CN113481756B - Free radical scavenging composition and preparation method and application thereof - Google Patents
Free radical scavenging composition and preparation method and application thereof Download PDFInfo
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- CN113481756B CN113481756B CN202110727612.0A CN202110727612A CN113481756B CN 113481756 B CN113481756 B CN 113481756B CN 202110727612 A CN202110727612 A CN 202110727612A CN 113481756 B CN113481756 B CN 113481756B
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- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H27/00—Special paper not otherwise provided for, e.g. made by multi-step processes
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/02—Manufacture of tobacco smoke filters
- A24D3/0204—Preliminary operations before the filter rod forming process, e.g. crimping, blooming
- A24D3/0212—Applying additives to filter materials
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/061—Use of materials for tobacco smoke filters containing additives entrapped within capsules, sponge-like material or the like, for further release upon smoking
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- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H17/00—Non-fibrous material added to the pulp, characterised by its constitution; Paper-impregnating material characterised by its constitution
- D21H17/03—Non-macromolecular organic compounds
- D21H17/04—Hydrocarbons
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- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H17/00—Non-fibrous material added to the pulp, characterised by its constitution; Paper-impregnating material characterised by its constitution
- D21H17/03—Non-macromolecular organic compounds
- D21H17/05—Non-macromolecular organic compounds containing elements other than carbon and hydrogen only
- D21H17/06—Alcohols; Phenols; Ethers; Aldehydes; Ketones; Acetals; Ketals
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- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H17/00—Non-fibrous material added to the pulp, characterised by its constitution; Paper-impregnating material characterised by its constitution
- D21H17/20—Macromolecular organic compounds
- D21H17/21—Macromolecular organic compounds of natural origin; Derivatives thereof
- D21H17/22—Proteins
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- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H17/00—Non-fibrous material added to the pulp, characterised by its constitution; Paper-impregnating material characterised by its constitution
- D21H17/20—Macromolecular organic compounds
- D21H17/21—Macromolecular organic compounds of natural origin; Derivatives thereof
- D21H17/24—Polysaccharides
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- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H17/00—Non-fibrous material added to the pulp, characterised by its constitution; Paper-impregnating material characterised by its constitution
- D21H17/20—Macromolecular organic compounds
- D21H17/21—Macromolecular organic compounds of natural origin; Derivatives thereof
- D21H17/24—Polysaccharides
- D21H17/25—Cellulose
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H17/00—Non-fibrous material added to the pulp, characterised by its constitution; Paper-impregnating material characterised by its constitution
- D21H17/20—Macromolecular organic compounds
- D21H17/21—Macromolecular organic compounds of natural origin; Derivatives thereof
- D21H17/24—Polysaccharides
- D21H17/28—Starch
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H21/00—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties
- D21H21/14—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties characterised by function or properties in or on the paper
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H21/00—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties
- D21H21/14—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties characterised by function or properties in or on the paper
- D21H21/38—Corrosion-inhibiting agents or anti-oxidants
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Abstract
The invention discloses a free radical scavenging composition and a preparation method and application thereof, wherein the free radical scavenging composition comprises an antioxidant, a synergistic antioxidant and a load material, wherein the antioxidant is at least one of curcumin and tetrahydrocurcumin, the synergistic antioxidant is at least one of beta-carotene and vitamin E, and the load material is at least one of cyclodextrin, silk fibroin, chitosan, cellulose and starch. The antioxidant and the synergistic antioxidant in the free radical scavenging composition prepared by the method are uniformly distributed in the load material, and meanwhile, the load material can reduce the loss of the antioxidant capacity of curcumin and/or tetrahydrocurcumin in the long-term storage process. The free radical scavenging composition prepared by the method can be added in the process of forming a cigarette filter stick or in paper filter stick paper-making slurry, is flexible and various in use mode, and has good application prospect.
Description
Technical Field
The invention relates to the field of tar and harm reduction of cigarettes, and in particular relates to a free radical scavenging composition and a preparation method and application thereof.
Background
Free radicals are atoms or groups with a strong reducing power, and generally contain unpaired electrons. Active oxygen radicals in the human body have certain functions, such as immunity and signal transduction processes. Modern biological research shows that external environments such as sunlight radiation, air pollution, smoking and pesticides can generate more active free radicals for human beings, so that DNA is mutated or protein is damaged, and normal cells and tissues of the human bodies are damaged, thereby causing various diseases such as heart disease, senile dementia, parkinson's disease and tumors.
Tobacco produces not only thousands of compounds, but also free radicals during combustion. The free radicals in the flue gas include particulate phase free radicals and gas phase free radicals. Particulate free radicals are generally present in tar and are mainly polymers containing semiquinone free radicals associated with quinone and hydroquinone groups, which have a relatively high molecular weight and high stability. The gas-phase free radicals mainly comprise alkane free radicals and alkyl oxygen free radicals, and have high activity and poor stability.
The grain-phase free radical content can be reduced while the tar content of smoke is reduced by means of optimizing cigarette formula, blending expanded cut tobacco and tobacco sheets, punching, ventilating and diluting, improving the interception and adsorption efficiency of a filter tip, selecting high-air-permeability coil paper and the like. For gas-phase free radicals, a free radical scavenger is generally added into tobacco shreds or filter sticks. Most of the free radical scavengers are antioxidants, and the generation of free radicals can be controlled by reducing the concentration of active free radical intermediates and reducing the efficiency of an expansion stage in the chain reaction of the free radicals. The free radical scavenger used at present is mainly a natural plant antioxidant, however, the antioxidants of the natural plant components are relatively active under the natural condition at normal temperature, and are easily subjected to autoxidation during the storage period, so that the antioxidant activity is reduced.
How to provide a free radical scavenger with high stability becomes a technical problem which needs to be solved urgently in the field.
Disclosure of Invention
The invention aims to provide a novel technical scheme of a free radical scavenging composition with high stability.
According to a first aspect of the present invention, there is provided a combination radical scavenger.
The free radical scavenging composition comprises an antioxidant, a synergistic antioxidant and a load material, wherein the antioxidant is at least one of curcumin and tetrahydrocurcumin, the synergistic antioxidant is at least one of beta-carotene and vitamin E, and the load material is at least one of cyclodextrin, silk fibroin, chitosan, cellulose and starch.
Optionally, the mass ratio of the antioxidant to the synergistic antioxidant to the load material is (10-20): (5-10): (70-85).
According to a second aspect of the present invention, there is provided a process for the preparation of a radical scavenger composition.
The preparation method of the free radical scavenging composition comprises the following steps:
step (1): dissolving an antioxidant, a synergistic antioxidant and a load material by taking an ionic liquid as a solvent to obtain a composite solution, wherein the antioxidant is at least one of curcumin and tetrahydrocurcumin, the synergistic antioxidant is at least one of beta-carotene and vitamin E, and the load material is at least one of cyclodextrin, silk fibroin, chitosan, cellulose and starch;
step (2): adding excessive water into the composite solution to obtain a precipitate;
and (3): and washing the precipitate, and drying the precipitate to obtain the free radical scavenging composition.
Optionally, the mass ratio of the antioxidant to the synergistic antioxidant to the load material in the step (1) is (10-20): (5-10): (70-85).
Optionally, the ionic liquid in step (1) is at least one of 1-butyl-3-methylimidazole chloride solution, 1-allyl-3-methylimidazole chloride, 1-allyl-3-methylimidazole acetate, 1-butyl-3-methylimidazole acetate, 1-ethyl-3-methylimidazole acetate, 1-butyl-3-methylimidazole nitrate and 1-ethyl-3-methylimidazole chloride.
Optionally, the concentration of the mixed liquid in the step (1) is 2-20wt%.
Optionally, the water in the step (2) and the detergent in the step (3) are both secondary water.
Optionally, the step (3) is specifically as follows:
step (3-1): washing the precipitate and drying the precipitate;
step (3-2): and grinding and sieving the dried precipitate to obtain the free radical scavenging composition.
According to a third aspect of the invention, there is provided a use of the free radical scavenging composition of the invention in a cigarette filter rod.
Optionally, the free radical scavenging composition is added to a cigarette filter stick or added to paper pulp for making a paper filter stick, and the addition amount of the free radical scavenging composition is 0.5-1.5wt%.
The free radical scavenging composition disclosed by the invention takes curcumin and/or tetrahydrocurcumin as an antioxidant, takes beta-carotene and/or vitamin E as a synergistic antioxidant, and utilizes the hydrogen bond interaction among the antioxidant, the synergistic antioxidant and a load material to form a complex ligand.
The preparation method of the free radical scavenging composition agent directly dissolves the antioxidant, the synergistic antioxidant and the load material in the ionic liquid to form a uniform solution, forms a complex by utilizing the mutual action of hydrogen bonds between the antioxidant and the load material as well as between the synergistic antioxidant and the load material, and then obtains a complex by adopting a coprecipitation mode to prepare the free radical scavenging composition agent.
The antioxidant and the synergistic antioxidant in the free radical scavenging composition prepared by the method are uniformly distributed in the load material, and meanwhile, the load material can reduce the loss of the antioxidant capacity of curcumin and/or tetrahydrocurcumin in the long-term storage process.
The free radical scavenging composition prepared by the method can be added in the cigarette filter stick forming process or added in paper filter stick paper making slurry, is flexible and various in use mode, and has good application prospect.
Detailed Description
Various exemplary embodiments of the present invention will now be described in detail. It should be noted that: the relative arrangement of the components and steps, the numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless specifically stated otherwise.
The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses.
Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate.
In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values.
The free radical scavenging combination agent provided by the present disclosure comprises an antioxidant, a synergistic antioxidant and a load material, wherein the antioxidant is at least one of curcumin and tetrahydrocurcumin, the synergistic antioxidant is at least one of beta-carotene and vitamin E, and the load material is at least one of cyclodextrin, silk fibroin, chitosan, cellulose and starch.
Optionally, the mass ratio of the antioxidant to the synergistic antioxidant to the load material is (10-20): (5-10): (70-85).
The preparation method of the free radical scavenging composition provided by the disclosure comprises the following steps:
step (1): dissolving an antioxidant, a synergistic antioxidant and a load material by taking an ionic liquid as a solvent to obtain a composite solution, wherein the antioxidant is at least one of curcumin and tetrahydrocurcumin, the synergistic antioxidant is at least one of beta-carotene and vitamin E, and the load material is at least one of cyclodextrin, silk fibroin, chitosan, cellulose and starch.
The mass ratio of the antioxidant, the synergistic antioxidant and the load material in the step (1) can be (10-20): (5-10): (70-85).
The ionic liquid in step (1) may be an imidazole ionic liquid, for example, the ionic liquid is at least one of 1-butyl-3-methylimidazole chloride solution, 1-allyl-3-methylimidazole chloride, 1-allyl-3-methylimidazole acetate, 1-butyl-3-methylimidazole acetate, 1-ethyl-3-methylimidazole acetate, 1-butyl-3-methylimidazole nitrate and 1-ethyl-3-methylimidazole chloride. The imidazole ionic liquid has better solubility for antioxidant, synergistic antioxidant and loading material.
The concentration of the mixed liquid in the step (1) may be 2 to 20wt%.
Further, the concentration of the mixed liquid may be 5 to 10wt%.
Step (2): an excess of water was added to the composite solution to obtain a precipitate. The antioxidant, the synergistic antioxidant and the support material are insoluble in water and can be coprecipitated using the dissolution-precipitation process described above to obtain a precipitate.
Both the water in the step (2) and the detergent in the step (3) can be secondary water.
And (3): and washing the precipitate, and drying the precipitate to obtain the free radical scavenging composition.
The step (3) is specifically as follows:
step (3-1): washing the precipitate and drying the precipitate;
step (3-2): and grinding and sieving the dried precipitate to obtain the free radical scavenging composition.
Specifically, the particle size of the ground and sieved precipitate is 20-100 meshes. Further, the grain size of the precipitate after grinding and sieving is 40-80 meshes.
The disclosure also provides an application of the free radical scavenging composition in a cigarette filter stick.
The application can add the free radical scavenging composition agent to the cigarette filter stick or the paper filter stick paper-making slurry, and the addition amount of the free radical scavenging composition agent is 0.5-1.5wt%.
The addition of the free radical scavenging composition to the cigarette filter rod may be, for example, sprayed onto the tow, or onto the tipping paper.
The experimental procedures used in the following examples are conventional unless otherwise specified, the materials and reagents used are commercially available unless otherwise specified, and the equipment used in the experiments are well known to those skilled in the art.
Example 1
Weighing 10 parts of curcumin, 5 parts of vitamin E and 85 parts of cyclodextrin, adding the curcumin, the 5 parts of vitamin E and the cyclodextrin into the 1-butyl-3-methylimidazolium chloride ionic liquid, and heating and stirring to obtain a 10wt% composite solution. And then adding excessive secondary water into the composite solution to obtain a precipitate, and washing the precipitate for multiple times by using the secondary water to remove the ionic liquid. And drying the obtained precipitate, grinding and sieving to obtain the free radical scavenging composition agent with the particle size of 50 meshes.
The obtained free radical scavenging composition is added into a cigarette filter stick, and the adding proportion is 0.5wt%.
And rolling the prepared filter stick to obtain a finished cigarette, and testing the gas-phase free radical content of cigarette smoke 1 day and 100 days after rolling respectively.
Example 2
Weighing 15 parts of curcumin, 5 parts of beta-carotene and 80 parts of cyclodextrin, adding the curcumin, the beta-carotene and the cyclodextrin into the 1-allyl-3-methylimidazolium chloride ionic liquid, and heating and stirring to obtain a 10wt% composite solution. And then adding excessive secondary water into the composite solution to obtain a precipitate, and washing the precipitate for multiple times by using the secondary water to remove the ionic liquid. And drying the obtained precipitate, grinding and sieving to obtain the free radical scavenging composition agent with the particle size of 50 meshes.
The obtained free radical scavenging composition is added into the cigarette filter stick, and the adding proportion is 0.5wt%.
And (4) rolling the prepared filter stick to obtain a finished cigarette, and testing the gas-phase free radical content of cigarette smoke 1 day and 100 days after rolling.
Example 3
Weighing 15 parts of tetrahydrocurcumin, 5 parts of beta-carotene and 80 parts of cellulose, adding the tetrahydrocurcumin, the beta-carotene and the cellulose into 1-allyl-3-methylimidazolium chloride ionic liquid, and heating and stirring to obtain a 10wt% composite solution. And then adding excessive secondary water into the composite solution to obtain a precipitate, and washing the precipitate for multiple times by using the secondary water to remove the ionic liquid. And drying the obtained precipitate, grinding and sieving to obtain the free radical scavenging composition agent with the particle size of 50 meshes.
The obtained free radical scavenging composition is added into the cigarette filter stick, and the adding proportion is 0.5wt%.
And (4) rolling the prepared filter stick to obtain a finished cigarette, and testing the gas-phase free radical content of cigarette smoke 1 day and 100 days after rolling.
Example 4
Weighing 20 parts of tetrahydrocurcumin, 5 parts of beta-carotene and 75 parts of silk fibroin, adding into 1-allyl-3-methylimidazolium chloride ionic liquid, and heating and stirring to obtain 8wt% of composite solution. And then adding excessive secondary water into the composite solution to obtain a precipitate, and washing the precipitate for multiple times by using the secondary water to remove the ionic liquid. And drying the obtained precipitate, grinding and sieving to obtain the free radical scavenging composition agent with the particle size of 60 meshes.
The obtained free radical scavenging composition is added into a cigarette filter stick, and the adding proportion is 0.3wt%.
And (4) rolling the prepared filter stick to obtain a finished cigarette, and testing the gas-phase free radical content of cigarette smoke 1 day and 100 days after rolling.
Example 5
Weighing 5 parts of curcumin, 10 parts of tetrahydrocurcumin, 10 parts of beta-carotene and 75 parts of silk fibroin, adding the curcumin, the tetrahydrocurcumin, the beta-carotene and the silk fibroin into 1-allyl-3-methylimidazolyl acetate ionic liquid, and heating and stirring the mixture to obtain a 5wt% composite solution. And then adding excessive secondary water into the composite solution to obtain a precipitate, and washing the precipitate for multiple times by using the secondary water to remove the ionic liquid. And drying the obtained precipitate, grinding and sieving to obtain the free radical scavenging composition agent with the particle size of 70 meshes.
The obtained free radical scavenging composition is added into the cigarette filter stick, and the adding proportion is 0.8wt%.
And (4) rolling the prepared filter stick to obtain a finished cigarette, and testing the gas-phase free radical content of cigarette smoke 1 day and 100 days after rolling.
Example 6
Weighing 10 parts of curcumin, 10 parts of tetrahydrocurcumin, 10 parts of vitamin E and 70 parts of silk fibroin, adding into 1-allyl-3-methylimidazolyl acetate ionic liquid, and heating and stirring to obtain a 10wt% composite solution. And then adding excessive secondary water into the composite solution to obtain a precipitate, and washing the precipitate for multiple times by using the secondary water to remove the ionic liquid. And drying the obtained precipitate, grinding and sieving to obtain the free radical scavenging composition agent with the particle size of 40 meshes.
The obtained free radical scavenging composition is added into paper making slurry of a paper filter stick, and the adding proportion is 1wt%.
And (3) rolling the prepared paper filter stick to obtain a finished cigarette, and testing the gas-phase free radical content of cigarette smoke 1 day and 100 days after rolling respectively.
Example 7
Weighing 5 parts of curcumin, 10 parts of tetrahydrocurcumin, 5 parts of vitamin E, 5 parts of beta-carotene and 75 parts of chitosan, adding the materials into 1-ethyl-3-methylimidazolium acetate ionic liquid, and heating and stirring to obtain a 10wt% composite solution. And then adding excessive secondary water into the composite solution to obtain a precipitate, and washing the precipitate for multiple times by using the secondary water to remove the ionic liquid. And drying the obtained precipitate, grinding and sieving to obtain the free radical scavenging composition agent with the particle size of 40 meshes.
The obtained free radical scavenging composition is added into paper making slurry of a paper filter stick, and the adding proportion is 1.5wt%.
And (3) rolling the prepared paper filter stick to obtain a finished cigarette, and testing the gas-phase free radical content of cigarette smoke 1 day and 100 days after rolling respectively.
Example 8
Weighing 15 parts of curcumin, 5 parts of vitamin E, 5 parts of beta-carotene and 75 parts of starch, adding the curcumin, the vitamin E, the beta-carotene and the starch into 1-ethyl-3-methylimidazolium chloride ionic liquid, and heating and stirring to obtain a 10wt% composite solution. And then adding excessive secondary water into the composite solution to obtain a precipitate, and washing the precipitate for multiple times by using the secondary water to remove the ionic liquid. And drying the obtained precipitate, grinding and sieving to obtain the free radical scavenging composition agent with the particle size of 60 meshes.
The obtained free radical scavenging composition agent is added into paper making pulp of a paper filter stick, and the adding proportion is 0.5wt%.
And (4) rolling the prepared paper filter stick to obtain a finished cigarette, and testing the gas-phase free radical content of cigarette smoke 1 day and 100 days after rolling respectively.
Comparative example 1
Blank cigarettes 1 were obtained by rolling cigarette filter rods without the free radical scavenging composition, and the gas-phase free radical content of cigarette smoke was measured 1 day and 100 days after rolling, respectively, and the gas-phase free radical scavenging rates of examples 1 to 5 were calculated as a control.
Comparative example 2
The blank cigarette 2 was obtained by using a paper filter-tipped cigarette to which no free-radical scavenging composition agent was added, and the gas-phase free-radical content of cigarette smoke was measured 1 day and 100 days after rolling, respectively, and the gas-phase free-radical scavenging rates of examples 6 to 8 were calculated as a control.
TABLE 1 gas phase free radical scavenging test results
As can be seen from table 1, the cigarette filter stick and the paper filter stick added with the free radical scavenging composition have excellent free radical scavenging ability, and still have strong free radical scavenging ability after being placed for a long time, which indicates that the free radical scavenging composition provided by the present disclosure has good application prospects.
Although some specific embodiments of the present invention have been described in detail by way of examples, it should be understood by those skilled in the art that the above examples are for illustrative purposes only and are not intended to limit the scope of the present invention. It will be appreciated by those skilled in the art that modifications may be made to the above embodiments without departing from the scope and spirit of the invention. The scope of the invention is defined by the appended claims.
Claims (5)
1. The preparation method of the free radical scavenging composition is characterized by comprising the following steps:
step (1): dissolving an antioxidant, a synergistic antioxidant and a load material by taking an ionic liquid as a solvent, wherein the mass ratio of the antioxidant to the synergistic antioxidant to the load material is (10-20): (5-10): (70-85), so as to obtain a composite solution, the antioxidant is at least one of curcumin and tetrahydrocurcumin, the synergistic antioxidant is at least one of beta-carotene and vitamin E, the load material is at least one of cyclodextrin, fibroin, chitosan, cellulose and starch, and the ionic liquid is at least one of 1-butyl-3-methylimidazole chloride solution, 1-allyl-3-methylimidazole chloride, 1-allyl-3-methylimidazole acetate, 1-butyl-3-methylimidazole acetate, 1-ethyl-3-methylimidazole acetate, 1-butyl-3-methylimidazole nitrate and 1-ethyl-3-methylimidazole chloride;
step (2): adding excessive water into the composite solution to obtain a precipitate;
and (3): and washing the precipitate, and drying the precipitate to obtain the free radical scavenging composition.
2. The method for preparing a radical scavenger composition according to claim 1, wherein the concentration of the mixed liquid in the step (1) is 2 to 20wt%.
3. The method for preparing a radical scavenger combination according to claim 1, wherein the step (3) is specifically as follows:
step (3-1): washing the precipitate and drying the precipitate;
step (3-2): and grinding and sieving the dried precipitate to obtain the free radical scavenging composition.
4. Use of a free radical scavenging composition prepared by the method of preparation of a free radical scavenging composition according to any one of claims 1 to 3 in a cigarette filter rod.
5. The application of the free radical scavenging composition prepared by the preparation method of the free radical scavenging composition in the cigarette filter stick according to claim 4 is characterized in that the free radical scavenging composition is added to the cigarette filter stick or added to paper filter stick paper making slurry, and the addition amount of the free radical scavenging composition is 0.5-1.5wt%.
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| CN1197492C (en) * | 2003-06-12 | 2005-04-20 | 玉溪金灿科技有限公司 | Filter tip for lowering harmful matter in cigarette, and its prepn. method |
| CA2820845C (en) * | 2011-05-16 | 2016-04-19 | Omniactive Health Technologies Ltd | A water soluble composition comprising curcumin having enhanced bioavailability and process thereof |
| CN103355743A (en) * | 2013-08-14 | 2013-10-23 | 中国烟草总公司郑州烟草研究院 | Preparation and application of crop waste cigarette filter additive carrier materials |
| CN103601672B (en) * | 2013-11-04 | 2016-08-17 | 广东中烟工业有限责任公司 | A kind of Curcuminoids and its preparation method and application |
| CN112674345A (en) * | 2019-10-17 | 2021-04-20 | 宁波合康生物医药科技有限公司 | Cyclodextrin additive and preparation method and application thereof |
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