CN113426313A - Heart contrast agent and preparation method thereof - Google Patents
Heart contrast agent and preparation method thereof Download PDFInfo
- Publication number
- CN113426313A CN113426313A CN202110823097.6A CN202110823097A CN113426313A CN 113426313 A CN113426313 A CN 113426313A CN 202110823097 A CN202110823097 A CN 202110823097A CN 113426313 A CN113426313 A CN 113426313A
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- contrast agent
- cardiac
- fixedly connected
- preparing
- bottom plate
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- 239000002872 contrast media Substances 0.000 title claims abstract description 60
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 238000002156 mixing Methods 0.000 claims abstract description 37
- 230000000747 cardiac effect Effects 0.000 claims abstract description 31
- 239000011259 mixed solution Substances 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 239000012856 weighed raw material Substances 0.000 claims abstract description 5
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 4
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 4
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 claims abstract description 4
- 229960004647 iopamidol Drugs 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 35
- 238000003756 stirring Methods 0.000 claims description 22
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 20
- 239000001301 oxygen Substances 0.000 claims description 20
- 229910052760 oxygen Inorganic materials 0.000 claims description 20
- 239000007789 gas Substances 0.000 claims description 19
- 230000005540 biological transmission Effects 0.000 claims description 10
- 238000011177 media preparation Methods 0.000 abstract description 2
- 238000002601 radiography Methods 0.000 description 4
- 238000013184 cardiac magnetic resonance imaging Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000010355 oscillation Effects 0.000 description 3
- 230000035939 shock Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
Abstract
The invention relates to the field of preparation of contrast agents, in particular to a cardiac contrast agent and a preparation method thereof, wherein the contrast agent comprises the following raw materials in parts by weight: 100 parts of colloidal solution, 25 parts of iopamidol and 10 parts of hemoglobin; the method comprises the following steps: i, fully mixing the weighed raw materials to obtain a mixed solution; II, inflating the mixed solution; III, shaking the mixed solution mixed with the gas, and taking the mixed solution below to obtain the cardiac contrast agent; still use a contrast medium preparation facilities, including blending barrel, delivery pipe, side seat, support frame, bottom plate, rabbling mechanism and power unit, bottom plate fixed connection is in the center department of blending barrel lower extreme, and the rabbling mechanism changes to be connected on the bottom plate, is equipped with the valve on the delivery pipe, and the lower extreme fixedly connected with delivery pipe of blending barrel, the blending barrel outside symmetry are equipped with two side seats, and support frame fixed connection is on one of them side seat, and power unit connects on the support frame, power unit and rabbling mechanism sliding connection.
Description
Technical Field
The invention relates to the field of preparation of contrast agents, in particular to a cardiac contrast agent and a preparation method thereof.
Background
In recent years, cardiac magnetic resonance imaging has gained wide attention and application in diagnosing heart diseases as a non-invasive image analysis means. By using the cardiac magnetic resonance imaging technology, the blood flow conditions of the left ventricle, the right ventricle, the myocardial structure and valve tissue of the heart can be clearly observed, and a powerful image basis is provided for finding and treating heart diseases. In the clinical practice of cardiac magnetic resonance imaging, it is often necessary to inject a contrast agent to improve image contrast in order to obtain high-resolution images.
Disclosure of Invention
The invention aims to provide a cardiac contrast agent and a preparation method thereof, which have the beneficial effect that the mixing efficiency of raw materials can be improved by using a contrast agent preparation device.
The purpose of the invention is realized by the following technical scheme:
a method of preparing a cardiac contrast agent, the method comprising the steps of:
i, fully mixing the weighed raw materials to obtain a mixed solution;
II, inflating the mixed solution;
and III, shaking the mixed solution mixed with the gas, and taking the mixed solution below to obtain the cardiac contrast agent.
Preferably, the inflation gas is oxygen.
Preferably, the preparation method of the cardiac contrast agent further uses a contrast agent preparation device, the contrast agent preparation device comprises a mixing barrel, a discharge pipe, side seats, a support frame, a bottom plate, a stirring mechanism and a power mechanism, the bottom plate is fixedly connected to the center of the lower end of the mixing barrel, the stirring mechanism is rotatably connected to the bottom plate, a valve is arranged on the discharge pipe, the discharge pipe is fixedly connected to the lower end of the mixing barrel, the two side seats are symmetrically arranged on the outer side of the mixing barrel, the support frame is fixedly connected to one of the side seats, the power mechanism is connected to the support frame, and the power mechanism is in sliding connection with the stirring mechanism.
Preferably, rabbling mechanism includes rotatory pipe, stirred tubular and driving block, and a plurality of stirred tubular evenly set up in the outer end of rotatory pipe, and the lower extreme of rotatory pipe rotates to be connected on the bottom plate, and the upper end fixedly connected with driving block of rotatory intraductal wall.
Preferably, power unit includes lift post, thread groove, connecting seat, interlock board, runner I and power shaft, and lift post sliding connection is in the rotary pipe, and the thread groove sets up the surface at the lift post, and sliding connection has the transmission piece in the thread groove, and the connecting seat setting is in the upper end of lift post, and the interlock board rotates with the connecting seat to be connected, and the interlock board rotates with the eccentric department of runner I to be connected, and power shaft fixed connection is in the center department of runner I, and the power shaft rotates the upper end of connecting at the support frame.
Preferably, the contrast agent preparation device further comprises a dissolved air cavity and an air duct, the dissolved air cavity is arranged at the center of the lower end of the lifting column, the air duct is arranged on the connecting seat, and the air duct is communicated with the dissolved air cavity.
Preferably, the air duct is provided with a one-way valve.
Preferably, the contrast agent preparation device further comprises a central column, liquid guide holes and a central hole, wherein the central column is fixedly connected to the bottom plate, the central column is slidably connected to the dissolved air cavity, the central hole is formed in the center of the central column, the liquid guide holes are formed in the lower end of the central column, and the liquid guide holes are communicated with the central hole.
Preferably, the contrast agent preparation device further comprises a rotating wheel II, an eccentric shaft and a bearing frame, wherein the two side seats are rotatably connected to the bearing frame, the rotating wheel II is fixedly connected to one end of the power shaft, the eccentric shaft is fixedly connected to the eccentric position of the rotating wheel II, and the eccentric shaft is in sliding connection with the bearing frame.
The contrast agent prepared by the preparation method of the cardiac contrast agent comprises the following raw materials in parts by weight: 100 parts of colloidal solution, 25 parts of iopamidol and 10 parts of hemoglobin.
The invention has the beneficial effects that: the invention provides a cardiac contrast agent and a preparation method thereof, and the mixing efficiency of raw materials can be improved by using a contrast agent preparation device.
Drawings
FIG. 1 is a schematic illustration of an embodiment of the present invention for mixing raw materials;
FIG. 2 is a schematic cross-sectional view of an embodiment of the present invention with mixing of the feedstock;
FIG. 3 is a schematic view of the mixing tub of the present invention;
FIG. 4 is a schematic structural view of a stem according to the present invention;
FIG. 5 is a schematic structural view of the stirring mechanism of the present invention;
FIG. 6 is a schematic view of the power mechanism of the present invention;
FIG. 7 is a diagram illustrating an embodiment of a rocking oscillation according to the present invention;
FIG. 8 is a schematic view of the construction of the loading ledge of the present invention;
FIG. 9 is a diagram illustrating an embodiment of the present invention for enhancing oscillation;
FIG. 10 is a schematic view of the construction of the base plate of the present invention;
fig. 11 is a schematic structural diagram of the counterweight of the present invention.
In the figure:
a mixing tub 101; a discharge pipe 102; a side seat 103; a support frame 104;
a base plate 201; a central column 202; a drain hole 203; a central bore 204;
a rotating tube 301; a stirring pipe 302; a transmission block 303;
a lifting column 401; a thread groove 402; a gas dissolving cavity 403; a connecting base 404; an airway tube 405; a trace board 406; a runner I407; a power shaft 408; a rotating wheel II 409; an eccentric shaft 410;
a block 501; a leg shaft 502; a fixed plate 503; a guide slide 504; a limit plate 505; a stop collar 506; a spring 507;
a base plate 601; a support platelet 602; a counterweight block 603; a web 604.
Detailed Description
The following detailed description of the present invention will be made with reference to the accompanying drawings, but the present invention is not limited to the specific embodiments.
A method of preparing a cardiac contrast agent, the method comprising the steps of:
i, fully mixing the weighed raw materials to obtain a mixed solution;
II, inflating the mixed solution;
and III, shaking the mixed solution mixed with the gas, and taking the mixed solution below to obtain the cardiac contrast agent.
Preferably, the inflation gas is oxygen.
The oxygen is filled into the mixed solution to obtain the contrast agent carrying the oil and the oxygen, and the contrast agent has no obvious influence on the state and the development of the cardiac vessels, so that the quality of the cardiac radiography can be ensured, the cardiac vessels of patients can be provided with sufficient oxygen during the radiography, the risks of insufficient blood supply of the heart and myocardial ischemia and hypoxia injury in the cardiac radiography operation are reduced, the defects of the existing cardiac radiography technology and the contrast agent are overcome, the medical quality is improved, and the prognosis of the patients is improved.
Referring to FIGS. 1-4, examples of raw material mixing are illustrated;
the preparation method of the cardiac contrast agent further uses a contrast agent preparation device, the contrast agent preparation device comprises a mixing barrel 101, a discharge pipe 102, side seats 103, a support frame 104, a bottom plate 201, a stirring mechanism and a power mechanism, the bottom plate 201 is fixedly connected to the center of the lower end of the mixing barrel 101, the stirring mechanism is rotatably connected to the bottom plate 201, a valve is arranged on the discharge pipe 102, the lower end of the mixing barrel 101 is fixedly connected with the discharge pipe 102, the two side seats 103 are symmetrically arranged on the outer side of the mixing barrel 101, the support frame 104 is fixedly connected to one of the side seats 103, the power mechanism is connected to the support frame 104, and the power mechanism is slidably connected with the stirring mechanism.
When the device is used, weighed raw materials are poured into the mixing barrel 101, the power mechanism is started, the power mechanism drives the stirring mechanism to stir the raw materials in the mixing barrel 101, mixed liquid is obtained after the raw materials are uniformly stirred, then high-pressure inflation is carried out on the mixed liquid, then the mixed liquid mixed with gas is subjected to oscillation treatment, and the mixed liquid below is taken out to obtain the cardiac contrast agent.
Referring to fig. 5, an embodiment of the stirring mechanism is illustrated;
rabbling mechanism includes rotatory pipe 301, stirred tube 302 and driving block 303, and a plurality of stirred tubes 302 evenly set up in the outer end of rotatory pipe 301, and the lower extreme of rotatory pipe 301 rotates to be connected on bottom plate 201, the upper end fixedly connected with driving block 303 of rotatory pipe 301 inner wall.
During stirring, the power mechanism drives the transmission block 303, so that the transmission block 303 drives the stirring pipe 302 to rotate through the rotating pipe 301, and raw materials are stirred to be fully mixed.
Referring to fig. 6, an embodiment of the power mechanism is illustrated;
the power mechanism comprises a lifting column 401, a thread groove 402, a connecting seat 404, a linkage plate 406, a rotating wheel I407 and a power shaft 408, the lifting column 401 is connected in the rotating pipe 301 in a sliding mode, the thread groove 402 is formed in the outer surface of the lifting column 401, a transmission block 303 is connected in the thread groove 402 in a sliding mode, the connecting seat 404 is arranged at the upper end of the lifting column 401, the linkage plate 406 is connected with the connecting seat 404 in a rotating mode, the linkage plate 406 is connected with the eccentric position of the rotating wheel I407 in a rotating mode, the power shaft 408 is fixedly connected to the center of the rotating wheel I407, and the power shaft 408 is connected to the upper end of the supporting frame 104 in a rotating mode.
The driving motor is started to drive the power shaft 408, the power shaft 408 drives the rotating wheel I407 to rotate, then the connecting seat 404 drives the lifting column 401 to reciprocate in the rotary pipe 301 through the linkage plate 406, the lifting column 401 passes through the thread groove 402 when lifting, the transmission block 303 slides in the thread groove 402, then the transmission block 303 is formed to drive the reciprocating rotation of the rotary pipe 301, the rotary pipe 301 is formed to drive the stirring pipe 302 to rotate in a reciprocating manner by taking the axis of the rotary pipe 301 as the axis, the raw materials are stirred, the lifting column 401 reciprocates in the rotary pipe 301, when the lifting column 401 ascends in the rotary pipe 301, the mixed liquid enters the rotary pipe 301 through the stirring pipe 302, when the lifting column 401 descends in the rotary pipe 301, the mixed liquid rushes out of the rotary pipe 301 through the stirring pipe 302, and the mixing efficiency of the raw materials is further improved.
Preferably, the contrast medium preparation device further comprises a dissolved air cavity 403 and an air duct 405, the dissolved air cavity 403 is arranged at the center of the lower end of the lifting column 401, the air duct 405 is arranged on the connecting seat 404, and the air duct 405 is communicated with the dissolved air cavity 403.
The gas guide tube 405 is connected with an external oxygen source, oxygen is introduced into the gas dissolving cavity 403, the formed oxygen is contacted with the mixed liquid in the rotary tube 301, the formed oxygen is contacted and mixed with the mixed liquid, particularly when the lifting column 401 descends in the rotary tube 301, the descending of the lifting column 401 increases the mixing pressure of the oxygen and the mixed liquid, and the efficiency of dissolving the oxygen into the mixed liquid is improved.
Preferably, a one-way valve is arranged on the air duct 405.
Through the setting of the one-way valve on the air duct 405, when the descending of the lifting column 401 increases the mixed pressure of the oxygen and the mixed liquid, the oxygen backflow is avoided, and the efficiency of the oxygen dissolved into the mixed liquid is not affected.
Referring to FIGS. 1-6, examples of increasing the efficiency of oxygen gas dissolution into the mixed liquor are illustrated;
the contrast agent preparation device further comprises a central column 202, a liquid guide hole 203 and a central hole 204, wherein the central column 202 is fixedly connected to the bottom plate 201, the central column 202 is connected in the dissolved air cavity 403 in a sliding mode, the central hole 204 is arranged in the center of the central column 202, the liquid guide holes 203 are arranged at the lower end of the central column 202, and the liquid guide holes 203 are all communicated with the central hole 204.
Through the arrangement of the central column 202, the liquid guide hole 203 and the central hole 204, when the lifting column 401 rises in the rotating tube 301, the mixed liquid enters between the rotating tube 301 and the central column 202 from the stirring tube 302, simultaneously, because the space between the central column 202 and the gas dissolving cavity 403 is enlarged, the mixed liquid between the rotating tube 301 and the central column 202 enters into the gas dissolving cavity 403 through the liquid guide hole 203 and the central hole 204 to contact with oxygen, when the lifting column 401 descends in the rotating tube 301, the pressure in the gas dissolving cavity 403 is increased by matching with the central column 202, the efficiency of dissolving oxygen into the mixed liquid is improved, compared with the case that oxygen contacts with the mixed liquid in the rotating tube 301, because the stirring tubes 302 are uniformly distributed on the rotating tube 301, when the lifting column 401 descends, gas is easy to be sprayed out through the stirring tubes 302, only one central hole 204 is arranged on the central column 202 and is positioned at the lower end of the gas dissolving cavity 403, when the gas dissolving cavity is provided with the mixed liquid, the oxygen cannot be discharged in the gas dissolving cavity 403, so that the pressure increase in the gas dissolving chamber 403 becomes large and the oxygen loss is small.
Referring to FIGS. 7-8, an embodiment of mixed liquor shaking is illustrated;
the contrast agent preparation device further comprises a rotating wheel II 409, an eccentric shaft 410 and a bearing frame, wherein the two side bases 103 are rotatably connected to the bearing frame, the rotating wheel II 409 is fixedly connected to one end of a power shaft 408, the eccentric shaft 410 is fixedly connected to the eccentric position of the rotating wheel II 409, and the eccentric shaft 410 is in sliding connection with the bearing frame.
The bearing frame comprises a square frame 501, a supporting leg rod 502, a fixing plate 503 and a guide slideway 504, wherein the supporting leg rods 502 are fixedly connected at four corners of the square frame 501, the fixing plate 503 is fixedly connected at one end of the square frame 501, the guide slideway 504 is arranged on the fixing plate 503, the two side seats 103 are rotatably connected on the square frame 501, and the eccentric shafts 410 are slidably connected in the guide slideway 504.
The two side seats 103 are rotatably connected to the frame 501, when the power shaft 408 rotates, the eccentric shaft 410 is driven by the rotating wheel II 409 to eccentrically rotate by taking the power shaft 408 as a shaft, and the eccentric shaft 410 is slidably connected to the guide slideway 504, so that the eccentric shaft 410 drives the support frame 104 when rotating, the mixing barrel 101 swings left and right in the frame 501 by taking the two side seats 103 as the shaft, and then vibration of mixed liquid in the mixing barrel 101 is formed, larger bubbles in the mixed liquid can float to the upper surface of the mixed liquid, and a high-quality contrast agent is obtained.
Referring to FIGS. 9-11, the embodiment of the mixed liquor shaking is further illustrated;
the contrast agent preparation device further comprises a limiting ring 506, springs 507, a base plate 601 and supporting small plates 602, wherein the four corners of the base plate 601 are fixedly connected with the supporting small plates 602, the four supporting leg rods 502 are respectively connected in the four supporting small plates 602 in a sliding mode, the lower ends of the four supporting leg rods 502 are fixedly connected with the limiting ring 506, the upper end and the lower end of each limiting ring 506 are fixedly connected with the springs 507, the four springs 507 below are tightly propped against the base plate 601, and the four springs 507 above are tightly propped against the four supporting small plates 602 respectively.
Through the setting of bed plate 601, make the device place at the desktop through bed plate 601 to through the setting of spacing ring 506 and spring 507, carry out elastic support to landing leg pole 502, when the device operation, because mixing drum 101 left and right rocking, make the device produce vibrations, the left and right rocking of cooperation mixing drum 101 further strengthens the device to mixing liquid's in the mixing drum 101 shock, improves the efficiency that great bubble was wafted to the upper surface of mixed liquid in the mixed liquid.
The contrast agent preparation device further comprises a limiting plate 505, a balancing weight 603 and a connecting plate 604, wherein the two sides of the fixing plate 503 are fixedly connected with the limiting plate 505, the balancing weight 603 is slidably connected between the two limiting plates 505, the balancing weight 603 is fixedly connected with the connecting plate 604, and the connecting plate 604 is rotatably connected with the eccentric shaft 410.
Through the setting of balancing weight 603, when the device operates, eccentric shaft 410 drives balancing weight 603 through even board 604 and reciprocates between two limiting plates 505, has strengthened the device and has passed through the shock ability of spring 507, simultaneously through the weight of balancing weight 603, forms the extrusion and the drawing-up to spring 507, when the reinforcing shock ability, improves the stability of device, has avoided the holistic big vibrations of device, makes mixed liquid splash.
The contrast agent prepared by the preparation method of the cardiac contrast agent comprises the following raw materials in parts by weight: 100 parts of colloidal solution, 25 parts of iopamidol and 10 parts of hemoglobin.
Claims (10)
1. A preparation method of a cardiac contrast agent is characterized by comprising the following steps: the method comprises the following steps:
i, fully mixing the weighed raw materials to obtain a mixed solution;
II, inflating the mixed solution;
and III, shaking the mixed solution mixed with the gas, and taking the mixed solution below to obtain the cardiac contrast agent.
2. A method of preparing a cardiac contrast agent as defined in claim 1, wherein: the inflation gas is oxygen.
3. A method for preparing a cardiac contrast agent according to claim 2, wherein: the preparation method of the cardiac contrast agent further uses a contrast agent preparation device, the contrast agent preparation device comprises a mixing barrel (101), a discharge pipe (102), side seats (103), a support frame (104), a bottom plate (201), a stirring mechanism and a power mechanism, the bottom plate (201) is fixedly connected to the center of the lower end of the mixing barrel (101), the stirring mechanism is rotatably connected to the bottom plate (201), a valve is arranged on the discharge pipe (102), the discharge pipe (102) is fixedly connected to the lower end of the mixing barrel (101), the two side seats (103) are symmetrically arranged on the outer side of the mixing barrel (101), the support frame (104) is fixedly connected to one side seat (103), the power mechanism is connected to the support frame (104), and the power mechanism is in sliding connection with the stirring mechanism.
4. A method of preparing a cardiac contrast agent as claimed in claim 3, wherein: rabbling mechanism includes rotatory pipe (301), stirred tube (302) and transmission piece (303), and the outer end of rotatory pipe (301) evenly is equipped with a plurality of stirred tubes (302), and the lower extreme of rotatory pipe (301) rotates to be connected on bottom plate (201), and transmission piece (303) fixed connection is in the upper end of rotatory pipe (301) inner wall.
5. A method of preparing a cardiac contrast agent as claimed in claim 4, wherein: the power mechanism comprises a lifting column (401), a thread groove (402), a connecting seat (404), a linkage plate (406), a rotating wheel I (407) and a power shaft (408), the lifting column (401) is connected in the rotary pipe (301) in a sliding mode, the thread groove (402) is formed in the outer surface of the lifting column (401), a transmission block (303) is connected in the thread groove (402) in a sliding mode, the connecting seat (404) is arranged at the upper end of the lifting column (401), the linkage plate (406) is connected to the connecting seat (404) in a rotating mode, the upper end of the linkage plate (406) is connected to the eccentric position of the rotating wheel I (407) in a rotating mode, the power shaft (408) is fixedly connected to the center of the rotating wheel I (407), and the power shaft (408) is connected to the upper end of the supporting frame (104) in a rotating mode.
6. A method of preparing a cardiac contrast agent as claimed in claim 5, wherein: the contrast agent preparation device further comprises a dissolved air cavity (403) and an air duct (405), the dissolved air cavity (403) is arranged at the center of the lower end of the lifting column (401), and the air duct (405) is fixedly connected to the connecting seat (404) and communicated with the dissolved air cavity (403).
7. A method of preparing a cardiac contrast agent as defined in claim 6, wherein: the air duct (405) is provided with a one-way valve.
8. A method for preparing a cardiac contrast agent according to claim 7, wherein: the contrast agent preparation device further comprises a central column (202), liquid guide holes (203) and a central hole (204), wherein the central column (202) is fixedly connected to the bottom plate (201) and is connected to the inside of the gas dissolving cavity (403) in a sliding mode, the central hole (204) is formed in the center of the central column (202), the liquid guide holes (203) are formed in the lower end of the central column (202), and the liquid guide holes (203) are communicated with the central hole (204).
9. A method of preparing a cardiac contrast agent as claimed in claim 5, wherein: the contrast agent preparation device further comprises a rotating wheel II (409), an eccentric shaft (410) and a bearing frame, wherein the two side bases (103) are rotatably connected to the bearing frame, the rotating wheel II (409) is fixedly connected to one end of the power shaft (408), the eccentric shaft (410) is fixedly connected to the eccentric position of the rotating wheel II (409), and the eccentric shaft (410) is in sliding connection with the bearing frame.
10. A contrast agent prepared by a method for preparing a cardiac contrast agent according to claim 1, wherein: the contrast agent comprises the following raw materials in parts by weight: 100 parts of colloidal solution, 25 parts of iopamidol and 10 parts of hemoglobin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110823097.6A CN113426313A (en) | 2021-07-21 | 2021-07-21 | Heart contrast agent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110823097.6A CN113426313A (en) | 2021-07-21 | 2021-07-21 | Heart contrast agent and preparation method thereof |
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| CN113426313A true CN113426313A (en) | 2021-09-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110823097.6A Pending CN113426313A (en) | 2021-07-21 | 2021-07-21 | Heart contrast agent and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477393A (en) * | 1978-08-30 | 1984-10-16 | Dorr-Oliver Incorporated | Apparatus for dissolution of gases in liquid |
| CN102114249A (en) * | 2009-12-30 | 2011-07-06 | 四川大学华西医院 | Oxygen carrying coronary contrast medium and preparation method thereof |
| CN210143656U (en) * | 2019-05-27 | 2020-03-17 | 黄勇 | Farming uses portable insecticide sprinkler |
| CN111729559A (en) * | 2020-07-05 | 2020-10-02 | 邱金梅 | Green printing type printing ink production facility |
| CN112725277A (en) * | 2021-01-18 | 2021-04-30 | 李香伟 | Stem cell culture solution and preparation method thereof |
-
2021
- 2021-07-21 CN CN202110823097.6A patent/CN113426313A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477393A (en) * | 1978-08-30 | 1984-10-16 | Dorr-Oliver Incorporated | Apparatus for dissolution of gases in liquid |
| CN102114249A (en) * | 2009-12-30 | 2011-07-06 | 四川大学华西医院 | Oxygen carrying coronary contrast medium and preparation method thereof |
| CN210143656U (en) * | 2019-05-27 | 2020-03-17 | 黄勇 | Farming uses portable insecticide sprinkler |
| CN111729559A (en) * | 2020-07-05 | 2020-10-02 | 邱金梅 | Green printing type printing ink production facility |
| CN112725277A (en) * | 2021-01-18 | 2021-04-30 | 李香伟 | Stem cell culture solution and preparation method thereof |
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