CN113521233A - Medicine for dredging channels and collaterals and preparation method thereof - Google Patents
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- CN113521233A CN113521233A CN202110594556.8A CN202110594556A CN113521233A CN 113521233 A CN113521233 A CN 113521233A CN 202110594556 A CN202110594556 A CN 202110594556A CN 113521233 A CN113521233 A CN 113521233A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
The invention provides a medicine for dredging channels and collaterals, which comprises the following raw materials in parts by weight: 35-25 parts of caulis spatholobi, 10-20 parts of radix paeoniae alba, 10-20 parts of cassia twig, 10-20 parts of Chinese date, 7-17 parts of angelica sinensis, 7-17 parts of radix paeoniae rubra, 7-17 parts of monkshood, 7-17 parts of radix glycyrrhizae preparata, 7-17 parts of ginger and 1-5 parts of asarum. The invention has the beneficial effects that: caulis Spatholobi has effects of promoting blood circulation, removing blood stasis, relieving nature, relaxing muscles and tendons, activating collaterals, and replenishing blood; radix Paeoniae alba has effects of nourishing yin and regulating nutrient; ramulus Cinnamomi has effects of expelling pathogenic wind, and dredging defensive yang; the Chinese date can tonify qi and regulate middle energizer, and also can help white peony root to harmonize ying; angelica and red peony root have the functions of enriching blood and promoting blood circulation; radix Aconiti lateralis has effects of restoring yang, relieving collapse, invigorating fire, supporting yang, dispelling cold, and relieving pain; radix Glycyrrhizae Preparata harmonizes the above drugs; ginger, rhizoma Zingiberis recens, pungent in flavor and warm in property, can stop vomiting and help ramulus Cinnamomi activate yang; the traditional Chinese medicine composition can be used for treating exterior deficiency and various diseases caused by disharmony between nutrient and defensive qi, has the advantages of quick absorption of active ingredients of the medicine, quick response, good curative effect, stable effect, wide application range, no toxic or side effect, good taste, slight bitterness and sweetness, easy acceptance by patients, mild property and long shelf life.
Description
Technical Field
The invention relates to the field of biotechnology, in particular to a medicine for dredging channels and collaterals and a preparation method thereof.
Background
The obstruction of meridians belongs to a theory of traditional Chinese medicine, also called qi-blood obstruction, and the theory of traditional Chinese medicine is as follows: the traditional Chinese medicine thinks that obstruction leads to pain, and obstruction of channels and collaterals can cause blockage of qi and blood circulation, so that clinical manifestations such as pain, lumps, bleeding and the like can appear, skin numbness can also appear, and symptoms such as decline of immunity, easy cold, emaciation and the like also appear. If the dredging and the treatment are not effectively achieved for a long time, not only can local blood circulation be affected to form some local diseases, such as frequent blockage and obstruction of liver meridian, diseases such as hyperplasia of mammary glands, mastitis and breast tumor easily occur, but also each viscera connected with the meridian can be affected, serious and even malignant tumors and the like can occur, such as long-term blockage of female belt vein, ineffective treatment cannot be achieved, female hysteromyoma, uterine cyst and the like easily occur, and other complications such as cardiovascular and cerebrovascular diseases and the like can also occur due to obstruction of the systemic meridian. At present, the common channel dredging modes are acupuncture, moxibustion, cupping and scraping therapy, or five birds play, Taiji fist and a conditioning method of traditional Chinese medicine are exercised to help dredge channels, but the traditional Chinese medicine is mainly used for prevention in advance, the general effect is weaker than the effect of medicine conditioning, in addition, once the channels and collaterals do not reach a certain degree, medicines are needed for conditioning, at present, a plurality of people are treated by western medicines, most of the western medicines have certain control action in the near future but cannot be fundamentally cured, the traditional Chinese medicine has a plurality of effective classical Chinese medicine formulas for dredging channels and collaterals, but all traditional Chinese medicine are ancient formulas, the dosage is small, the application range is small, because the difference between the ancient and the current living environment is large, the quality of medicinal materials also changes, the traditional Chinese medicine can only be used by reference or addition and subtraction, meanwhile, the traditional Chinese medicine is suitable for the current life segment, the preparation technology needs to be updated, the traditional Chinese medicine formula and the traditional Chinese medicine preparation are singly used, the traditional Chinese medicine components are slowly absorbed, the effect is slow, the curative effect is low, the decoction is not easy, the carrying is inconvenient, and a plurality of diseases caused by the blockage of the channels and collaterals can not be cured and cured in time.
Disclosure of Invention
The invention provides a medicine for dredging channels and collaterals and a preparation method thereof, which solve the problems in the prior art.
The technical scheme of the invention is realized as follows:
a medicine for dredging channels and collaterals comprises the following raw materials in parts by weight: 35-25 parts of caulis spatholobi, 10-20 parts of radix paeoniae alba, 10-20 parts of cassia twig, 10-20 parts of Chinese date, 7-17 parts of angelica sinensis, 7-17 parts of radix paeoniae rubra, 7-17 parts of monkshood, 7-17 parts of radix glycyrrhizae preparata, 7-17 parts of ginger and 1-5 parts of asarum.
Preferably, the medicine for dredging the channels and collaterals comprises the following raw materials in parts by weight: 30 parts of caulis spatholobi, 15 parts of white peony root, 15 parts of cassia twig, 15 parts of Chinese date, 12 parts of angelica, 12 parts of red peony root, 9 parts of monkshood, 9 parts of honey-fried licorice root, 9 parts of ginger and 3 parts of asarum.
Further, the medicine for dredging the channels and collaterals also comprises the following raw materials in parts by weight: 10-20 parts of notopterygium root and 10-20 parts of radix angelicae pubescentis.
Preferably, the medicine for dredging the channels and collaterals comprises the following raw materials in parts by weight: 15 parts of notopterygium root and 15 parts of pubescent angelica root.
Further, the medicine for dredging the channels and collaterals also comprises the following raw materials in parts by weight: 7-17 parts of divaricate saposhnikovia root and 7-17 parts of large-leaved gentian.
Further, the medicine for dredging the channels and collaterals also comprises the following raw materials in parts by weight: 10-20 parts of medicinal cyathula root and 10-20 parts of chaenomeles speciosa.
Further, the medicine for dredging the channels and collaterals also comprises the following raw materials in parts by weight: adding 5-15 parts of earthworm and 5-15 parts of clematis root.
The preparation method of the medicine for dredging the channels and collaterals comprises the following steps:
s1, cleaning and selecting raw materials: removing worm-eaten, rat-bitten, rotten and deteriorated, fake and inferior products, adopting rotten and deteriorated-free traditional Chinese medicine decoction pieces, and repeatedly cleaning the decoction pieces by using clear water;
s2, extracting volatile oil: weighing the selected medicinal materials containing volatile components according to a formula proportion, placing the medicinal materials into an extraction tank, adding 5-10 times of water to soak for one night, distilling for 6 hours, extracting volatile oil, and using medicine residues and liquid medicine for later use;
s3, soaking in warm water: weighing the selected medicinal materials without volatile components according to a formula proportion, placing the medicinal materials in an extraction tank, adding warm water at the temperature of 30-36 ℃ to soak the surfaces of the medicinal materials for 10cm, and soaking for 120-180 min;
s4, decocting the medicinal materials: putting the dregs and the liquid medicine after extracting the volatile oil and the soaked medicinal materials without volatile components into a decocting device, adding water with preset weight to soak the surfaces of the medicinal materials for decocting, wherein the decocting air pressure is 0.08MPa, heating and decocting until the water temperature reaches 100 ℃, keeping for 45-60 min, stopping heating, filtering, and taking the primary filtrate to a blending tank;
adding water with a preset weight into the decocting device, soaking the surface of the medicinal material, heating and decocting until the water temperature reaches 100 ℃, keeping for 90-120 min, stopping heating after the second decocting, filtering, taking the second filtrate, conveying the second filtrate into a blending tank, and combining the second filtrate with the first filtrate;
adding water with a preset weight into the decocting device to immerse the surfaces of the medicinal materials, heating and decocting until the water temperature reaches 100 ℃, keeping for 60-90 min, stopping heating after the third decocting, filtering to obtain a third filtrate, conveying the third filtrate into a blending tank, and combining the third filtrate with the first filtrate and the second filtrate;
s5, concentrating the liquid medicine: the thin film evaporation treatment process is adopted to quickly concentrate the liquid medicine, and the evaporation of the concentrated liquid medicine is stopped when the relative density of the concentrated liquid medicine is 1.1-1.2 at 60-70 ℃;
s6, refining the liquid medicine: gradually adding 95% medical ethanol into the concentrated liquid medicine when the concentrated liquid medicine is cooled to room temperature, fully and uniformly stirring, testing the alcohol content in the liquid medicine, and transferring the liquid medicine into a sealing device to cool to 3-5 ℃ for separation when the alcohol content reaches 80-90%;
s7, seasoning with liquid medicine: adding stachyose into the refined liquid medicine and the extracted volatile oil according to a formula proportion;
s8, sterilizing the liquid medicine: after the traditional Chinese medicine extracting solution is prepared to meet the internal control index, reheating and sterilizing are carried out in a preparation tank, wherein the sterilizing temperature is 100 ℃, and the sterilizing time is 30-40 min;
s9, filling liquid medicine: sterilizing the medicinal liquid with glass bottle, and canning.
Further, the following steps are also included between steps S4 and S5:
s10, centrifuging medicine residues: and (3) placing the dregs into a centrifuge for centrifugal treatment for 5-8 min, conveying the centrifugate into a blending tank, and combining the centrifugate with the first filtrate, the second filtrate and the third filtrate.
Preferably, step S9 is specifically: washing the glass bottle for the liquid medicine with clear water of a bottle washing machine, sterilizing the glass bottle for the liquid medicine with a drier at 100 ℃, and feeding the glass bottle into a hundred thousand grade clean room through a sterile passage to be canned with the liquid medicine.
The invention has the beneficial effects that:
the medicine for dredging the channels and collaterals, provided by the invention, has the advantages that the caulis spatholobi is warm but not strong, the blood circulation is promoted, the blood stasis is removed, the nature is mild, the muscles and the tendons are relaxed, the collaterals are activated, and the blood replenishing function is realized; radix Paeoniae alba has effects of nourishing yin and regulating nutrient; ramulus Cinnamomi has effects of expelling pathogenic wind, and dredging defensive yang; the Chinese dates can tonify qi and regulate middle energizer, and also can help the white peony root to harmonize ying; adding radix Angelicae sinensis and radix Paeoniae Rubra for tonifying blood and promoting blood circulation; radix Aconiti lateralis has effects of restoring yang, relieving collapse, invigorating fire, supporting yang, dispelling cold, and relieving pain; radix Glycyrrhizae Preparata harmonizes the above drugs; ginger, rhizoma Zingiberis recens, pungent in flavor and warm in property, can stop vomiting and help ramulus Cinnamomi activate yang; the traditional Chinese medicine composition can be used for treating exterior deficiency and various diseases caused by disharmony between nutrient and defensive qi, has the advantages of quick absorption of effective components of the medicine, quick response, good curative effect, stable effect, wide application range, no toxic or side effect, good taste, slight bitterness and sweetness, easy acceptance by most patients, mild property and long shelf life.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely below, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
The invention relates to a medicine for dredging channels and collaterals, which comprises the following raw materials in parts by weight: 35-25 parts of caulis spatholobi, 10-20 parts of radix paeoniae alba, 10-20 parts of cassia twig, 10-20 parts of Chinese date, 7-17 parts of angelica sinensis, 7-17 parts of radix paeoniae rubra, 7-17 parts of monkshood, 7-17 parts of radix glycyrrhizae preparata, 7-17 parts of ginger and 1-5 parts of asarum.
Wherein:
spatholobus stem, bitter and sweet, warm, enters liver and kidney meridians; the medicine can promote blood circulation, relax muscles and tendons, nourish blood and regulate menstruation, belongs to the medicine classified under the medicines for promoting blood circulation and removing blood stasis, and is used for treating numbness of hands and feet, acroparalysis, rheumatic arthralgia, irregular menstruation, dysmenorrheal, amenorrhea, blood enriching, blood activating and meridian dredging, and is used for irregular menstruation, blood deficiency, sallow complexion, numbness, paralysis and rheumatic arthralgia; modern pharmacology proves that the caulis spatholobi has the effects of resisting cancer, regulating lipid metabolism and treating arteriosclerosis;
white peony root, slightly cold in nature, bitter and sour in taste, enters liver and spleen meridians; has spasmolytic, analgesic, antiinflammatory, and myocardial ischemia resisting effects; has spasmolytic, antiinflammatory, antiulcer, cellular and humoral immunity enhancing, blood vessel dilating, blood flow increasing, anoxia resisting, blood pressure lowering, platelet aggregation inhibiting, antibacterial, liver calming, pain relieving, blood nourishing, menstruation regulating, yin astringing, and antiperspirant effects, and is classified as blood tonifying medicine under deficiency tonifying medicine;
cassia twig, pungent and sweet in flavor and warm in nature, enters bladder meridian, heart meridian and lung meridian; has certain antibacterial and antiviral effects; has antipyretic, analgesic, tranquilizing, and anticonvulsive effects on central system; has obvious anti-inflammatory effect; can increase myocardial nutritional blood flow, and has antiallergic and anticoagulant effects; has the effects of relieving exterior syndrome and muscles, warming channels and promoting blood circulation, supporting yang and regulating qi, and calming the adverse-rising energy, and belongs to the pungent and warm exterior-syndrome-relieving medicines;
the Chinese dates are warm in nature and sweet in taste and enter spleen, stomach and heart meridians; has effects in inhibiting central nervous system, protecting liver, improving muscle strength, resisting allergy, relieving fatigue, resisting tumor, tranquilizing, increasing cAMP of leukocyte, and enhancing immunity; tonify middle-jiao and Qi, nourish blood and soothe nerves, which belongs to the category of tonics under deficiency-tonifying herbs;
chinese angelica, warm in nature, sweet and pungent in flavor, enters liver meridian, heart meridian and spleen meridian; the traditional Chinese medicine composition has the effects of enriching blood and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels, and is used for treating blood deficiency and chlorosis, dizziness and palpitation, irregular menstruation, amenorrhea and dysmenorrheal, deficiency cold and abdominal pain, intestinal dryness and constipation, rheumatic arthralgia, traumatic injury, carbuncle, cellulitis and pyocutaneous disease, and belongs to the blood tonics classified under deficiency-tonifying medicines;
red peony root, slightly cold in nature, bitter in taste, enters liver and spleen meridians; anti-thrombosis; anti-platelet aggregation; reducing blood lipid and resisting arteriosclerosis; the small dosage slightly inhibits the heart, and the large dosage obviously inhibits the heart and has the function of conduction block, so that the coronary flow is increased and the peripheral resistance is reduced; treatment and prevention of reduced cardiac function; anti-tumor; has effects in protecting liver, scavenging oxygen free radicals, relieving intestinal spasm, and inhibiting bacteria; clearing heat and cooling blood, and removing blood stasis and relieving pain, which belongs to the category of heat-clearing and blood-cooling medicines;
fu Zi, hot in nature, pungent and sweet in flavor, enters heart, kidney and spleen meridians; the Chinese medicinal composition has the effects of tonifying heart, resisting myocardial ischemia and myocardial ischemia, resisting huike, inhibiting blood coagulation function and thrombosis, resisting inflammation, relieving pain, locally anaesthetizing, enhancing humoral immunity, restoring yang, rescuing from collapse, tonifying fire, supporting yang, dispelling cold, relieving pain and the like, and belongs to interior warming medicaments;
prepared licorice root, radix Glycyrrhizae Praeparata, warm in nature, sweet in flavor, enters heart, lung, stomach and spleen meridians; tonify spleen and stomach, and benefit qi and recover pulse, which belongs to the category of tonics under deficiency-tonifying herbs;
fresh ginger, mild in nature and pungent in flavor, enters lung, spleen and stomach meridians; has antipyretic, analgesic and antiinflammatory effects; has tranquilizing and anticonvulsive effects; relaxing gastrointestinal smooth muscle; antiemetic and anti-motion sickness; exciting the heart, enhancing the atrial contractility and protecting the gastric mucosa; protecting liver and benefiting gallbladder; anti-platelet aggregation; anti-5-hydroxytryptamine, antioxidant, antimicrobial, central excitation, promoting in vivo active substance release, promoting absorption, relieving cough, reducing blood lipid, resisting allergy, mutagenesis and antimutation, and inhibiting nitrosamine synthesis; expelling cold and relieving exterior syndrome, lowering adverse qi and arresting vomiting, eliminating phlegm and stopping cough, and relieving fish and crab toxicity, belonging to the category of exterior-releasing herbs;
asarum herb, with warm nature and pungent taste, enters heart, lung and kidney meridians; has local anesthetic effect, has a certain degree of inhibition effect on arthritis, also has a certain bacteriostatic effect, has the effects of enhancing lipid metabolism and increasing blood sugar, and regulates the function of organism smooth muscle; the volatile oil can reduce blood pressure of anesthetized animals; and has anti-inflammatory and anti-convulsion effects; also has analgesic, tranquilizing, fever inhibiting, antipyretic, antihistaminic, antiallergic and respiratory exciting effects; expelling wind, dispersing cold, inducing resuscitation, alleviating pain, warming lung and eliminating phlegm, which belongs to the category of exterior-releasing herbs.
Preferably, the medicine for dredging the channels and collaterals comprises the following raw materials in parts by weight: 30 parts of caulis spatholobi, 15 parts of radix paeoniae alba, 15 parts of cassia twig, 15 parts of Chinese date, 12 parts of angelica, 12 parts of radix paeoniae rubra, 9 parts of monkshood, 9 parts of honey-fried licorice root, 9 parts of ginger and 3 parts of asarum.
The medicine for dredging the channels and collaterals, provided by the invention, has the advantages that the caulis spatholobi is warm but not strong, the blood circulation is promoted, the blood stasis is removed, the nature is mild, the muscles and the tendons are relaxed, the collaterals are activated, and the blood replenishing function is realized; radix Paeoniae alba has effects of nourishing yin and regulating nutrient; ramulus Cinnamomi has effects of expelling pathogenic wind, and dredging defensive yang; the Chinese dates can tonify qi and regulate middle energizer, and also can help the white peony root to harmonize ying; adding radix Angelicae sinensis and radix Paeoniae Rubra for tonifying blood and promoting blood circulation; radix Aconiti lateralis has effects of restoring yang, relieving collapse, invigorating fire, supporting yang, dispelling cold, and relieving pain; radix Glycyrrhizae Preparata harmonizes the above drugs; ginger, rhizoma Zingiberis recens, pungent in flavor and warm in property, can stop vomiting and help ramulus Cinnamomi activate yang; the traditional Chinese medicine composition can be used for treating exterior deficiency and various diseases caused by disharmony between nutrient and defensive qi, has the advantages of quick absorption of effective components of the medicine, quick response, good curative effect, stable effect, wide application range, no toxic or side effect, good taste, slight bitterness and sweetness, easy acceptance by most patients, mild property and long shelf life.
The medicine for dredging the channels and collaterals also comprises the following raw materials in parts by weight: 10-20 parts of notopterygium root and 10-20 parts of radix angelicae pubescentis.
Wherein:
notopterygium root, rhizoma Et radix Notopterygii, warm in nature, pungent and bitter in flavor, enters bladder meridian and kidney meridian; has antipyretic, analgesic, antiinflammatory, antiallergic, myocardial ischemia resisting, arrhythmia resisting, thrombosis resisting, epilepsy resisting, antioxidant, antibacterial, sleep time prolonging, and anticancer effects; pungent-warm exterior-releasing herbs which can release exterior and dispel cold, dispel wind and remove dampness and alleviate pain belong to the category of exterior-releasing herbs;
pubescent angelica root, slightly warm in nature, pungent and bitter in flavor, enters kidney and bladder meridians; animal experiments show that the alcohol extract has platelet aggregation and thrombosis resisting effects, and the active ingredients are dihydrocarveol, dihydrocarveol acetate and the like; the water decoction or fluid extract has sedative, hypnotic, analgesic and anti-inflammatory effects on rat; it also has blood pressure lowering and arrhythmia resisting effects; has photosensitive, spasmolytic, antitumor, antibacterial, lipolysis promoting, and respiratory exciting effects; expelling wind and removing dampness, relieving arthralgia and alleviating pain, which belongs to the wind-damp-dispelling and cold-dispersing medicine classified under the wind-damp-dispelling herbs.
Preferably, the medicine for dredging the channels and collaterals comprises the following raw materials in parts by weight: 15 parts of notopterygium root and 15 parts of pubescent angelica root.
The medicine for dredging the channels and collaterals is added with notopterygium root and radix angelicae pubescentis, and can be used for treating rheumatism characterization, dispelling rheumatism symptoms up and down the whole body, relieving exterior syndrome, dispelling cold and activating yang qi.
The medicine for dredging the channels and collaterals also comprises the following raw materials in parts by weight: 7-17 parts of divaricate saposhnikovia root and 7-17 parts of large-leaved gentian.
Wherein:
ledebouriella root, warm in nature, sweet and pungent in flavor, enters bladder, liver and spleen meridians; clearing heat and cooling; analgesia, tranquilization and anticonvulsion; antibacterial; anti-inflammatory; enhancing immune system function; inhibiting contraction of isolated duodenum, isolated trachea and ileocecal smooth muscle; an antihistamine; anticoagulation; the radix Saposhnikoviae decoction has antibacterial and antiviral effects; exterior-releasing, wind-dispelling and dampness-removing, belonging to the category of exterior-releasing herbs, pungent-warm exterior-releasing herbs;
gentiana macrophylla, mild in nature, bitter and pungent in flavor, enters stomach meridian, liver meridian and gallbladder meridian; has antiallergic and analgesic effects; wind-damp-dispelling, deficiency-heat-relieving, tendon-relaxing and pain-relieving, which belong to wind-damp-dispelling and heat-clearing herbs classified under wind-damp-dispelling herbs.
The medicine for dredging the channels and collaterals is added with the divaricate saposhnikovia root and the large-leaved gentian, and can expel wind and remove dampness, relax muscles and tendons and relieve pain.
The medicine for dredging the channels and collaterals also comprises the following raw materials in parts by weight: 10-20 parts of radix cyathulae and 10-20 parts of chaenomeles speciosa.
Wherein:
cyathula root, radix Cyathulae, mild in nature, sweet and slightly bitter in taste, enters liver and kidney meridians; modern pharmacological effects prove that the extract has the effects of resisting inflammation, relieving pain, reducing blood sugar, reducing blood fat and the like; it has effects of enhancing immunity of animals with normal or low immune function, and enhancing cellular immunity and humoral immunity; in addition, it has been demonstrated to have anti-aging and anti-tumor effects; has effects in inhibiting heart, dilating blood vessel, lowering blood pressure, resisting ulcer, relieving inflammation and pain, promoting function of gallbladder, exciting uterus, resisting fertility, resisting blood coagulation, removing blood stasis, lowering blood sugar, reducing blood lipid, promoting protein assimilation, enhancing immunity, delaying aging, and promoting urination; tonify liver and kidney, strengthen tendons and bones, remove blood stasis and dredge channels, draw blood and descend, remove blood stasis and dredge channels, remove joints and induce diuresis to treat stranguria, belonging to the blood-activating and stasis-removing herbs and classified as blood-activating and menstruation-regulating herbs;
xuanchao, sexual acid, warm; it enters liver meridian, lung meridian, kidney meridian and spleen meridian; it has effects in dredging channels and collaterals, dispelling pathogenic wind, promoting blood circulation, strengthening body constitution, exciting, relieving pain, suppressing hyperactive liver, regulating kidney, eliminating dampness, and relaxing muscles and tendons, and can be used for treating tinea pedis, edema, and damp arthralgia; it is administered after soaking in wine for treating rheumatic arthralgia.
The medicine for dredging the channels and collaterals is added with the medicinal cyathula root and the chaenomeles speciosa, has the effects of warming and dredging channels and collaterals, transversely moving limbs and arms, promoting blood circulation and removing blood stasis, dredging channels, tonifying liver and kidney, strengthening muscles and bones, descending the sexual desire, entering blood, warming middle-jiao to dispel cold, promoting blood circulation and relieving pain, treats both the upper and lower aspects, and is mainly used for treating amenorrhea and dysmenorrheal caused by back and waist pain or qi-blood cold stagnation due to liver and kidney deficiency, weak muscles and bones and wind cold.
The medicine for dredging the channels and collaterals also comprises the following raw materials in parts by weight: 5-15 parts of earthworm and 5-15 parts of clematis root.
Wherein:
earthworm, cold in nature, salty in taste, enters liver, spleen and bladder meridians; has thrombolytic and anticoagulant effects; has antiarrhythmic effect, and can inhibit cardiac conduction; has effects in dilating blood vessel of viscera, promoting natrium, promoting urination, and reducing triacylglycerol; has antipyretic, tranquilizing, and anticonvulsive effects; clearing heat, arresting convulsion, dredging collaterals, relieving asthma and promoting urination, which belong to the wind-extinguishing and spasm-stopping medicines classified under the liver-calming and wind-extinguishing medicines;
clematis chinensis, warm in nature, pungent and salty in flavor, enters bladder meridian; has rhythm enhancing or relaxation effects on smooth muscle, and has analgesic, cholagogic, labor inducing, antimicrobial, diuretic, and blood pressure lowering effects; expelling wind and removing dampness, and removing obstruction in channels to relieve pain, which belongs to the category of wind-damp-dispelling and cold-dispersing medicine for expelling wind-damp disease.
The earthworm and the clematis root are added into the medicine for dredging the channels and collaterals, the medicine can be used for treating primary sciatica and neuralgia with symptoms of cold-dampness obstruction and qi and blood stagnation, meanwhile, the cassia twig and the clematis root can treat upper limb arthralgia, but the cassia twig is heavy in weight and is suitable for new patients, the clematis root is heavy in weight and is suitable for dredging channels, the long-term patients allow the medicine, and the three medicines are combined for treating the wind-cold-dampness arthralgia, so that the medicine is suitable for new and long-term use and has quick response.
The preparation method of the medicine for dredging the channels and collaterals comprises the following steps:
s1, cleaning and selecting raw materials: removing worm-eaten, rat-bitten, rotten and deteriorated, fake and inferior products, adopting rotten and deteriorated-free traditional Chinese medicine decoction pieces, and repeatedly cleaning the decoction pieces by using clear water;
s2, extracting volatile oil: weighing the selected medicinal materials containing volatile components according to a formula proportion, placing the medicinal materials into an extraction tank, adding 5-10 times of water to soak for one night, distilling for 6 hours, extracting volatile oil, and using medicine residues and liquid medicine for later use;
s3, soaking in warm water: weighing the selected medicinal materials without volatile components according to a formula proportion, placing the medicinal materials in an extraction tank, adding warm water at the temperature of 30-36 ℃ to soak the surfaces of the medicinal materials for 10cm, and soaking for 120-180 min;
s4, decocting the medicinal materials: putting the dregs and the liquid medicine after extracting the volatile oil and the soaked medicinal materials without volatile components into a decocting device, adding water with preset weight to soak the surfaces of the medicinal materials for decocting, wherein the decocting air pressure is 0.08MPa, heating and decocting until the water temperature reaches 100 ℃, keeping for 45-60 min, stopping heating, filtering, and taking the primary filtrate to a blending tank;
adding water with a preset weight into the decocting device, soaking the surface of the medicinal material, heating and decocting until the water temperature reaches 100 ℃, keeping for 90-120 min, stopping heating after the second decocting, filtering, taking the second filtrate, conveying the second filtrate into a blending tank, and combining the second filtrate with the first filtrate;
adding water with a preset weight into the decocting device to immerse the surfaces of the medicinal materials, heating and decocting until the water temperature reaches 100 ℃, keeping for 60-90 min, stopping heating after the third decocting, filtering to obtain a third filtrate, conveying the third filtrate into a blending tank, and combining the third filtrate with the first filtrate and the second filtrate;
s5, concentrating the liquid medicine: the thin film evaporation treatment process is adopted to quickly concentrate the liquid medicine, and the evaporation of the concentrated liquid medicine is stopped when the relative density of the concentrated liquid medicine is 1.1-1.2 at 60-70 ℃;
s6, refining the liquid medicine: gradually adding 95% medical ethanol into the concentrated liquid medicine when the concentrated liquid medicine is cooled to room temperature, fully and uniformly stirring, testing the alcohol content in the liquid medicine, and transferring the liquid medicine into a sealing device to cool to 3-5 ℃ for separation when the alcohol content reaches 80-90%;
s7, seasoning with liquid medicine: adding stachyose into the refined liquid medicine and the extracted volatile oil according to a formula proportion;
s8, sterilizing the liquid medicine: after the traditional Chinese medicine extracting solution is prepared to meet the internal control index, reheating and sterilizing are carried out in a preparation tank, wherein the sterilizing temperature is 100 ℃, and the sterilizing time is 30-40 min;
s9, filling liquid medicine: sterilizing the medicinal liquid with glass bottle, and canning.
Wherein the preset weight of water is calculated according to the following formula:
m1＝m2×W+m3+t1×H
wherein: m1 is the water addition amount; m2 is the weight of the medicinal materials; w is the water absorption rate of the medicinal material; m3 is the amount of liquid medicine obtained by filtration for each decoction; t1 is the time for each decoction in min; h is the water evaporation amount in unit time.
Wherein, the water absorption W of the medicinal material is calculated according to the following formula:
W＝(m4-m1)/m1
wherein: m4 is the weight of herb residue.
Wherein, the water evaporation capacity H in unit time is calculated according to the following formula:
H＝(m5-m6)/t2
wherein: m5 is the initial amount of water for decoction; m6 is the water amount after the decoction time t 2; t2 is decoction time, and unit is min.
Wherein, the stachyose is contained in vegetables which are eaten daily and traditional Chinese medicinal materials for treating diseases, has the highest content in cordyceps ginseng and long eating history, can promote the formation of dominant bacteria status of beneficial bacteria in alimentary canals, has very obvious proliferation effect on beneficial bacteria groups such as bifidobacteria, lactobacillus and the like in human gastrointestinal tracts, inhibits the production of putrefying bacteria such as gas-producing acidogenic clostridium and the like, generates a large amount of physiological active substances, regulates the pH value of intestinal tracts, kills pathogenic bacteria, inhibits the generation of putrefying products, inhibits the generation and absorption of endogenous carcinogens, decomposes and derives multiple immunologic function factors, can rapidly improve the internal environment of the alimentary canals of human bodies, regulates the balance of micro-ecological bacteria groups, is not hydrolyzed by digestive enzymes, does not depend on insulin for metabolism, can meet the requirements of special groups suffering from diabetes, obesity, hyperlipoidemia and the like, does not cause the endocrine burden of the adverse reaction of the patient.
Specifically, the stachyose is selected, so that the stachyose has high medicinal value and good seasoning effect, the phenomenon that liquid medicine is increased year by year due to the adoption of cane sugar and the like, so that phlegm is thickened and not easy to cough out, the stability of the medicine is influenced, and dental caries, diabetes, hyperglycemia, obesity and the like are generated is avoided.
Wherein, the following steps are also included between steps S4 and S5:
s10, centrifuging medicine residues: and (3) placing the dregs into a centrifuge for centrifugal treatment for 5-8 min, conveying the centrifugate into a blending tank, and combining the centrifugate with the first filtrate, the second filtrate and the third filtrate.
Specifically, the medicine dregs are centrifuged to obtain centrifugate, the centrifugate is added into the first filtrate, the second filtrate and the third filtrate, so that the medicinal materials can be saved by 40 percent, the effective components which are not decocted can be inevitably remained in the medicine dregs due to the limitation of factors such as concentration difference and the like in the decocting process of the traditional Chinese medicine components, and the effective components remained in the medicine dregs can be fully obtained through centrifugation.
Preferably, step S9 specifically includes: washing the glass bottle for the liquid medicine with clear water of a bottle washing machine, sterilizing the glass bottle for the liquid medicine with a drier at 100 ℃, and feeding the glass bottle into a hundred thousand grade clean room through a sterile passage to be canned with the liquid medicine.
The medicine for dredging the channels and collaterals provided by the invention is proved by experiments in curative effect, and specifically comprises the following components:
60 patients with limb or joint pain, spasm and movement difficulty in 60 cases of a hospital are selected, the age of the patient is 22-37 years, the medicine for dredging the channels and collaterals is taken for 1 branch/time and 3 times/day, the treatment course is 6 weeks, and the curative effect is judged.
According to the treatment effect of a patient, the treatment effect is divided into three conditions of effective treatment, effective treatment and ineffective treatment, the clinical treatment effect of the patient after treatment is compared, and the effective treatment and the effective level are used as the judgment standard of the treatment effect, specifically:
the effect is shown: the symptoms of joint and lumbosacral soreness almost disappeared.
The method has the following advantages: the symptoms of joint and lumbosacral ache are obviously relieved.
And (4) invalidation: the symptoms of joint and lumbosacral soreness are not obviously changed compared with those before treatment.
Total effective rate (number of effective cases + number of effective cases)/total number of cases in this group × 100%.
The treatment effect is as follows: 38 cases of obvious effect, 19 cases of effect and 3 cases of no effect, and the total effective rate is 95 percent.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. The medicine for dredging the channels and collaterals is characterized by comprising the following raw materials in parts by weight: 35-25 parts of caulis spatholobi, 10-20 parts of radix paeoniae alba, 10-20 parts of cassia twig, 10-20 parts of Chinese date, 7-17 parts of angelica sinensis, 7-17 parts of radix paeoniae rubra, 7-17 parts of monkshood, 7-17 parts of radix glycyrrhizae preparata, 7-17 parts of ginger and 1-5 parts of asarum.
2. The medicine for dredging the channels and collaterals as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight: 30 parts of caulis spatholobi, 15 parts of radix paeoniae alba, 15 parts of cassia twig, 15 parts of Chinese date, 12 parts of angelica, 12 parts of radix paeoniae rubra, 9 parts of monkshood, 9 parts of honey-fried licorice root, 9 parts of ginger and 3 parts of asarum.
3. The medicine for dredging the channels and collaterals as claimed in claim 1, further comprising the following raw materials in parts by weight: 10-20 parts of notopterygium root and 10-20 parts of radix angelicae pubescentis.
4. The medicine for dredging the channels and collaterals as claimed in claim 3, which is characterized by comprising the following raw materials in parts by weight: 15 parts of notopterygium root and 15 parts of pubescent angelica root.
5. The medicine for dredging the channels and collaterals as claimed in claim 1, further comprising the following raw materials in parts by weight: 7-17 parts of divaricate saposhnikovia root and 7-17 parts of large-leaved gentian.
6. The medicine for dredging the channels and collaterals as claimed in claim 1, further comprising the following raw materials in parts by weight: 10-20 parts of medicinal cyathula root and 10-20 parts of chaenomeles speciosa.
7. The medicine for dredging the channels and collaterals as claimed in claim 1, further comprising the following raw materials in parts by weight: adding 5-15 parts of earthworm and 5-15 parts of clematis root.
8. A preparation method of the medicine for dredging the channels and collaterals as claimed in any one of claims 1 to 7, which comprises the following steps:
s1, cleaning and selecting raw materials: removing worm-eaten, rat-bitten, rotten and deteriorated, fake and inferior products, adopting rotten and deteriorated-free traditional Chinese medicine decoction pieces, and repeatedly cleaning the decoction pieces by using clear water;
s2, extracting volatile oil: weighing the selected medicinal materials containing volatile components according to a formula proportion, placing the medicinal materials into an extraction tank, adding 5-10 times of water to soak for one night, distilling for 6 hours, extracting volatile oil, and using medicine residues and liquid medicine for later use;
s3, soaking in warm water: weighing the selected medicinal materials without volatile components according to a formula proportion, placing the medicinal materials in an extraction tank, adding warm water at the temperature of 30-36 ℃ to soak the surfaces of the medicinal materials for 10cm, and soaking for 120-180 min;
s4, decocting the medicinal materials: putting the dregs and the liquid medicine after extracting the volatile oil and the soaked medicinal materials without volatile components into a decocting pot, adding water with preset weight to soak the surfaces of the medicinal materials for decocting, wherein the decocting air pressure is 0.08MPa, heating and decocting until the water temperature reaches 100 ℃, keeping for 45-60 min, stopping heating, filtering, and taking the primary filtrate to a blending tank;
adding water with a preset weight into the decocting device to immerse the surfaces of the medicinal materials, heating and decocting until the water temperature reaches 100 ℃, keeping for 90-120 min, stopping heating after the second decocting, filtering to obtain a second filtrate, conveying the second filtrate into a blending tank, and combining the second filtrate with the first filtrate;
adding water with a preset weight into the decocting device to immerse the surfaces of the medicinal materials, heating and decocting until the water temperature reaches 100 ℃, keeping for 60-90 min, stopping heating after the third decocting, filtering to obtain a third filtrate, conveying the third filtrate into a blending tank, and combining the third filtrate with the first filtrate and the second filtrate;
s5, concentrating the liquid medicine: the thin film evaporation treatment process is adopted to quickly concentrate the liquid medicine, and the evaporation of the concentrated liquid medicine is stopped when the relative density of the concentrated liquid medicine is 1.1-1.2 at 60-70 ℃;
s6, refining the liquid medicine: gradually adding 95% medical ethanol into the concentrated liquid medicine when the concentrated liquid medicine is cooled to room temperature, fully and uniformly stirring, testing the alcohol content in the liquid medicine, and transferring the liquid medicine into a sealing device to cool to 3-5 ℃ for separation when the alcohol content reaches 80-90%;
s7, seasoning with liquid medicine: adding stachyose into the refined liquid medicine and the extracted volatile oil according to a formula proportion;
s8, sterilizing the liquid medicine: after the traditional Chinese medicine extracting solution is prepared to meet the internal control index, reheating and sterilizing are carried out in a preparation tank, wherein the sterilizing temperature is 100 ℃, and the sterilizing time is 30-40 min;
s9, filling liquid medicine: sterilizing the medicinal liquid with glass bottle, and canning.
9. The method for preparing a medicament for dredging meridians according to claim 8, further comprising the following steps between steps S4 and S5:
s10, centrifuging medicine residues: and (3) placing the dregs into a centrifuge for centrifugal treatment for 5-8 min, conveying the centrifugal liquid into a blending tank, and combining the centrifugal liquid with the primary filtrate, the secondary filtrate and the tertiary filtrate.
10. The method for preparing a medicament for dredging meridians according to claim 8, wherein the step S9 specifically comprises: washing the glass bottle for the liquid medicine with clear water of a bottle washing machine, sterilizing the glass bottle for the liquid medicine with a drier at 100 ℃, and feeding the glass bottle into a hundred thousand grade clean room through a sterile passage to be canned with the liquid medicine.
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| CN101647878A (en) * | 2009-08-21 | 2010-02-17 | 范雪伟 | Traditional Chinese medicine preparation for treating rheumatism and numbness |
| CN103316295A (en) * | 2013-06-24 | 2013-09-25 | 柳晖 | Traditional Chinese composition for treating rheumatic arthritis |
| CN105079732A (en) * | 2014-05-16 | 2015-11-25 | 王杰欣 | Medicine for treating cervical spondylosis |
| CN106606754A (en) * | 2015-10-25 | 2017-05-03 | 李家涛 | Traditional Chinese medicine formula for treating scapulohumeral periarthritis |
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2021
- 2021-05-28 CN CN202110594556.8A patent/CN113521233A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647878A (en) * | 2009-08-21 | 2010-02-17 | 范雪伟 | Traditional Chinese medicine preparation for treating rheumatism and numbness |
| CN103316295A (en) * | 2013-06-24 | 2013-09-25 | 柳晖 | Traditional Chinese composition for treating rheumatic arthritis |
| CN105079732A (en) * | 2014-05-16 | 2015-11-25 | 王杰欣 | Medicine for treating cervical spondylosis |
| CN106606754A (en) * | 2015-10-25 | 2017-05-03 | 李家涛 | Traditional Chinese medicine formula for treating scapulohumeral periarthritis |
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Application publication date: 20211022 |
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