CN113521185A - Traditional Chinese medicine sachet capable of relieving emotion as well as preparation method and application of traditional Chinese medicine sachet - Google Patents
Traditional Chinese medicine sachet capable of relieving emotion as well as preparation method and application of traditional Chinese medicine sachet Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine sachet for relieving emotion, a preparation method and application thereof, wherein the traditional Chinese medicine sachet comprises the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of peony, 10-20 parts of rose, 10-20 parts of flos Pruni mume, 10-20 parts of magnolia officinalis, 8-15 parts of hyacinth dolichos, 8-15 parts of peach blossom, 8-15 parts of nard, 8-15 parts of rhizoma cyperi, 5-10 parts of gardenia, 5-10 parts of albizia flower and 5-10 parts of lily. The invention adopts more than ten natural plant medicines with the functions of fragrance, spleen enlivening, liver soothing, qi circulation promoting, depression relieving and nerve soothing, such as peony, rose, flos mume, magnolia officinalis, hyacinth bean flower, peach flower, nardostachys root, rhizoma cyperi, gardenia, albizia flower and lily flower, as raw materials to process and prepare the sachet. The Chinese medicinal composition is a pure Chinese medicinal plant, is safe, has no toxic or side effect, can be used for a long time, not only can effectively relieve and adjust the stress, anxiety and depression of people, but also provides an economic, simple and safe adjusting method for the early stage of depression.
Description
Technical Field
The invention relates to a traditional Chinese medicine sachet for relieving emotion, a preparation method and application, and belongs to the technical field of medicines.
Background
With the rapid development of social economy, the gradual increase of working pressure and the acceleration of life rhythm, people have large mood fluctuation and are more easily in negative mental states such as anxiety, depression, anxiety and the like, and the depression is caused over time. Therefore, it is important to develop long-lasting depression prevention and treatment measures and to form a normal mental health prevention. In traditional Chinese medicine, the liver governs smoothing flow of qi, governs emotion, and the regulation of mental emotion is closely related to the liver. On the one hand, liver qi stagnation and qi circulation disorder of viscera and meridians may cause emotional activity disorder manifested as depression and frequent sighing; on the other hand, abnormal mood caused by external adverse stimulation can affect the abnormal ascending, descending, exiting, entering and moving of qi of the body, so that qi of the viscera and meridians is stagnated, the liver fails to dredge, the activity of the youth is further affected, and a vicious circle is formed. Liver pertains to wood, spleen pertains to earth, in Yun from jin Kui Yao L ü e: "Fu treats disease before it, and knows that the liver transmits spleen when it first strengthens the spleen. Liver qi failing to disperse and purge tends to cause dysfunction of the spleen in transportation, and conversely, spleen qi failing to transport and counter-restrict liver wood, resulting in "stagnation of earth and wood", and poor causal circulation. Therefore, external adverse emotional stimulation causes depression and anxiety, firstly impairs the function of liver governing flow of qi, then reaches spleen, and makes spleen governing transportation and transformation function abnormal, and clinical researches on depression also prove that the liver-qi stagnation syndrome and liver-qi stagnation and spleen deficiency syndrome reside in the first two clinical syndromes of depression, the most common pathological syndrome elements are liver and spleen, so Zhang Jingyue has proposed: the indications that excessive liver and spleen, either pacifying liver qi or strengthening spleen, or rescuing spleen by removing liver qi indicate that emotional diseases should be treated from liver and spleen.
The negative emotions such as anxiety and depression caused by external psychological stress are only a transition state from the negative mental state to the depression, and although the drug therapy is the most main treatment method of the depression at present, the treatment by using the anti-depression and anxiety drugs is premature, and in addition, the anti-depression drugs easily cause the side effects such as gastrointestinal discomfort, dyspepsia, nausea, weight gain, sexual dysfunction, blurred vision, suicide tendency and the like. Therefore, the product which is safe and effective, has no toxic or side effect, is low in cost, is convenient to use, is suitable for the early stage of depression and is especially important for relieving depression and anxiety.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the traditional Chinese medicine sachet for relieving the emotion, the preparation method and the application.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a traditional Chinese medicine sachet for relieving emotion comprises the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of peony, 10-20 parts of rose, 10-20 parts of flos Pruni mume, 10-20 parts of magnolia officinalis, 8-15 parts of hyacinth dolichos, 8-15 parts of peach blossom, 8-15 parts of nard, 8-15 parts of rhizoma cyperi, 5-10 parts of gardenia, 5-10 parts of albizia flower and 5-10 parts of lily.
Preferably, the traditional Chinese medicine sachet comprises the following traditional Chinese medicine raw materials in parts by weight: 12-20 parts of peony, 12-20 parts of rose, 12-20 parts of flos Pruni mume, 12-20 parts of magnolia officinalis, 9-15 parts of hyacinth dolichos, 9-15 parts of peach blossom, 9-15 parts of nard, 9-15 parts of rhizoma cyperi, 6-10 parts of gardenia, 6-10 parts of albizia flower and 6-10 parts of lily.
More preferably, the traditional Chinese medicine sachet comprises the following traditional Chinese medicine raw materials in parts by weight: 18 parts of peony, 18 parts of rose, 18 parts of flos cuprifoliae, 18 parts of magnolia flower, 12 parts of hyacinth bean flower, 12 parts of peach flower, 12 parts of nardostachyos root and rhizome, 12 parts of rhizoma cyperi, 9 parts of gardenia, 9 parts of albizia flower and 9 parts of lily.
A method for preparing traditional Chinese medicine sachet for relieving emotion comprises pulverizing the raw materials, mixing, and making into sachet. The method specifically comprises the following steps:
step 1: weighing peony, rose, flos Pruni mume, flos Magnoliae officinalis, flos lablab album, flos persicae, rhizoma Nardostachyos, rhizoma Cyperi, flos Gardeniae, flos Albizziae, and flos Lilii Viriduli;
step 2: sequentially adding flos moutan, flos Rosae Rugosae, flos Pruni mume, flos Magnoliae officinalis, flos Dolichoris, flos persicae, rhizoma et radix Valerianae, rhizoma Cyperi, flos Gardeniae, flos Albizziae, and flos Lilii Viriduli into a pulverizer, pulverizing, and making into Chinese medicinal powder;
and step 3: sieving the pulverized Chinese medicinal powder, mixing the powders, and packaging to obtain sachet.
Wherein the rotation speed of the pulverizer is 5000-. Sieving with 100 mesh sieve.
An application of the above traditional Chinese medicine sachet in the preparation of medicine for relieving emotion is provided.
The sachet can be placed at the side of an office desk or carried with the user, when the emotion is impatient and nervous, the sachet is taken out and placed at the mouth and nose, and the medicine fragrance is inhaled through the mouth and nose, so that the emotion can be relieved, and the problems of mental stress and anxiety and vexation can be relieved. The medicine in the sachet was changed every 7 days.
In the formula, the peony flower has the property of calming the liver and spleen, and is good at soothing the liver, regulating qi, activating spleen and eliminating dampness; the rose is fragrant and light in taste, can harmonize blood and calm liver, and can relieve chest stuffiness and disperse stagnation; the Prunus mume has the effects of soothing liver-qi stagnation, regulating qi and regulating the middle warmer; the magnolia officinalis flower is warm in nature and fragrant in nature, has the functions of moving qi and dispelling melancholy, invigorating spleen and eliminating dampness, and has the functions of aromatic qi circulation, soothing liver and dispelling melancholy by combining the four medicines, which are monarch medicines. The hyacinth bean flower is slightly fragrant in smell and light in taste, and has the effects of relieving depression and tonifying spleen; the peach blossom is bitter and neutral, and can promote qi and blood circulation, relax the bowels and induce diuresis, and improve the symptoms of stagnation of the spleen and stomach; the nard is capable of regulating qi to alleviate pain, relieving depression and activating spleen; the cyperus rotundus has the effects of regulating qi and relieving depression, the four medicines are used as ministerial medicines together, the effects of soothing the liver and promoting the circulation of qi and strengthening the spleen and eliminating dampness are realized, and the effects of strengthening the spleen, activating the spleen and activating the spleen are realized aiming at the symptoms of wood-depression soil congestion while the force of soothing the liver and relieving depression of the monarch medicines is enhanced. The albizia flower regulates qi and stomach, relieves depression and soothes nerves; lily, for clearing heart fire and tranquilizing mind, it is good at treating restlessness and insomnia due to internal heat or emotional disorders; the gardenia has the effects of purging fire and relieving restlessness, and can relieve the symptoms of vexation and depression and dysphoria, and the three medicines are used as adjuvant medicines, so that the effects of soothing liver and relieving depression are enhanced by monarch and minister medicines, the restlessness is relieved, and the nerves are calmed by the monarch and minister medicines. According to the whole formula, the aromatic flower medicines are mainly used, and the medicines are combined together to play the effects of soothing the liver, promoting the circulation of qi, activating the spleen with fragrance, relieving depression and calming the nerves.
The invention has the beneficial effects that:
the invention provides a sachet which plays roles of relieving emotion and relieving mental stress through the efficacies of soothing liver, promoting qi circulation, activating spleen by fragrance, relieving depression and calming the nerves and the like and a formula thereof, and the sachet has the following effects: the invention adopts more than ten natural plant medicines of peony, rose, flos Pruni mume, magnolia officinalis, hyacinth bean flower, peach flower, nardostachys root, rhizoma cyperi, gardenia, albizia flower and lily flower as raw materials to be processed into the sachet, the medicine fragrance of the traditional Chinese medicine materials in the sachet is volatilized into the air, and people can breathe into the heart, the liver and the spleen, so that people can keep fresh and cool and have joyful mood in busy and nervous life and work. Long-time smell has the effects of soothing liver, promoting qi circulation, activating spleen by fragrance, relieving depression and soothing nerves. The traditional Chinese medicine composition is a pure traditional Chinese medicine plant, is safe, has no toxic or side effect, can be used for a long time, can effectively relieve and adjust the stress, anxiety and depression of people, and provides an economic, simple and safe adjusting method for the early stage of depression.
Drawings
FIG. 1 shows the movement locus of each group of mice in the open field experiment.
Detailed Description
The following examples further illustrate the embodiments of the present invention in detail.
Example 1
A traditional Chinese medicine sachet for relieving emotion comprises the following traditional Chinese medicine raw materials in parts by weight: 18 parts of peony, 18 parts of rose, 18 parts of flos cuprifoliae, 18 parts of magnolia flower, 12 parts of hyacinth bean flower, 12 parts of peach flower, 12 parts of nardostachyos root and rhizome, 12 parts of rhizoma cyperi, 9 parts of gardenia, 9 parts of albizia flower and 9 parts of lily.
The preparation method comprises the following steps:
step 1: weighing peony, rose, flos Pruni mume, flos Magnoliae officinalis, flos lablab album, flos persicae, rhizoma Nardostachyos, rhizoma Cyperi, flos Gardeniae, flos Albizziae, and flos Lilii Viriduli;
step 2: sequentially adding flos moutan, flos Rosae Rugosae, flos Pruni mume, flos Magnoliae officinalis, flos lablab album, flos persicae, rhizoma et radix Valerianae, rhizoma Cyperi, flos Gardeniae, flos Albizziae, and flos Lilii into a pulverizer, pulverizing at a speed of 5000 r/min for 5min to obtain Chinese medicinal powder;
and step 3: sieving the pulverized Chinese medicinal powder with 100 mesh sieve, mixing the sieved Chinese medicinal powder, and packaging into cotton-flax bags (20 g per bag) to obtain sachet.
Example 2
A traditional Chinese medicine sachet for relieving emotion comprises the following traditional Chinese medicine raw materials in parts by weight: 20 parts of peony, 20 parts of rose, 20 parts of flos cuprifoliae praecox, 20 parts of magnolia officinalis, 15 parts of hyacinth dolichos, 15 parts of peach blossom, 15 parts of nardostachys root and rhizome, 15 parts of rhizoma cyperi, 10 parts of gardenia, 10 parts of albizia flower and 10 parts of lily.
The preparation method comprises the following steps:
step 1: weighing peony, rose, flos Pruni mume, flos Magnoliae officinalis, flos lablab album, flos persicae, rhizoma Nardostachyos, rhizoma Cyperi, flos Gardeniae, flos Albizziae, and flos Lilii Viriduli;
step 2: sequentially adding flos moutan, flos Rosae Rugosae, flos Pruni mume, flos Magnoliae officinalis, flos lablab album, flos persicae, rhizoma et radix Valerianae, rhizoma Cyperi, flos Gardeniae, flos Albizziae, and flos Lilii into a pulverizer, pulverizing at 5500 rpm for 8min to obtain Chinese medicinal powder;
and step 3: sieving the pulverized Chinese medicinal powder with 100 mesh sieve, mixing the sieved Chinese medicinal powder, and packaging into cotton-flax bags (20 g per bag) to obtain sachet.
Example 3
A traditional Chinese medicine sachet for relieving emotion comprises the following traditional Chinese medicine raw materials in parts by weight: 12 parts of peony, 12 parts of rose, 12 parts of flos cuprifoliae, 12 parts of magnolia flower, 9 parts of hyacinth bean flower, 9 parts of peach flower, 9 parts of nardostachyos root and rhizome, 9 parts of rhizoma cyperi, 6 parts of gardenia, 6 parts of albizia flower and 6 parts of lily.
The preparation method comprises the following steps:
step 1: weighing peony, rose, flos Pruni mume, flos Magnoliae officinalis, flos lablab album, flos persicae, rhizoma Nardostachyos, rhizoma Cyperi, flos Gardeniae, flos Albizziae, and flos Lilii Viriduli;
step 2: sequentially adding flos moutan, flos Rosae Rugosae, flos Pruni mume, flos Magnoliae officinalis, flos lablab album, flos persicae, rhizoma et radix Valerianae, rhizoma Cyperi, flos Gardeniae, flos Albizziae, and flos Lilii into a pulverizer, pulverizing at 6000 rpm for 10min to obtain Chinese medicinal powder;
and step 3: sieving the pulverized Chinese medicinal powder with 100 mesh sieve, mixing the sieved Chinese medicinal powder, and packaging into cotton-flax bags (20 g per bag) to obtain sachet.
The following is a description of the beneficial effects of the present invention in conjunction with clinical and experimental use data:
experimental study (one): influence of traditional Chinese medicine sachet for relieving emotion on behaviourology of chronic constraint stress mice
The purpose is as follows: discussing the influence of the traditional Chinese medicine sachet for relieving emotion on anxiety and depression behaviors of the chronic constraint stress mice.
The method comprises the following steps: 30C 57BL/6J mice were randomly divided into a blank control group, a model group and a Chinese medicinal sachet formula group, and each group contained 10 mice. Except for the blank control group, the other two groups of mice are restrained for 14 days by adopting a chronic restraint stress method for modeling, a mouse depression and anxiety model is established, and the traditional Chinese medicine sachet prepared by mixing the traditional Chinese medicine composition in the proportion of the example 1 is placed around the mice of the traditional Chinese medicine sachet formula group during modeling. After the restraint stress modeling and the sachet treatment are finished for 14 days, the behaviourology of each group of mice is evaluated by adopting an open field experiment and an elevated plus maze experiment.
As a result: the open field test results show (see table 1, fig. 1), compared to the blank control group: the residence time of the central zone of the model group mice is obviously increased (P is less than 0.01), and the entering times and the total movement distance of the central zone are obviously reduced (P is less than 0.01); compared to the model set: the residence time of the mouse central area in the traditional Chinese medicine sachet formula group is obviously reduced (P is less than 0.01), and the entering times and the total movement distance of the central area are both obviously increased (P is less than 0.05 or P is less than 0.01). The results of the elevated plus maze experiment (see table 2) show that, compared to the blank control group: the proportion of the number of times of entering the open arm and the residence time of the model group mouse is obviously reduced (P is less than 0.01); compared to the model set: the ratio of the times of entering the open arms and the retention time of the mice in the formula group of the traditional Chinese medicine sachet is obviously increased (P is less than 0.01).
TABLE 1 statistical description of the indexes of open field experiments in each group of mice
Note: comparison with blank control:*P＜0.05，**p is less than 0.01; comparison with model groups:△P＜0.05，△△P＜0.01。
TABLE 2 statistical description of the ratio of the number of entries and the residence time of the open arms of the elevated plus maze for each group of mice
Note: comparison with blank control:*P＜0.05，**p is less than 0.01; comparison with model groups:△P＜0.05，△△P＜0.01。
and (4) conclusion: the traditional Chinese medicine sachet formula can obviously improve depression and anxiety-like behaviors of mice.
(II) clinical research: influence of traditional Chinese medicine sachet formula for relieving emotion on anxiety and depression mood of tumor patient
The purpose is as follows: the traditional Chinese medicine sachet formula for relieving emotion is discussed to improve anxiety and depression of clinical tumor patients.
The method comprises the following steps: 32 patients with tumor and depression, who were diagnosed in the oncology department of the first subsidiary hospital of the university of traditional Chinese medicine in Henan between 1 month and 2021 month in 2019, were selected as study subjects and were randomly divided into a control group and an observation group. Inclusion criteria were: the malignant tumor of middle and late stages is diagnosed according to the diagnosis standard of clinical tumor internal science; referring to the diagnosis standard of depressive episode in CCMD-3 classification and diagnosis standard of Chinese mental disorder; age 18-86 years old, male and female; the Hamilton Depression Scale (HAMD-24) score is more than or equal to 25 points; before the visit, the antidepressant medicines are not taken; the patients and family members sign informed consent. Exclusion criteria: there is a history of psychosis, and patients who do not meet the clinical diagnostic criteria for depression and cannot cooperate with the study. The control group adopts conventional western medicine treatment, and the conventional treatment method comprises the following steps: after the chemotherapy period is finished, the fluoxetine hydrochloride capsule (national standard HI 9980114; produced by Shanghai medicine and Western medicine Co., Ltd.) is orally taken 20 mg/time and 1 time/d, and the observation group is interfered by the traditional Chinese medicine sachet for relieving emotion on the basis of the conventional treatment of the western medicine. 7 days is a treatment course, and 3 treatment courses are continued. After 3 courses of treatment, clinical effects of the two groups of patients are evaluated by using Hamilton depression scale, the significant effect is that the reduction rate exceeds 75%, the significant effect is that the reduction rate is 50% -75%, the ineffective effect is that the reduction rate is lower than 50%, and the significant effect and the effective effect are regarded as effective clinical treatment.
As a result: as shown in tables 3 and 4. As can be seen from Table 3, the total effective rate of the observed group is 93.75%, which is increased by 87.50% compared with the control group, and the number of significant persons is significantly greater than that of the control group. A comparison of the HAMD-24 and SDS scores before and after treatment (Table 4) in the two groups of patients revealed that the HAMD-24 and SDS scores were significantly reduced (P < 0.01) before and after treatment in the two groups of patients, but the HAMD-24 and SDS scores were significantly better than those in the control group (P < 0.01) after treatment in the patients in the observation group.
TABLE 3 comparison of clinical efficacy of the treated and control groups
TABLE 4 comparison of HAMD-24 and SDS scores before and after treatment in two groups
Note: pre-and post-treatment comparisons in groups:*P＜0.05，**p is less than 0.01; post treatment comparisons between groups:△P＜0.05，△△P＜0.01。
and (4) conclusion: the traditional Chinese medicine sachet for relieving emotion can effectively relieve depression and anxiety mood of tumor patients on the basis of clinical basic treatment.
Part of the clinical cases:
case 1: a female patient is 25 years old, has an initial diagnosis of 'emotional depression 2 weeks, intermittent violent splenic qi 3 days' due to 6-month 6-day main cause in 2020, and is low in emotion, sad, baldness and whisper, and is uninteresting to work due to too large working pressure and harmony with coworkers 2 weeks ago, but sometimes the violent splenic qi cannot be automatically controlled. There are symptoms of palpitation, shortness of breath, chest distress, fatigue, insomnia, etc. Secondly, the tongue is pale red, the coating is thin and white, and the pulse is rapid. The traditional Chinese medicine diagnosis is depression (mild disease), and the prescription is as follows: example 1 traditional Chinese medicine sachets. The product is worn with the body, changed for 1 time in 7 days, continuously worn for 3 weeks, and has no abnormality after 3 months of follow-up.
Case 2: the female is 44 years old, and has a preliminary diagnosis for 16 days 8 and 16 months in 2020, because of 'low mood, vexation and insomnia 3 weeks', and the patient has low mood, difficulty in falling asleep, pain around temple on the left, dysphoria, chest distress, short breath, hypodynamia, normal stool, dietetic, pale red tongue, thin and white fur and wiry pulse after 3 weeks before home contradiction. The diagnosis is depression (mild disease). Prescription: example 2 traditional Chinese medicine sachets. The product is worn with the body, changed for 1 time in 7 days, continuously worn for 3 weeks, and has no abnormality after 3 months of follow-up.
Although embodiments of the present invention have been illustrated and described, it will be appreciated by those skilled in the art that various modifications, substitutions and alternatives can be made to the embodiments described above without departing from the principles of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The traditional Chinese medicine sachet capable of relieving emotion is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of peony, 10-20 parts of rose, 10-20 parts of flos Pruni mume, 10-20 parts of magnolia officinalis, 8-15 parts of hyacinth dolichos, 8-15 parts of peach blossom, 8-15 parts of nard, 8-15 parts of rhizoma cyperi, 5-10 parts of gardenia, 5-10 parts of albizia flower and 5-10 parts of lily.
2. The traditional Chinese medicine sachet according to claim 1, preferably comprising the following traditional Chinese medicine raw materials in parts by weight: 12-20 parts of peony, 12-20 parts of rose, 12-20 parts of flos Pruni mume, 12-20 parts of magnolia officinalis, 9-15 parts of hyacinth dolichos, 9-15 parts of peach blossom, 9-15 parts of nard, 9-15 parts of rhizoma cyperi, 6-10 parts of gardenia, 6-10 parts of albizia flower and 6-10 parts of lily.
3. The traditional Chinese medicine sachet according to claim 2, more preferably comprising the following traditional Chinese medicine raw materials in parts by weight: 18 parts of peony, 18 parts of rose, 18 parts of flos cuprifoliae, 18 parts of magnolia flower, 12 parts of hyacinth bean flower, 12 parts of peach flower, 12 parts of nardostachyos root and rhizome, 12 parts of rhizoma cyperi, 9 parts of gardenia, 9 parts of albizia flower and 9 parts of lily.
4. A method for preparing the traditional Chinese medicine sachet as claimed in any one of claims 1 to 3, wherein the traditional Chinese medicine raw materials are pulverized and mixed to prepare the sachet.
5. The preparation method according to claim 4, characterized by comprising the following steps:
step 1: weighing peony, rose, flos Pruni mume, flos Magnoliae officinalis, flos lablab album, flos persicae, rhizoma Nardostachyos, rhizoma Cyperi, flos Gardeniae, flos Albizziae, and flos Lilii Viriduli;
step 2: sequentially adding flos moutan, flos Rosae Rugosae, flos Pruni mume, flos Magnoliae officinalis, flos Dolichoris, flos persicae, rhizoma et radix Valerianae, rhizoma Cyperi, flos Gardeniae, flos Albizziae, and flos Lilii Viriduli into a pulverizer, pulverizing, and making into Chinese medicinal powder;
and step 3: sieving the pulverized Chinese medicinal powder, mixing the powders, and packaging to obtain sachet.
6. The method as claimed in claim 5, wherein the rotation speed of the pulverizer is 5000-.
7. The method of claim 5, wherein the screening is through a 100 mesh screen.
8. Use of a traditional Chinese medicine sachet as claimed in any one of claims 1 to 3 in the preparation of a mood-soothing medicament.
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