comprises a funnel and a supporting plate, wherein the inlet of the funnel is provided with a filter screen, the outlet of the funnel is provided with a valve, one end of the supporting plate is provided with a mounting hole which penetrates up and down, the funnel is arranged in the mounting hole, and the other end of the supporting plate can rotate along an axis which extends up and down so as to drive the funnel to rotate below the grinder or above the solid-phase extraction tube;

The compaction unit comprises a pressing plug and a fourth driving device, and the fourth driving device is connected with the pressing plug to drive the pressing plug to descend to the inner cavity of the solid-phase extraction tube;

the elution unit comprises a sealing plug, a perfusion tube, a pump and a fifth driving device, wherein the sealing plug is provided with a tube hole which penetrates up and down, one end of the perfusion tube is arranged in the tube hole, the other end of the perfusion tube is connected with the pump, and the fifth driving device is connected with the sealing plug to drive the sealing plug to descend and block the tube orifice of the solid-phase extraction tube.

The invention has at least the following beneficial effects: one side of the grinder is provided with a screw rod, the other side of the grinder is provided with a rotating shaft which coincides with the axis of the screw rod, the rotating shaft and the screw rod are respectively connected with the frame and can axially move along the screw rod, the first driving device drives the screw rod to rotate, the screw rod is driven to linearly move relative to the frame while rotating, the grinder is further driven to automatically perform three-dimensional movement, the grinder is provided with a grinding cavity for storing grinding beads, dispersing agents and samples, in the three-dimensional movement process of the grinder, the grinding beads, the dispersing agents and the samples do not only circular movement but also linear movement in the grinding cavity, the mixing sufficiency between the grinding beads, the dispersing agents and the samples are enhanced, and the extraction efficiency of the dispersing agents to the objects to be detected in the samples is improved.

The funnel is established in the backup pad, can impel the funnel to make a round trip to rotate between grinding ball and solid-phase extraction pipe through rotating the backup pad, accomplishes the transfer of the mixture after grinding, and the funnel sets up the filter screen moreover, can separate the grinding pearl, prevents that the grinding pearl from falling into in the solid-phase extraction pipe. The solid phase extraction tube and the collecting bottle are both arranged on the movable seat, the collecting bottle is arranged below the solid phase extraction tube, can collect liquid flowing out of the solid phase extraction tube, and the movable seat can move linearly to convey the solid phase extraction tube to the compacting unit or the eluting unit. The compaction unit drives the pressing plug to descend through the fourth driving device, and the mixture in the solid-phase extraction tube is automatically compacted. The elution unit drives the sealing plug to move downwards through the fifth driving device, plugs the pipe orifice of the solid-phase extraction pipe, prevents liquid from overflowing during elution, and the liquid conveyed by the pump is injected into the solid-phase extraction pipe through the infusion pipe arranged on the sealing plug to perform an elution procedure.

By adopting the structure, the invention can finish the automatic grinding, automatic compaction and automatic elution, greatly reduce the working intensity of operators, improve the precision of sample pretreatment, reduce the deviation among different operators and further improve the reproducibility of detection results.

As a further improvement of the above technical solution, the first driving device is a first motor, the first motor is connected with the frame and can move along the axial direction of the screw rod, and an output shaft of the first motor is connected with the screw rod. The first driving device adopts a first motor, the first motor is arranged on the frame and can move along the axial direction of the screw rod, an output shaft of the first motor is connected with the screw rod in a transmission way so as to drive the screw rod to rotate rapidly, and the screw rod is in threaded connection with the frame, so that the screw rod can move linearly relative to the frame at the same time, the screw rod can drive the first motor to move linearly, and the grinder can move linearly and circularly at the same time.

As a further improvement of the technical scheme, the axis of the screw rod, the axis of the rotating shaft and the axis of the grinder are three-line overlapped; the grinding cavity is spherical; the grinder is a sphere. The axes of the screw rod, the rotating shaft and the grinder are completely overlapped, so that the screw rod and the rotating shaft are uniformly stressed when the grinder rotates, and the screw rod and the rotating shaft are prevented from being damaged due to eccentric rotation of the grinder. And the grinding cavity is arranged into a spherical cavity, and in the spiral movement process of the grinder, the grinding beads, the dispersing agent and the sample can move in three dimensions along the wall surface of the spherical cavity, so that the collision among the three components is enhanced, the full mixing degree of the three components is improved, and the efficiency of extracting the to-be-detected object in the sample by the dispersing agent is improved. The grinder is designed into a sphere, and when the grinder rotates rapidly, the screw rod and the rotating shaft are stressed more uniformly, so that the grinder is ensured to move more stably.

As a further improvement of the above technical solution, the three-dimensional grinding unit further includes a ranging sensor and a first controller; the range finding sensor can emit light beams along the axial direction of the screw rod, the first motor is provided with an induction piece capable of reflecting the light beams of the range finding sensor, and the range finding sensor and the first motor are respectively and electrically connected with the first controller.

Set up range sensor and first controller, range sensor and first motor all with first controller electric connection, and first motor sets up the response piece, range sensor is to response piece transmission light beam, is received by range sensor after the reflection of response piece to measure the real-time distance of response piece relative range sensor, and then the position of control first motor, avoid first motor linear movement distance too big.

As a further improvement of the technical scheme, the grinder comprises a first shell and a second shell, one side of the first shell is elastically hinged with one side of the second shell, a lock body is arranged on the other side of the first shell, and the lock body is respectively connected with the first shell and the second shell. One side of the first shell and one side of the second shell are connected in a hinged mode, and a lock body is arranged to lock the other side of the first shell and the other side of the second shell, so that grinding beads, dispersing agents and samples placed in the grinding cavity are prevented from leaking outside the grinder, and the locking effect of the lock body is conveniently relieved, so that the dispersing agents, the grinding beads and the samples can be taken out.

As a further improvement of the technical scheme, the lock body is arranged on the first shell, and the second shell is provided with a lock hole; the lock body includes:

the lock shell is provided with a cavity and a locking port, and the locking port is communicated with the cavity;

the fixed rod is arranged in the cavity, and two ends of the fixed rod are connected with the lock shell;

the guide block is provided with a lock rod which can enter and exit the locking port and is inserted into the locking hole, and the axial direction of the lock rod is consistent with the axial direction of the screw rod; the guide block is provided with a sliding hole which can be sleeved on the fixed rod;

the spring is sleeved on the fixed rod, one end of the spring is connected with the guide block, and the other end of the spring is connected with the lock shell;

the iron core is arranged in the cavity, the iron core is connected with the lock shell, the iron core is wound with an electrified coil, and the iron core and the guide block are oppositely arranged to drive the guide block to move towards the direction of the spring;

a built-in power supply electrically connected to the energizing coil;

and the time control switch is electrically connected with the built-in power supply and the closed loop of the electrified coil.

The lock body is fixed on first casing, and the lock body includes lock shell, dead lever, takes guide block, spring, the iron core that winds the power coil, built-in power and time switch, and the dead lever is installed at the cavity of lock shell, and the guide block cover is on the dead lever, and the spring cover is connected with lock shell and guide block respectively on the dead lever and its both ends, through the elasticity of spring, makes the locking lever on the guide block stretch out the fore shaft of lock shell to insert the lockhole of second casing correspondingly, and then accomplish the locking of first casing and second casing.

And the iron core is arranged in the cavity and is opposite to the guide block, the built-in power supply is electrically connected with the electrified coil, and after the electrified coil is electrified, the iron core generates magnetic force to generate magnetic attraction to the guide block so as to drive the guide block to overcome the acting force of the spring and move, thereby withdrawing the lock rod on the guide block from the lock hole, releasing the locking effect of the lock body on the second shell, facilitating the quick opening of the grinder by a worker, and placing or taking out the grinding beads, the sample and the dispersing agent. The time control switch, the built-in power supply and the energizing coil are electrically connected in a closed loop, the time of energizing the energizing coil by the built-in power supply is accurately controlled through the time control switch, and the lock body can be automatically opened without manual operation.

As a further improvement of the above technical solution, the column loading unit further includes a third driving device, and the third driving device is connected with the moving seat to drive the moving seat to move linearly. The third driving device drives the movable seat to linearly move, so that the solid-phase extraction tube on the movable seat is sequentially compacted and eluted after the unloading and column filling process is completed, and the degree of automation is improved.

As a further improvement of the technical scheme, the discharging unit further comprises a weighing sensor, a base plate, a second controller and a second driving device; the base plate is positioned above the supporting plate, the base plate is provided with a through hole communicated with the mounting hole, the funnel is arranged in the through hole, and the weighing sensor is arranged between the supporting plate and the base plate; the second driving device is connected with the other end of the supporting plate to drive the supporting plate to rotate; the valve is an electric valve, and the weighing sensor and the electric valve are electrically connected with the second controller.

The second driving device is connected with the supporting plate to drive the supporting plate to rotate, so that the funnel is driven to automatically rotate to the upper part of the solid-phase extraction tube after the mixture poured from the grinder is collected, and the mixture is conveniently transferred into the solid-phase extraction tube. And the valve is set as the motorised valve, set up the backing plate that is used for supporting the funnel in the backup pad, set up weighing sensor between backing plate and backup pad, weighing sensor and motorised valve are respectively with second controller electric connection, the second controller controls the motorised valve and opens, the mixture falls to solid phase extraction pipe department from the funnel, weighing sensor detects the weight of funnel in real time, utilize differential principle, calculate the real-time weight of the mixture that gets into the solid phase extraction pipe, when real-time weight reaches the numerical value of settlement, the second controller is according to weighing sensor's signal rapid control motorised valve shutoff, thereby the weight of the mixture in the accurate control solid phase extraction pipe, and then accomplish the metering process of mixture automatically.

As a further improvement of the above technical solution, the electric valve includes:

the mounting plate is arranged on the hopper and is provided with a discharge hole;

the adjustable diaphragm is arranged on one side of the mounting plate and corresponds to the discharging hole, and the adjustable diaphragm is provided with a pulling handle;

The rotary ring is sleeved on the adjustable diaphragm, the rotary ring is provided with a bayonet which is clamped with the pulling handle, and the peripheral surface of the rotary ring is provided with a tooth part;

the driving motor is arranged on the mounting plate, a gear is arranged on an output shaft of the driving motor, and the gear is meshed with the tooth part.

The mounting panel is established in funnel department, and be equipped with the discharge opening that makes things convenient for the mixture in the funnel to flow out, adjustable diaphragm is fixed on the mounting panel, and the diaphragm hole and the coaxial setting of discharge opening of adjustable diaphragm can control opening and close of discharge opening, rotatory ring cover is on adjustable diaphragm, and be equipped with the bayonet socket that can block the pulling handle of adjustable diaphragm, driving motor's output shaft setting and the gear of rotatory ring tooth meshing, at driving motor during operation, through the meshing effect of gear and tooth, promote rotatory ring and rotate around its axis, thereby drive pulling handle rotation, realize the diaphragm hole automatic start and stop of adjustable diaphragm.

As a further improvement of the technical scheme, the solid phase extraction tube and the collection bottle are arranged at intervals along the moving direction of the moving seat. The movable seat is provided with a plurality of solid-phase extraction pipes and collecting bottles, and in the process of linear movement of the movable seat, one solid-phase extraction pipe is promoted to perform unloading and column filling or compaction when the other solid-phase extraction pipe performs an elution process, so that the efficiency is improved.

Drawings

The invention is further described below with reference to the drawings and examples;

FIG. 1 is a perspective view of an embodiment of an automatic matrix solid phase dispersion extraction apparatus according to the present invention;

FIG. 2 is a perspective view of the structure of the three-dimensional grinding unit of FIG. 1;

FIG. 3 is a perspective view of the three-dimensional abrasive unit of FIG. 1 from another perspective;

fig. 4 is a front view of the three-dimensional grinding unit of fig. 1;

FIG. 5 is a schematic view of the internal structure of the lock body according to the present invention;

FIG. 6 is a perspective view of the structure of the discharge unit of FIG. 1;

FIG. 7 is a perspective view showing the structure of the automatic matrix solid-phase dispersion extraction device according to the present invention in a state where the three-dimensional grinding unit is omitted;

FIG. 8 is a schematic view of a compacting unit provided by the present invention;

FIG. 9 is a perspective view of the structure of the column packing unit provided by the present invention;

fig. 10 is an exploded view of the structure of the electric valve provided by the present invention.

The reference numerals are as follows: 100. a three-dimensional grinding unit; 110. a grinder; 111. a first housing; 112. a second housing; 120. a rotating shaft; 130. a screw rod; 140. a slide rail; 150. a slide block; 160. a ranging sensor; 170. a first motor; 180. a frame; 191. a hinge; 192. a connection part; 210. a lock case; 220. a fixed rod; 230. a guide block; 240. a lock lever; 250. a spring; 260. an iron core; 270. a power-on coil; 280. a built-in power supply; 290. a switch;

300. A compacting unit; 310. a first bracket; 320. pressing down the plug; 330. a fourth driving device; 331. a fourth motor; 332. a fourth screw rod; 333. a loop bar; 334. a moving rod; 400. an elution unit; 410. a second bracket; 420. a pump; 430. an infusion tube; 440. sealing the plugs; 451. a third screw rod; 452. a third motor; 453. a third slider;

500. a column loading unit; 510. a movable seat; 511. a waist-shaped hole; 520. a fixing frame; 530. a positioning frame; 540. a third driving device; 600. a solid phase extraction tube; 700. a collection bottle; 800. a discharging unit; 810. a funnel; 820. a backing plate; 830. a support plate; 840. a rotation shaft; 850. a filter screen; 860. a second motor; 870. a synchronous pulley; 880. a synchronous belt; 890. a support;

910. a driving motor; 920. a gear; 930. a mounting plate; 931. a discharge hole; 940. an adjustable aperture; 941. pulling the handle; 950. a fixing ring; 951. a notch; 960. a rotating ring; 961. a bayonet; 962. teeth.

Detailed Description

Reference will now be made in detail to the present embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein the accompanying drawings are used to supplement the description of the written description so that one can intuitively and intuitively understand each technical feature and overall technical scheme of the present invention, but not to limit the scope of the present invention.

In the description of the present invention, it should be understood that references to orientation descriptions such as upper, lower, front, rear, left, right, etc. are based on the orientation or positional relationship shown in the drawings, are merely for convenience of description of the present invention and to simplify the description, and do not indicate or imply that the apparatus or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present invention.

In the description of the present invention, if there is a word description such as "a plurality" or the like, the meaning of the plurality is one or more, the meaning of the plurality is two or more, and greater than, less than, exceeding, etc. are understood to exclude the present number, and above, below, within, etc. are understood to include the present number. The description of first, second, and third is for the purpose of distinguishing between technical features only and should not be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of technical features indicated.

It should be noted that, in the drawing, the X direction is from the rear side to the front side of the automatic matrix solid-phase dispersion extraction device; the Y direction is from the left side to the right side of the automatic matrix solid-phase dispersion extraction device; the Z direction is from the lower side to the upper side of the automatic matrix solid-phase dispersion extraction device.

In the description of the present invention, unless explicitly defined otherwise, terms such as arrangement, installation, connection, etc. should be construed broadly and the specific meaning of the terms in the present invention can be reasonably determined by a person skilled in the art in combination with the specific contents of the technical scheme.

Referring to fig. 1 to 10, the following are examples of the automatic matrix solid phase dispersion extraction apparatus according to the present invention.

As shown in fig. 1 to 10, an embodiment of the present invention provides an automatic matrix solid phase dispersion extraction apparatus, which includes a three-dimensional grinding unit 100, a column loading unit 500, a discharging unit 800, a compacting unit 300, and an eluting unit 400.

As shown in fig. 1 to 4, the three-dimensional grinding unit 100 includes a frame 180, a grinder 110, and a first driving device.

The grinder 110 may be made of metal or polytetrafluoroethylene, and the grinder 110 is spherical. The grinder 110 is provided with a grinding cavity, and a worker can put grinding beads, a sample and a dispersing agent (or an adsorbent) into the grinding cavity, and the grinding beads (stainless steel balls or zirconium balls), the sample and the dispersing agent are collided and ground in the grinding cavity, so that the dispersing agent can adsorb an object to be detected in the sample, and the extraction work of the object to be detected is completed. The grinding cavity is spherical.

In this embodiment, the grinder 110 is a sphere, the grinder 110 includes a first housing 111 and a second housing 112, the first housing 111 and the second housing 112 may be hemispherical housings with uniform dimensions, and of course, the first housing 111 and the second housing 112 may also be housings with non-uniform dimensions and form a sphere after being combined. The first housing 111 is connected to the second housing 112 to facilitate movement of the polishing beads, dispersant and sample placed in the polishing chamber within the polishing chamber without leaking out of the polishing chamber.

Specifically, one side of the first casing 111 is hinged to one side of the second casing 112 through a hinge 191, further, a torsion spring is arranged on the hinge shaft, one end of the torsion spring is connected with the first casing 111, the other end of the torsion spring is connected with the second casing 112, elastic hinge of the first casing 111 and the second casing 112 is achieved through the action of the torsion spring, and the first casing 111 and the second casing 112 are enabled to be automatically sprung after unlocking. The other side of the first housing 111 is provided with a connecting portion 192, the connecting portion 192 is fixedly connected with the first housing 111, the connecting portion 192 is provided with a lock body, and the lock body is respectively connected with the first housing 111 and the second housing 112. The lock body is arranged on the first shell 111, the other side of the second shell 112 is provided with a connecting part 192, the connecting part 192 is provided with a lock hole, the lock hole can be a round hole, a square hole or other, and the axial direction of the lock hole is consistent with that of the screw rod 130.

As shown in fig. 5, more specifically, the lock body includes: the lock case 210, the fixing rod 220, the guide block 230, the spring 250, the iron core 260 and the built-in power supply 280.

The lock case 210 may be made of metal or plastic, the lock case 210 may be fastened to the connection portion 192 of the first housing 111 by bolts, the lock case 210 is provided with a cavity and a locking notch, the locking notch communicates with the cavity, and the locking notch may be circular, square or others.

The fixing rod 220 may be a plastic or metal piece, and is a round rod or a square rod. The fixing rod 220 is disposed in the cavity, and both ends of the fixing rod 220 and the lock case 210 may be fixedly connected by bolts.

The guide block 230 may be an iron block, and has a magnetic attraction property by a magnet, the guide block 230 is provided with a sliding hole capable of being sleeved on the fixing rod 220, and the shape of the sliding hole is matched with that of the fixing rod 220, so that the guide block 230 can linearly move back and forth along the length direction of the fixing rod 220.

The guide block 230 is provided with a locking bar 240, and the locking bar 240 and the guide block 230 may be integrally formed. The axial direction of the locking bar 240 is identical to the axial direction of the screw 130, and the locking bar 240 can enter and exit the locking notch of the locking housing 210 and be inserted into the locking hole of the second housing 112. Locking bar 240 is adapted to the locking hole, in this embodiment, locking bar 240 is a round bar.

The spring 250 is sleeved on the fixing rod 220, one end of the spring 250 is connected with the guide block 230 in a welding or clamping manner, and the other end of the spring 250 is connected with the lock case 210 in a welding or clamping manner, and as the spring 250 is in a compressed state, the spring 250 applies a force to the guide block 230 to promote the lock rod 240 on the guide block 230 to be inserted into the lock hole on the second housing 112. In this embodiment, the left end of the spring 250 is abutted against the right side surface of the guide block 230, the right end of the spring 250 is abutted against the inner wall surface of the lock case 210, and the spring 250 is not required to be fixed, so that the difficulty in assembling the lock body is reduced.

The iron core 260 is arranged in the cavity of the lock shell 210, the iron core 260 is connected with the lock shell 210 in a clamping way, specifically, the inner wall surface of the cavity of the lock shell 210 is protruded to form a clamping groove, and the iron core 260 is arranged in the clamping groove, so that the iron core 260 is fixed with the lock shell 210.

The iron core 260 is wound with an energizing coil 270, and the iron core 260 is disposed opposite to the guide block 230 to drive the guide block 230 to move toward the spring 250. In the present embodiment, the iron core 260 is located at the front side of the fixing lever 220 and at the right side of the guide block 230.

The built-in power supply 280 may be a dry cell battery, a button cell battery, or a lithium cell battery. When the internal power supply 280 is a lithium battery, the lock case 210 is provided with a charging socket for connecting the lithium battery. The internal power supply 280 is electrically connected to the energizing coil 270. In this embodiment, the switch 290 is disposed on the outer surface of the lock case 210, and the switch 290 may be a push button switch, a toggle switch, or the like. The built-in power supply 280, switch 290 and energizing coil 270 are electrically connected in a closed loop in sequence to form a loop.

When the worker closes the switch 290, the circuit is energized to supply power to the energizing coil 270 by the built-in power supply 280, so that the iron core 260 generates a magnetic field, the guide block 230 is magnetically attracted by a strong enough magnetic force, the guide block 230 is urged to move to the right against the elastic force of the spring 250, the lock rod 240 is urged to withdraw from the lock hole on the second housing 112, the first housing 111 and the second housing 112 can be separated, and the grinding beads, the sample and the dispersing agent in the grinding cavity are taken out.

In some embodiments, the lock body further comprises a time-controlled switch. A time-controlled switch is mounted on the lock housing 210, and the time-controlled switch may be a CN101A model of the electric brand of wink (or called timer). The timed switch, the built-in power supply 280 and the energized coil 270 are electrically connected in a closed loop. Time is set on the operation panel of the time control switch, and when the set time is reached, the built-in power supply 280 can supply power for the electrified coil 270, so that the lock body can be automatically opened.

The design is favorable for the automatic opening of the lock body after the grinding work is finished, and the mixture in the grinding cavity is promoted to automatically fall to the discharging unit 800.

In addition, a bolt connection method may be adopted, and the connection portion 192 of the first housing 111 and the connection portion 192 of the second housing 112 may be provided with screw holes penetrating up and down, respectively, to lock the first housing 111 and the second housing 112 together.

One side of the grinder 110 is provided with a screw rod 130, the other side of the grinder 110 is provided with a rotating shaft 120, the screw rod 130 is fixedly connected with the grinder 110 through welding or bolts, the rotating shaft 120 is fixedly connected with the grinder 110 through welding or bolts, and the axis of the screw rod 130 is coincident with the axis of the rotating shaft 120, so that the grinder 110 can rotate along with the screw rod 130 and the rotating shaft 120 when rotating.

In this embodiment, the screw 130 and the rotating shaft 120 are fixedly connected to the second housing 112, and the axis of the screw 130, the axis of the rotating shaft 120 and the axis of the grinder 110 are three-line coincident. Of course, it is not excluded that the axis of the grinder 110 does not coincide with the axes of the screw 130 and the rotation shaft 120, so that the grinder 110 makes an eccentric motion around the axial direction of the screw 130.

The rotating shaft 120 is connected to the frame 180 and can move along the axial direction thereof, specifically, the frame 180 is provided with a bearing, and the rotating shaft 120 is mounted on the bearing and can move linearly relative to the bearing. The screw 130 is connected with the frame 180 and can move along the axial direction thereof, specifically, the frame 180 is provided with a screw hole, the frame 180 is in threaded connection with the screw 130 through the screw hole, and the screw 130 can move linearly relative to the frame 180 while the screw 130 rotates.

In some embodiments, the outer circumference of the rotating shaft 120 is provided with external threads, and the frame 180 is provided with a screw hole in threaded connection with the rotating shaft 120.

The first driving means is connected to the screw 130 to drive the screw 130 to rotate around its axial direction. Specifically, the first driving device is a first motor 170, and an output shaft of the first motor 170 is connected to the screw 130. Specifically, the first motor 170 is in driving connection with the screw 130 through a coupling. The first motor 170 is a forward/reverse rotation motor, and an output shaft thereof can be rotated clockwise or counterclockwise. The first motor 170 is a servo motor, and can precisely control the total rotation angle of the screw 130, thereby controlling the linear movement distance of the screw 130.

When the screw rod 130 moves to the left, the output shaft of the first motor 170 rotates reversely to drive the screw rod 130 to move to the right, so that the grinder 110 moves linearly back and forth in the rotating process, the violent collision among the grinding beads, the sample and the dispersing agent is promoted, the mixing is more complete, and the extraction efficiency of the dispersing agent is further improved.

The first motor 170 is connected to the frame 180 and is movable in the axial direction of the screw 130. Specifically, the rack 180 is provided with one, two or more slide rails 140, the cross section of the slide rails 140 may be square or round, the length direction (i.e., Y direction) of the slide rails 140 is consistent with the axial direction of the screw rod 130, the bottom of the first motor 170 is provided with a slide block 150, the slide block 150 is slidably connected with the slide rails 140, and the slide block 150 slides on the slide rails 140 to promote the first motor 170 to move more stably in the linear movement process. In this embodiment, the frame 180 is provided with a chute, and the slider 150 is disposed in the chute.

In addition, instead of the slider 150, three guide wheels may be used to respectively contact the top surface and the two side surfaces of the slide rail 140, so that the friction between the first motor 170 and the frame 180 can be reduced.

The first motor 170 is started, the output shaft of the first motor 170 drives the screw rod 130 to rotate, and the screw rod 130 is in threaded connection with the rack 180, so that the screw rod 130 can move leftwards relative to the rack 180, and meanwhile, the first motor 170 is in sliding connection with the rack 180, so that the screw rod 130 can move linearly with the first motor 170. When the screw 130 moves linearly in place, the first motor 170 stops and drives the output shaft to rotate reversely, so that the screw 130 can move rightward relative to the frame 180 with the first motor 170.

In the spiral movement process of the screw rod 130, the grinder 110 rotates and moves linearly due to the fixed connection with the screw rod 130, so that the dispersing agent, the sample and the grinding beads placed in the grinding cavity of the grinder 110 collide more strongly and are mixed more fully, the extraction efficiency of the dispersing agent on the to-be-detected object in the sample is improved, the reproducibility of the detection result is enhanced, the working intensity of staff is reduced, and time and labor are saved.

In some embodiments, the three-dimensional grinding unit 100 further includes a ranging sensor 160 and a first controller.

The ranging sensor 160 may be a laser ranging sensor or an infrared ranging sensor. The ranging sensor 160 is fixed on the frame 180 through a bracket, the ranging sensor 160 can emit light beams along the axial direction of the screw rod 130, the first motor 170 is provided with a sensing piece which can reflect the light beams of the ranging sensor 160, the sensing piece can be a plastic plate or a metal plate, and the sensing piece can move linearly along with the first motor 170 through being fixed on the first motor 170 or the sliding block 150 through a bolt.

The first controller may be a PLC controller. The ranging sensor 160 and the first motor 170 are electrically connected to the first controller, respectively. The minimum distance value and the maximum distance value of the sensing piece from the distance measuring sensor 160 are set, and the distance measuring sensor 160 emits a light beam toward the sensing piece during the operation of the first motor 170 and the rotation of the screw 130, and the distance between the sensing piece and the distance measuring sensor 160 is detected in real time.

The first motor 170 drives the screw rod 130 to rotate, so that the sensing piece is driven to move towards the distance measuring sensor 160, when the real-time distance reaches the minimum distance value, the distance measuring sensor 160 generates a first detection signal and sends the first detection signal to the first controller, and the first controller generates a first control instruction after receiving the first detection signal, and the first control instruction controls the first motor 170 to stop running.

Next, the output shaft of the first motor 170 is controlled to rotate reversely, so as to drive the sensing piece to move back to the direction of the distance measuring sensor 160, when the real-time distance reaches the maximum distance value, the distance measuring sensor 160 generates a second detection signal and sends the second detection signal to the first controller, and the first controller generates a second control instruction after receiving the second detection signal, and the second control instruction controls the first motor 170 to stop working.

The above-mentioned actions are repeated continuously, so that the grinder 110 is driven by the screw 130 to perform three-dimensional motion (rotational motion plus linear motion) continuously.

As shown in fig. 1, 7 and 9, the column packing unit 500 includes a movable base 510, a solid phase extraction tube 600 and a collection bottle 700.

The solid phase extraction tube 600 is a syringe type extraction tube, the solid phase extraction tube 600 is arranged on the movable seat 510, specifically, the movable seat 510 is L-shaped, the fixed frame 520 is arranged, the fixed frame 520 is provided with a fixing hole, the solid phase extraction tube 600 is conveniently inserted into the fixing hole from top to bottom, and the solid phase extraction tube 600 is fixed on the movable seat 510.

The collection bottle 700 may be a conical glass bottle. The collecting bottle 700 is arranged on the movable seat 510 and is positioned below the solid-phase extraction tube 600, specifically, the movable seat 510 can be provided with a positioning frame 530, the movable seat 510 is provided with a waist-shaped hole 511 with two ends extending up and down, one end of the positioning frame 530 passes through the waist-shaped hole 511, one end of the positioning frame 530 is provided with two limiting blocks which are arranged at intervals, and the two limiting blocks are respectively abutted with the left side surface and the right side surface of the movable seat 510, so that the positioning frame 530 can only be driven to move up and down. The positioning frame 530 is provided with a positioning hole, and the positioning frame 530 moves from top to bottom until the bottle mouth of the collection bottle 700 is correspondingly inserted into the positioning hole, so that the collection bottle 700 is prevented from moving relative to the moving seat 510, and the bottle mouth of the collection bottle 700 is ensured to be aligned with the outlet of the solid phase extraction tube 600.

In addition, a positioning groove can be formed on the upper surface of the movable seat 510, and the collection bottle 700 can be correspondingly placed in the positioning groove, so that the bottle mouth of the collection bottle 700 can be aligned with the outlet of the solid phase extraction tube 600. The movable base 510 can linearly move along the Y direction, which is advantageous for the solid phase extraction tube 600 to move to the compacting unit 300 along with the movable base 510 after the column filling process is completed.

The solid phase extraction tube 600 and the collection vial 700 may be provided in one piece. In this embodiment, the solid phase extraction tube 600 and the collection bottle 700 are disposed at intervals along the moving direction (i.e., Y direction) of the moving base 510, and are arranged at uniform intervals. As shown in fig. 9, three solid phase extraction tubes 600 and collection bottles 700 are provided, respectively, so that one solid phase extraction tube 600 can be discharged and packed or compacted when the other solid phase extraction tube 600 performs the elution process, thereby improving the efficiency. Before the column loading operation is performed, a gasket for leakage prevention is placed in the solid phase extraction tube 600, and after the column loading operation is completed, another gasket is placed in the solid phase extraction tube 600.

In some embodiments, the column loading unit 500 further includes a third driving device 540, where the third driving device 540 is connected with the moving seat 510 to drive the moving seat 510 to perform linear motion, and specifically, the third driving device 540 may be a linear module, in this embodiment, a screw linear module is selected, the moving seat 510 is mounted on a slider of the screw linear module through a bolt, and a motor of the linear module may be a servo motor, so that the position of the solid phase extraction tube 600 in the Y direction can be accurately controlled, which is beneficial to implementing accurate movement of the solid phase extraction tube 600 to the unloading unit 800, the compacting unit 300 and the eluting unit 400.

As shown in fig. 1 and 6, the discharge unit 800 includes a hopper 810 and a support plate 830.

The inlet of the funnel 810 is provided with a filter screen 850, through which filter screen 850 the grinding beads are filtered out as the mixture is transferred from the grinder 110 to the funnel 810, avoiding the grinding beads falling through the funnel 810 into the solid phase extraction tube 600. The outlet of the funnel 810 is provided with a valve, which can be an electric valve or a manual valve, and the opening and closing of the outlet of the funnel 810 are controlled by the valve, and when the funnel 810 is positioned right above the solid phase extraction tube 600, the valve is opened to promote the mixture to fall into the solid phase extraction tube 600.

One end of the support plate 830 is provided with a mounting hole penetrating up and down, and the funnel 810 is provided in the mounting hole to facilitate the fixation of the funnel 810 on the support plate 830. The other end of the support plate 830 can rotate along the axis extending up and down to drive the funnel 810 to rotate below the grinder 110 or above the solid phase extraction tube 600, specifically, a rotating shaft 840 is mounted on the support 890 through a bearing, the other end of the support plate 830 is fixed at the upper end of the rotating shaft 840, the funnel 810 is driven to rotate below the grinder 110 by manually rotating the support plate 830 to collect the mixture falling from the grinder 110, and the funnel 810 can be driven to rotate above the solid phase extraction tube 600, so that the mixture can flow into the solid phase extraction tube 600 after being filtered.

In some embodiments, the discharge unit 800 further includes a load cell, a pad 820, a second controller, and a second drive device.

The second driving device is connected with the other end of the support plate 830 to drive the support plate 830 to rotate, specifically, the second driving device includes a second motor 860, a synchronous pulley 870, a synchronous belt 880 and a rotating shaft 840, the second motor 860 is a forward and reverse rotating motor, an output shaft of the second motor 860 can rotate clockwise or anticlockwise, the second motor 860 is a servo motor, the second motor 860 is arranged on the support 890, the synchronous pulley 870 is arranged on the output shaft of the second motor 860, the rotating shaft 840 is correspondingly provided with a synchronous pulley, and the synchronous belt 880 winds the synchronous pulley arranged on the rotating shaft 840 and the synchronous pulley 870 on the output shaft. The other end of the support plate 830 is fixed to the rotation shaft 840.

When the second motor 860 operates, the rotation shaft 840 is automatically rotated by the transmission of the timing belt 880. In this embodiment, the rotation shaft 840 automatically rotates through 180 ° to rotate the funnel 810 from below the grinder 110 to above the solid phase extraction tube 600. So designed, the position of the funnel 810 can be precisely controlled.

And, the pad 820 is positioned above the support plate 830, the pad 820 is provided with a through hole communicating with the mounting hole, and the funnel 810 is provided in the through hole, so that the funnel 810 and the pad 820 are fixed. The bottom surface of the pad 820 extends downwards to form a sleeve-shaped limiting part, and the limiting part is correspondingly inserted into the mounting hole of the support plate 830 from top to bottom, so that the support plate 830 is caused to limit the pad 820, and the pad 820 is prevented from moving on a horizontal plane. The load cell is arranged between the supporting plate 830 and the base plate 820, the base plate 820 is used for supporting the funnel 810, and the load cell is arranged to monitor the real-time weight of the funnel 810 in real time.

In this embodiment, the valve is an electric valve, and the weighing sensor and the electric valve are electrically connected to the second controller. The second controller may be a PLC controller. The second controller is set with a certain weight value m (i.e. the total mass of the mixture in the solid phase extraction tube 600), and the opening and closing of the electric valve is controlled by a subtraction method. For example, when all the mixture falls from the grinder 110 to the funnel 810, the total mass of the funnel 810 is M, the weighing sensor monitors the real-time weight of the funnel 810 in real time during the process that the mixture falls to the solid phase extraction tube 600 after the electric valve is opened, and when the real-time weight is (M-M), the second controller controls the electric valve to be closed, and this indicates that the weight of the mixture in the solid phase extraction tube 600 reaches the requirement.

When the solid phase extraction tubes 600 are provided in plurality, after the first solid phase extraction tube 600 is completely filled, the second solid phase extraction tube 600 can be moved to the lower part of the funnel 810, and when the real-time weight detected by the weighing sensor is (M-M-M), the second controller controls the electric valve to be closed, so that the filling operation of the solid phase extraction tube 600 is completed.

With the above structural design, the mixture can be transferred from the three-dimensional grinding unit 100 to the solid phase extraction tube 600, and the weight of the mixture in the solid phase extraction tube 600 can be precisely controlled.

In some embodiments, as shown in fig. 10, the electrically operated valve includes: a mounting plate 930, an adjustable diaphragm 940, a rotation ring 960 and a drive motor 910.

The mounting plate 930 is arranged on the funnel 810, the mounting plate 930 is fixed with the funnel 810, the mounting plate 930 is provided with a discharging hole 931, and the discharging hole 931 corresponds to an outlet of the funnel 810.

The adjustable diaphragm 940 is provided with a diaphragm aperture and a toggle handle 941, and the aperture size of the diaphragm aperture can be adjusted by rotating the toggle handle 941. The adjustable diaphragm 940 belongs to the prior art, and therefore, a detailed structure of the adjustable diaphragm 940 will not be described here. The adjustable diaphragm 940 is arranged on one side of the mounting plate 930, the diaphragm hole of the adjustable diaphragm 940 corresponds to the unloading hole 931, specifically, a fixed ring 950 is arranged, the fixed ring 950 is fixedly connected with the mounting plate 930 through bolts, the fixed ring 950 protrudes towards the surface of the adjustable diaphragm 940 to form a limit groove, the adjustable diaphragm 940 is enabled to be mounted in the limit groove, a notch 951 is arranged in the limit groove, and the turning handle 941 is convenient to rotate.

The rotating ring 960 is sleeved on the adjustable diaphragm 940, specifically, the rotating ring 960 is sleeved on the fixed ring 950, and the rotating ring 960 can rotate around the axis thereof. The rotating ring 960 is provided with a bayonet 961 which is clamped with the pulling handle 941, when the rotating ring 960 is sleeved on the fixed ring 950, the pulling handle 941 is clamped at the bayonet 961, and when the rotating ring 960 rotates, the pulling handle 941 can rotate along with the rotating ring. The outer circumferential surface of the rotating ring 960 is provided with teeth 962.

The driving motor 910 is a forward/reverse rotation motor, and an output shaft thereof can be rotated clockwise or counterclockwise. The driving motor 910 is a servo motor, the driving motor 910 is arranged on the mounting plate 930 through bolts, a gear 920 is arranged on an output shaft of the driving motor 910, and the gear 920 is in meshed connection with the tooth portion 962. When the driving motor 910 works, the rotating ring 960 is driven to rotate by the meshing action of the gear 920 and the tooth portion 962, so that the diaphragm aperture of the adjustable diaphragm 940 is opened and closed.

In this embodiment, two electric valves are provided, and the two electric valves are arranged up and down, and the diaphragm aperture axes of the adjustable diaphragm 940 are not coincident and are staggered, so as to precisely control the quality of the mixture passing through the electric valves.

As shown in fig. 1, 7 and 8, the compacting unit 300 includes a pressing plug 320 and a fourth driving device 330, and the fourth driving device 330 is connected with the pressing plug 320 to drive the pressing plug 320 to descend to the inner cavity of the solid phase extraction tube 600, and in particular, the fourth driving device 330 includes a fourth motor 331, a fourth screw 332, a sleeve 333 and a moving rod 334.

The fourth motor 331 is a forward/reverse rotation motor, and its output shaft can rotate clockwise or counterclockwise. The fourth motor 331 is a servo motor, and is mounted on the first bracket 310. One end of the sleeve lever 333 is fixed to the fourth motor 331, and the sleeve lever 333 is provided with a cavity capable of accommodating the moving lever 334. One end of the fourth screw rod 332 is connected with an output shaft of the fourth motor 331, the moving rod 334 is provided with an inner cavity, an inner thread is arranged on the peripheral wall surface of the inner cavity, the moving rod 334 is in threaded connection with the fourth screw rod 332, the moving rod 334 is axially provided with a sliding groove, the sleeve rod 333 is correspondingly provided with a sliding strip positioned in the cavity, the sliding strip is matched with and connected with the sliding groove, and the moving rod 334 can be caused to linearly move relative to the sleeve rod 333 and cannot rotate.

When the fourth motor 331 drives the fourth screw 332 to rotate, the fourth screw 332 drives the moving rod 334 to move up and down with the pressing plug 320, so as to compact the mixture in the solid phase extraction tube 600.

The pressing plug 320 may be a rubber piston, and the pressing plug 320 is provided with a chamfer to play a guiding role, so that the pressing plug 320 can be accurately inserted into the inner cavity of the solid phase extraction tube 600.

Further, the fourth driving device 330 may be an electric push rod.

The compacting unit 300 is arranged on the right side of the unloading unit 800, so that after the solid-phase extraction tube 600 finishes column loading, the movable seat 510 moves right with the solid-phase extraction tube 600 and moves to the compacting unit 300, and then the compacting unit 300 is controlled to automatically compact the mixture in the solid-phase extraction tube 600.

As shown in fig. 1 and 7, the elution unit 400 is disposed on the right side of the compacting unit 300, so that after the solid phase extraction tube 600 completes the compacting operation, the movable seat 510 moves to the right with the solid phase extraction tube 600, and moves to the elution unit 400, thereby controlling the elution unit 400 to automatically elute the mixture in the solid phase extraction tube 600. The elution unit 400 includes a sealing stopper 440, an infusion tube 430, a pump 420, and a fifth drive device.

The sealing plug 440 may be a rubber piston, and the sealing plug 440 is in a boss shape and can seal the pipe orifice (i.e. the inlet) of the solid phase extraction pipe 600. The sealing plug 440 is provided with a pipe hole penetrating up and down, one end of the infusion pipe 430 is arranged in the pipe hole, and the other end of the infusion pipe 430 is connected with the pump 420. The infusion tube 430 is a rubber tube. The pump 420 is a peristaltic pump, and the inlet end of the pump 420 can be respectively communicated with the eluent bottle and the eluent bottle through a switching valve and a pipeline, so that the eluent and the eluent are promoted to be conveyed into the solid-phase extraction tube 600.

The fifth driving device is connected with the sealing plug 440 to drive the sealing plug 440 to descend and plug the nozzle of the solid phase extraction tube 600, and specifically, the fifth driving device includes a third motor 452, a third screw rod 451, a third guide rod and a third sliding block 453. The third motor 452 is a counter-rotating motor, and its output shaft can rotate clockwise or counterclockwise. The third motor 452 is a servo motor and is mounted on the second bracket 410. One end of the third screw rod 451 is connected with an output shaft of the third motor 452, the axial direction of the third guide rod is consistent with that of the third screw rod 451, the third sliding block 453 is in sliding connection with the third guide rod and in threaded connection with the third screw rod 451, a connecting part is arranged at the upper end of the sealing plug 440, and the connecting part is fixedly connected with the third sliding block 453.

When the third motor 452 drives the third screw rod 451 to rotate, the third screw rod 451 can drive the third sliding block 453 to move downwards with the sealing plug 440, so as to seal the orifice of the solid phase extraction tube 600 and prevent the liquid from overflowing from the solid phase extraction tube 600. Moreover, the infusion tube 430 can move downwards along with the sealing plug 440, after the sealing plug 440 plugs the solid-phase extraction tube 600, the infusion tube 430 can inject the liquid conveyed by the pump 420 into the solid-phase extraction tube 600, and the output power of the pump 420 can be controlled to control the injection flow rate and pressure of the liquid, so that the eluent or the eluent is fully contacted with the mixture in the solid-phase extraction tube 600, and the analytes or impurities in the mixture are eluted or leached out. The waste liquid of the leaching agent flowing out of the solid phase extraction tube 600 is collected and discarded, and the eluent is collected for later use. If desired, some MSPD procedures may be eluted directly without a rinsing step.

Further, the fifth driving means may be an electric putter.

According to the automatic matrix solid-phase dispersion extraction device provided by the invention, through the organic cooperation of the three-dimensional grinding unit 100, the unloading unit 800, the column loading unit 500, the compacting unit 300 and the elution unit 400, the automation of mixing, grinding, column loading and leaching in the MSPD is realized, the automation of the MSPD process is effectively improved, and the grinding efficiency and the grinding precision (the relative standard deviation between grinding is reduced); meanwhile, the automatic matrix solid-phase dispersion extraction device can realize multi-tube simultaneous leaching (elution), and improves the flux and speed of analysis and detection.

The three-dimensional grinding unit 100, the unloading unit 800, the column loading unit 500, the compacting unit 300 and the elution unit 400 can be coordinated through the electric signal transmission and logic control of each servo motor, the weighing sensor and the controller, the grinding, metering, filling, compacting and eluting work can be automatically completed, and only the gasket is needed to be placed manually, so that the working strength is greatly reduced.

While the preferred embodiments of the present invention have been illustrated and described, the present invention is not limited to the embodiments, and various equivalent modifications and substitutions can be made by one skilled in the art without departing from the spirit of the present invention, and these are intended to be included in the scope of the present invention as defined in the appended claims.

Claims

1. An automatic matrix solid-phase dispersion extraction device, comprising:

a three-dimensional grinding unit (100) comprising a grinder (110), a frame (180) and a first drive means; the grinding device is characterized in that the grinding device (110) is provided with a grinding cavity, one side of the grinding device (110) is provided with a screw rod (130), the other side of the grinding device (110) is provided with a rotating shaft (120), the screw rod (130) is connected with the grinding device (110), the rotating shaft (120) is connected with the grinding device (110), the axis of the screw rod (130) coincides with the axis of the rotating shaft (120), the rotating shaft (120) is connected with a frame (180) and can axially move along the frame (180), the screw rod (130) is connected with the frame (180) and can axially move along the frame, and the first driving device is connected with the screw rod (130) to drive the screw rod (130) to axially rotate around the frame;

The column loading unit (500) comprises a movable seat (510), a solid phase extraction tube (600) and a collecting bottle (700), wherein the solid phase extraction tube (600) is arranged on the movable seat (510), the collecting bottle (700) is arranged on the movable seat (510) and is positioned below the solid phase extraction tube (600), and the movable seat (510) can move linearly;

the discharging unit (800) comprises a funnel (810) and a supporting plate (830), wherein a filter screen (850) is arranged at the inlet of the funnel (810), a valve is arranged at the outlet of the funnel (810), one end of the supporting plate (830) is provided with a mounting hole penetrating up and down, the funnel (810) is arranged in the mounting hole, and the other end of the supporting plate (830) can rotate along an axis extending up and down so as to drive the funnel (810) to rotate below the grinder (110) or above the solid-phase extraction tube (600);

the compaction unit (300) comprises a pressing plug (320) and a fourth driving device (330), wherein the fourth driving device (330) is connected with the pressing plug (320) to drive the pressing plug (320) to descend to the inner cavity of the solid-phase extraction tube (600);

the elution unit (400) comprises a sealing plug (440), an infusion tube (430), a pump (420) and a fifth driving device, wherein the sealing plug (440) is provided with a tube hole which is communicated with the upper portion and the lower portion, one end of the infusion tube (430) is arranged in the tube hole, the other end of the infusion tube (430) is connected with the pump (420), and the fifth driving device is connected with the sealing plug (440) to drive the sealing plug (440) to descend and block the tube orifice of the solid-phase extraction tube (600).

2. The automatic matrix solid phase dispersion extraction device according to claim 1, wherein the first driving device is a first motor (170), the first motor (170) is connected with the frame (180) and can move along the axial direction of the screw (130), and an output shaft of the first motor (170) is connected with the screw (130).

3. The automatic matrix solid phase dispersion extraction device according to claim 2, wherein the axis of the screw (130), the axis of the rotating shaft (120) and the axis of the grinder (110) are three-line coincident; the grinding cavity is spherical; the grinder (110) is a sphere.

4. An automated matrix solid phase dispersion extraction apparatus according to claim 3, wherein the three-dimensional milling unit (100) further comprises a ranging sensor (160) and a first controller; the distance measuring sensor (160) can emit light beams along the axial direction of the screw rod (130), the first motor (170) is provided with a sensing piece capable of reflecting the light beams of the distance measuring sensor (160), and the distance measuring sensor (160) and the first motor (170) are respectively and electrically connected with the first controller.

5. The apparatus according to any one of claims 1 to 4, wherein the grinder (110) comprises a first housing (111) and a second housing (112), one side of the first housing (111) is elastically hinged to one side of the second housing (112), and a lock body is provided on the other side of the first housing (111) and is connected to the first housing (111) and the second housing (112), respectively.

6. The automatic matrix solid phase dispersion extraction device according to claim 5, wherein the lock body is provided on the first housing (111), and the second housing (112) is provided with a lock hole; the lock body includes:

a lock housing (210) provided with a cavity and a locking notch, the locking notch being in communication with the cavity;

a fixing rod (220) arranged in the cavity, wherein two ends of the fixing rod (220) are connected with the lock shell (210);

a guide block (230) provided with a lock rod (240) which can enter and exit the locking opening and is inserted into the locking hole, wherein the axial direction of the lock rod (240) is consistent with the axial direction of the screw rod (130); the guide block (230) is provided with a sliding hole which can be sleeved on the fixed rod (220);

the spring (250) is sleeved on the fixed rod (220), one end of the spring (250) is connected with the guide block (230), and the other end of the spring (250) is connected with the lock shell (210);

the iron core (260) is arranged in the cavity, the iron core (260) is connected with the lock shell (210), the iron core (260) is wound with an energizing coil (270), and the iron core (260) and the guide block (230) are oppositely arranged to drive the guide block (230) to move towards the direction of the spring (250);

a built-in power supply (280) electrically connected to the energizing coil (270);

And the time control switch is electrically connected with the built-in power supply (280) and the closed loop of the energizing coil (270).

7. The apparatus according to claim 6, wherein the column unit (500) further comprises a third driving device (540), and the third driving device (540) is connected to the movable base (510) to drive the movable base (510) to move linearly.

8. The automated matrix solid phase dispersion extraction apparatus of claim 7, wherein the discharge unit (800) further comprises a load cell, a pad (820), a second controller, and a second drive means; the base plate (820) is positioned above the supporting plate (830), the base plate (820) is provided with a through hole communicated with the mounting hole, the funnel (810) is arranged in the through hole, and the weighing sensor is arranged between the supporting plate (830) and the base plate (820); the second driving device is connected with the other end of the supporting plate (830) to drive the supporting plate (830) to rotate; the valve is an electric valve, and the weighing sensor and the electric valve are electrically connected with the second controller.

9. The automated matrix solid phase dispersion extraction device of claim 8, wherein the motorized valve comprises:

a mounting plate (930) provided to the hopper (810), the mounting plate (930) being provided with a discharge hole (931);

An adjustable diaphragm (940) which is arranged on one side of the mounting plate (930) and corresponds to the discharging hole (931), wherein the adjustable diaphragm (940) is provided with a pulling handle (941);

a rotary ring (960) which is sleeved on the adjustable diaphragm (940), wherein the rotary ring (960) is provided with a bayonet (961) which is clamped with the pulling handle (941), and the outer circumferential surface of the rotary ring (960) is provided with a tooth part (962);

and the driving motor (910) is arranged on the mounting plate (930), a gear (920) is arranged on an output shaft of the driving motor (910), and the gear (920) is in meshed connection with the tooth part (962).

10. The apparatus according to claim 9, wherein the solid phase extraction tube (600) and the collection bottle (700) are provided in plural at intervals along the moving direction of the moving base (510).