CN113521191A - 一种治疗非重型再生障碍性贫血的中药组合物及制备方法 - Google Patents
一种治疗非重型再生障碍性贫血的中药组合物及制备方法 Download PDFInfo
- Publication number
- CN113521191A CN113521191A CN202110926166.6A CN202110926166A CN113521191A CN 113521191 A CN113521191 A CN 113521191A CN 202110926166 A CN202110926166 A CN 202110926166A CN 113521191 A CN113521191 A CN 113521191A
- Authority
- CN
- China
- Prior art keywords
- aplastic anemia
- traditional chinese
- chinese medicine
- treating non
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗非重型再生障碍性贫血的中药组合物,包括:黄芪、当归、熟地、淫羊藿、枸杞、鹿角胶、党参、黄精、茯苓、白术、仙鹤草、鸡血藤、茜草、灸甘草;以及治疗非重型再生障碍性贫血的中药组合物的制备方法;本发明的配方对治疗成本低,治疗再生障碍性贫血疗效高,无毒副作用,具有益气养血,补肾填精,化瘀止血等功效。临床实验证明本发明治疗再生障碍性贫血具有疗效好和安全性较高的特点,值得临床应用、推广。
Description
技术领域
本发明属于中药组合物技术领域,具体涉及一种治疗非重型再生障碍性贫血的中药组合物及制备方法。
背景技术
再生障碍性贫血简称再障(AA),是一种由不同病因或机制引起的骨髓造血功能衰竭症。主要表现为骨髓造血功能低下、全血细胞减少及所致的贫血、出血、感染综合征。该病分为重型(SAA)和非重型(NSAA)。SAA患者发病急、病情重,死亡率高。NSAA患者病程长,多数需要长期乃至终身治疗。现行NSAA的治疗方法主要是免疫抑制治疗及支持治疗。患者在长期使用免疫抑制剂期间容易罹患感染;长期输血可能发生病毒感染、铁过载,部分患者输注无效;而使用雄激素治疗对女性,尤其是年轻女性患者会带来男性化的困扰及内分泌紊乱;单纯使用造血生长因子往往治疗效果不佳。因此NSAA患者由于疾病和治疗的特点导致治疗时间长,费用高昂,生活质量极低,患者及家庭负担沉重,也占用了大量的社会医疗资源。
发明内容
本发明所要解决的问题是提供一种用于治疗非重型再生障碍性贫血的中药组合物配方,该配方成本低、疗效肯定、无毒副作用、具有益气养血、补肾填精、化瘀止血的功效;
为了达到上述技术效果,本发明是通过以下技术方案实现的:一种治疗非重型再生障碍性贫血的中药组合物,其特征在于,包括如下重量组分:黄芪10%-15%、当归6%-10%、熟地8%-12%、淫羊藿6%-10%、枸杞6%-10%、鹿角胶6%-10%、党参8%-12%、黄精6%-10%、茯苓10%-15%、白术10%-15%、仙鹤草10%-20%、鸡血藤10%-15%、茜草6%-10%、灸甘草4%-6%;
优选的,所述治疗非重型再生障碍性贫血的中药组合物包括如下重量组分:黄芪15g、当归10g、熟地12g、淫羊藿10g、枸杞10g、鹿角胶10g、党参10g、黄精10g、茯苓15g、白术10g、仙鹤草20g、鸡血藤15g、茜草10g、炙甘草6g;
优选的,所述治疗非重型再生障碍性贫血的中药组合物包括如下重量组分:黄芪10g、当归8g、熟地15g、淫羊藿8g、枸杞8g、鹿角胶6g、党参12g、黄精8g、茯苓10g、白术12g、仙鹤草15g、鸡血藤12g、茜草8g、炙甘草4g;
优选的,所述治疗非重型再生障碍性贫血的中药组合物包括如下重量组分:黄芪12g、当归6g、熟地10g、淫羊藿6g、枸杞6g、鹿角胶8g、党参8g、黄精6g、茯苓12g、白术15g、仙鹤草10g、鸡血藤10g、茜草6g、炙甘草5g;
本发明的另一目的在于提供一种治疗非重型再生障碍性贫血的中药组合物的制备方法:
1)先将鹿角胶单包;
2)余下13味药物加入净水900-1000ml,浸泡半小时;
3)浸泡充分后,利用180-200℃武火加热至煮沸,后转120-150℃文火煎熬20-30min;
4)滤除药渣,取药液200ml;
5)药渣再次添加净水300ml,同样武火煮沸后,转文火煎熬30-40min;
6)滤除药渣,得药液100ml,共计得药液300ml;
7)将烊化的鹿角胶加入所得300ml药液中,搅拌混合均匀,即制得再生障碍性贫血的汤剂;
8)将制得的汤剂转入无菌玻璃瓶内,密封瓶盖备用。
本发明中所用中药物及组方的药理药性如下:
黄芪,为豆科植物蒙古黄芪Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao或膜荚黄芪Astragalus membranaceus(Fisch.)Bge.的干燥根。性味甘,温。归肺、脾经。功可补气固表,利尿消肿,托毒排脓,敛疮生肌。
党参,为桔梗科植物党参Codonopisis pilosula(Franch.)Nannf.及同属多种植物的根。味甘,性平,归脾、肺经。功能补中益气,健脾益肺。
熟地,为玄参科植物地黄Rehmannia glutinosa.(Gaerth.)Libosch的块根,加工炮制而成。味甘,性微温。归肝、肾经。功能补益肝肾、养血填精。
仙灵脾,为小檗科植物淫羊藿Epimedium brevicornum Maxim.及其所属植物的全草。性辛、温,味甘,归肝、肾经。功能补肾阳,强筋骨,祛风湿。
枸杞,为茄科植物宁夏枸杞Lycium barbarumL.和Lycium chinensis Miller的成熟果实。味甘,性平,归肝、肾经。功能滋补肝肾,明目益精。
鹿角胶,为鹿角煎熬浓缩而成的胶体物。味甘,性缓。归肝、肾经。功能大补虚羸补肾填精髓,益阴血、止血。
黄精,为百合科植物滇黄精Polygonatum kingianum Coll.et Hemsl.、黄精Polygonatum sibiricum Red.或多花黄精Polygonatum cyrtonema Hua的干燥根茎。性味甘,平。归脾、肺、肾经。功可补气养阴,健脾,润肺,益肾。
茯苓,为多孔菌科真菌茯苓Poria cocos(Schw.)Wolf.的菌核。味甘淡,性平。归心、肺、脾、膀胱经。功能利水渗湿、健脾补中、宁心安神。
白术,为菊科植物白术Atractylodes macrocephala Koidz.的干燥根茎。性味苦、甘,温。归脾、胃经。功可健脾益气,燥湿利水,止汗,安胎。
当归,为伞形科植物当归Angelica sinensis(Oliv.)Diels的干燥根。性味甘、辛,温。归肝、心、脾经。功可补血活血,调经止痛,润肠通便。
鸡血藤,为豆科植物鸡血藤Millettia reticulate Benth.的藤。味苦、甘,性微温。归肝、肾经。功能补血、活血、通络。
仙鹤草,为蔷薇科植物龙芽Agrimonia pilosa Ledeb.的全草。味苦、涩,性平。归肺、肝、脾经。功能收敛止血、止痢,强心,去脱力劳乏。
茜草:为茜草科植物茜草Rubia cordifolia L.的根。味苦,性寒,归肝经,功能凉血止血、活血祛瘀。
炙甘草为豆科植物甘草Glycyrrhiza uralensis Fisch的根及根茎蜜炙而成。味甘,性平,归心、脾、肺、胃经。功能补中益气复脉。
组方原理:现代医学所述的再生障碍性贫血,属中医“虚劳”、“血证”等范畴。中医认为,血液的化生有赖于五脏功能的协调。其中脾肾是血液化生的关键。因肾为先天之本,主藏精而生髓化血;脾胃为后天之本,气血化生之根源。若脾虚生化无权,则精髓不充;肾虚精气亏损,则血源不足。另外,脾虚统摄无权,血溢脉外成瘀;或气虚血脉鼓动无力,血行不畅而变为瘀血;或肾虚精血不足,虚热内生,扰血妄行,溢于脉外成瘀血。瘀血不去,新血难生,致髓海瘀阻,久渐枯竭,故瘀血是慢性再生障碍性贫血的主要病理因素。然而活血多伤正气,本病患者多正虚不耐攻伐,需以“缓中补虚”为治疗前提,佐以活血化瘀,才能达到祛瘀生新的效果。本发明方中黄芪补气扶正,益表固脱,党参健脾益气,以资生化之源,二者合用大补肺脾之气,寓生气周流之意为君药;熟地黄、枸杞、淫羊藿益肾填精,鹿角片为血肉有情之品,善补肾强督;茯苓、白术、黄精健脾益气,配伍当归补血活血共为臣药。茜草、仙鹤草化瘀止血,鸡血藤活血通络使诸药具流动之性共为佐药;炙甘草调和诸药为使。诸药合用,共奏益气养血、益肾填精、化瘀止血之功。
药理研究证实,黄芪、党参具有提高患者免疫功能,改善血液和造血功能,同时具有抗菌抗病毒、抗肿瘤、调节消化道等作用;熟地、鸡血藤可刺激造血系统,增加红细胞及血红蛋白,升高血小板,还有抗炎、抗过敏、抑菌等作用;当归是临床中常用的补血药,研究发现其可改善造血功能、扩张血管、保肝等作用;白术主要活性成分为倍半萜类的化合物,具有抗菌消炎、镇痛、抗氧化、保肝、抗肿瘤、免疫调节等广泛的药理作用;枸杞子其有效成分枸杞多糖能促进骨髓干细胞造血功能,还有调脂、降糖、抗肿瘤、增强免疫力等作用;茜草、仙鹤草、鹿角胶在临床多用于血小板减少症,其具有升高血小板之功效,明显缩短出血时间;
茯苓有刺激造血系统,促进红系造血组细胞的生长,还具有保肝、抗溃疡、增强免疫力、抗肿瘤、抗菌等作用;淫羊藿能促进性腺机能,增强免疫功能、抗菌、抗病毒等药理作用等。
本发明的有益效果是:
本发明的有益效果是,成本低,治疗再生障碍性贫血疗效高,无毒副作用,具有益气养血,补肾填精,化瘀止血等功效。临床实验证明本发明治疗再生障碍性贫血具有疗效好和安全性较高的特点,值得临床应用、推广。
具体实施方式
结合以下实施例,可以更好的理解本发明;然而,本领域的技术人员容易理解,实施例所描述的内容仅用于说明本发明,而不应当也不会限制权利要求书中所详细描述的本发明;
实施例1
采用黄芪、当归、熟地、淫羊藿、枸杞、鹿角胶、党参、黄精、茯苓、白术、仙鹤草、鸡血藤、茜草、炙甘草为原料而制成。原料药重量配比为:黄芪15g;当归10g;熟地12g;淫羊藿10g;枸杞10g;鹿角胶10g;党参10g;黄精10g;茯苓15g;白术10g;仙鹤草20g;鸡血藤15g;茜草10g;炙甘草6g。先将鹿角胶单包,余将13味中草药加水900-1000ml,浸泡半小时,武火煮沸后,文火煎熬20-30分钟,去渣得滤液200ml,药渣再加水300ml,煎熬30-40分钟,去渣得滤液100ml,共得300ml药汁,再兑入烊化的鹿角胶混合均匀,即制得再生障碍性贫血的汤剂,装入无菌玻璃瓶内,密封瓶盖备用。每日1剂分2次口服,每次空腹温服150m1。4周为一疗程,一般服用3个疗程。至临床症状体征缓解,化验检查正常后,再巩固疗效服用一个疗程。
实施例2
原料药重量配比:黄芪10g;当归8g;熟地15g;淫羊藿8g;枸杞8g;鹿角胶6g;党参12g;黄精8g;茯苓10g;白术12g;仙鹤草15g;鸡血藤12g;茜草8g;炙甘草4g。制备工艺、服药方法与实施例1相同。
实施例3
原料药重量配比:黄芪12g;当归6g;熟地10g;淫羊藿6g;枸杞6g;鹿角胶8g;党参8g;黄精6g;茯苓12g;白术15g;仙鹤草10g;鸡血藤10g;茜草6g;炙甘草5g。制备工艺、服药方法与实施例1相同。
实施例4
上述药物的有效组合,互相协调,可以有效达到治疗再生障碍性贫血之目的,且副作用较少。上述结果为临床资料充分证明,有关资料如下,其中研究药物使用为实施例1中的原料药重量配比。
1、病例对象:
所选病例为我院血液科、中医科门诊及住院的慢性再生障碍性贫血患者50例。其临床表现为乏力、头昏、心悸和纳差;58%患者有发热,以呼吸道感染最常见,其次有肠道感染、尿路感染及皮肤黏膜感染;40%患者有不同程度的出血,以皮肤瘀斑瘀点最常见,其次有鼻衄、口腔血泡、牙龈出血,结膜出血等;4%出现深部脏器。所有患者均达到慢性再生障碍性贫血的诊断标准。实验组26例,其中男性12例,女性14例,年龄19~69岁;对照组24例,其中男性10例,女性14例,年龄15~70岁。两组比较无统计学差异。
2、方法:
(1)治疗方案:对照组口服环孢素(杭州中美华东制药有限公司,国药准字H10960122)治疗,每次75~150mg,2次/d(根据环孢素血药浓度调整剂量)。实验组在对照组基础上加服本发明实施例1所得中药汤剂,2次/d。3个月随访1次相关指标,包括乏力、纳差、发热、出血,输血次数与时间、肝肾功能及血常规、骨髓涂片评价其疗效。
(2)疗效评价标准:
1)基本治愈:贫血和出血症状消失,血红蛋白男性达120g/L、女性达110g/L,白细胞达4.0×109/L,血小板达100×109/L,随访1年以上未复发;
2)缓解:贫血和出血症状消失,血红蛋白男性达120g/L、女性达100g/L,白细胞达3.5×109/L,血小板也有一定程度增加,随访3个月病情稳定或继续进步;
3)明显进步:贫血和出血症状明显好转,不输血,血红蛋白较治疗前1个月内常见值增长30g/L以上,并能维持3个月;
4)无效:经治疗3个疗程后,症状、血常规未达明显进步
(3)统计学分析:用成组t检验进行统计分析,P<0.05表示有显著性意义。
3、结果
两组病例的疗效比较:见下表,显效率和总有效率治疗组明显优于对照组:
疗效比较
两组不良反应比较:对照组24例中有4例出现转氨酶升高(16.7%),实验组26例均未发生转氨酶异常。
4、结论
研究结果显示,本发明治疗再生障碍性贫血疗效确切,不良反应发生率低,值得推广和应用。
以上公开的本发明优选实施例只是用于帮助阐述本发明。优选实施例并没有详尽叙述所有的细节,也不限制该发明仅为所述的具体实施方式。显然,根据本说明书的内容,可作很多的修改和变化。本说明书选取并具体描述这些实施例,是为了更好地解释本发明的原理和实际应用,从而使所属技术领域技术人员能很好地理解和利用本发明。本发明仅受权利要求书及其全部范围和等效物的限制。
Claims (7)
1.一种治疗非重型再生障碍性贫血的中药组合物,其特征在于,包括如下重量组分:黄芪10%-15%、当归6%-10%、熟地8%-12%、淫羊藿6%-10%、枸杞6%-10%、鹿角胶6%-10%、党参8%-12%、黄精6%-10%、茯苓10%-15%、白术10%-15%、仙鹤草10%-20%、鸡血藤10%-15%、茜草6%-10%、灸甘草4%-6%。
2.根据权利要求1所述一种治疗非重型再生障碍性贫血的中药组合物,其特征在于,包括如下重量组分:所述治疗非重型再生障碍性贫血的中药组合物包括如下重量组分:黄芪15g、当归10g、熟地12g、淫羊藿10g、枸杞10g、鹿角胶10g、党参10g、黄精10g、茯苓15g、白术10g、仙鹤草20g、鸡血藤15g、茜草10g、炙甘草6g。
3.根据权利要求1所述一种治疗非重型再生障碍性贫血的中药组合物,其特征在于,包括如下重量组分:黄芪10g、当归8g、熟地15g、淫羊藿8g、枸杞8g、鹿角胶6g、党参12g、黄精8g、茯苓10g、白术12g、仙鹤草15g、鸡血藤12g、茜草8g、炙甘草4g。
4.根据权利要求1所述一种治疗非重型再生障碍性贫血的中药组合物,其特征在于,包括如下重量组分:黄芪12g、当归6g、熟地10g、淫羊藿6g、枸杞6g、鹿角胶8g、党参8g、黄精6g、茯苓12g、白术15g、仙鹤草10g、鸡血藤10g、茜草6g、炙甘草5g。
5.根据权利要求1-4任一项所述一种治疗非重型再生障碍性贫血的中药组合物的制备方法,其特征在于:
1)先将鹿角胶单包;
2)余下13味药物加入净水900-1000ml,浸泡半小时;
3)浸泡充分后,利用180-200℃武火加热至煮沸,后转120-150℃文火煎熬20-30min;
4)滤除药渣,取药液200ml;
5)药渣再次添加净水300ml,同样武火煮沸后,转文火煎熬30-40min;
6)滤除药渣,得药液100ml,共计得药液300ml;
7)将烊化的鹿角胶加入所得300ml药液中,搅拌混合均匀,即制得再生障碍性贫血的汤剂;
8)将制得的汤剂转入无菌玻璃瓶内,密封瓶盖备用。
6.根据权利要求1-5任一项所述一种治疗非重型再生障碍性贫血的中药组合物,其公开了一种治疗非重型再生障碍性贫血的中药组合物在治疗非重型(NSAA)再生障碍性贫血药物中的应用。
7.根据权利要求1-4任一项所述一种治疗非重型再生障碍性贫血的中药组合物,其特征在于,所述的药物其剂型包括但不限于:汤剂、片剂、颗粒剂、胶囊剂。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110926166.6A CN113521191A (zh) | 2021-08-12 | 2021-08-12 | 一种治疗非重型再生障碍性贫血的中药组合物及制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110926166.6A CN113521191A (zh) | 2021-08-12 | 2021-08-12 | 一种治疗非重型再生障碍性贫血的中药组合物及制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN113521191A true CN113521191A (zh) | 2021-10-22 |
Family
ID=78122332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110926166.6A Withdrawn CN113521191A (zh) | 2021-08-12 | 2021-08-12 | 一种治疗非重型再生障碍性贫血的中药组合物及制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN113521191A (zh) |
-
2021
- 2021-08-12 CN CN202110926166.6A patent/CN113521191A/zh not_active Withdrawn
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103330805A (zh) | 一种治疗月经过多的中药组合物 | |
CN102872381B (zh) | 一种治疗流行性腮腺炎的中药组合物 | |
CN103083476B (zh) | 一种治疗急性乳腺炎的中药 | |
CN108653434A (zh) | 一种治疗脾虚痰湿型多囊卵巢综合征的药物组合物 | |
CN103330868B (zh) | 一种慢性肾衰竭用肠道给液 | |
CN104958448A (zh) | 一种治疗产褥感染的药物 | |
CN104173950A (zh) | 一种治疗前列腺癌的中草药组合物 | |
CN104984296A (zh) | 一种治疗女性更年期综合症的药物组合物及其制备方法 | |
CN104606561A (zh) | 一种治疗自汗的中药组合物 | |
CN110215485B (zh) | 用于治疗糖尿病皮肤溃疡的中药组合物及其制备方法 | |
CN113521191A (zh) | 一种治疗非重型再生障碍性贫血的中药组合物及制备方法 | |
CN103341095B (zh) | 一种慢性肾衰竭用灌肠液 | |
CN104984027A (zh) | 一种治疗骨髓增生异常综合征的中药制剂及其制备方法 | |
CN105343578A (zh) | 一种治疗痔疮的药物组合物 | |
CN105169338A (zh) | 一种治疗女性更年期综合症的药物组合物及其制备方法 | |
CN106074912B (zh) | 一种治疗心脑血管疾病的中药制剂 | |
CN104435545A (zh) | 一种治疗苯中毒致白细胞减少症的中药制剂 | |
CN111514237B (zh) | 一种治疗病毒性心肌炎的中药组合物及其制备方法 | |
CN103432422B (zh) | 一种治疗慢性胃炎的中药 | |
CN102727749B (zh) | 一种治疗再生障碍性贫血的药物 | |
CN118021899A (zh) | 一种治疗骨髓增生异常综合征的中药组合物及其制备方法和应用 | |
CN108567926B (zh) | 一种治疗瘀血阻络型自身免疫性肝炎的中药组合物及其制备方法 | |
CN105362849A (zh) | 一种制备治疗不孕症的中药组合物的方法 | |
CN117482158A (zh) | 一种治疗子宫复旧不全的中药组合物 | |
CN105456447A (zh) | 一种含有艾叶的具有活血化淤功能的中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20211022 |
|
WW01 | Invention patent application withdrawn after publication |