CN113498343A - 用于治疗真菌性骨关节感染的三萜抗真菌剂 - Google Patents

用于治疗真菌性骨关节感染的三萜抗真菌剂 Download PDF

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Publication number
CN113498343A
CN113498343A CN202080014666.6A CN202080014666A CN113498343A CN 113498343 A CN113498343 A CN 113498343A CN 202080014666 A CN202080014666 A CN 202080014666A CN 113498343 A CN113498343 A CN 113498343A
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CN
China
Prior art keywords
fungal
compound
osteoarticular
infections
formula
Prior art date
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Pending
Application number
CN202080014666.6A
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English (en)
Chinese (zh)
Inventor
D·A·安古洛·冈萨雷斯
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Sinics
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Sinics
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Publication date
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Publication of CN113498343A publication Critical patent/CN113498343A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CN202080014666.6A 2019-01-30 2020-01-30 用于治疗真菌性骨关节感染的三萜抗真菌剂 Pending CN113498343A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962798743P 2019-01-30 2019-01-30
US62/798,743 2019-01-30
PCT/US2020/015948 WO2020160316A1 (en) 2019-01-30 2020-01-30 Triterpenoid antifungals for the treatment of fungal osteo-articular infections

Publications (1)

Publication Number Publication Date
CN113498343A true CN113498343A (zh) 2021-10-12

Family

ID=69740705

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080014666.6A Pending CN113498343A (zh) 2019-01-30 2020-01-30 用于治疗真菌性骨关节感染的三萜抗真菌剂

Country Status (7)

Country Link
US (2) US20220117948A1 (https=)
EP (1) EP3917534B1 (https=)
JP (1) JP7562542B2 (https=)
CN (1) CN113498343A (https=)
EA (1) EA202192107A1 (https=)
MA (1) MA54866A (https=)
WO (1) WO2020160316A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020276595B2 (en) * 2019-05-16 2025-12-04 Scynexis, Inc. Antifungal Agents for Candida Auris Decolonization

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010019203A1 (en) * 2008-08-12 2010-02-18 Merck Sharp & Dohme Corp. Antifungal agents
CN102176827A (zh) * 2008-08-12 2011-09-07 默克夏普和道赫莫公司 抗真菌制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
JP5245057B2 (ja) 2006-04-03 2013-07-24 メルク・シャープ・アンド・ドーム・コーポレーション 抗真菌剤
WO2018102407A1 (en) * 2016-11-29 2018-06-07 Cidara Therapeutics, Inc Methods for preventing fungal infections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010019203A1 (en) * 2008-08-12 2010-02-18 Merck Sharp & Dohme Corp. Antifungal agents
CN102176827A (zh) * 2008-08-12 2011-09-07 默克夏普和道赫莫公司 抗真菌制剂

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NATHAN P WIEDERHOLD等: "Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrata", 《JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY》, vol. 73, no. 2, pages 448 - 451 *
WRING, STEPHEN等: "SCY-078, a Novel Fungicidal Agent, Demonstrates Distribution to Tissues Associated with Fungal Infections during Mass Balance Studies with Intravenous and Oral [14C] SCY-078 in Albino and Pigmented Rats", 《 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY》, vol. 63, no. 2, 29 January 2019 (2019-01-29), pages 1 - 9 *
WRING,STEPHEN A.等: "Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis", 《ANTIMICROBIAL AGENTS AND CHEMOTHERAPY》, vol. 61, no. 4, pages 1 - 50, XP055518287, DOI: 10.1128/AAC.02068-16 *

Also Published As

Publication number Publication date
US20220117948A1 (en) 2022-04-21
JP7562542B2 (ja) 2024-10-07
EA202192107A1 (ru) 2021-10-21
MA54866A (fr) 2022-05-04
JP2022519500A (ja) 2022-03-24
EP3917534A1 (en) 2021-12-08
US20250248983A1 (en) 2025-08-07
EP3917534B1 (en) 2024-07-03
WO2020160316A1 (en) 2020-08-06

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