CN113454115B - 靶向唾液酸化路易斯a的嵌合抗原受体及其用途 - Google Patents

靶向唾液酸化路易斯a的嵌合抗原受体及其用途 Download PDF

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CN113454115B
CN113454115B CN201980082824.9A CN201980082824A CN113454115B CN 113454115 B CN113454115 B CN 113454115B CN 201980082824 A CN201980082824 A CN 201980082824A CN 113454115 B CN113454115 B CN 113454115B
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polypeptide
car
cells
amino acid
acid sequence
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CN113454115A (zh
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M·萨德兰
J·D·汉森
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Biotechnology Research And Development Co ltd
Memorial Sloan Kettering Cancer Center
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Memorial Sloan Kettering Cancer Center
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    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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CN201980082824.9A 2018-10-19 2019-10-18 靶向唾液酸化路易斯a的嵌合抗原受体及其用途 Active CN113454115B (zh)

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US201862748198P 2018-10-19 2018-10-19
US62/748,198 2018-10-19
PCT/US2019/057017 WO2020081988A1 (en) 2018-10-19 2019-10-18 Chimeric antigen receptor targeting sialyl lewis a and uses thereof

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CN113454115B true CN113454115B (zh) 2025-06-13

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US (1) US20210246221A1 (https=)
EP (1) EP3867279A4 (https=)
JP (2) JP7672340B2 (https=)
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WO (1) WO2020081988A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014332442B2 (en) * 2013-08-26 2019-12-19 Biontech Research And Development, Inc. Nucleic acids encoding human antibodies to Sialyl-Lewis
WO2021105989A1 (en) * 2019-11-26 2021-06-03 Ramot At Tel-Aviv University Ltd. Chimeric antigen receptor to carbohydrate antigens
EP4065605A4 (en) 2019-11-26 2023-07-12 Ramot at Tel-Aviv University Ltd. Antibodies to carbohydrate antigens
CN112457416B (zh) * 2020-12-15 2021-08-17 吴菲 一种靶向bcma的嵌合抗原受体(car)及其应用
CN115876993B (zh) * 2022-11-17 2024-10-15 沈阳农业大学 基于生物膜干涉技术检测病原生物凝集素与唾液酸乳糖亲和力方法的建立
CN117092046B (zh) * 2023-08-03 2024-03-08 首都医科大学附属北京安定医院 一种检测精神病患者口腔是否藏匿药物的方法
WO2025252894A1 (en) * 2024-06-06 2025-12-11 BioNTech SE Ca19-9 binding molecule

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108137695A (zh) * 2015-08-25 2018-06-08 诺丁汉大学 作为功能性癌症靶标的、不在糖脂而在糖蛋白上表达的唾液酸化二路易斯a及其抗体
CN108463248A (zh) * 2015-11-12 2018-08-28 希亚迈博治疗公司 聚糖相互作用化合物及使用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014332442B2 (en) * 2013-08-26 2019-12-19 Biontech Research And Development, Inc. Nucleic acids encoding human antibodies to Sialyl-Lewis
US20170335281A1 (en) * 2014-03-15 2017-11-23 Novartis Ag Treatment of cancer using chimeric antigen receptor
EP4166148B1 (en) * 2014-06-06 2026-02-18 Memorial Sloan-Kettering Cancer Center Mesothelin-targeted chimeric antigen receptors and uses thereof
CN118271463A (zh) * 2014-12-05 2024-07-02 纪念斯隆-凯特琳癌症中心 靶向g-蛋白偶联受体的嵌合抗原受体及其用途
MY191537A (en) * 2014-12-05 2022-06-30 Memorial Sloan Kettering Cancer Center Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof
KR20230148844A (ko) * 2016-03-29 2023-10-25 유니버시티 오브 써던 캘리포니아 암을 표적하는 키메라 항원 수용체
JP7416695B2 (ja) * 2017-12-29 2024-01-17 メモリアル スローン－ケタリング キャンサー センター 増強されたキメラ抗原受容体およびその使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108137695A (zh) * 2015-08-25 2018-06-08 诺丁汉大学 作为功能性癌症靶标的、不在糖脂而在糖蛋白上表达的唾液酸化二路易斯a及其抗体
CN108463248A (zh) * 2015-11-12 2018-08-28 希亚迈博治疗公司 聚糖相互作用化合物及使用方法

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JP7672340B2 (ja) 2025-05-07
CN113454115A (zh) 2021-09-28
WO2020081988A1 (en) 2020-04-23
JP2025085740A (ja) 2025-06-05
EP3867279A1 (en) 2021-08-25
JP2022513372A (ja) 2022-02-07
US20210246221A1 (en) 2021-08-12
EP3867279A4 (en) 2022-07-13

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