CN113498340A - 用于治疗皮肤疾病噻吩基苯胺化合物 - Google Patents

用于治疗皮肤疾病噻吩基苯胺化合物 Download PDF

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Publication number
CN113498340A
CN113498340A CN201980089585.XA CN201980089585A CN113498340A CN 113498340 A CN113498340 A CN 113498340A CN 201980089585 A CN201980089585 A CN 201980089585A CN 113498340 A CN113498340 A CN 113498340A
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compound
alkyl
substituted
group
amino
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CN201980089585.XA
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Chinese (zh)
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J·金凯德
M·邓克顿
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Enfreixon Treatment Co ltd
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Enfreixon Treatment Co ltd
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Priority to CN202311548396.9A priority Critical patent/CN117551073A/zh
Publication of CN113498340A publication Critical patent/CN113498340A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201980089585.XA 2018-11-20 2019-11-20 用于治疗皮肤疾病噻吩基苯胺化合物 Pending CN113498340A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311548396.9A CN117551073A (zh) 2018-11-20 2019-11-20 用于治疗皮肤疾病噻吩基苯胺化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862769832P 2018-11-20 2018-11-20
US62/769,832 2018-11-20
PCT/US2019/000067 WO2020106305A1 (en) 2018-11-20 2019-11-20 Thienyl-aniline compounds for treatment of dermal disorders

Related Child Applications (1)

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CN202311548396.9A Division CN117551073A (zh) 2018-11-20 2019-11-20 用于治疗皮肤疾病噻吩基苯胺化合物

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Publication Number Publication Date
CN113498340A true CN113498340A (zh) 2021-10-12

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CN201980089585.XA Pending CN113498340A (zh) 2018-11-20 2019-11-20 用于治疗皮肤疾病噻吩基苯胺化合物
CN202311548396.9A Pending CN117551073A (zh) 2018-11-20 2019-11-20 用于治疗皮肤疾病噻吩基苯胺化合物

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US (1) US12466818B2 (https=)
EP (1) EP3911313A4 (https=)
JP (1) JP7546297B2 (https=)
CN (2) CN113498340A (https=)
AU (1) AU2019384645B2 (https=)
CA (1) CA3120352A1 (https=)
MA (1) MA54741A (https=)
WO (1) WO2020106305A1 (https=)

Families Citing this family (6)

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US12466818B2 (en) 2018-11-20 2025-11-11 Nflection Therapeutics, Inc. Thienyl-aniline compounds for treatment of dermal disorders
CN113473986B (zh) 2018-11-20 2024-10-11 恩福莱克逊治疗有限公司 用于治疗皮肤疾病萘啶酮苯胺化合物
AU2019383311B2 (en) 2018-11-20 2024-12-05 Nflection Therapeutics, Inc. Cyanoaryl-aniline compounds for treatment of dermal disorders
MA55143A (fr) * 2018-11-20 2021-09-29 H Lee Moffitt Cancer Center & Res Institute Inc Composés aryl-aniline et hétéroaryl-aniline pour le traitement de cancers de la peau
US11010862B1 (en) * 2019-11-14 2021-05-18 Advanced Micro Devices, Inc. Reduced bandwidth tessellation factors
KR20240125577A (ko) 2021-11-23 2024-08-19 엔플렉션 테라퓨틱스, 인코포레이티드 피롤로피리딘-아닐린 화합물의 제형

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JP7546297B2 (ja) 2024-09-06
MA54741A (fr) 2021-11-24
CN117551073A (zh) 2024-02-13
US12466818B2 (en) 2025-11-11
EP3911313A1 (en) 2021-11-24
WO2020106305A1 (en) 2020-05-28
US20220204486A1 (en) 2022-06-30
AU2019384645A1 (en) 2021-06-10
CA3120352A1 (en) 2020-05-28
EP3911313A4 (en) 2022-10-12
AU2019384645B2 (en) 2025-08-21
JP2022510586A (ja) 2022-01-27

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Application publication date: 20211012