CN113475659A - Jelly beverage and preparation method thereof - Google Patents
Jelly beverage and preparation method thereof Download PDFInfo
- Publication number
- CN113475659A CN113475659A CN202110835484.1A CN202110835484A CN113475659A CN 113475659 A CN113475659 A CN 113475659A CN 202110835484 A CN202110835484 A CN 202110835484A CN 113475659 A CN113475659 A CN 113475659A
- Authority
- CN
- China
- Prior art keywords
- jelly beverage
- acid
- jelly
- preparation
- sleep
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000013361 beverage Nutrition 0.000 title claims abstract description 38
- 235000015110 jellies Nutrition 0.000 title claims abstract description 35
- 239000008274 jelly Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims description 17
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims abstract description 52
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims abstract description 26
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims abstract description 25
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 24
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 24
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 22
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 16
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960003966 nicotinamide Drugs 0.000 claims abstract description 12
- 235000005152 nicotinamide Nutrition 0.000 claims abstract description 12
- 239000011570 nicotinamide Substances 0.000 claims abstract description 12
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 claims abstract description 11
- 102000008186 Collagen Human genes 0.000 claims abstract description 10
- 108010035532 Collagen Proteins 0.000 claims abstract description 10
- 229920001436 collagen Polymers 0.000 claims abstract description 10
- 102000016942 Elastin Human genes 0.000 claims abstract description 9
- 108010014258 Elastin Proteins 0.000 claims abstract description 9
- 239000000679 carrageenan Substances 0.000 claims abstract description 9
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 9
- 229920001525 carrageenan Polymers 0.000 claims abstract description 9
- 229940113118 carrageenan Drugs 0.000 claims abstract description 9
- 229920002549 elastin Polymers 0.000 claims abstract description 9
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 9
- 229920002752 Konjac Polymers 0.000 claims abstract description 8
- 235000010485 konjac Nutrition 0.000 claims abstract description 8
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000001103 potassium chloride Substances 0.000 claims abstract description 8
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 8
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims abstract description 4
- 239000000252 konjac Substances 0.000 claims abstract description 4
- 235000015165 citric acid Nutrition 0.000 claims abstract description 3
- 235000013312 flour Nutrition 0.000 claims abstract description 3
- 241001312219 Amorphophallus konjac Species 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000000654 additive Substances 0.000 claims description 14
- 239000000084 colloidal system Substances 0.000 claims description 9
- 230000000996 additive effect Effects 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 241000962514 Alosa chrysochloris Species 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 4
- 239000011726 vitamin B6 Substances 0.000 claims description 4
- 235000019158 vitamin B6 Nutrition 0.000 claims description 4
- 229940011671 vitamin b6 Drugs 0.000 claims description 4
- KIUKXJAPPMFGSW-YXBJCWEESA-N (2s,4s,5r,6s)-6-[(2s,3r,5s,6r)-3-acetamido-2-[(3s,4r,5r,6r)-6-[(3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@@H]3[C@@H]([C@@H](O)C(O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)C(C(O)=O)O1 KIUKXJAPPMFGSW-YXBJCWEESA-N 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
- 108010011485 Aspartame Proteins 0.000 claims description 3
- 239000004386 Erythritol Substances 0.000 claims description 3
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 3
- 239000004376 Sucralose Substances 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 238000009924 canning Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000010411 cooking Methods 0.000 claims description 3
- 235000019414 erythritol Nutrition 0.000 claims description 3
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 3
- 229940009714 erythritol Drugs 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 238000003801 milling Methods 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 239000004302 potassium sorbate Substances 0.000 claims description 3
- 229940069338 potassium sorbate Drugs 0.000 claims description 3
- 235000010241 potassium sorbate Nutrition 0.000 claims description 3
- 239000012257 stirred material Substances 0.000 claims description 3
- 235000019408 sucralose Nutrition 0.000 claims description 3
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 24
- 241000269851 Sarda sarda Species 0.000 abstract description 3
- 230000000052 comparative effect Effects 0.000 description 43
- 238000012360 testing method Methods 0.000 description 27
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 24
- 229960001412 pentobarbital Drugs 0.000 description 22
- 238000001514 detection method Methods 0.000 description 18
- 239000000047 product Substances 0.000 description 17
- 230000004622 sleep time Effects 0.000 description 15
- 241001465754 Metazoa Species 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 12
- 241000699670 Mus sp. Species 0.000 description 9
- 230000004620 sleep latency Effects 0.000 description 9
- 239000000686 essence Substances 0.000 description 8
- 230000000147 hypnotic effect Effects 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 108010038807 Oligopeptides Proteins 0.000 description 4
- 102000015636 Oligopeptides Human genes 0.000 description 4
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 4
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 229960002275 pentobarbital sodium Drugs 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 244000247812 Amorphophallus rivieri Species 0.000 description 2
- 241001076416 Dendrobium tosaense Species 0.000 description 2
- 210000000683 abdominal cavity Anatomy 0.000 description 2
- 229960000796 barbital sodium Drugs 0.000 description 2
- FTOAOBMCPZCFFF-UHFFFAOYSA-N barbitone sodium Natural products CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 230000028527 righting reflex Effects 0.000 description 2
- 239000011265 semifinished product Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 2
- RGHFKWPGWBFQLN-UHFFFAOYSA-M sodium;5,5-diethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC1(CC)C([O-])=NC(=O)NC1=O RGHFKWPGWBFQLN-UHFFFAOYSA-M 0.000 description 2
- KFSJYZYQSZKRRQ-BYPYZUCNSA-N (2s)-2-(hydroxyamino)-4-methylsulfanylbutanoic acid Chemical compound CSCC[C@H](NO)C(O)=O KFSJYZYQSZKRRQ-BYPYZUCNSA-N 0.000 description 1
- 241000881711 Acipenser sturio Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 244000068645 Carya illinoensis Species 0.000 description 1
- 235000009025 Carya illinoensis Nutrition 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 210000004227 basal ganglia Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 210000001638 cerebellum Anatomy 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000517 effect on sleep Effects 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 210000001320 hippocampus Anatomy 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000007830 nerve conduction Effects 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 210000001103 thalamus Anatomy 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/62—Clouding agents; Agents to improve the cloud-stability
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/10—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by heating materials in packages which are not progressively transported through the apparatus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Non-Alcoholic Beverages (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention provides a jelly beverage, which comprises carrageenan, konjac flour, potassium chloride, citric acid, DL-malic acid, gamma-aminobutyric acid, bonito elastin peptide, N-acetylneuraminic acid, collagen peptide, nicotinamide and the like. The jelly beverage provided by the invention well solves the problem of product stability on one hand, and also has the effect of assisting in improving sleep on the other hand, so that the jelly beverage has a good market prospect.
Description
Technical Field
The invention belongs to the field of food, and particularly relates to a jelly beverage and a preparation method thereof.
Background
Gamma-aminobutyric acid (GABA) is a compound, also known as 4-aminobutyric acid (GABA), an amino acid, and widely exists in vertebrates, plants, and microorganisms.
Gamma-aminobutyric acid is an important nerve conduction substance in the central nervous system, is mainly present in the brain and spinal cord, plays an important role in the cerebral cortex, hippocampus, thalamus, basal ganglia and cerebellum of the human body, and has a regulatory effect on various functions of the body. About 50% of the central synapses in humans are mediated by gamma-aminobutyric acid.
There are many patents in the prior art that add gamma-aminobutyric acid to food.
Chinese patent 202011091522.9 discloses a sleep-aiding small-molecule peptide solid beverage and a preparation method and application thereof. The sleep-aiding small molecular peptide solid beverage comprises sturgeon skin oligopeptide, wheat oligopeptide, pecan oligopeptide, cow milk oligopeptide, gamma-aminobutyric acid, N-acetylneuraminic acid and compound vitamins. The sleep-aiding small molecular peptide solid beverage has an obvious sleep-aiding effect, can greatly shorten the sleep latency time and prolong the sleep valid period time, and overcomes the defects of unobvious efficacy and large side effect of the existing sleep-aiding products to a great extent.
Chinese patent 201810460431.4 discloses a tranquilization sleep-aiding medicine and a waterless preparation method, wherein the tranquilization sleep-aiding medicine comprises the following raw materials in parts by weight: 1-3 parts of gamma-aminobutyric acid, 5-15 parts of dendrobium officinale dry powder, 1-2 parts of sialic acid, 5-10 parts of xanthan gum, 15-30 parts of ethyl cellulose and 50-80 parts of hydroxypropyl cellulose. The invention combines the gamma-aminobutyric acid, the dendrobium officinale and the sialic acid for use, can effectively enhance the functional activity of the gamma-aminobutyric acid, has better nerve calming and sleep aiding effects, and has high safety.
Has wide prospect and important market significance for further development of the application of the gamma-aminobutyric acid in food.
Disclosure of Invention
The invention provides a jelly beverage, which is prepared into a semisolid beverage by adding carrageenan and konjac powder, and is added with components of gamma-aminobutyric acid, bonito elastin peptide, N-acetylneuraminic acid, collagen peptide and nicotinamide.
In one aspect, the invention provides a jelly beverage.
The additives in the jelly beverage comprise carrageenan, konjac flour, potassium chloride, citric acid and DL-malic acid, and the mass ratio of the additives is as follows:
carrageenan | 1-10 |
Konjak powder | 1-10 |
Potassium chloride | 1-10 |
Citric acid | 1-30 |
DL-malic acid | 1-10 |
The total content of the additive in the jelly beverage is 8-15g/L, preferably 11 g/L.
The jelly beverage also comprises: gamma-aminobutyric acid, skipjack elastin peptide, N-acetylneuraminic acid, collagen peptide and nicotinamide.
Wherein, the function of the gamma-aminobutyric acid is as follows: tranquilizing nerves, resisting anxiety, reducing sleep time, and improving sleep quality;
the effect of bonito elastin peptide is: the skin elasticity is improved in an auxiliary mode;
the action of N-acetylneuraminic acid is as follows: has antioxidant and skin whitening effects, and also has auxiliary effect of gamma-aminobutyric acid;
the collagen peptide has the following functions: can improve moisture, elasticity and wrinkle of human skin;
the effect of nicotinamide is: can assist in improving skin condition and assisting in the action of gamma-aminobutyric acid.
Preferably, the formula of the jelly beverage is as follows:
further preferably, the formula of the jelly beverage is as follows:
raw materials | Added amount (g) |
Collagen peptide | 3.0 |
Erythritol and its preparation method | 5.2 |
Gamma-aminobutyric acid | 1.5 |
Hyaluronic acid sodium salt | 0.17 |
Additive agent | 1.1 |
Skipjack elastin peptide | 0.0068 |
N-acetylneureAmino acid | 0.0032 |
Nicotinamide | 0.0015 |
Vitamin B6 | 0.00013 |
Potassium sorbate | 0.04 |
Sucralose | 0.022 |
Aspartame | 0.055 |
Edible essence | 0.1 |
Water (W) | The volume is up to 100mL |
The edible essences include but are not limited to: chamomile essence, orange essence and strawberry essence.
In another aspect, the invention provides a method for preparing a jelly beverage.
The preparation method is used for preparing the jelly beverage.
The preparation method comprises the production processes of weighing, material preparation, blending, canning, sterilization, packaging and the like.
The sterilization condition is 85 ℃ and 20 min.
The blending method comprises the following steps: and turning on a switch of the process cold water and the colloid mill, and slowly milling the uniformly stirred materials into the cooking tank through the colloid mill along with the vortex of the process water. The grinding time is controlled to be more than 40s, and the ingredients are required to be dissolved uniformly and fully without caking. And simultaneously turning on a steam switch, and controlling the steam pressure to be 0.2-0.25 MPa.
The preparation method comprises the following steps: accurately weighing the essence according to the formula standard, slowly adding the weighed essence into the feed liquid, washing the inner wall of the container with 1kg of process hot water with the temperature of more than 85 ℃, and pouring the hot water into the feed liquid.
The invention has the beneficial effects that:
(1) the stability of the product is easily influenced and precipitates are caused when the beverage containing high content of collagen peptide and sodium hyaluronate is prepared, and the product has a certain gel state, so that the stability problem of the product is solved;
(2) the product of the invention can assist in improving the sleep condition of experimental mice;
(3) the raw materials of the product are easy to obtain.
Detailed Description
The present invention will be further illustrated in detail with reference to the following specific examples, which are not intended to limit the present invention but are merely illustrative thereof. The experimental methods used in the following examples are not specifically described, and the materials, reagents and the like used in the following examples are generally commercially available under the usual conditions without specific descriptions.
Examples 1 to 3
The formulations of the jelly beverages of examples 1 to 3 were as follows:
name of raw materials | Example 1(g) | Example 2(g) | Example 3(g) |
Collagen peptide | 3.0 | 2.5 | 3.5 |
Erythritol and its preparation method | 5.2 | 5.4 | 5.6 |
Gamma-aminobutyric acid | 1.5 | 1.3 | 1.8 |
Hyaluronic acid sodium salt | 0.17 | 0.26 | 0.19 |
Additive agent | 1.1 | 1.2 | 1.5 |
Skipjack elastin peptide | 0.0068 | 0.0072 | 0.0080 |
N-acetylneuraminic acid | 0.0032 | 0.0025 | 0.0038 |
Nicotinamide | 0.0015 | 0.0025 | 0.0030 |
Vitamin B6 (pyridoxine hydrochloride) | 0.00013 | 0.00021 | 0.00028 |
Potassium sorbate | 0.04 | 0.03 | 0.04 |
Sucralose | 0.022 | 0.025 | 0.025 |
Aspartame | 0.055 | 0.055 | 0.055 |
Essence | 0.1 | 0.1 | 0.1 |
Water (W) | The volume is up to 100mL | The volume is up to 100mL | The volume is up to 100mL |
Wherein the additive comprises the following components in percentage by mass:
name of raw materials | Example 1 | Example 2 | Example 3 |
Carrageenan | 5 | 7 | 6 |
Konjak powder | 5 | 6 | 5 |
Potassium chloride | 5 | 4 | 6 |
Citric acid | 20 | 18 | 22 |
DL-malic acid | 5 | 5 | 7 |
Example 4A method for preparing a jelly beverage
The preparation method of this example was used to prepare the jelly beverages provided in examples 1 to 3.
The preparation method comprises the following steps:
(1) weighing the raw materials according to the proportion of each component;
(2) blending a semi-finished product: and turning on a switch of the process cold water and the colloid mill, and slowly milling the uniformly stirred materials into the cooking tank through the colloid mill along with the vortex of the process water. The grinding time is controlled to be more than 40s, and the ingredients are required to be dissolved uniformly and fully without caking. Simultaneously, a steam switch is opened, and the steam pressure is controlled to be 0.2-0.25 Mpa;
(3) canning: transferring the blended semi-finished product obtained in the step (2) to sterilization equipment;
(4) and (3) sterilization: sterilizing the product with pasteurization equipment at 85 deg.C for 20 min;
(5) packaging: and cooling and subpackaging the product.
EXAMPLE 5 stability of jelly beverage
This example is to test the stability of the product of example 1.
In the stability detection, 2 accelerating conditions are provided for shortening the detection time, wherein the specific conditions for accelerating for 1 month are as follows: 37 ℃ and 75% humidity; the specific conditions for 2 months acceleration are: 37 ℃ and 75% humidity.
The colony detection method is referred to GB 4789.2.
The detection method of coliform bacteria is referred to GB 4789.3.
The salmonella detection method refers to GB 4789.4.
The staphylococcus aureus detection method is referred to GB 4789.10.
The mould and yeast detection method is referred to GB 4789.15.
The detection method of gamma-aminobutyric acid is referred to QB/T4587.
The detection method of vitamin B6 refers to GB 5009.15.
The detection method of nicotinamide is referred to the second method of GB 5009.89.
The detection method of the hydroxyl methionine is referred to GB/T9695.23.
The detection method of protein is referred to GB 5009.5.
For the detection of total sugars, reference is made to GB 5009.8.
The detection method of lead is referred to GB 5009.12.
The detection data and results are as follows:
example 6 detection of Effect on improving sleep in mice
This example used the product of example 1 as a test sample for testing.
Sodium pentobarbital in this example was purchased from Sigma-Aldrich.
(1) Direct sleep experiments: the animals in 4 groups of test groups are orally given test samples, and after the animals in 4 groups of negative control groups are given water solvents with the same volume, a blank control group is arranged to observe whether the animals have sleep phenomena. The number of animals falling asleep and the sleep time were recorded for each group.
(2) Experiment for prolonging sleep time of sodium pentobarbital: the method is carried out on the basis of a direct sleep experiment, and if the direct sleep experiment is negative (not sleeping), an experiment for prolonging the sleep time of the sodium pentobarbital is carried out. After animals are given solvent and test samples with different concentrations (35, 40 and 45mg/kg) for the last time, 10min-15min before peak effect appears, injecting sodium pentobarbital into the abdominal cavity of each group of animals, and observing whether the test samples can prolong the sleep time of the sodium pentobarbital by taking the disappearance of positive turning reflex as an index.
(3) Pentobarbital sodium subthreshold dose hypnosis test: a pre-experiment is carried out before a formal experiment is carried out, and the sub-threshold hypnotic dose of the sodium pentobarbital, namely the maximum sub-threshold dose of the sodium pentobarbital of which 80% -90% of mouse righting reflex does not disappear, is determined, and the value obtained by the experiment is 29mg/kg & BW. After animals are given the solvent and test samples with different concentrations for the last time, 10min-15min before peak effect occurs, the maximum sub-threshold hypnotic dose of the sodium pentobarbital is injected into the abdominal cavity of each group of animals, and the number of the animals falling asleep within 30min is recorded.
(4) Pentobarbital sodium sleep latency experiments: after animals are given solvent and tested samples with different concentrations for 10min-20min in the last time, the animals are injected with barbital sodium (the experimental dosage is 240 mg/kg. BW), the influence of the tested samples on the sleep latency of the barbital sodium is observed by taking the disappearance of righting reflex as an index.
And (4) judging a result:
the test for prolonging the sleep time of the sodium pentobarbital, the test for hypnotizing the sodium pentobarbital at the subthreshold dose and the test for sleep latency of the sodium pentobarbital have two positive results without obvious direct sleep effect, and the test sample can be judged to have the function of improving the sleep function.
The statistical method comprises the following steps:
data were statistically analyzed using SPSS 17.0. The sleep time is measured data, the data is counted by analysis of variance, the non-normal or non-uniform variance data is subjected to proper variable conversion, and the converted data is used for counting after the requirements of normal or uniform variance are met; if the variable still does not reach the goal of being normal or uniform in variance after conversion, the statistics is carried out by using the rank sum test. The number of animals falling asleep is counted and tested by X2.
Results and analysis:
(1) direct sleep experiment
After the test samples are given to each test group and the solvent with the same volume is given to the negative control group, the positive turning reflex exists and the sleep phenomenon does not appear at all after the observation for 30 min.
(2) Test for prolonging sleep time of sodium pentobarbital
Compared with a blank control group, the average sleep time of the mice in the control group and the test group is slightly prolonged, wherein the sleep time of the mice in the test group is remarkably increased (P < 0.05) compared with the control group, namely the test group has a function of prolonging the average sleep time of the mice induced by pentobarbital. The method comprises the following specific steps:
Note: the comparison of the blank control group is carried out,▲P<0.05,▲▲P<0.01。
(3) pentobarbital sodium subthreshold dose hypnosis experiment
Compared with the blank group, the sleep incidence rate of the mice of the control group and the test group has no obvious change and has no statistical significance (P > 0.05), so the product has no obvious effect on the sleep incidence rate of the mice induced by the sub-threshold dose of pentobarbital.
Note: the comparison of the blank control group is carried out,▲P<0.05,▲▲P<0.01。
(4) test of sleep latency of sodium pentobarbital
Compared with the blank group, the sleep time latency of the control group and the test group mice is shortened, the average sleep latency of the test group mice is obviously shortened with the control group (P is less than 0.05), and the statistical significance is achieved.
Note: the comparison of the blank control group is carried out,▲P<0.05,▲▲P<0.01。
comparative examples 1 to 4
Comparative examples are set and the stability effect of each comparative product is observed (the specific operation steps refer to example 5), and the setting and detection results of the comparative examples are as follows:
comparative example | Differences from example 1 | Stability results |
Comparative example 1 | Without adding carrageenan | The jelly has poor effect, and the separation of water and colloid is obvious |
Comparative example 2 | Rhizoma Amorphophalli powder is not added | The jelly has poor effect, and the separation of water and colloid is obvious |
Comparative example 3 | Without adding potassium chloride | Poor gelling effect and no gelling |
Comparative example 4 | Without addition of citric acid | Accelerated generation of white turbidity and flocculent precipitate |
Comparative example 5 | Without addition of DL-malic acid | Accelerated generation of white turbidity and flocculent precipitate |
Comparative examples 5 to 6
Comparative examples are set and the stability effect of each comparative product is observed (the specific operation steps refer to example 5), and the setting and detection results of the comparative examples are as follows:
comparative example | Differences from example 1 | Stability results |
Comparative example 5 | The additive content is 3g/L | The product is unstable and nonuniform |
Comparative example 6 | The additive content is 25g/L | Too strong colloid, poor taste and poor stability |
Comparative examples 7 to 11
Comparative examples were set and observed for sleep-aiding effect of each comparative product, respectively (the specific procedure is referred to as example 6), and the comparative examples were set as follows:
comparative example | Differences from example 1 |
Comparative example 7 | Without addition of gamma-aminobutyric acid |
Comparative example 8 | Without adding skipjack elastin peptide |
Comparative example 9 | Without addition of N-acetylneuraminic acid |
Comparative example 10 | Collagen peptide is not added |
Comparative example 11 | Without addition of nicotinamide |
The resulting data are as follows:
(1) effect on prolonging sleep time of sodium pentobarbital
From the results, it is clear that, in comparative examples 8 to 11, comparative example 8 and comparative example 10 have no significant difference from the data of example 1; comparative example 11 differs greatly from example 1, and comparative example 9 differs most from example 1.
(2) Test of sleep latency of sodium pentobarbital
Comparative example 12
According to the results of comparative example 9 and comparative example 11, comparative example 12 was set, and the sleep-aiding effect was observed (the specific operation procedure was referred to example 6), and comparative example 12 was set as follows:
comparative example | Differences from example 1 |
Comparative example 12 | Without addition of nicotinamide and N-acetylneuraminic acid |
The resulting data are as follows:
(1) effect on prolonging sleep time of sodium pentobarbital
(2) Test of sleep latency of sodium pentobarbital
From comparative example 7, it can be seen that γ -aminobutyric acid is the main ingredient having sleep-aiding effect in example 1;
as is clear from comparative example 9, comparative example 11 and comparative example 12, nicotinamide and N-acetylneuraminic acid have a sleep-aiding effect on gamma-aminobutyric acid.
Claims (10)
1. The jelly beverage is characterized in that additives in the jelly beverage comprise carrageenan, konjac flour, potassium chloride, citric acid and DL-malic acid, and the mass ratio of the additives is as follows:
The jelly beverage also comprises: gamma-aminobutyric acid, skipjack elastin peptide, N-acetylneuraminic acid, collagen peptide and nicotinamide.
2. The jelly beverage according to claim 1, wherein the total content of the additives in the jelly beverage is 8 to 15 g/L.
3. The jelly beverage according to claim 2, wherein the total content of the additives in the jelly beverage is 11 g/L.
5. the jelly beverage according to claim 4, wherein the formulation of the jelly beverage is as follows:
6. The jelly beverage according to claim 5, wherein the additives comprise the following components in parts by weight:
7. A preparation method of the jelly beverage is characterized in that the preparation method is used for preparing the jelly beverage as claimed in any one of claims 1 to 6, and the preparation method comprises the production processes of weighing and preparing materials, blending, canning, sterilizing, packaging and the like.
8. The method according to claim 7, wherein the sterilization is carried out at 85 ℃ for 20 min.
9. The method of claim 7, wherein the formulation method comprises: turning on a switch of the process cold water and the colloid mill, and slowly milling the uniformly stirred materials into the cooking tank through the colloid mill along with the vortex of the process water; the grinding time is controlled to be more than 40s, the ingredients are required to be dissolved uniformly and fully, and no caking is required; and simultaneously turning on a steam switch, and controlling the steam pressure to be 0.2-0.25 MPa.
10. The method of claim 9, wherein the formulation method comprises: accurately weighing the essence according to the formula standard, slowly adding the weighed essence into the feed liquid, washing the inner wall of the container with 1kg of process hot water with the temperature of more than 85 ℃, and pouring the hot water into the feed liquid.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110835484.1A CN113475659A (en) | 2021-07-23 | 2021-07-23 | Jelly beverage and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110835484.1A CN113475659A (en) | 2021-07-23 | 2021-07-23 | Jelly beverage and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN113475659A true CN113475659A (en) | 2021-10-08 |
Family
ID=77943298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110835484.1A Pending CN113475659A (en) | 2021-07-23 | 2021-07-23 | Jelly beverage and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN113475659A (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103719995A (en) * | 2014-01-15 | 2014-04-16 | 广东仙乐制药有限公司 | Collagen and ceramide beverage |
CN105918742A (en) * | 2016-04-26 | 2016-09-07 | 北京晚安科技有限责任公司 | Beverage capable of promoting sleep, expelling toxins, and nourishing skin |
CN108850751A (en) * | 2017-05-11 | 2018-11-23 | 康师傅饮品控股有限公司 | The production method of flavor jelly powder and flavor fruit syrup |
CN112006198A (en) * | 2020-09-01 | 2020-12-01 | 宣城柏维力生物工程有限公司 | Anti-sugar collagen drink and preparation method thereof |
CN112056482A (en) * | 2020-10-13 | 2020-12-11 | 广州小象健康产业有限公司 | Sleep-aiding small-molecule peptide solid beverage and preparation method and application thereof |
-
2021
- 2021-07-23 CN CN202110835484.1A patent/CN113475659A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103719995A (en) * | 2014-01-15 | 2014-04-16 | 广东仙乐制药有限公司 | Collagen and ceramide beverage |
CN105918742A (en) * | 2016-04-26 | 2016-09-07 | 北京晚安科技有限责任公司 | Beverage capable of promoting sleep, expelling toxins, and nourishing skin |
CN108850751A (en) * | 2017-05-11 | 2018-11-23 | 康师傅饮品控股有限公司 | The production method of flavor jelly powder and flavor fruit syrup |
CN112006198A (en) * | 2020-09-01 | 2020-12-01 | 宣城柏维力生物工程有限公司 | Anti-sugar collagen drink and preparation method thereof |
CN112056482A (en) * | 2020-10-13 | 2020-12-11 | 广州小象健康产业有限公司 | Sleep-aiding small-molecule peptide solid beverage and preparation method and application thereof |
Non-Patent Citations (1)
Title |
---|
张东华,等: "魔芋果冻粉工艺配方", 《食品工业科技》 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101498780B1 (en) | Composition for preventing or treating hangover | |
JP2023538664A (en) | Compositions of ginsenoside Rg3 and ginsenoside Rg5 and their pharmaceutical uses, including antitumor effects | |
CN103476421A (en) | Composition, glucose metabolism-improving agent, and method for improving glucose metabolism | |
CN102836340A (en) | Pharmaceutical composition for benefiting vital energy, enriching blood and nourishing liver and kidney as well as preparation method and application thereof | |
JPWO2006033412A1 (en) | Radiation damage reducing agent | |
CN106667915A (en) | Baicalin-aluminum dry suspension for treating pigling diarrhoea | |
CN102823871A (en) | Health care product for promoting lead removal and preparation method thereof | |
CN111820414A (en) | Health food for improving sleep and preparation method thereof | |
CN114642258A (en) | Beverage composition for relieving stress, relaxing mood and improving sleep of young people and preparation method thereof | |
DE60133781T2 (en) | ORAL PREPARATIONS WITH JEWELRY LIGHTER OR ANTIPRURITIC EFFECT | |
CN114271490A (en) | Health formula containing SOD and ergothioneine and having anti-fatigue, antioxidant and anti-hangover effects | |
RU2521369C1 (en) | Agent or stimulation of metabolic processes, prevention and treatment of gastrointestinal diseases in calves in early postnatal period | |
CN113475659A (en) | Jelly beverage and preparation method thereof | |
CN104687048A (en) | Maca tablet and preparation method thereof | |
KR102040809B1 (en) | Calcium complex comprising mussel shell and oligosaccharide and uses thereof | |
CN108420890B (en) | Composition with blood fat reducing effect and preparation method thereof | |
CN110613031B (en) | Apple enzyme fat burning slimming powder and preparation method thereof | |
CN115316670A (en) | Composition for improving skin condition, health-care beverage and preparation method | |
CN106387915B (en) | Qi and coffee vigor-benefiting effervescent tablet and preparation process and application thereof | |
CN108743809B (en) | Throat clearing composition and preparation method and application thereof | |
KR101041044B1 (en) | A composition for reducing sleep induction time and prolonging sleeping time, and a method for preparing the same | |
CN112089696A (en) | Marbofloxacin flavor tablet and preparation method thereof | |
US8124138B2 (en) | Composition for prevention and/or treatment of pruritus containing acacia bark derivative | |
JP2020534281A (en) | A composition for relieving hangover or a composition for preventing, ameliorating or treating alcoholic liver disease containing beta-glucan as an active ingredient. | |
RU2812611C1 (en) | Compositions of ginsenoside rg3 and ginsenoside rg5 and their pharmaceutical uses, including antitumor effects |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211008 |
|
RJ01 | Rejection of invention patent application after publication |