CN113426313B - Heart contrast agent and preparation method thereof - Google Patents
Heart contrast agent and preparation method thereof Download PDFInfo
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- CN113426313B CN113426313B CN202110823097.6A CN202110823097A CN113426313B CN 113426313 B CN113426313 B CN 113426313B CN 202110823097 A CN202110823097 A CN 202110823097A CN 113426313 B CN113426313 B CN 113426313B
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- mixed solution
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- 239000002872 contrast media Substances 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 238000002156 mixing Methods 0.000 claims abstract description 39
- 239000011259 mixed solution Substances 0.000 claims abstract description 22
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000000243 solution Substances 0.000 claims abstract description 7
- 230000010355 oscillation Effects 0.000 claims abstract description 6
- 239000012856 weighed raw material Substances 0.000 claims abstract description 5
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 4
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 4
- 239000000084 colloidal system Substances 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 34
- 238000003756 stirring Methods 0.000 claims description 32
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 20
- 239000001301 oxygen Substances 0.000 claims description 20
- 229910052760 oxygen Inorganic materials 0.000 claims description 20
- 230000000747 cardiac effect Effects 0.000 claims description 12
- 230000005540 biological transmission Effects 0.000 claims description 11
- 239000007789 gas Substances 0.000 claims description 8
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 abstract 1
- 229960004647 iopamidol Drugs 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 description 5
- 238000013184 cardiac magnetic resonance imaging Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention relates to the field of contrast agent preparation, in particular to a heart contrast agent and a preparation method thereof, wherein the contrast agent comprises the following raw materials in parts by weight: 100 parts of colloid solution, 25 parts of iopamidol and 10 parts of hemoglobin; the method comprises the following steps: i, fully mixing the weighed raw materials to obtain a mixed solution; II, aerating the mixed solution; III, carrying out oscillation treatment on the mixed solution mixed with the gas, and taking the mixed solution below to obtain a heart contrast agent; still use a contrast agent preparation facilities, including mixing drum, discharge tube, side seat, support frame, bottom plate, rabbling mechanism and power unit, bottom plate fixed connection is in the center department of mixing drum lower extreme, and rabbling mechanism swivelling joint is on the bottom plate, is equipped with the valve on the discharge tube, and the lower extreme fixedly connected with discharge tube of mixing drum, mixing drum outside symmetry are equipped with two side seats, and support frame fixed connection is on one of them side seat, and power unit connects on the support frame, power unit and rabbling mechanism sliding connection.
Description
Technical Field
The invention relates to the field of contrast agent preparation, in particular to a heart contrast agent and a preparation method thereof.
Background
In recent years, cardiac magnetic resonance imaging has been widely focused and applied as a noninvasive image analysis means in diagnosing heart diseases. By using the cardiac magnetic resonance imaging technology, the blood flow conditions of the left ventricle, the right ventricle, the myocardial structure and valve tissues of the heart can be clearly observed, and a powerful image basis is provided for finding and treating heart diseases. In the clinical practice of cardiac magnetic resonance imaging, in order to obtain high definition images, it is often necessary to inject contrast agents to improve image contrast.
Disclosure of Invention
The invention aims to provide a heart contrast agent and a preparation method thereof, which have the beneficial effects that the mixing efficiency of raw materials can be improved by using the contrast agent preparation device.
The aim of the invention is achieved by the following technical scheme:
a method of preparing a cardiac contrast agent, the method comprising the steps of:
i, fully mixing the weighed raw materials to obtain a mixed solution;
II, aerating the mixed solution;
And III, carrying out oscillation treatment on the mixed solution mixed with the gas, and taking the mixed solution below to obtain the heart contrast agent.
Preferably, the inflation gas is oxygen.
Preferably, the method for preparing the heart contrast agent further uses a contrast agent preparation device, the contrast agent preparation device comprises a mixing drum, a discharge pipe, side seats, a support frame, a bottom plate, a stirring mechanism and a power mechanism, wherein the bottom plate is fixedly connected to the center of the lower end of the mixing drum, the stirring mechanism is connected to the bottom plate in a rotating mode, a valve is arranged on the discharge pipe, the lower end of the mixing drum is fixedly connected with the discharge pipe, two side seats are symmetrically arranged on the outer side of the mixing drum, the support frame is fixedly connected to one of the side seats, the power mechanism is connected to the support frame, and the power mechanism is in sliding connection with the stirring mechanism.
Preferably, the stirring mechanism comprises a rotating pipe, a stirring pipe and a transmission block, wherein a plurality of stirring pipes are uniformly arranged at the outer end of the rotating pipe, the lower end of the rotating pipe is rotationally connected to the bottom plate, and the upper end of the inner wall of the rotating pipe is fixedly connected with the transmission block.
Preferably, the power unit includes lift post, thread groove, connecting seat, interlock board, runner I and power shaft, and lift post sliding connection is in the swivelling joint, and the thread groove sets up the surface at the lift post, and sliding connection has the drive block in the thread groove, and the connecting seat setting is in the upper end of lift post, and the interlock board rotates with the connecting seat to be connected, and the interlock board rotates with the eccentric part of runner I to be connected, and power shaft fixed connection is in the center department of runner I, and the power shaft rotates the upper end of connecting at the support frame.
Preferably, the contrast agent preparation device further comprises a dissolving cavity and an air duct, wherein the dissolving cavity is arranged at the center of the lower end of the lifting column, the air duct is arranged on the connecting seat, and the air duct is communicated with the dissolving cavity.
Preferably, the air duct is provided with a one-way valve.
Preferably, the contrast agent preparation device further comprises a center column, a liquid guide hole and a center hole, wherein the center column is fixedly connected to the bottom plate, the center column is slidably connected to the inside of the dissolution cavity, the center hole is arranged at the center of the center column, the liquid guide holes are formed in the lower end of the center column, and the liquid guide holes are communicated with the center hole.
Preferably, the contrast agent preparation device further comprises a rotating wheel II, an eccentric shaft and a bearing frame, wherein the two side seats are both rotationally connected to the bearing frame, the rotating wheel II is fixedly connected to one end of the power shaft, the eccentric shaft is fixedly connected to the eccentric position of the rotating wheel II, and the eccentric shaft is in sliding connection with the bearing frame.
The contrast agent prepared by the preparation method of the heart contrast agent comprises the following raw materials in parts by weight: 100 parts of colloid solution, 25 parts of lopamidol and 10 parts of hemoglobin.
The invention has the beneficial effects that: the invention provides a heart contrast agent and a preparation method thereof, and the use of a contrast agent preparation device can improve the mixing efficiency of raw materials.
Drawings
FIG. 1 is a schematic illustration of an embodiment of the invention for mixing raw materials;
FIG. 2 is a schematic cross-sectional view of an embodiment of the invention for mixing raw materials;
FIG. 3 is a schematic structural view of a mixing drum according to the present invention;
FIG. 4 is a schematic view of the structure of the center post of the present invention;
FIG. 5 is a schematic view of the stirring mechanism of the present invention;
FIG. 6 is a schematic view of the power mechanism of the present invention;
FIG. 7 is a schematic diagram of an embodiment of a wobble oscillation of the present invention;
FIG. 8 is a schematic view of the structure of the carrier of the present invention;
FIG. 9 is a schematic diagram of an embodiment of the present invention for enhancing concussion;
FIG. 10 is a schematic view of the structure of the base plate of the present invention;
FIG. 11 is a schematic view of the weight of the present invention.
In the figure:
a mixing tub 101; a discharge pipe 102; a side seat 103; a support frame 104;
a bottom plate 201; a center post 202; a liquid guiding hole 203; a central aperture 204;
A rotating tube 301; a stirring tube 302; a transmission block 303;
a lifting column 401; a thread groove 402; a dissolution chamber 403; a connection base 404; an airway tube 405; a linkage plate 406; wheel I407; a power shaft 408; wheel II 409; an eccentric shaft 410;
Block 501; a leg bar 502; a fixing plate 503; a guide chute 504; a limiting plate 505; a stop collar 506; a spring 507;
a base plate 601; a support platelet 602; a weight 603; a link plate 604.
Detailed Description
Specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings, but the present invention is not limited to these specific embodiments.
A method of preparing a cardiac contrast agent, the method comprising the steps of:
i, fully mixing the weighed raw materials to obtain a mixed solution;
II, aerating the mixed solution;
And III, carrying out oscillation treatment on the mixed solution mixed with the gas, and taking the mixed solution below to obtain the heart contrast agent.
Preferably, the inflation gas is oxygen.
The mixed liquid is filled with oxygen to obtain the oil-oxygen-carrying contrast agent, and the state and the development of the cardiac blood vessels are not obviously influenced, so that the cardiac contrast quality can be ensured, the cardiac blood vessels of a patient can be sufficiently supplied with oxygen during the contrast, the risks of insufficient cardiac blood supply and myocardial ischemia and hypoxia injury in the cardiac contrast operation are reduced, the defects of the existing cardiac contrast technology and contrast agent are overcome, the medical quality is improved, and the prognosis of a patient is improved.
1-4, An example of raw material mixing is described;
The preparation method of the heart contrast agent further comprises a contrast agent preparation device, the contrast agent preparation device comprises a mixing barrel 101, a discharge pipe 102, side seats 103, a support frame 104, a bottom plate 201, a stirring mechanism and a power mechanism, wherein the bottom plate 201 is fixedly connected to the center of the lower end of the mixing barrel 101, the stirring mechanism is connected to the bottom plate 201 in a rotating mode, a valve is arranged on the discharge pipe 102, the lower end of the mixing barrel 101 is fixedly connected with the discharge pipe 102, two side seats 103 are symmetrically arranged on the outer side of the mixing barrel 101, the support frame 104 is fixedly connected to one of the side seats 103, the power mechanism is connected to the support frame 104, and the power mechanism is connected with the stirring mechanism in a sliding mode.
When the heart contrast agent is used, weighed raw materials are poured into the mixing barrel 101, the power mechanism is started, the power mechanism drives the stirring mechanism to stir the raw materials in the mixing barrel 101, mixed liquid is obtained after the raw materials are uniformly stirred, high-pressure inflation is carried out in the mixed liquid, then the mixed liquid mixed with gas is subjected to vibration treatment, and the heart contrast agent is obtained by taking the mixed liquid below.
Referring to fig. 5, an embodiment of the stirring mechanism is illustrated;
The stirring mechanism comprises a rotating pipe 301, a stirring pipe 302 and a transmission block 303, wherein a plurality of stirring pipes 302 are uniformly arranged at the outer end of the rotating pipe 301, the lower end of the rotating pipe 301 is rotationally connected to the bottom plate 201, and the upper end of the inner wall of the rotating pipe 301 is fixedly connected with the transmission block 303.
During stirring, the power mechanism drives the transmission block 303, so that the transmission block 303 drives the stirring pipe 302 to rotate through the rotating pipe 301, and raw materials are stirred, so that the raw materials are fully mixed.
Referring to FIG. 6, an embodiment of a power mechanism is illustrated;
The power mechanism comprises a lifting column 401, a thread groove 402, a connecting seat 404, a linkage plate 406, a rotating wheel I407 and a power shaft 408, wherein the lifting column 401 is slidably connected in the rotating tube 301, the thread groove 402 is formed in the outer surface of the lifting column 401, a transmission block 303 is slidably connected in the thread groove 402, the connecting seat 404 is arranged at the upper end of the lifting column 401, the linkage plate 406 is rotatably connected with the connecting seat 404, the linkage plate 406 is rotatably connected with the eccentric part of the rotating wheel I407, the power shaft 408 is fixedly connected at the center of the rotating wheel I407, and the power shaft 408 is rotatably connected with the upper end of the support frame 104.
The driving motor is started to drive the power shaft 408, the power shaft 408 drives the rotating wheel I407 to rotate, then the connecting seat 404 drives the lifting column 401 to reciprocate in the rotating tube 301 through the linkage plate 406, the driving block 303 slides in the threaded groove 402 through the threaded groove 402 when the lifting column 401 ascends and descends, and then the driving block 303 is formed to drive the rotating tube 301 to reciprocate, so that the rotating tube 301 drives the stirring tube 302 to reciprocate by taking the axis of the rotating tube 301 as the shaft, stirring of raw materials is formed, and the lifting column 401 ascends in the rotating tube 301 through the lifting column 401 in a reciprocating manner, mixed liquid enters the rotating tube 301 through the stirring tube 302, and when the lifting column 401 descends in the rotating tube 301, the mixed liquid washes out the rotating tube 301 through the stirring tube 302, so that the mixing efficiency of the raw materials is further improved.
Preferably, the contrast agent preparation device further includes a solution chamber 403 and an air duct 405, the solution chamber 403 is disposed at the center of the lower end of the lifting column 401, the air duct 405 is disposed on the connection seat 404, and the air duct 405 is communicated with the solution chamber 403.
The air duct 405 is connected with an external oxygen source, oxygen is led into the dissolved air cavity 403, oxygen is formed to contact with the mixed liquid in the rotary pipe 301, contact mixing of the oxygen and the mixed liquid is formed, and particularly when the lifting column 401 descends in the rotary pipe 301, the descending of the lifting column 401 increases the mixing pressure of the oxygen and the mixed liquid, and the efficiency of dissolving the oxygen into the mixed liquid is improved.
Preferably, the air duct 405 is provided with a one-way valve.
Through the setting of the check valve on the air duct 405, when having avoided the decline of lifting column 401 to increase the mixed pressure of oxygen and mixed solution, the oxygen backward flow influences the efficiency that the oxygen dissolved into the mixed solution.
1-6, Embodiments for improving the efficiency of oxygen dissolution into a mixed liquor are described;
The contrast agent preparation device further comprises a center column 202, a liquid guide hole 203 and a center hole 204, wherein the center column 202 is fixedly connected to the bottom plate 201, the center column 202 is slidably connected to the inside of the dissolution cavity 403, the center hole 204 is arranged at the center of the center column 202, a plurality of liquid guide holes 203 are formed in the lower end of the center column 202, and the liquid guide holes 203 are communicated with the center hole 204.
Through the arrangement of the central column 202, the liquid guide hole 203 and the central hole 204, when the lifting column 401 ascends in the rotary tube 301, the mixed liquid enters between the rotary tube 301 and the central column 202 through the stirring tube 302, meanwhile, the space between the central column 202 and the dissolved air cavity 403 is enlarged, so that the mixed liquid between the rotary tube 301 and the central column 202 enters into the dissolved air cavity 403 to be contacted with oxygen through the liquid guide hole 203 and the central hole 204, when the lifting column 401 descends in the rotary tube 301, the pressure in the dissolved air cavity 403 is increased by matching with the central column 202, the efficiency of oxygen dissolution into the mixed liquid is improved, compared with the contact of oxygen in the rotary tube 301 with the mixed liquid, because the stirring tube 302 is uniformly distributed on the rotary tube 301, when the lifting column 401 descends, gas is easy to be sprayed out through the stirring tube 302, and the central column 202 is only provided with one central hole 204 and is positioned at the lower end of the dissolved air cavity 403, when the mixed liquid is arranged in the dissolved air cavity 403, the oxygen cannot be discharged in the dissolved air cavity 403, so that the air pressure in the dissolved air cavity 403 is enlarged, and the air pressure in the oxygen loss is small.
7-8, Embodiments of the shaking of the mixed liquor are described;
The contrast agent preparation device further comprises a rotating wheel II 409, an eccentric shaft 410 and a bearing frame, wherein the two side seats 103 are both rotatably connected to the bearing frame, the rotating wheel II 409 is fixedly connected to one end of the power shaft 408, the eccentric shaft 410 is fixedly connected to the eccentric position of the rotating wheel II 409, and the eccentric shaft 410 is in sliding connection with the bearing frame.
The bearing frame comprises a frame 501, support leg rods 502, fixing plates 503 and guide slide ways 504, the support leg rods 502 are fixedly connected to four corners of the frame 501, one end of the frame 501 is fixedly connected with the fixing plates 503, the fixing plates 503 are provided with the guide slide ways 504, two side seats 103 are rotatably connected to the frame 501, and the eccentric shafts 410 are slidably connected to the guide slide ways 504.
The two side seats 103 are both rotationally connected to the block 501, when the power shaft 408 rotates, the rotating wheel II 409 drives the eccentric shaft 410 to eccentrically rotate by taking the power shaft 408 as an axis, and the eccentric shaft 410 is slidably connected to the setting in the guide slideway 504, so that the eccentric shaft 410 drives the support frame 104 when rotating, the mixing drum 101 swings left and right in the block 501 by taking the two side seats 103 as an axis, and then vibration of mixed liquid in the mixing drum 101 is formed, so that larger bubbles in the mixed liquid float to the upper surface of the mixed liquid, and a high-quality contrast agent is obtained.
An embodiment of the shaking of the mixed liquor will be further described with reference to fig. 9-11;
A contrast agent preparation facilities still includes spacing ring 506, spring 507, bed plate 601 and supports platelet 602, the equal fixedly connected with in four corners department of bed plate 601 supports platelet 602, four landing leg poles 502 sliding connection respectively in four supports platelet 602, the equal fixedly connected with spacing ring 506 of lower extreme of four landing leg poles 502, the equal fixedly connected with spring 507 in upper and lower both ends of every spacing ring 506, four springs 507 that are located the below all jack up bed plate 601, four springs 507 that are located the top jack up four supports platelet 602 respectively.
Through the setting of bed plate 601, make the device place at the desktop through the bed plate 601 to through the setting of spacing ring 506 and spring 507, carry out elastic support to landing leg pole 502, when the device operation, because the side-to-side of mixing drum 101 sways, make the device produce vibrations, the cooperation mixing drum 101 sways side-to-side, further strengthen the vibration of device to the interior mixed solution of mixing drum 101, improve the efficiency that great bubble in the mixed solution wafts to the upper surface of mixed solution.
The contrast agent preparation device further comprises a limiting plate 505, a balancing weight 603 and a connecting plate 604, wherein the limiting plate 505 is fixedly connected to two sides of the fixing plate 503, the balancing weight 603 is slidably connected between the two limiting plates 505, the connecting plate 604 is fixedly connected to the balancing weight 603, and the connecting plate 604 is rotatably connected with the eccentric shaft 410.
Through the setting of balancing weight 603, when the device is operated, eccentric shaft 410 drives balancing weight 603 and carries out reciprocal lift between two limiting plates 505 through link plate 604, has strengthened the vibration ability of device through spring 507, simultaneously through the weight of balancing weight 603, forms the extrusion and the rising to spring 507, when strengthening vibration ability, improves the stability of device, has avoided the holistic vibrations of device, makes the mixed solution splash.
The contrast agent prepared by the preparation method of the heart contrast agent comprises the following raw materials in parts by weight: 100 parts of colloid solution, 25 parts of lopamidol and 10 parts of hemoglobin.
Claims (5)
1. A method for preparing a heart contrast agent, which is characterized in that: the method comprises the following steps:
i, fully mixing the weighed raw materials to obtain a mixed solution;
II, aerating the mixed solution;
III, carrying out oscillation treatment on the mixed solution mixed with the gas, and taking the mixed solution below to obtain a heart contrast agent;
the preparation method of the heart contrast agent further comprises the step of using a contrast agent preparation device, wherein the contrast agent preparation device comprises a mixing barrel (101), a discharge pipe (102), side seats (103), a support frame (104), a bottom plate (201), a stirring mechanism and a power mechanism, wherein the bottom plate (201) is fixedly connected to the center of the lower end of the mixing barrel (101), the stirring mechanism is rotationally connected to the bottom plate (201), a valve is arranged on the discharge pipe (102), the discharge pipe (102) is fixedly connected to the lower end of the mixing barrel (101), two side seats (103) are symmetrically arranged on the outer side of the mixing barrel (101), the support frame (104) is fixedly connected to one side seat (103), the power mechanism is connected to the support frame (104), and the power mechanism is in sliding connection with the stirring mechanism;
The stirring mechanism comprises a rotating pipe (301), a stirring pipe (302) and a transmission block (303), wherein a plurality of stirring pipes (302) are uniformly arranged at the outer end of the rotating pipe (301), the lower end of the rotating pipe (301) is rotationally connected to the bottom plate (201), and the transmission block (303) is fixedly connected to the upper end of the inner wall of the rotating pipe (301);
The power mechanism comprises a lifting column (401), a thread groove (402), a connecting seat (404), a linkage plate (406), a rotating wheel I (407) and a power shaft (408), wherein the lifting column (401) is slidably connected in a rotating pipe (301), the thread groove (402) is arranged on the outer surface of the lifting column (401), a transmission block (303) is slidably connected in the thread groove (402), the connecting seat (404) is arranged at the upper end of the lifting column (401), the linkage plate (406) is rotationally connected on the connecting seat (404), the upper end of the linkage plate (406) is rotationally connected at the eccentric position of the rotating wheel I (407), the power shaft (408) is fixedly connected at the center of the rotating wheel I (407), and the power shaft (408) is rotationally connected at the upper end of the supporting frame (104);
The contrast agent preparation device further comprises a dissolving cavity (403) and an air duct (405), wherein the dissolving cavity (403) is arranged at the center of the lower end of the lifting column (401), and the air duct (405) is fixedly connected to the connecting seat (404) and is communicated with the dissolving cavity (403);
The contrast agent preparation device further comprises a center column (202), a liquid guide hole (203) and a center hole (204), wherein the center column (202) is fixedly connected to the bottom plate (201) and is slidably connected to the inside of the dissolving cavity (403), the center of the center column (202) is provided with the center hole (204), the lower end of the center column (202) is provided with a plurality of liquid guide holes (203), and the liquid guide holes (203) are all communicated with the center hole (204).
2. A method of preparing a cardiac contrast agent according to claim 1, wherein: the inflation gas is oxygen.
3. A method of preparing a cardiac contrast agent according to claim 1, wherein: the air duct (405) is provided with a one-way valve.
4. A method of preparing a cardiac contrast agent according to claim 1, wherein: the contrast agent preparation device further comprises a rotating wheel II (409), an eccentric shaft (410) and a bearing frame, wherein the two side seats (103) are both rotatably connected to the bearing frame, the rotating wheel II (409) is fixedly connected to one end of a power shaft (408), the eccentric shaft (410) is fixedly connected to the eccentric position of the rotating wheel II (409), and the eccentric shaft (410) is in sliding connection with the bearing frame;
The bearing frame comprises a square frame (501), supporting leg rods (502), fixing plates (503) and guide slide ways (504), the supporting leg rods (502) are fixedly connected to four corners of the square frame (501), one end of the square frame (501) is fixedly connected with the fixing plates (503), the guide slide ways (504) are arranged on the fixing plates (503), the two side seats (103) are both rotatably connected to the square frame (501), and the eccentric shafts (410) are slidably connected in the guide slide ways (504);
The two side seats (103) are both rotationally connected to the square frame (501), when the power shaft (408) rotates, the rotating wheel II (409) drives the eccentric shaft (410) to eccentrically rotate by taking the power shaft (408) as an axis, and the eccentric shaft (410) is in sliding connection with the setting in the guide slide way (504), so that the eccentric shaft (410) drives the support frame (104) when rotating, the mixing barrel (101) swings left and right in the square frame (501) by taking the two side seats (103) as an axis, and then the oscillation of the mixed liquid in the mixing barrel (101) is formed, so that larger bubbles in the mixed liquid float to the upper surface of the mixed liquid, and the high-quality contrast agent is obtained.
5. A contrast agent prepared using a method for preparing a cardiac contrast agent as claimed in claim 1, characterized in that: the contrast agent comprises the following raw materials in parts by weight: 100 parts of colloid solution, 25 parts of lopamidol and 10 parts of hemoglobin.
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| CN202110823097.6A CN113426313B (en) | 2021-07-21 | 2021-07-21 | Heart contrast agent and preparation method thereof |
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| CN202110823097.6A CN113426313B (en) | 2021-07-21 | 2021-07-21 | Heart contrast agent and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102114249A (en) * | 2009-12-30 | 2011-07-06 | 四川大学华西医院 | Oxygen-carrying coronary contrast agent and preparation method thereof |
| CN210143656U (en) * | 2019-05-27 | 2020-03-17 | 黄勇 | Farming uses portable insecticide sprinkler |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477393A (en) * | 1978-08-30 | 1984-10-16 | Dorr-Oliver Incorporated | Apparatus for dissolution of gases in liquid |
| CN111729559B (en) * | 2020-07-05 | 2022-04-01 | 江苏佳饰家新材料集团股份有限公司 | Green printing type printing ink production facility |
| CN112725277A (en) * | 2021-01-18 | 2021-04-30 | 李香伟 | Stem cell culture solution and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102114249A (en) * | 2009-12-30 | 2011-07-06 | 四川大学华西医院 | Oxygen-carrying coronary contrast agent and preparation method thereof |
| CN210143656U (en) * | 2019-05-27 | 2020-03-17 | 黄勇 | Farming uses portable insecticide sprinkler |
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