CN113488218A - Radionuclide shielding and protecting device for SPECT developer labeling - Google Patents
Radionuclide shielding and protecting device for SPECT developer labeling Download PDFInfo
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- CN113488218A CN113488218A CN202110585875.2A CN202110585875A CN113488218A CN 113488218 A CN113488218 A CN 113488218A CN 202110585875 A CN202110585875 A CN 202110585875A CN 113488218 A CN113488218 A CN 113488218A
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- 238000002372 labelling Methods 0.000 title claims description 19
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Images
Classifications
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F5/00—Transportable or portable shielded containers
- G21F5/015—Transportable or portable shielded containers for storing radioactive sources, e.g. source carriers for irradiation units; Radioisotope containers
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F5/00—Transportable or portable shielded containers
- G21F5/06—Details of, or accessories to, the containers
Abstract
The invention discloses a radionuclide shielding and protecting device for SPECT developer marking, which comprises a leaching unit for leaching operation to obtain radionuclide, a marking unit for marking operation to obtain radionuclide medicine, a subpackaging unit for performing injection subpackaging operation on the radionuclide medicine and a packaging unit for packaging the radionuclide medicine, wherein each of the leaching unit and the packaging unit comprises a first operation cabinet for maintaining A-level clean and positive pressure environment inside, and each of the marking unit and the subpackaging unit comprises a second operation cabinet for maintaining A-level clean and closed positive pressure environment inside. The invention can respectively provide the production processes of leaching, marking, subpackaging and packaging the radionuclide, accords with the GMP certification requirement, prevents the radionuclide from irradiating, reduces the absorption dose of operators to volatile substances, has excellent filtering and purifying effects and effectively protects the personal safety of the operators.
Description
Technical Field
The invention belongs to the technical field of radiation, and particularly relates to a radionuclide shielding and protecting device for SPECT developer labeling.
Background
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.
In recent years, with the civilized popularization of nuclear technology application, pharmaceutical enterprises and hospitals, particularly production devices for radionuclides such as single photon pharmaceuticals (SPECT imaging agents/Tc-99 m) and the like, lack production protection devices meeting GMP certification requirements only from the perspective of radiation safety, and the drug production environment cannot meet the requirements of grade a and positive pressure required by GMP certification, so that the quality of the produced drugs has great potential safety hazards. The hidden dangers are not only local problems of laboratories, but also environmental safety (such as leakage and discharge of hazardous substances) and social safety (such as escape and loss of dangerous goods) are involved, and a warning clock is sounded to safety protection problems of various levels of biosafety laboratories and biomedical laboratories, so that high attention of governments of various countries in the world is attracted, and the hidden dangers become the focus of general attention all over the world.
In the prior art, the marking and the subpackaging of medical isotope medicines (such as radionuclides containing Tc-99m, F-18, I-131 and the like) are finished in one or more different independent operation cabinets, and after the isotope medicines are marked in one operation cabinet, the isotope medicines need to be taken out and taken into another cabinet to finish the subpackaging, so that the working procedure of radiation workers is complicated, and the contamination probability of the radionuclides is increased.
The protection cabinet applied to SPECT developer marking and subpackaging in the current market mainly relates to the following two structural schemes:
the first method comprises the following steps: the simple production line is formed by adopting one or more ventilation protection cabinets with hundred-grade positive pressure, the structure is simple, the market share is high, the procedures of leaching, marking and subpackaging are sequentially completed in the protection cabinets during production, leacheate and marking liquid are transferred to another protection cabinet temporarily from the protection cabinet, so that the purification grade jump phenomenon exists in medicine transfer, and the whole medicine production process cannot be guaranteed to be in an A-grade positive pressure production environment.
And the second method comprises the following steps: the ordinary negative pressure sealing ventilation protection cabinet is adopted, although the structure is simple, the structure is only used for the operation of volatile nuclide, the production environment of hundred-level positive pressure required by the production of SPECT developer under GMP certification condition cannot be met, the medicine safety cannot be guaranteed, and safety accidents are easily caused.
Both systems can not meet the requirements of GMP certification for producing an integrated hundred-grade purification and positive pressure environment required by a SPECT developer.
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is how to solve the shielding protection problem of the radionuclide.
In order to solve the technical problem, the invention provides a radionuclide shielding and protecting device for SPECT developer marking, which comprises a washing unit for washing to obtain radionuclide, a marking unit for marking to obtain radionuclide drug, a subpackaging unit for performing injection subpackaging operation on the radionuclide drug and a packaging unit for performing packaging operation on the radionuclide drug,
each of the leaching unit and the packaging unit comprises a first operation cabinet, a circulating fan and a circulating air filter, wherein the first operation cabinet keeps an A-level clean and positive pressure environment inside, the circulating fan circulates air in the first operation cabinet, the circulating air filter filters air circulated by the circulating fan, the first operation cabinet is a shielding protection box, the first operation cabinet is provided with a first operation opening and a first viewing window, the first operation opening is provided with a shielding protection door which can be opened and closed, and the first viewing window is provided with a first shielding protection window;
each of the marking unit and the subpackaging unit comprises a second operation cabinet, an air supply fan, an air exhaust fan, an air supply filter and an air exhaust filter, wherein the second operation cabinet keeps A-level clean and sealed positive pressure environment inside, the air supply fan sends outside air into the second operation cabinet, the air exhaust fan exhausts the air in the second operation cabinet, the air supply filter filters the air sent by the air supply fan, the air exhaust filter filters the air exhausted by the air exhaust fan, the second operation cabinet is a shielding protection cabinet, a second operation port and a second viewing window are arranged on the second operation cabinet, the second operation port is provided with operation gloves and a shielding protection cover capable of being opened and closed, and the second viewing window is provided with a second shielding protection window;
the first operation cabinet of drip washing unit, the second operation cabinet of mark unit, the second operation cabinet of partial shipment unit and the first operation cabinet of packing unit sets gradually, is equipped with the first transfer mouth that is used for conveying the material between adjacent two, first transfer mouth is equipped with the delivery door that can open and close.
Furthermore, in the leaching unit and the packaging unit, each further comprises a first air cabinet arranged above the first operation cabinet, the circulating fan is arranged in the first air cabinet, the first operation port and the first viewing window are arranged on the first operation cabinet, the marking unit and the sub-packaging unit are further provided, each further comprises a second air cabinet arranged above the second operation cabinet, the air supply fan and the air exhaust fan are arranged in the second air cabinet, and the second operation port and the second viewing window are arranged on the second operation cabinet.
Further, each of the washing unit and the packing unit further includes a first pressure difference meter for detecting a pressure difference between the inside of the first operation cabinet and the outside air, and each of the labeling unit and the dispensing unit further includes a second pressure difference meter for detecting a pressure difference between the inside of the second operation cabinet and the outside air.
Further, in the first operation cabinet and the second operation cabinet, the air flow direction inside each of the first operation cabinet and the second operation cabinet is from top to bottom.
Furthermore, the circulating air filter and the air supply filter are HEPA filters, and the exhaust air filter is an activated carbon filter.
Furthermore, the leaching unit further comprises a source storage box arranged below the first operation cabinet, the source storage box is a shielding protection box, the source storage box is used for placing the radionuclide generator, a second transfer port for material transfer is arranged between the first operation cabinet and the source storage box, and the second transfer port is provided with a sliding cover capable of being opened and closed;
the marking unit with among the partial shipment unit, each still including locating production auxiliary material transmission auxiliary tank, activity well and the vice case of discarded object transmission of second operation cabinet below, production auxiliary material transmission auxiliary tank the activity well and the vice case of discarded object transmission is the shielding guard box, required production auxiliary material when production auxiliary material transmission auxiliary tank is used for over-and-under type transport operation, the activity well is used for carrying out the activity detection to the radionuclide medicine, the vice case of discarded object transmission is used for the over-and-under type produced discarded object when carrying the operation, production auxiliary material transmission auxiliary tank the activity well and in the vice case of discarded object transmission, each with be equipped with the third transmission mouth that is used for carrying on the material transmission between the second operation cabinet.
Furthermore, the transfer door is provided with a sealing ring which is in sealing connection with the first transfer port where the transfer door is located and a lock catch which is locked with the first transfer port where the transfer door is located, so that the respective air tightness of the first operating cabinet and the second operating cabinet is realized.
Furthermore, the shielding protective door is a liftable lifting door, the first operation opening is further provided with a screen which can horizontally move and block different positions of the first operation opening, and the shielding protective cover can be self-locked on the second operation opening.
Furthermore, the shielding protection box comprises a stainless steel outer box, a stainless steel inner box and a shielding protection layer arranged in the stainless steel outer box and the stainless steel inner box interlayer.
Further, in the washing unit and the packaging unit, each further includes a first ultraviolet lamp for sterilizing and disinfecting the inside of the respective first operation cabinet, a first LED lighting lamp for lighting the inside of the respective first operation cabinet, and a first control panel for electrical control, and in the labeling unit and the sub-packaging unit, each further includes a second ultraviolet lamp for sterilizing and disinfecting the inside of the respective second operation cabinet, a second LED lighting lamp for lighting the inside of the respective second operation cabinet, and a second control panel for electrical control.
Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages: the radionuclide shielding and protecting device for SPECT developer marking provided by the invention conforms to the isotope protection production line required by GMP certification, has good shielding, protecting and sealing effects, can be applied to the environment shielding of the SPECT developer in the experimental operation and treatment process of a non-sealed workplace, prevents the radiation accident in personnel caused by nuclide overflow, can be widely applied to scientific research, teaching, clinical examination and production in the application field of nuclear technology such as medicine release enterprises, scientific research institutions and the like, the radiation protection device is an optimal solution for safety protection equipment in radiation shielding protection and primary protection barriers in the field of nuclear technology application, is simple in overall structure, simple to process and install, and excellent in protection compatibility, provides an effective radiation safety protection negative pressure environment, can prevent radionuclide irradiation and reduce the absorption dose of operators to volatile substances, and effectively protects the personal safety of the operators.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the application and, together with the description, serve to explain the application and are not intended to limit the application.
FIG. 1 is an overall schematic view of the radionuclide shielding guard for SPECT imaging agent labeling disclosed in the present invention;
FIG. 2 is a cross-sectional view taken along line A-A of FIG. 1;
FIG. 3 is a cross-sectional view taken along line B-B of FIG. 1;
fig. 4 is a schematic connection diagram of the exhaust fan.
101, a leaching unit; 102. a marking unit; 103. a dispensing unit; 104. a packaging unit; 105. a pass-through gate; 106. a support;
201. a first operation cabinet; 202. a circulating fan; 203. a circulating air filter; 204. a shielding guard gate; 205. a first shielding protection window; 206. a first blower cabinet; 207. a first differential pressure gauge; 208. a source storage box; 209. a screen; 210. A first ultraviolet lamp; 211. a first LED lighting lamp; 212. a first control panel;
301. a second operation cabinet; 302. an air supply fan; 303. an exhaust fan; 304. an air supply filter; 305. an exhaust air filter; 306. a shielding protective cover; 307. a second shielding protection window; 308. a second cabinet; 309. a second differential pressure gauge; 310. a production auxiliary material transfer auxiliary box; 311. an activity well; 312. a waste transfer sub-tank; 313. a second ultraviolet lamp; 314. a second LED lighting lamp; 315. a second control panel.
Detailed Description
The following detailed description of embodiments of the present invention is provided in connection with the accompanying drawings and examples.
It should be noted that the following detailed description is exemplary and is intended to provide further improvements to the present application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise. In the present disclosure, terms such as "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "side", "bottom", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only relational terms determined for convenience in describing structural relationships of the parts or elements of the present disclosure, and do not refer to any parts or elements of the present disclosure, and are not to be construed as limiting the present disclosure. In the present disclosure, terms such as "fixedly connected", "connected", and the like are to be understood in a broad sense, and mean either a fixed connection or an integrally connected or detachable connection; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present disclosure can be determined on a case-by-case basis by persons skilled in the relevant art or technicians, and are not to be construed as limitations of the present disclosure.
The following is a preferred embodiment of the present invention, but is not intended to limit the scope of the present invention.
Example one
Referring to fig. 1 to 4, as shown in the drawings, a radionuclide shielding and protecting apparatus for SPECT imaging agent labeling includes a washing unit 101 for performing a washing operation to obtain a radionuclide, a labeling unit 102 for performing a labeling operation to obtain a radionuclide drug, a dispensing unit 103 for performing a syringe dispensing operation on the radionuclide drug, and a packing unit 104 for performing a packing operation on the radionuclide drug,
in the leaching unit 101 and the packaging unit 104, each of the leaching unit 101 and the packaging unit 104 comprises a first operation cabinet 201 maintaining a class-A clean and positive pressure environment inside, a circulating fan 202 circulating air in the first operation cabinet 201, and a circulating air filter 203 filtering air circulating by the circulating fan 202, the first operation cabinet 201 is a shielding protection box, the first operation cabinet 201 is provided with a first operation port and a first window, the first operation port is provided with a shielding protection door 204 capable of being opened and closed, and the first window is provided with a first shielding protection window 205;
the marking unit 102 and the sub-packaging unit 103 each include a second operation cabinet 301 for maintaining a clean and airtight positive pressure environment of class a inside, an air supply fan 302 for supplying outside air into the second operation cabinet 301, an air exhaust fan 303 for exhausting air from the second operation cabinet 301, an air supply filter 304 for filtering air supplied by the air supply fan 302, and an air exhaust filter 305 for filtering air exhausted by the air exhaust fan 303, the second operation cabinet 301 is a shielding protection cabinet, the second operation cabinet 301 is provided with a second operation port and a second viewing window, the second operation port is provided with operation gloves (not shown) and a shielding protection cover 306 capable of being opened and closed, and the second viewing window is provided with a second shielding protection window 307;
the first operation cabinet 201 of the leaching unit 101, the second operation cabinet 301 of the marking unit 102, the second operation cabinet 301 of the sub-packaging unit 103 and the first operation cabinet 201 of the packaging unit 104 are sequentially arranged, a first transfer port for transferring materials is arranged between the adjacent first operation cabinets and the second operation cabinet, and the first transfer port is provided with a transfer door 105 which can be opened and closed.
In a preferred embodiment of this embodiment, each of the rinsing unit 101 and the packaging unit 104 further includes a first blower cabinet 206 disposed above the first operation cabinet 201, the circulating blower 202 is disposed in the first blower cabinet 206, the first operation port and the first viewing window are disposed on the first operation cabinet 201, the marking unit 102 and the dispensing unit 103, each further includes a second blower cabinet 308 disposed above the second operation cabinet 301, the air supply blower 302 and the air exhaust blower 303 are disposed in the second blower cabinet 308, and the second operation port and the second viewing window are disposed on the second operation cabinet 301.
In the preferred embodiment of this embodiment, each of the washing unit 101 and the packaging unit 104 further comprises a first pressure difference gauge 207 for detecting the pressure difference between the inside of the first operating cabinet 201 and the outside air, and each of the labeling unit 102 and the dispensing unit 103 further comprises a second pressure difference gauge 309 for detecting the pressure difference between the inside of the second operating cabinet 301 and the outside air.
In the preferred embodiment of the present embodiment, the air flow direction inside each of the first and second operation cabinets 201 and 301 is from top to bottom.
In a preferred embodiment of the present embodiment, both the circulating air filter 203 and the air supply filter 304 are HEPA filters, and the exhaust air filter 305 is an activated carbon filter.
In a preferred embodiment of this embodiment, the leaching unit 101 further includes a source storage box 208 disposed below the first operation cabinet 201, the source storage box 208 is a shielding protection box, the source storage box 208 is used for placing the radionuclide generator, a second transfer port for transferring the material is disposed between the first operation cabinet 201 and the source storage box 208, and the second transfer port is provided with a sliding cover (not shown in the figure) that can be opened and closed;
in marking unit 102 and partial shipment unit 103, each still includes the production auxiliary material transmission subtank 310 of locating second operation cabinet 301 below, activity well 311 and discarded object transmission subtank 312, production auxiliary material transmission subtank 310, activity well 311 and discarded object transmission subtank 312 are the shielding guard box, production auxiliary material transmission subtank 310 is used for the required production auxiliary material when over-and-under type transport operation, activity well 311 is used for carrying out the activity detection to the radionuclide medicine, waste transmission subtank 312 is used for the produced discarded object when over-and-under type transport operation, in production auxiliary material transmission subtank 310, activity well 311 and the discarded object transmission subtank 312, be equipped with the third transfer mouth that is used for carrying out the material transfer between each and the second operation cabinet 301.
In the preferred embodiment of the present invention, the transfer door 105 is provided with a sealing ring (not shown) for sealing connection with the first transfer opening where the transfer door is located and a lock catch (not shown) for locking with the first transfer opening where the transfer door is located, so as to achieve the respective air tightness of the first operation cabinet 201 and the second operation cabinet 301.
In the preferred embodiment of this embodiment, the shielding protection door 204 is a lifting door, the first operation opening is further provided with a screen 209 capable of moving horizontally and blocking different positions of the first operation opening, and the shielding protection cover 306 is self-locked on the second operation opening.
In a preferred embodiment of this embodiment, the shielding and protecting box includes a stainless steel outer box, a stainless steel inner box, and a shielding and protecting layer disposed in an interlayer between the stainless steel outer box and the stainless steel inner box.
In the preferred embodiment of the present embodiment, each of the washing unit 101 and the packing unit 104 further includes a first ultraviolet lamp 210 for sterilizing and disinfecting the inside of the respective first operation cabinet 201, a first LED illumination lamp 211 for illuminating the inside of the respective first operation cabinet 201, and a first control panel 212 for electrical control, and each of the labeling unit 102 and the dispensing unit 103 further includes a second ultraviolet lamp 313 for sterilizing and disinfecting the inside of the respective second operation cabinet 301, a second LED illumination lamp 314 for illuminating the inside of the respective second operation cabinet 301, and a second control panel 315 for electrical control.
Specifically, under circulating fan's effect, outside air filters through HEPA filter to in even aspect gets into first operation cabinet by the top, guarantee that the clean grade in the first operation cabinet of drip washing unit and the first operation cabinet of packing unit reaches A level and purifies and the malleation environment. Under air supply fan's effect, outside air filters through the HEPA filter, get into in the second operation cabinet by the top with even aspect, filter the back through the active carbon filter, gaseous through the fan of airing exhaust discharges, guarantee that the second operation cabinet of mark unit and the clean grade of the second operation cabinet of partial shipment unit reach A level and purify and airtight malleation environment, and then provide the drug production environment that accords with GMP authentication requirement, prevent that the workspace air from escaping outward, play protection operating personnel's purpose. Clean air continuously enters the first operating cabinet and the second operating cabinet, the flow velocity of sinking air flow (vertical air flow) is not less than 0.3m/s, the cleanliness of the first operating cabinet and the second operating cabinet is ensured to reach A level, and meanwhile, the outward air flow is also purified, so that the environment is prevented from being polluted; the core component of the system is a high-efficiency filter, including a HEPA filter, a frame is made of special fireproof materials, the frame is divided into grid shapes by corrugated aluminum sheets, emulsified glass fiber submicron particles are filled in the grid shapes, and the filtering efficiency can reach 99.99% -100%; the air inlet of the HEPA filter is provided with the pre-filtering cover, so that air enters the high-efficiency filter after being pre-filtered and purified, and the service life of the high-efficiency filter can be prolonged.
The first fan cabinet and the second fan cabinet are rectangular box bodies without bottoms, and the first operation cabinet and the second operation cabinet are rectangular box bodies without tops. Independent air ducts are arranged at the bottoms and back interlayers of the first operating cabinet and the second operating cabinet.
The source storage box is used for storing the molybdenum technetium generator. The auxiliary production auxiliary material transmission box is used for temporarily storing auxiliary materials for production, the auxiliary waste transmission box is used for temporarily storing waste during production, the auxiliary production auxiliary material transmission box and the auxiliary waste transmission box are respectively provided with a pneumatic lifting device, the pneumatic lifting device comprises a pneumatic lifter and a lifting platform arranged in the auxiliary transmission box, the lifting platform is connected with the pneumatic lifter, the pneumatic lifter drives the lifting platform to vertically reciprocate in the auxiliary transmission box after being started, and the auxiliary production auxiliary materials or the waste are conveniently transmitted and used.
The shielding protective cover can be self-locked to prevent the worker from forgetting to close the second operation port to cause the false irradiation, and the method can be realized by adopting the prior art, and is not described herein any more. The long arm latex gloves that second operation mouth was equipped with guarantees that the second operation cabinet forms airtight environment when can operate, still can set up other auxiliary assembly according to actual demand, satisfies daily demand.
Every shielding and protecting case is independent box, and stainless steel inner box and stainless steel outer container material are SUS304 stainless steel, six all are equipped with shielding material board (adopt organic glass or stereotype), and the shielding nature is good, and the corner of inner box sets up the fillet, the clean decontamination of being convenient for.
The pneumatic lifting device, the ultraviolet lamp, the LED illuminating lamp, the fan and the power socket are controlled to be opened and closed through the electric control panel.
The operation steps are illustrated by taking the marking and operation of a single photon medicine (SPECT developer/Tc-99 m) as an example:
1. in a C-level purification workplace, firstly, respectively starting circulating fans at the tops of the leaching unit and the packaging unit, allowing outside air to enter a corresponding first operation cabinet after being filtered by an HEPA filter under the action of the circulating fans, blowing the outside air through an air hole on the bottom surface and an independent air duct on the back surface in the cabinet, and circulating the outside air to the front end of the HEPA filter to form a virtuous circulating air flow, so that the cleanness grade in the first operation cabinets of the leaching unit and the packaging unit can reach an A-level purification and positive pressure environment. And then the air supply fan and the air exhaust fan of the marking unit and the sub-packaging unit are sequentially started, under the action of the air supply fan, outside air is filtered by an HEPA filter, enters the second operation cabinet of the marking unit and the second operation cabinet of the sub-packaging unit from the top in an even layer, flows through the air holes on the bottom surface and the independent air channels on the back surface in the cabinets, is exhausted to the outside through the air exhaust fan via the exhaust pipe after being filtered by the active carbon filter layer, and a closed positive pressure environment with a clean grade A grade is formed in the second operation cabinet of the marking unit and the second operation cabinet of the sub-packaging unit, so that an injection sub-packaging production environment meeting the GMP certification requirement is provided, and the relatively independent A grade, positive pressure purification and protection environments required by the radionuclide leaching, marking, sub-packaging and packaging production processes are ensured.
2. Temporarily storing the molybdenum-technetium generator to be leached in a source storage box, protecting an operator facing a movable screen, observing through a first shielding protection window, enabling arms to enter a first operation cabinet of a leaching unit through two sides of the movable screen to perform leaching operation, inserting a sterile negative pressure bottle with a leaching tank into the generator to leach in the first operation cabinet of the leaching unit, after leaching solution is obtained, penetrating the leaching tank into a second operation cabinet of a marking unit from a transfer port, and closing a transfer door;
3. an operator observes facing a second shielding protection window of the marking unit, articles such as production auxiliary materials and the like placed on a pneumatic lifting platform in the production auxiliary material transmission auxiliary box are used for marking medicines, arms of the operator enter a second operation cabinet of the marking unit from long-arm latex gloves arranged at second operation ports on two sides to carry out marking operation at the second operation port of the marking unit, after marking is completed, marked isotope medicament bottles are placed into an activity meter well of the marking unit for activity measurement, measurement marks are made, the marked nuclide bottles are conveyed into the second operation cabinet of the subpackaging unit through a conveying port after marking is completed, a conveying door is closed, and wastes generated in the second operation cabinet of the marking unit are conveyed out through a waste conveying auxiliary box after production is completed;
4. in a second operation cabinet of the sub-packaging unit, a worker observes facing a second shielding protection window of the sub-packaging unit, and uses production auxiliary materials and other articles placed on a pneumatic lifting platform in a production auxiliary material transmission sub-box to sub-package medicines;
5. in the first operation cabinet of the packaging unit, an operator protects the movable screen, the operator observes through the first shielding protection window, the arm enters the first operation cabinet of the packaging unit through two sides of the movable screen to carry out labeling and packaging operations, and after surface pollution monitoring, finished product packages are moved out of the first operation cabinet of the packaging unit from the side, and the whole work is finished.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention, including any reference to the above-mentioned embodiments. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. The radionuclide shielding and protecting device for the SPECT developer marking is characterized by comprising a leaching unit for leaching to obtain radionuclide, a marking unit for marking to obtain radionuclide drugs, a subpackaging unit for performing injection subpackaging operation on the radionuclide drugs and a packaging unit for performing packaging operation on the radionuclide drugs;
each of the leaching unit and the packaging unit comprises a first operation cabinet, a circulating fan and a circulating air filter, wherein the first operation cabinet keeps an A-level clean and positive pressure environment inside, the circulating fan circulates air in the first operation cabinet, the circulating air filter filters air circulated by the circulating fan, the first operation cabinet is a shielding protection box, the first operation cabinet is provided with a first operation opening and a first viewing window, the first operation opening is provided with a shielding protection door which can be opened and closed, and the first viewing window is provided with a first shielding protection window;
each of the marking unit and the subpackaging unit comprises a second operation cabinet, an air supply fan, an air exhaust fan, an air supply filter and an air exhaust filter, wherein the second operation cabinet keeps A-level clean and sealed positive pressure environment inside, the air supply fan sends outside air into the second operation cabinet, the air exhaust fan exhausts the air in the second operation cabinet, the air supply filter filters the air sent by the air supply fan, the air exhaust filter filters the air exhausted by the air exhaust fan, the second operation cabinet is a shielding protection cabinet, a second operation port and a second viewing window are arranged on the second operation cabinet, the second operation port is provided with operation gloves and a shielding protection cover capable of being opened and closed, and the second viewing window is provided with a second shielding protection window;
the first operation cabinet of drip washing unit, the second operation cabinet of mark unit, the second operation cabinet of partial shipment unit and the first operation cabinet of packing unit sets gradually, is equipped with the first transfer mouth that is used for conveying the material between adjacent two, first transfer mouth is equipped with the delivery door that can open and close.
2. The radionuclide shielding prevention device for SPECT imaging agent labeling of claim 1, wherein each of the washing unit and the packing unit further comprises a first blower cabinet disposed above the first operation cabinet, the circulating blower is disposed in the first blower cabinet, the first operation port and the first viewing window are disposed on the first operation cabinet, each of the labeling unit and the packing unit further comprises a second blower cabinet disposed above the second operation cabinet, the supply blower and the exhaust blower are disposed in the second blower cabinet, and the second operation port and the second viewing window are disposed on the second operation cabinet.
3. The SPECT imaging agent labeled radionuclide shielding containment device of claim 2, wherein each of the washing unit and the packaging unit further comprises a first pressure differential gauge for detecting a pressure differential between the interior of the first operating cabinet and the outside air, and each of the labeling unit and the racking unit further comprises a second pressure differential gauge for detecting a pressure differential between the interior of the second operating cabinet and the outside air.
4. The radionuclide-shielding shield for SPECT imaging agent labeling of claim 2, wherein inside each of the first and second operating cabinets, an air flow direction is from top to bottom.
5. The radionuclide-shielding prevention device for SPECT imaging agent labeling of claim 1, wherein the circulating air filter and the blowing air filter are HEPA filters, and the ventilation filter is an activated carbon filter.
6. The SPECT imaging agent labeled radionuclide shielding and protection device of claim 1, wherein the washing unit further comprises a source storage box disposed below the first operating cabinet, the source storage box being a shielding and protecting box in which the radionuclide generator is disposed, a second transfer port for material transfer is disposed between the first operating cabinet and the source storage box, and the second transfer port is provided with a slide cover that can be opened and closed;
the marking unit with among the partial shipment unit, each still including locating production auxiliary material transmission auxiliary tank, activity well and the vice case of discarded object transmission of second operation cabinet below, production auxiliary material transmission auxiliary tank the activity well and the vice case of discarded object transmission is the shielding guard box, required production auxiliary material when production auxiliary material transmission auxiliary tank is used for over-and-under type transport operation, the activity well is used for carrying out the activity detection to the radionuclide medicine, the vice case of discarded object transmission is used for the over-and-under type produced discarded object when carrying the operation, production auxiliary material transmission auxiliary tank the activity well and in the vice case of discarded object transmission, each with be equipped with the third transmission mouth that is used for carrying on the material transmission between the second operation cabinet.
7. The SPECT imaging agent labeled radionuclide shielding prevention device of claim 1, wherein the transfer door is provided with a gasket for sealing connection with the first transfer opening where the transfer door is located and a latch for locking with the first transfer opening where the transfer door is located to achieve airtightness of each of the first and second operation cabinets.
8. The SPECT imaging agent labeled radionuclide shielding and protection device of claim 1, wherein the shielding and protection door is a liftable and lowerable elevating door, the first operation port is further provided with a screen capable of horizontally moving and blocking, the first operation port is at different positions, and the shielding and protection cover is self-locked on the second operation port.
9. The radionuclide shielding and shielding device for SPECT imaging agent labeling of any of claims 1 to 8, wherein the shielding and shielding case comprises a stainless steel outer case, a stainless steel inner case, and a shielding and shielding layer provided in an interlayer of the stainless steel outer case and the stainless steel inner case.
10. The SPECT imaging agent labeled radionuclide shielding protection device of claim 1, wherein each of the washing unit and the packaging unit further comprises a first ultraviolet lamp for sterilizing and disinfecting the interior of the respective first operating cabinet, a first LED illumination lamp for illuminating the interior of the respective first operating cabinet, a switch for switching the circulation fan, and a first control panel for electrical control, and wherein each of the labeling unit and the racking unit further comprises a second ultraviolet lamp for sterilizing and disinfecting the interior of the respective second operating cabinet, a second LED illumination lamp for illuminating the interior of the respective second operating cabinet, a switch for switching the supply fan and the exhaust fan, and a second control panel for electrical control.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110585875.2A CN113488218A (en) | 2021-05-27 | 2021-05-27 | Radionuclide shielding and protecting device for SPECT developer labeling |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110585875.2A CN113488218A (en) | 2021-05-27 | 2021-05-27 | Radionuclide shielding and protecting device for SPECT developer labeling |
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| CN113488218A true CN113488218A (en) | 2021-10-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110585875.2A Pending CN113488218A (en) | 2021-05-27 | 2021-05-27 | Radionuclide shielding and protecting device for SPECT developer labeling |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101882476A (en) * | 2010-06-12 | 2010-11-10 | 上海同普放射防护设备有限公司 | Sub-packaging and marking system of 99Tc with 100-level purification and isotope protection |
| CN204872877U (en) * | 2015-07-28 | 2015-12-16 | 上海伽邦防辐射科技有限公司 | Single -stop -type production system of tc radiopharmaceutical |
| CN111872978A (en) * | 2020-08-26 | 2020-11-03 | 江苏华益科技有限公司 | Isotope protection production device meeting GMP (good manufacturing practice) certification requirements |
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2021
- 2021-05-27 CN CN202110585875.2A patent/CN113488218A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101882476A (en) * | 2010-06-12 | 2010-11-10 | 上海同普放射防护设备有限公司 | Sub-packaging and marking system of 99Tc with 100-level purification and isotope protection |
| CN204872877U (en) * | 2015-07-28 | 2015-12-16 | 上海伽邦防辐射科技有限公司 | Single -stop -type production system of tc radiopharmaceutical |
| CN111872978A (en) * | 2020-08-26 | 2020-11-03 | 江苏华益科技有限公司 | Isotope protection production device meeting GMP (good manufacturing practice) certification requirements |
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