CN113532980A

CN113532980A - Automatic matrix solid phase dispersion extraction device

Info

Publication number: CN113532980A
Application number: CN202110643466.3A
Authority: CN
Inventors: 吴友谊; 张占恩; 高仕谦; 李勇
Original assignee: Foshan Nanhai Suke Environmental Research Institute; Suzhou University of Science and Technology
Current assignee: Foshan Nanhai Suke Environmental Research Institute; Suzhou University of Science and Technology
Priority date: 2021-06-09
Filing date: 2021-06-09
Publication date: 2021-10-22
Anticipated expiration: 2041-06-09
Also published as: CN113532980B

Abstract

The invention discloses an automatic matrix solid phase dispersion extraction device which automatically finishes grinding, compacting and elution. In the three-dimensional grinding unit, one side of a grinder with a grinding cavity is provided with a screw rod, the other side of the grinder is provided with a rotating shaft, the screw rod and the rotating shaft are both connected with the grinder, the rotating shaft and the screw rod are both connected with a rack and can move along the axial direction of the rack, and a first driving device can drive the screw rod to rotate; in the column filling unit, the solid phase extraction tube and the collection bottle are both arranged on a movable seat, the collection bottle is positioned below the solid phase extraction tube, and the movable seat can move linearly; in the discharging unit, one end of a supporting plate is provided with a funnel with a filter screen and a valve, and the other end of the supporting plate can rotate along a vertical axis to drive the funnel to rotate below the grinder or above the solid-phase extraction tube; in the compaction unit, the fourth driving device can drive the lower pressing plug to descend into the solid-phase extraction tube; in the elution unit, one end of the liquid conveying pipe is connected with the sealing plug, the other end of the liquid conveying pipe is connected with the pump, and the fifth driving device can drive the sealing plug to descend and block the solid-phase extraction pipe.

Description

Automatic matrix solid phase dispersion extraction device

Technical Field

The invention relates to the technical field of sample treatment, in particular to an automatic matrix solid-phase dispersion extraction device.

Background

It is known that sample pretreatment is an important step before sample measurement. The sample pretreatment process occupies about 40% of the time of the analysis and determination, and the quality of the sample pretreatment directly affects the accuracy of the analysis and determination and even the analysis result, so that the selection of a stable and reliable sample pretreatment technology is very important.

Matrix solid-phase dispersion (MSPD) is an environmental sample pretreatment technology integrating sample crushing, dispersing, purifying and extracting steps, simplifies the sample pretreatment process, and is suitable for solid, semisolid and viscous samples. However, each step of MSPD, including weighing, mixing, grinding, column packing, and washing (elution), is performed manually, which is time-consuming and labor-consuming, and the pretreatment results are often different depending on the strength and technical skill of the operator, and even the same operator can process the MSPD, the batch-to-batch results are also greatly different. Meanwhile, the MSPD is completed in a manual mode, and the problems of low sample processing speed and small sample flux exist.

Disclosure of Invention

The invention aims to provide an automatic matrix solid phase dispersion extraction device, which solves one or more technical problems in the prior art and at least provides a beneficial selection or creation condition.

The technical scheme adopted for solving the technical problems is as follows:

the invention provides an automatic matrix solid phase dispersion extraction device, which comprises:

the three-dimensional grinding unit comprises a grinder, a rack and a first driving device; the grinding device is provided with a grinding cavity, a screw rod is arranged on one side of the grinding device, a rotating shaft is arranged on the other side of the grinding device, the screw rod is connected with the grinding device, the rotating shaft is connected with the grinding device, the axis of the screw rod is overlapped with the axis of the rotating shaft, the rotating shaft is connected with the rack and can move along the axial direction of the rack, the screw rod is connected with the rack and can move along the axial direction of the rack, and the first driving device is connected with the screw rod to drive the screw rod to rotate around the axial direction of the screw rod;

the column filling unit comprises a moving seat, a solid-phase extraction tube and a collection bottle, wherein the solid-phase extraction tube is arranged on the moving seat, the collection bottle is arranged on the moving seat and is positioned below the solid-phase extraction tube, and the moving seat can move linearly;

the discharging unit comprises a funnel and a supporting plate, a filter screen is arranged at the inlet of the funnel, a valve is arranged at the outlet of the funnel, a mounting hole penetrating through the funnel from top to bottom is formed in one end of the supporting plate, the funnel is arranged in the mounting hole, and the other end of the supporting plate can rotate along the axis extending up and down of the supporting plate so as to drive the funnel to rotate below the grinder or above the solid-phase extraction tube;

the compaction unit comprises a pressing plug and a fourth driving device, and the fourth driving device is connected with the pressing plug to drive the pressing plug to descend to the inner cavity of the solid-phase extraction tube;

the elution unit comprises a sealing plug, a transfusion pipe, a pump and a fifth driving device, wherein the sealing plug is provided with a pipe hole which is through from top to bottom, one end of the transfusion pipe is arranged in the pipe hole, the other end of the transfusion pipe is connected with the pump, and the fifth driving device is connected with the sealing plug to drive the sealing plug to descend and block the pipe orifice of the solid-phase extraction pipe.

The invention has at least the following beneficial effects: one side of mill sets up the lead screw, the opposite side sets up the pivot with lead screw axial line coincidence, pivot and lead screw are connected with the frame respectively and can follow its axial displacement, first drive arrangement drive lead screw is rotatory, make the lead screw rotatory while and carry out relative frame rectilinear movement, and then the automatic three dimensional motion that is of drive mill, and, the mill sets up the grinding chamber that is used for depositing the grinding pearl, dispersant and sample, in the three dimensional motion in-process of mill, the grinding pearl, dispersant and sample not only are circular motion in grinding the chamber, still be rectilinear motion, strengthen the abundant degree of mixture between them, promote the extraction efficiency of dispersant to the determinand in the sample.

The funnel is established in the backup pad, can make the funnel make a round trip to rotate between grinding ball and solid phase extraction pipe through rotating the backup pad, accomplishes the transfer of grinding back mixture, and the funnel sets up the filter screen moreover, but separation grinding pearl prevents that the grinding pearl from falling to in the solid phase extraction pipe. Solid phase extraction pipe and receiving flask all establish on removing the seat, and the receiving flask is located solid phase extraction pipe below, can collect the liquid from solid phase extraction pipe outflow, removes seat ability rectilinear movement, sends solid phase extraction pipe to compaction unit or elution unit. The compaction unit drives the pressing plug to descend through a fourth driving device, and the mixture in the solid-phase extraction pipe is automatically compacted. The elution unit drives the sealing plug to move downwards through the fifth driving device to plug the pipe orifice of the solid-phase extraction pipe, so that liquid is prevented from overflowing during elution, and the liquid conveying pipe arranged on the sealing plug injects the liquid conveyed by the pump into the solid-phase extraction pipe to perform an elution process.

By adopting the structure, the automatic grinding, compacting and eluting device can finish automatic grinding, automatic compacting and automatic eluting, greatly reduce the working intensity of operators, improve the precision of sample pretreatment, reduce the deviation among different operators and further improve the repeatability of detection results.

As a further improvement of the above technical solution, the first driving device is a first motor, the first motor is connected to the frame and can move along the axial direction of the screw rod, and an output shaft of the first motor is connected to the screw rod. The first driving device adopts a first motor, the first motor is installed on the rack and can move along the axial direction of the screw rod, an output shaft of the first motor is connected with the screw rod in a transmission mode to drive the screw rod to rotate rapidly, and the screw rod is in threaded connection with the rack, so that the screw rod can move linearly relative to the rack, the screw rod can drive the first motor to move linearly, and finally the grinder can move linearly and circularly simultaneously.

As a further improvement of the technical scheme, the axis of the screw rod, the axis of the rotating shaft and the axis of the grinder are superposed in three lines; the grinding cavity is spherical; the grinder is a spheroid. The axes of the screw rod, the rotating shaft and the grinder are completely overlapped, so that the screw rod and the rotating shaft are stressed uniformly when the grinder rotates, and the grinder is prevented from being eccentrically rotated to damage the screw rod and the rotating shaft. And the grinding cavity is provided with a spherical cavity, and in the process of the spiral motion of the grinder, the grinding beads, the dispersing agent and the sample can move in three dimensions along the wall surface of the spherical cavity, so that the collision among the grinding beads, the dispersing agent and the sample is enhanced, the full mixing degree of the grinding beads, the dispersing agent and the sample is improved, and the efficiency of extracting the substance to be detected in the sample by the dispersing agent is improved. The grinder is designed into a spheroid, and when the grinder rotates rapidly, the stress of the screw rod and the rotating shaft is balanced, so that the movement of the grinder is more stable.

As a further improvement of the above technical solution, the three-dimensional grinding unit further comprises a distance measuring sensor and a first controller; the distance measuring sensor can be along the axial of lead screw is launched the beam, first motor is equipped with the response piece that can reflect distance measuring sensor's beam, distance measuring sensor with first motor respectively with first controller electricity is connected.

Set up range sensor and first controller, range sensor and first motor all with first controller electric connection, and first motor sets up the response piece, and range sensor is to the response piece transmission beam, is received by range sensor after the response piece reflection to measure the relative range sensor's of response piece real-time distance, and then the position of control first motor, avoid first motor rectilinear movement distance too big.

As a further improvement of the above technical solution, the grinder includes a first housing and a second housing, one side of the first housing is elastically hinged to one side of the second housing, and the other side of the first housing is provided with a lock body, which is respectively connected to the first housing and the second housing. One side of first casing and one side of second casing are connected through articulated mode to, set up the lock body, lock the opposite side of first casing and the other side of second casing, to prevent to place grinding bead, dispersant and the sample in grinding the chamber and leak outside the mill, and conveniently remove the locking effect of lock body, in order to take out dispersant, grinding bead and sample.

As a further improvement of the above technical solution, the lock body is arranged on the first housing, and the second housing is provided with a lock hole; the lock body includes:

the lock shell is provided with a cavity and a locking port, and the locking port is communicated with the cavity;

the fixed rod is arranged in the cavity, and two ends of the fixed rod are connected with the lock shell;

the guide block is provided with a lock rod which can enter and exit the lock opening and is inserted into the lock hole, and the axial direction of the lock rod is consistent with the axial direction of the screw rod; the guide block is provided with a sliding hole which can be sleeved on the fixed rod;

the spring is sleeved on the fixed rod, one end of the spring is connected with the guide block, and the other end of the spring is connected with the lock shell;

the iron core is arranged in the cavity, connected with the lock shell and wound with an electrified coil, and is arranged opposite to the guide block so as to drive the guide block to move towards the spring direction;

a built-in power supply electrically connected to the energizing coil;

and the time control switch is electrically connected with the built-in power supply and the electrified coil in a closed loop manner.

The lock body is fixed on first casing, the lock body is including the lock shell, the dead lever, the guide block of taking the locking lever, a spring, around the iron core that has electrical coil, built-in power supply and time control switch, the dead lever is installed at the cavity of lock shell, the guide block cover is on the dead lever, and the spring housing is connected with lock shell and guide block respectively on the dead lever and its both ends, elasticity through the spring makes the locking lever on the guide block stretch out the fore shaft of lock shell, and correspond the lockhole that inserts the second casing, and then accomplish the locking of first casing and second casing.

And the iron core is arranged in the cavity and is opposite to the guide block, the built-in power supply is electrically connected with the electrified coil, after the electrified coil is electrified, the iron core generates magnetic force to generate magnetic attraction effect on the guide block so as to drive the guide block to overcome the acting force of the spring and move, so that the lock rod on the guide block is withdrawn from the lock hole, the locking effect of the lock body on the second shell is removed, the grinder is conveniently and quickly opened by a worker, and grinding beads, samples and dispersing agents are placed or taken out. Carry out the closed loop electricity with time switch, built-in power supply and circular telegram coil and connect, through the time of the circular telegram coil circular telegram of the accurate control of time switch built-in power supply, can realize that the lock body is automatic to be opened, need not manual operation.

As a further improvement of the above technical solution, the column mounting unit further includes a third driving device, and the third driving device is connected with the movable base to drive the movable base to move linearly. The third driving device drives the movable seat to move linearly, so that the solid-phase extraction tube on the movable seat is sequentially compacted and eluted after the discharging and column filling process is completed, and the automation degree is improved.

As a further improvement of the above technical solution, the discharging unit further comprises a weighing sensor, a pad, a second controller and a second driving device; the base plate is positioned above the supporting plate, the base plate is provided with a through hole communicated with the mounting hole, the funnel is arranged in the through hole, and the weighing sensor is arranged between the supporting plate and the base plate; the second driving device is connected with the other end of the supporting plate to drive the supporting plate to rotate; the valve is an electric valve, and the weighing sensor and the electric valve are both electrically connected with the second controller.

The second driving device is connected with the supporting plate to drive the supporting plate to rotate, so that the funnel automatically rotates to the upper part of the solid-phase extraction tube after the mixture poured out of the grinder is collected, and the mixture is conveniently transferred into the solid-phase extraction tube. And, the valve sets up to the motorised valve, set up the backing plate that is used for supporting the funnel in the backup pad, set up weighing sensor between backing plate and backup pad, weighing sensor and motorised valve respectively with second controller electric connection, second controller control motorised valve is opened, the mixture falls to solid phase extraction pipe department from the funnel, weighing sensor real-time detection funnel's weight, utilize the subtraction principle, calculate the real-time weight of the mixture that gets into the solid phase extraction pipe, when real-time weight reaches the numerical value of settlement, the motorised valve is controlled rapidly to the second controller according to weighing sensor's signal and is closed, thereby the weight of the intraductal mixture of accurate control solid phase extraction, and then accomplish the measurement process of mixture automatically.

As a further improvement of the above technical solution, the electric valve includes:

the mounting plate is arranged on the hopper and provided with a discharge hole;

the adjustable diaphragm is arranged on one side of the mounting plate and corresponds to the discharging hole, and a pulling handle is arranged on the adjustable diaphragm;

the rotating ring is sleeved on the adjustable diaphragm and provided with a bayonet in clamping connection with the pulling handle, and the outer peripheral surface of the rotating ring is provided with a tooth part;

and the driving motor is arranged on the mounting plate, and an output shaft of the driving motor is provided with a gear which is meshed with the tooth part.

The mounting panel is established in funnel department, and be equipped with the discharge opening that makes things convenient for the mixture outflow in the funnel, adjustable diaphragm is fixed on the mounting panel, and the diaphragm hole and the coaxial setting of discharge opening of adjustable diaphragm, can control opening and close of discharge opening, rotatory ring sleeve is on adjustable diaphragm, and be equipped with the bayonet socket that pulls the handle that can block adjustable diaphragm, driving motor's output shaft sets up the gear with rotatory ring's tooth portion meshing, at driving motor during operation, through the meshing effect of gear and tooth portion, impel rotatory ring to rotate round its axis, thereby it rotates to drive the handle of pulling, realize the automatic opening and closing of diaphragm hole of adjustable diaphragm.

As a further improvement of the technical proposal, a plurality of the solid phase extraction tubes and the collection bottles are arranged at intervals along the moving direction of the moving seat. Set up a plurality of solid phase extraction pipes and receiving flask on removing the seat, at the in-process that removes seat rectilinear motion, impel a solid phase extraction pipe to carry out the column packing of unloading or compaction when another solid phase extraction pipe carries out the elution process, raise the efficiency.

Drawings

The invention is further described with reference to the accompanying drawings and examples;

FIG. 1 is a perspective view of an embodiment of an automatic matrix solid phase dispersion extractor provided in the present invention;

FIG. 2 is a perspective view of the three-dimensional polishing unit of FIG. 1;

FIG. 3 is a perspective view of the three-dimensional polishing unit of FIG. 1 from another perspective;

FIG. 4 is a front view of the three-dimensional grinding unit of FIG. 1;

FIG. 5 is a schematic view of the internal structure of the lock body provided by the present invention;

FIG. 6 is a perspective view of the discharge unit of FIG. 1;

FIG. 7 is a perspective view of the automatic matrix solid phase dispersion extractor of the present invention without the three-dimensional milling unit;

FIG. 8 is a schematic view of a compaction unit provided by the present invention;

FIG. 9 is a perspective view of the structure of the column unit provided by the present invention;

fig. 10 is an exploded view of the structure of the electric valve provided in the present invention.

The reference numbers are as follows: 100. a three-dimensional grinding unit; 110. a grinder; 111. a first housing; 112. a second housing; 120. a rotating shaft; 130. a screw rod; 140. a slide rail; 150. a slider; 160. a ranging sensor; 170. a first motor; 180. a frame; 191. a hinge; 192. a connecting portion; 210. a lock case; 220. fixing the rod; 230. a guide block; 240. a lock lever; 250. a spring; 260. an iron core; 270. an electrified coil; 280. a built-in power supply; 290. a switch;

300. a compaction unit; 310. a first bracket; 320. pressing down the plug; 330. a fourth drive device; 331. a fourth motor; 332. a fourth screw rod; 333. a loop bar; 334. a travel bar; 400. an elution unit; 410. a second bracket; 420. a pump; 430. a transfusion tube; 440. sealing the plug; 451. a third screw rod; 452. a third motor; 453. a third slider;

500. a column loading unit; 510. a movable seat; 511. a kidney-shaped hole; 520. a fixed mount; 530. a positioning frame; 540. a third driving device; 600. a solid phase extraction tube; 700. a collection bottle; 800. a discharging unit; 810. a funnel; 820. a base plate; 830. a support plate; 840. a rotating shaft; 850. a filter screen; 860. a second motor; 870. a synchronous pulley; 880. a synchronous belt; 890. a support;

910. a drive motor; 920. a gear; 930. mounting a plate; 931. a discharge opening; 940. an adjustable diaphragm; 941. pulling the handle; 950. a fixing ring; 951. a notch; 960. a rotating ring; 961. a bayonet; 962. a tooth portion.

Detailed Description

Reference will now be made in detail to the present preferred embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to like elements throughout.

In the description of the present invention, it should be understood that the orientation or positional relationship referred to in the description of the orientation, such as the upper, lower, front, rear, left, right, etc., is based on the orientation or positional relationship shown in the drawings, and is only for convenience of description and simplification of description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, if words such as "a plurality" are described, it means one or more, a plurality is two or more, more than, less than, more than, etc. are understood as not including the present number, and more than, less than, etc. are understood as including the present number. If any description to first, second and third is only for the purpose of distinguishing technical features, it is not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.

It should be noted that, in the figure, the X direction is from the back side of the automatic matrix solid phase dispersion extraction device to the front side; the Y direction is from the left side of the automatic matrix solid phase dispersion extraction device to the right side; the Z direction is directed from the lower side to the upper side of the automatic matrix solid phase dispersion extraction apparatus.

In the description of the present invention, unless otherwise explicitly limited, terms such as arrangement, installation, connection and the like should be understood in a broad sense, and those skilled in the art can reasonably determine the specific meanings of the above terms in the present invention in combination with the specific contents of the technical solutions.

Referring to FIGS. 1 to 10, several examples of the automatic matrix solid phase dispersion extraction apparatus of the present invention will be described.

As shown in fig. 1 to 10, an embodiment of the present invention provides an automatic matrix solid phase dispersion extraction apparatus including a three-dimensional milling unit 100, a column loading unit 500, a discharging unit 800, a compacting unit 300, and an elution unit 400.

As shown in fig. 1 to 4, the three-dimensional grinding unit 100 includes a frame 180, a grinder 110, and a first driving means.

The grinder 110 may be made of metal or teflon and the grinder 110 is spherical. The grinder 110 is provided with a grinding chamber, and a worker can put grinding beads, a sample and a dispersant (or an adsorbent) into the grinding chamber, and the grinding beads (stainless steel beads or zirconium beads), the sample and the dispersant are subjected to collision grinding in the grinding chamber, so that the dispersant can adsorb an object to be detected in the sample, and the extraction of the object to be detected is completed. The grinding cavity is spherical.

In this embodiment, the grinder 110 is a spheroid, the grinder 110 includes a first shell 111 and a second shell 112, the first shell 111 and the second shell 112 may be hemispherical shells with the same size, and of course, the first shell 111 and the second shell 112 may also be shells with different sizes and form a spheroid after being spliced. The first housing 111 is connected to the second housing 112 to facilitate movement of the grinding beads, dispersant and sample in the grinding chamber without leakage from the grinding chamber.

Specifically, one side of the first housing 111 is hinged to one side of the second housing 112 through the hinge 191, and further, a torsion spring is arranged on the hinged shaft, one end of the torsion spring is connected with the first housing 111, the other end of the torsion spring is connected with the second housing 112, and under the action of the torsion spring, the first housing 111 is elastically hinged to the second housing 112, so that the first housing 111 and the second housing 112 can be automatically bounced off after being unlocked. The other side of the first shell 111 is provided with a connecting portion 192, the connecting portion 192 is fixedly connected with the first shell 111, and the connecting portion 192 is provided with a lock body which is respectively connected with the first shell 111 and the second shell 112. The lock body is arranged on the first shell 111, the connecting part 192 is arranged on the other side of the second shell 112, the connecting part 192 is provided with a lock hole which can be a round hole, a square hole or the like, and the axial direction of the lock hole is consistent with the axial direction of the screw rod 130.

As shown in fig. 5, more specifically, the lock body includes: a lock case 210, a fixing rod 220, a guide block 230, a spring 250, an iron core 260 and a built-in power supply 280.

The lock case 210 may be made of metal or plastic, the lock case 210 may be fixed to the connecting portion 192 of the first housing 111 by bolts, and the lock case 210 is provided with a cavity and a locking notch, the locking notch may be circular, square or other.

The fixing rod 220 may be a plastic or metal member, and may be a round rod or a square rod. The fixing rod 220 is disposed in the cavity, and both ends of the fixing rod 220 may be fixedly connected to the lock case 210 by bolts.

The guide block 230 may be an iron block having a magnetic property, and the guide block 230 has a sliding hole capable of being fitted on the fixing rod 220, and the shape of the sliding hole is matched with the shape of the fixing rod 220, so that the guide block 230 can move linearly back and forth along the length direction of the fixing rod 220.

The guide block 230 is provided with a locking bar 240, and the locking bar 240 and the guide block 230 may be integrally formed. The locking rod 240 has an axial direction corresponding to the axial direction of the lead screw 130, and the locking rod 240 can enter and exit the locking hole of the lock case 210 and be inserted into the locking hole of the second housing 112. The lock bar 240 is adapted to the lock hole, and in this embodiment, the lock bar 240 is a round bar.

The spring 250 is sleeved on the fixing rod 220, one end of the spring 250 is connected with the guide block 230 in a welding or clamping manner, the other end of the spring 250 is connected with the lock case 210 in a welding or clamping manner, and since the spring 250 is in a compressed state, the spring 250 applies an acting force to the guide block 230 to urge the lock rod 240 on the guide block 230 to be inserted into the lock hole on the second housing 112. In this embodiment, the left end of the spring 250 abuts against the right side surface of the guide block 230, and the right end of the spring 250 abuts against the inner wall surface of the lock case 210, so that the spring 250 does not need to be fixed, and the difficulty in assembling the lock body is reduced.

The iron core 260 is arranged in the cavity of the lock case 210, the iron core 260 is connected with the lock case 210 in a clamping mode, specifically, the inner wall surface of the cavity of the lock case 210 protrudes to form a clamping groove, and the iron core 260 is arranged in the clamping groove to realize that the iron core 260 is fixed with the lock case 210.

The iron core 260 is wound with an electrified coil 270, and the iron core 260 is disposed opposite to the guide block 230 to drive the guide block 230 to move toward the spring 250. In the present embodiment, the iron core 260 is positioned at the front side of the fixing lever 220 and at the right side of the guide block 230.

The internal power supply 280 may be a dry cell, button cell, or lithium cell. When the internal power source 280 is a lithium battery, the lock case 210 is provided with a charging jack for connection of the lithium battery. The built-in power supply 280 is electrically connected to the energizing coil 270. In this embodiment, a switch 290 is disposed on the outer surface of the lock case 210, and the switch 290 may be a push button switch, a toggle switch, or the like. The internal power supply 280, the switch 290 and the energizing coil 270 are electrically connected in sequence in a closed loop to form a circuit.

When the worker closes the switch 290, the circuit is powered on, the built-in power supply 280 supplies power to the powered coil 270, so that the iron core 260 generates a magnetic field, the guide block 230 is magnetically attracted by sufficiently strong magnetic force, the guide block 230 is driven to move to the right against the elastic force of the spring 250, the lock rod 240 is driven to exit from the lock hole in the second shell 112, the first shell 111 and the second shell 112 are driven to be separated, and the grinding beads, the sample and the dispersing agent in the grinding chamber are taken out.

In some embodiments, the lock body further comprises a time controlled switch. A time switch, which may be a geodetic model CN101A (or timer), is mounted on the lock housing 210. The time switch, internal power supply 280 and energizing coil 270 are electrically connected in a closed loop. Time is set on an operation panel of the time control switch, and when the set time is reached, the built-in power supply 280 can supply power to the electrified coil 270, so that the lock body is automatically opened.

Such a design is beneficial to the lock body to be automatically opened after the grinding work is finished, so that the mixture in the grinding cavity is automatically dropped to the discharging unit 800.

Further, a bolt connection method may be adopted, in which the connection portion 192 of the first housing 111 and the connection portion 192 of the second housing 112 are provided with vertically penetrating screw holes in correspondence to each other, and the first housing 111 and the second housing 112 are locked together.

One side of the grinder 110 is provided with a screw rod 130, the other side of the grinder 110 is provided with a rotating shaft 120, the screw rod 130 is fixedly connected with the grinder 110 through welding or bolts, the rotating shaft 120 is fixedly connected with the grinder 110 through welding or bolts, and the axis of the screw rod 130 is overlapped with the axis of the rotating shaft 120, so that the grinder 110 can rotate along with the screw rod 130 and the rotating shaft 120 when the screw rod 130 and the rotating shaft 120 rotate.

In the present embodiment, the screw 130 and the rotating shaft 120 are both fixedly connected to the second housing 112, and the axis of the screw 130, the axis of the rotating shaft 120 and the axis of the grinder 110 are overlapped by three lines. Of course, it is not excluded that the axis of the grinder 110 does not coincide with the axes of the screw 130 and the rotating shaft 120, so that the grinder 110 eccentrically moves around the axial direction of the screw 130.

The rotating shaft 120 is connected with the frame 180 and can move along the axial direction thereof, specifically, the frame 180 is provided with a bearing, and the rotating shaft 120 is mounted on the bearing and can move linearly relative to the bearing. The screw rod 130 is connected with the frame 180 and can move along the axial direction of the screw rod, specifically, the frame 180 is provided with a screw hole, the frame 180 is in threaded connection with the screw rod 130 through the screw hole, and the screw rod 130 can move linearly relative to the frame 180 while the screw rod 130 rotates.

In some embodiments, the outer circumferential surface of the shaft 120 is provided with external threads, and the frame 180 is provided with screw holes to be threadedly coupled with the shaft 120.

The first driving device is connected to the screw 130 to drive the screw 130 to rotate around its axial direction. Specifically, the first driving device is a first motor 170, and an output shaft of the first motor 170 is connected to the screw 130. Specifically, the first motor 170 is in transmission connection with the lead screw 130 through a coupling. The first motor 170 is a forward-reverse motor, and an output shaft thereof can rotate clockwise or counterclockwise. The first motor 170 is a servo motor, and can precisely control the total rotation angle of the lead screw 130, thereby controlling the linear movement distance of the lead screw 130.

When the screw 130 moves to the left in place, the output shaft of the first motor 170 rotates in the opposite direction to drive the screw 130 to move to the right, so that the grinder 110 moves linearly back and forth in the rotating process, the grinding beads, the sample and the dispersant are promoted to collide strongly, the mixing is more sufficient, and the extraction efficiency of the dispersant is further improved.

The first motor 170 is connected to the frame 180 and is movable in the axial direction of the lead screw 130. Specifically, the rack 180 is provided with one, two or more slide rails 140, the slide rails 140 may be provided, the cross section of each slide rail 140 may be square or circular, the length direction (i.e., the Y direction) of each slide rail 140 is consistent with the axial direction of the lead screw 130, the bottom of the first motor 170 is provided with the slider 150, the slider 150 is slidably connected with the slide rails 140, and the slider 150 slides on the slide rails 140 to promote the first motor 170 to move more stably in the linear movement process. In this embodiment, the frame 180 is provided with a sliding slot, and the sliding block 150 is provided in the sliding slot.

In addition, a guide wheel may be used instead of the sliding block 150, and three guide wheels may be used to respectively abut against the top surface and two side surfaces of the sliding rail 140, so as to reduce the friction between the first motor 170 and the frame 180.

The first motor 170 is started, the output shaft of the first motor 170 drives the screw rod 130 to rotate, the screw rod 130 can move leftwards relative to the rack 180 due to the threaded connection of the screw rod 130 and the rack 180, and meanwhile, the screw rod 130 can drive the first motor 170 to move linearly due to the sliding connection of the first motor 170 and the rack 180. When the screw 130 moves linearly to the right, the first motor 170 stops and drives the output shaft to rotate in the opposite direction, so that the screw 130 can drive the first motor 170 to move right relative to the frame 180.

In the screw motion process of lead screw 130, mill 110 is because of rotating and rectilinear movement with lead screw 130 fixed connection, and the dispersion agent, the sample and the grinding bead collision of the grinding chamber of the promotion of placing in mill 110 are violent, and mixed more fully to improve the extraction efficiency of dispersion agent to the determinand in the sample and strengthen the test result reproducibility, in addition, alleviateed staff's working strength, labour saving and time saving.

In some embodiments, the three-dimensional grinding unit 100 further includes a ranging sensor 160 and a first controller.

The ranging sensor 160 may be a laser ranging sensor or an infrared ranging sensor. The distance measuring sensor 160 is fixed on the frame 180 through a support, the distance measuring sensor 160 can emit a light beam along the axial direction of the screw rod 130, the first motor 170 is provided with a sensing piece which can reflect the light beam of the distance measuring sensor 160, the sensing piece can be a plastic plate or a metal plate and is fixed on the first motor 170 or the sliding block 150 through a bolt, and the sensing piece can move linearly along with the first motor 170.

The first controller may be a PLC controller. The distance measuring sensor 160 and the first motor 170 are electrically connected to the first controller, respectively. The minimum distance value and the maximum distance value between the sensing piece and the distance measuring sensor 160 are set, and in the process that the first motor 170 operates and drives the screw 130 to rotate, the distance measuring sensor 160 emits a light beam towards the sensing piece, so that the distance between the sensing piece and the distance measuring sensor 160 is detected in real time.

The first motor 170 drives the screw rod 130 to rotate, so that the induction sheet moves towards the distance measuring sensor 160, when the real-time distance reaches a minimum distance value, the distance measuring sensor 160 generates a first detection signal and sends the first detection signal to the first controller, the first controller generates a first control instruction after receiving the first detection signal, and the first control instruction controls the first motor 170 to stop running.

Next, the output shaft of the first motor 170 is controlled to rotate in the reverse direction, so that the sensing piece moves away from the distance measuring sensor 160, when the real-time distance reaches the maximum distance value, the distance measuring sensor 160 generates a second detection signal and sends the second detection signal to the first controller, the first controller generates a second control command after receiving the second detection signal, and the second control command controls the first motor 170 to stop working.

The above actions are repeated continuously, so that the grinder 110 is driven by the screw 130 to make three-dimensional motion (rotational motion plus linear motion).

As shown in fig. 1, 7 and 9, the cartridge unit 500 includes a movable base 510, a solid phase extraction tube 600 and a collection bottle 700.

The solid phase extraction tube 600 is a syringe type extraction tube, and the solid phase extraction tube 600 is arranged on the movable base 510, specifically, the movable base 510 is L-shaped, and the fixed base 520 is arranged, and the fixed base 520 is provided with a fixed hole, so that the solid phase extraction tube 600 can be conveniently inserted into the fixed hole from top to bottom, and the solid phase extraction tube 600 is fixed on the movable base 510.

The collection bottle 700 may be a glass cone. The collecting bottle 700 is arranged on the movable base 510 and is located below the solid-phase extraction tube 600, specifically, the movable base 510 can be provided with a positioning frame 530, the movable base 510 is provided with waist-shaped holes 511, two ends of each waist-shaped hole 511 extend vertically, one end of the positioning frame 530 penetrates through the waist-shaped holes 511, one end of the positioning frame 530 is provided with two limiting blocks arranged at intervals, and the two limiting blocks are respectively abutted to the left side face and the right side face of the movable base 510 to enable the positioning frame 530 to move up and down only. The positioning frame 530 is provided with positioning holes, and the positioning frame 530 moves from top to bottom until the opening of the collection bottle 700 is inserted into the positioning holes, so as to prevent the collection bottle 700 from moving relative to the movable base 510 and ensure that the opening of the collection bottle 700 can be aligned with the outlet of the solid-phase extraction tube 600.

In addition, the upper surface of the movable seat 510 may be provided with a positioning groove, and the collection bottle 700 is correspondingly placed in the positioning groove, so that the bottle mouth of the collection bottle 700 can be aligned with the outlet of the solid phase extraction tube 600. The movable base 510 can move linearly along the Y-direction, which is beneficial to the solid phase extraction tube 600 moving to the compacting unit 300 along with the movable base 510 after completing the column packing process.

The solid phase extraction tube 600 and the collection bottle 700 may be provided as one. In the present embodiment, the solid phase extraction tubes 600 and the collection bottles 700 are provided in plurality at intervals along the moving direction (i.e., Y direction) of the moving base 510, and are arranged at uniform intervals. As shown in fig. 9, three solid phase extraction tubes 600 and three collection bottles 700 are provided, so that one solid phase extraction tube 600 can be unloaded and packed or compacted when another solid phase extraction tube 600 is used for an elution process, thereby improving efficiency. Before the column packing work is carried out, a gasket for leakage prevention is placed in the solid-phase extraction tube 600, and after the column packing work is completed, another gasket is placed in the solid-phase extraction tube 600.

In some embodiments, the column loading unit 500 further includes a third driving device 540, the third driving device 540 is connected to the movable base 510 to drive the movable base 510 to move linearly, specifically, the third driving device 540 may be a linear module, in this embodiment, a lead screw linear module is selected, the movable base 510 is installed on a slider of the lead screw linear module through a bolt, a motor of the linear module may be a servo motor, which can precisely control the position of the solid phase extraction tube 600 in the Y direction, and is favorable for realizing that the solid phase extraction tube 600 accurately moves to the unloading unit 800, the compacting unit 300 and the elution unit 400.

As shown in fig. 1 and 6, the discharging unit 800 includes a hopper 810 and a supporting plate 830.

The inlet of the funnel 810 is provided with a filter screen 850, and when the mixture is transferred from the grinder 110 to the funnel 810, the grinding beads are filtered by the filter screen 850, so that the grinding beads are prevented from falling into the solid phase extraction tube 600 through the funnel 810. The outlet of the funnel 810 is provided with a valve, which can be an electric valve or a manual valve, and the opening and closing of the outlet of the funnel 810 are controlled by the valve, and when the funnel 810 is positioned right above the solid phase extraction tube 600, the valve is opened to cause the mixture to fall into the solid phase extraction tube 600.

One end of the supporting plate 830 is provided with a mounting hole penetrating up and down, and the funnel 810 is arranged in the mounting hole, so that the funnel 810 is fixed on the supporting plate 830. The other end of the supporting plate 830 can rotate along the axis extending up and down to drive the funnel 810 to rotate to the lower part of the grinder 110 or the upper part of the solid phase extraction tube 600, specifically, a rotating shaft 840 is mounted on the support 890 through a bearing, the other end of the supporting plate 830 is fixed on the upper end of the rotating shaft 840, the funnel 810 is driven to rotate to the lower part of the grinder 110 by manually rotating the supporting plate 830 to collect the mixture falling from the grinder 110, and the funnel 810 can be driven to rotate to the upper part of the solid phase extraction tube 600, so that the mixture can flow into the solid phase extraction tube 600 after being filtered.

In some embodiments, the discharge unit 800 further includes a load cell, a tie plate 820, a second controller, and a second drive.

The second driving device is connected to the other end of the supporting plate 830 to drive the supporting plate 830 to rotate, and specifically, the second driving device includes a second motor 860, a synchronous pulley 870, a synchronous belt 880 and a rotating shaft 840, the second motor 860 is a forward/reverse motor, an output shaft of the forward/reverse motor can rotate clockwise or counterclockwise, the second motor 860 is a servo motor, the second motor 860 is disposed on the support 890, the synchronous pulley 870 is disposed on an output shaft of the second motor 860, the rotating shaft 840 is correspondingly provided with a synchronous pulley, and the synchronous belt 880 is wound around the synchronous pulley disposed on the rotating shaft 840 and the synchronous pulley 870 disposed on the output shaft. The other end of the support plate 830 is fixed to the rotational shaft 840.

When the second motor 860 is operated, the rotation shaft 840 is automatically rotated by the driving action of the timing belt 880. In this embodiment, the rotating shaft 840 automatically rotates through 180 ° such that the funnel 810 rotates from below the grinder 110 to above the solid phase extraction tube 600. By such design, the position of the funnel 810 can be precisely controlled.

And, the backing plate 820 is located above the supporting plate 830, the backing plate 820 is provided with a through hole communicated with the mounting hole, and the funnel 810 is arranged in the through hole, so that the funnel 810 and the backing plate 820 are fixed. The bottom surface of backing plate 820 extends downwards and forms the spacing portion of cover barrel-shaped, and spacing portion from top to bottom corresponds and inserts in the mounting hole of backup pad 830, makes backup pad 830 produce limiting displacement to backing plate 820, avoids backing plate 820 to remove on the horizontal plane. The load cell is positioned between the support plate 830 and the support plate 820, the support plate 820 supports the funnel 810, and the load cell is configured to monitor the real-time weight of the funnel 810 in real time.

In this embodiment, the valve is an electric valve, and the weighing sensor and the electric valve are both electrically connected to the second controller. The second controller may be a PLC controller. A certain weight value m (i.e. the total mass of the mixture in the solid phase extraction tube 600) is set for the second controller, and the opening and closing of the electric valve are controlled by using a subtraction method. For example, when all the mixture falls from the grinder 110 into the funnel 810, the total mass of the funnel 810 is M, and the mixture falls into the solid phase extraction tube 600 after the electric valve is opened, the weighing sensor will monitor the real-time weight of the funnel 810 in real time, and when the real-time weight is (M-M), the second controller controls the electric valve to close, which indicates that the weight of the mixture in the solid phase extraction tube 600 meets the requirement.

When a plurality of solid phase extraction tubes 600 are provided, after the column loading of the first solid phase extraction tube 600 is completed, the second solid phase extraction tube 600 can be moved to the position below the funnel 810, and when the real-time weight detected by the weighing sensor is (M-M), the second controller controls the electric valve to close, which indicates that the column loading of the solid phase extraction tube 600 is completed.

By adopting the above structural design, the mixture can be transferred from the three-dimensional grinding unit 100 to the solid-phase extraction tube 600, and the weight of the mixture in the solid-phase extraction tube 600 can be accurately controlled.

In some embodiments, as shown in fig. 10, the electric valve comprises: a mounting plate 930, an adjustable diaphragm 940, a rotating ring 960 and a drive motor 910.

The mounting plate 930 is disposed on the funnel 810, the mounting plate 930 is fixed to the funnel 810, the mounting plate 930 is provided with a discharge hole 931, and the discharge hole 931 corresponds to an outlet of the funnel 810.

The adjustable diaphragm 940 is provided with a diaphragm hole and a pulling handle 941, and the aperture size of the diaphragm hole can be adjusted by rotating the pulling handle 941. The adjustable diaphragm 940 belongs to the prior art, and therefore, detailed description of the structure of the adjustable diaphragm 940 is omitted here. The diaphragm 940 that sets up in one side of mounting panel 930 and the diaphragm hole of diaphragm 940 that can adjust corresponds with discharge opening 931, and is concrete, sets up solid fixed ring 950, and gu fixed ring 950 passes through bolt and mounting panel 930 fixed connection, gu fixed ring 950 forms the spacing groove towards the surperficial arch of diaphragm 940 that can adjust, makes diaphragm 940 that can adjust install in the spacing inslot, and the spacing groove is equipped with breach 951, conveniently rotates the operation to pulling handle 941.

The rotating ring 960 is sleeved on the adjustable diaphragm 940, specifically, the rotating ring 960 is sleeved on the fixed ring 950, and the rotating ring 960 can rotate around the axis of the rotating ring 960. The rotating ring 960 is provided with a bayonet 961 for engaging with the wrenching handle 941, when the rotating ring 960 is sleeved on the fixed ring 950, the wrenching handle 941 is engaged with the bayonet 961, and when the rotating ring 960 rotates, the wrenching handle 941 can rotate along with the rotating ring. The outer peripheral surface of the rotating ring 960 is provided with a tooth portion 962.

The driving motor 910 is a forward and reverse rotation motor, and an output shaft thereof can rotate clockwise or counterclockwise. The driving motor 910 is a servo motor, the driving motor 910 is mounted on the mounting plate 930 through bolts, a gear 920 is provided on an output shaft of the driving motor 910, and the gear 920 is engaged with the tooth 962. When the driving motor 910 works, the gear 920 and the tooth 962 are engaged to drive the rotating ring 960 to rotate the pulling handle 941, so as to open and close the aperture of the adjustable aperture 940.

In this embodiment, there are two electric valves, the two electric valves are vertically disposed, and the axes of the aperture holes of the adjustable aperture 940 are not overlapped and staggered, so as to precisely control the quality of the mixture passing through the electric valves.

As shown in fig. 1, 7 and 8, the compacting unit 300 includes a pressing plug 320 and a fourth driving device 330, the fourth driving device 330 is connected to the pressing plug 320 to drive the pressing plug 320 to descend to the inner cavity of the solid phase extraction tube 600, and in particular, the fourth driving device 330 includes a fourth motor 331, a fourth lead screw 332, a sleeve rod 333 and a moving rod 334.

The fourth motor 331 is a forward-reverse motor, and an output shaft thereof can rotate clockwise or counterclockwise. The fourth motor 331 is a servo motor and is mounted on the first bracket 310. One end of the sleeve rod 333 is fixed to the fourth motor 331, and the sleeve rod 333 is provided with a cavity capable of receiving the moving rod 334. One end of the fourth screw rod 332 is connected with an output shaft of the fourth motor 331, the moving rod 334 is provided with an inner cavity, an inner thread is arranged on the circumferential wall surface of the inner cavity, the moving rod 334 is in threaded connection with the fourth screw rod 332, a sliding groove is arranged along the moving rod 334 in the axial direction, the loop bar 333 is correspondingly provided with a sliding strip which is positioned in the inner cavity, and the sliding strip is matched and connected with the sliding groove, so that the moving rod 334 can linearly move and cannot rotate relative to the loop bar 333.

When the fourth motor 331 drives the fourth lead screw 332 to rotate, the fourth lead screw 332 can drive the moving rod 334 to carry the pressing plug 320 to move up and down, so as to compact the mixture in the solid phase extraction tube 600.

The downward pressing plug 320 may be a rubber piston, and the downward pressing plug 320 is provided with a chamfer to play a guiding role, so that the downward pressing plug 320 can be accurately inserted into the inner cavity of the solid-phase extraction tube 600.

Further, the fourth driving means 330 may be an electric push rod.

The compacting unit 300 is arranged on the right side of the discharging unit 800, so that after the solid-phase extraction tube 600 completes the column loading operation, the moving seat 510 drives the solid-phase extraction tube 600 to move to the right, and moves to the compacting unit 300, so as to control the compacting unit 300 to automatically compact the mixture in the solid-phase extraction tube 600.

As shown in fig. 1 and 7, the elution unit 400 is disposed at the right side of the compacting unit 300, so that after the solid-phase extraction tube 600 completes compacting, the movable seat 510 drives the solid-phase extraction tube 600 to move to the elution unit 400, and then the elution unit 400 is controlled to perform automatic elution on the mixture in the solid-phase extraction tube 600. The elution unit 400 includes a sealing stopper 440, an infusion tube 430, a pump 420, and a fifth drive.

The sealing plug 440 may be a rubber piston, and the sealing plug 440 is in a boss shape and can plug the opening (i.e., inlet) of the solid phase extraction tube 600. The sealing plug 440 is provided with a tube hole penetrating up and down, one end of the infusion tube 430 is arranged in the tube hole, and the other end of the infusion tube 430 is connected with the pump 420. The infusion tube 430 is a rubber tube. The pump 420 is a peristaltic pump, and the inlet end of the pump 420 can be respectively communicated with the eluent bottle and the eluent bottle through a switching valve and a pipeline, so that the eluent and the eluent are conveyed into the solid-phase extraction tube 600.

The fifth driving device is connected to the sealing plug 440 to drive the sealing plug 440 to descend and block the opening of the solid phase extraction tube 600, and specifically, the fifth driving device includes a third motor 452, a third lead screw 451, a third guide rod, and a third slide block 453. The third motor 452 is a forward-reverse rotation motor, and an output shaft thereof can rotate clockwise or counterclockwise. The third motor 452 is a servo motor and is installed on the second support 410. One end of the third screw 451 is connected with an output shaft of the third motor 452, the axial direction of the third guide rod is consistent with that of the third screw 451, the third slide block 453 is connected with the third guide rod in a sliding manner and is in threaded connection with the third screw 451, the upper end of the sealing plug 440 is provided with a connecting part, and the connecting part is fixedly connected with the third slide block 453.

When the third motor 452 drives the third screw 451 to rotate, the third screw 451 can drive the third slide block 453 to move the sealing plug 440 downward, so as to seal the opening of the solid phase extraction tube 600 and prevent the liquid from overflowing from the solid phase extraction tube 600. Moreover, the infusion tube 430 can move downwards along with the sealing plug 440, after the sealing plug 440 plugs the solid phase extraction tube 600, the infusion tube 430 can inject the liquid conveyed by the pump 420 into the solid phase extraction tube 600, and the output power of the pump 420 can be controlled to control the liquid injection flow rate and pressure, so that the eluent or the eluent is fully contacted with the mixture in the solid phase extraction tube 600, and the analytes or the impurities in the mixture are eluted or leached out. The eluent effluent from the solid phase extraction tube 600 is collected and discarded, while the eluent is collected for further use. Some MSPD processes may be eluted directly without a rinsing step, if desired.

Further, the fifth driving means may be an electric push rod.

According to the automatic matrix solid-phase dispersion extraction device provided by the invention, through the organic cooperation of the three-dimensional grinding unit 100, the unloading unit 800, the column loading unit 500, the compacting unit 300 and the elution unit 400, the automation of mixing, grinding, column loading and leaching in MSPD is realized, the automation of the MSPD process is effectively improved, and the grinding efficiency and the grinding precision (the relative standard deviation between grinding is reduced) are improved; meanwhile, the automatic matrix solid-phase dispersion extraction device can realize multi-tube simultaneous leaching (elution), and improve the flux and speed of analysis and detection.

The invention can drive the three-dimensional grinding unit 100, the unloading unit 800, the column loading unit 500, the compacting unit 300 and the elution unit 400 to work coordinately through the electric signal transmission and logic control of each servo motor, the weighing sensor and the controller, automatically finish the grinding, metering, filling, compacting and elution works, and only need to manually place a gasket, thereby greatly reducing the working intensity.

While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that the present invention is not limited to the details of the embodiments shown and described, but is capable of numerous equivalents and substitutions without departing from the spirit of the invention as set forth in the claims appended hereto.

Claims

1. An automatic matrix solid phase dispersion extraction device, comprising:

a three-dimensional grinding unit (100) comprising a grinder (110), a frame (180) and a first drive means; the grinding device (110) is provided with a grinding cavity, one side of the grinding device (110) is provided with a screw rod (130), the other side of the grinding device (110) is provided with a rotating shaft (120), the screw rod (130) is connected with the grinding device (110), the rotating shaft (120) is connected with the grinding device (110), the axis of the screw rod (130) is superposed with the axis of the rotating shaft (120), the rotating shaft (120) is connected with a rack (180) and can move along the axial direction of the rack, the screw rod (130) is connected with the rack (180) and can move along the axial direction of the rack, and the first driving device is connected with the screw rod (130) to drive the screw rod (130) to rotate around the axial direction of the screw rod (130);

the column loading unit (500) comprises a moving seat (510), a solid phase extraction tube (600) and a collection bottle (700), wherein the solid phase extraction tube (600) is arranged on the moving seat (510), the collection bottle (700) is arranged on the moving seat (510) and is positioned below the solid phase extraction tube (600), and the moving seat (510) can move linearly;

the discharging unit (800) comprises a funnel (810) and a supporting plate (830), a filter screen (850) is arranged at the inlet of the funnel (810), a valve is arranged at the outlet of the funnel (810), a mounting hole penetrating through the upper part and the lower part is formed in one end of the supporting plate (830), the funnel (810) is arranged in the mounting hole, and the other end of the supporting plate (830) can rotate along the axis extending up and down to drive the funnel (810) to rotate below the grinder (110) or above the solid-phase extraction tube (600);

the compaction unit (300) comprises a pressing plug (320) and a fourth driving device (330), wherein the fourth driving device (330) is connected with the pressing plug (320) to drive the pressing plug (320) to descend to the inner cavity of the solid phase extraction tube (600);

the elution unit (400) comprises a sealing plug (440), an infusion tube (430), a pump (420) and a fifth driving device, wherein the sealing plug (440) is provided with tube holes which are communicated up and down, one end of the infusion tube (430) is arranged in the tube holes, the other end of the infusion tube (430) is connected with the pump (420), and the fifth driving device is connected with the sealing plug (440) to drive the sealing plug (440) to descend and block the tube opening of the solid-phase extraction tube (600).

2. The automated matrix solid phase dispersion extraction apparatus of claim 1, wherein the first driving device is a first motor (170), the first motor (170) is connected to the frame (180) and is capable of moving along the axial direction of the screw (130), and an output shaft of the first motor (170) is connected to the screw (130).

3. The automatic substrate solid-phase dispersion extraction device according to claim 2, wherein the axis of the screw (130), the axis of the rotating shaft (120) and the axis of the grinder (110) are three-line coincident; the grinding cavity is spherical; the grinder (110) is a spheroid.

4. The automated matrix solid phase dispersion extraction apparatus of claim 3, wherein the three-dimensional milling unit (100) further comprises a distance measuring sensor (160) and a first controller; the distance measuring sensor (160) can emit a light beam along the axial direction of the screw rod (130), the first motor (170) is provided with a sensing sheet capable of reflecting the light beam of the distance measuring sensor (160), and the distance measuring sensor (160) and the first motor (170) are respectively electrically connected with the first controller.

5. The automated substrate solid phase dispersion extraction apparatus according to any one of claims 1 to 4, wherein the grinder (110) comprises a first housing (111) and a second housing (112), one side of the first housing (111) is elastically hinged with one side of the second housing (112), and the other side of the first housing (111) is provided with a lock body, and the lock bodies are respectively connected with the first housing (111) and the second housing (112).

6. The automated matrix solid phase dispersion extraction apparatus of claim 5, wherein the lock is provided on the first housing (111) and the second housing (112) is provided with a lock hole; the lock body includes:

a lock case (210) provided with a cavity and a locking notch, wherein the locking notch is communicated with the cavity;

a fixing rod (220) arranged in the cavity, wherein two ends of the fixing rod (220) are connected with the lock shell (210);

the guide block (230) is provided with a lock rod (240) which can enter and exit the lock opening and be inserted into the lock hole, and the axial direction of the lock rod (240) is consistent with the axial direction of the screw rod (130); the guide block (230) is provided with a sliding hole which can be sleeved on the fixing rod (220);

the spring (250) is sleeved on the fixing rod (220), one end of the spring (250) is connected with the guide block (230), and the other end of the spring (250) is connected with the lock shell (210);

the iron core (260) is arranged in the cavity, the iron core (260) is connected with the lock shell (210), the iron core (260) is wound with an electrified coil (270), and the iron core (260) and the guide block (230) are arranged oppositely to drive the guide block (230) to move towards the spring (250);

a built-in power supply (280) electrically connected to the energizing coil (270);

and the time control switch is electrically connected with the built-in power supply (280) and the energizing coil (270) in a closed loop mode.

7. The automated matrix solid phase dispersion extraction apparatus of claim 6, wherein the column unit (500) further comprises a third driving means (540), the third driving means (540) is connected to the movable base (510) to drive the movable base (510) to move linearly.

8. The automated matrix solid phase dispersion extraction apparatus of claim 7, wherein the discharge unit (800) further comprises a load cell, a pad (820), a second controller, and a second drive device; the base plate (820) is positioned above the supporting plate (830), the base plate (820) is provided with a through hole communicated with the mounting hole, the funnel (810) is arranged in the through hole, and the weighing sensor is arranged between the supporting plate (830) and the base plate (820); the second driving device is connected with the other end of the supporting plate (830) to drive the supporting plate (830) to rotate; the valve is an electric valve, and the weighing sensor and the electric valve are both electrically connected with the second controller.

9. The automated matrix solid phase dispersion extraction apparatus of claim 8, wherein the motorized valve comprises:

a mounting plate (930) provided at the hopper (810), the mounting plate (930) being provided with a discharge hole (931);

the adjustable diaphragm (940) is arranged on one side of the mounting plate (930) and corresponds to the discharging hole (931), and the adjustable diaphragm (940) is provided with a pulling handle (941);

the rotating ring (960) is sleeved on the adjustable diaphragm (940), the rotating ring (960) is provided with a bayonet (961) clamped with the wrenching handle (941), and the outer peripheral surface of the rotating ring (960) is provided with a tooth part (962);

and the driving motor (910) is arranged on the mounting plate (930), the output shaft of the driving motor (910) is provided with a gear (920), and the gear (920) is meshed and connected with the tooth part (962).

10. The automated matrix solid phase dispersion extraction apparatus of claim 9, wherein the solid phase extraction tube (600) and the collection vial (700) are provided in plurality at intervals along the moving direction of the moving base (510).