CN113405326A - Efficient and continuous medicine drying device - Google Patents
Efficient and continuous medicine drying device Download PDFInfo
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- CN113405326A CN113405326A CN202110724147.5A CN202110724147A CN113405326A CN 113405326 A CN113405326 A CN 113405326A CN 202110724147 A CN202110724147 A CN 202110724147A CN 113405326 A CN113405326 A CN 113405326A
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/16—Drying solid materials or objects by processes not involving the application of heat by contact with sorbent bodies, e.g. absorbent mould; by admixture with sorbent materials
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/001—Handling, e.g. loading or unloading arrangements
- F26B25/002—Handling, e.g. loading or unloading arrangements for bulk goods
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/04—Agitating, stirring, or scraping devices
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B9/00—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards
- F26B9/06—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards in stationary drums or chambers
Abstract
The invention relates to a high-efficiency continuous medicine drying device which comprises a drying device body, wherein the drying device body comprises a device cavity and a device shell arranged on the surface of the device cavity, a discharge hole is formed in the upper port of the device cavity, a feed hole is formed in the lower port of the device cavity, a guide plate is arranged on one side, close to the discharge hole, in the device cavity, a flow dispersing plate is arranged on one side, close to the feed hole, in the device cavity, and a drying agent is filled between the guide plate and the flow dispersing plate. The medicine drying equipment provided by the invention has a good drying effect on gas or volatile medicines, and overcomes the defects of high danger, low dehydration efficiency and poor dehydration effect existing in the conventional drying of gas medicines. The air dispersing plate, the flow guide plate and the drying agent are arranged to contribute to the drying of air, and the heating layer and the heat insulation layer are used for providing a drying environment suitable for drying for the drying device.
Description
Technical Field
The invention relates to the field of medicine production equipment, in particular to an efficient and continuous medicine drying device.
Background
In the production of medicines, in order to ensure the uniformity and good fluidity of medicines, the raw materials are usually made into solid particles (pills, capsules and moments) by a certain method, the internal temperature of the medicines is raised by utilizing the heat effect and the non-heat effect of microwaves, pressure is generated, the transfer of confined water molecules is accelerated, the moisture in the processed objects is gradually evaporated outwards, and at the moment, proper hot air is further introduced into drying equipment to take away the evaporated moisture, so that the drying of the medicines is completed.
This is effective for drying solid chemicals, but is difficult to dry gaseous or volatile chemicals, and particularly, some of them are corrosive. The drying method of most of the currently used gas medicines comprises the following steps: first, wet drying, i.e., drying with a water-absorbing liquid; second, dry drying, i.e., dehydrating the gas with a different solid desiccant. The wet drying method generally adopts concentrated sulfuric acid for drying, so that the device is high in corrosivity and the risk of the concentrated sulfuric acid is high; in the dry drying process, because the contact area between the gas and the drying agent is small, the moisture in the gas is difficult to completely remove, and the defects of low dehydration efficiency, poor dehydration effect and the like generally exist.
Disclosure of Invention
The invention aims to overcome the defects of high danger, low dehydration efficiency and poor dehydration effect of the conventional method for drying gas medicines, and provides a high-efficiency continuous medicine drying device.
The purpose of the invention is realized by adopting the following technical scheme:
the utility model provides a high-efficient continuous medicine drying device, includes the drying device body, and the drying device body includes device cavity and sets up the device casing on device cavity surface, and the last port position of device cavity is provided with the discharge gate, and the lower port position of device cavity is provided with the feed inlet, and the inside one side that is close to the discharge gate of device cavity is provided with the guide plate, and the inside one side that is close to the feed inlet of device cavity is provided with the board that looses, and the packing is provided with the drier between guide plate and the board that looses.
Preferably, a plurality of groups of first baffles and second baffles are arranged between the guide plate and the flow dispersing plate, the first baffles are arranged on the left side of the inner wall of the device cavity, the second baffles are arranged on the right side of the inner wall of the device cavity, and the first baffles and the second baffles are arranged in a staggered mode at equal intervals.
Preferably, a heating layer and a heat preservation layer are arranged between the device cavity and the device shell, wherein the heating layer is arranged close to the device cavity, and the heat preservation layer is arranged close to the device shell.
Preferably, the heat-insulating layer is filled with a heat-insulating material, and the heat-insulating material is at least one of glass wool, mineral wool, aluminum silicate wool and asbestos.
Preferably, the guide plate and the flow dispersing plate are both made of ceramic materials. The flow dispersing plate is a plate with apertures of various sizes and directions, and the flow guide plate is a plate with apertures of uniform size and consistent direction.
The flow dispersing plate is used for dispersing gas entering from the feeding hole to form turbulent airflow, and the flow guide plate guides the turbulent airflow to form more uniform and stable airflow.
Preferably, the first baffle and the second baffle are both made of heat-conducting materials.
Preferably, the desiccant is a modified molecular sieve.
Preferably, the preparation method of the modified molecular sieve comprises the following steps:
s1, weighing a molecular sieve, crushing the molecular sieve into powder, and sieving the powder with a 120-mesh sieve to obtain micron-sized molecular sieve powder; weighing sodium polyacrylate and a sodium hydroxide solution, mixing, and fully mixing until the sodium polyacrylate and the sodium hydroxide are dissolved to obtain a sodium polyacrylate solution; wherein the mass ratio of the sodium polyacrylate to the sodium hydroxide solution is 1.2-1.8: 10, and the concentration of the sodium hydroxide solution is 0.1 mol/L;
s2, weighing seleno-L-cysteine and bismuth chloride, mixing, adding the mixture into N, N-dimethylformamide, fully stirring until the mixture is completely dissolved, adding micron-sized molecular sieve powder, performing ultrasound to form uniform mixed liquid, placing the mixture into a reaction kettle for reaction, setting the temperature of the reaction kettle to be 120-150 ℃, setting the reaction time to be 10-15 h, centrifuging, taking down a lower-layer solid, and washing and drying to obtain bismuth selenide/molecular sieve powder; wherein the mass ratio of the seleno-L-cysteine to the bismuth chloride to the N, N-dimethylformamide is 4.6-5.8: 1: 12-15, and the mass ratio of the micron-sized molecular sieve powder to the N, N-dimethylformamide is 1: 13-17;
s3, weighing basic zirconium carbonate powder, mixing the basic zirconium carbonate powder with bismuth selenide/molecular sieve powder, performing ball milling treatment in a planetary ball mill for 0.5-1 h, dropwise adding a sodium polyacrylate solution, and performing ball milling treatment again for 0.2-0.5 h to obtain a ball-milled mixture; wherein the mass ratio of the zirconium basic carbonate powder, the bismuth selenide/molecular sieve powder and the sodium polyacrylate solution is 1: 0.28-0.56: 3.2-4.8;
s4, performing compression molding on the ball-milled mixture, then placing the ball-milled mixture into a high-temperature reaction furnace for high-temperature treatment, cooling the ball-milled mixture to room temperature along with the furnace, and collecting a solid obtained after the high-temperature treatment, namely the modified molecular sieve; wherein the temperature of the high-temperature reaction furnace is set to be 545-585 ℃, the reaction time is set to be 8-12 h, and the heating speed is 2-5 ℃/min.
Preferably, the molecular sieve is at least one of a 5A molecular sieve, a 4A molecular sieve and a 3A molecular sieve.
The invention has the beneficial effects that:
1. the medicine drying equipment provided by the invention has a good drying effect on gas or volatile medicines, and overcomes the defects of high danger, low dehydration efficiency and poor dehydration effect existing in the conventional drying of gas medicines. The flow dispersing plate, the flow guide plate and the drying agent are arranged to contribute to the drying of the gas, and the heating layer and the heat insulation layer are arranged to provide a drying environment suitable for drying for the drying device.
2. The heating layer is arranged to prevent partial volatile gas from condensing on the drying agent due to cooling and provide heat for subsequent drying or activation of the drying agent, and the heat insulation layer is arranged to keep the whole body at a relatively stable temperature, so that the heat in the drying device is not wasted due to too fast heat dissipation.
3. The invention arranges the flow dispersing plate in the cavity of the device for dispersing the gas flowing into the drying agent to ensure that the gas is diffused in all directions, thereby not only enlarging the contact between the gas and the drying agent, but also preventing the gas from passing through the drying agent at the same position every time, ensuring that other drying agents can not fully play a role, and the flow guide plate is used for gathering the finally dried gas and leading the gas to the discharge hole so as to finish drying.
4. Compared with the molecular sieve in the conventional market, the modified molecular sieve prepared by the invention has more effective adsorption to water and can improve the integral dehydration efficiency of drying equipment.
Drawings
The invention is further illustrated by means of the attached drawings, but the embodiments in the drawings do not constitute any limitation to the invention, and for a person skilled in the art, other drawings can be obtained on the basis of the following drawings without inventive effort.
Fig. 1 is a schematic structural view of a high-efficiency continuous medicine drying device according to the present invention.
Reference numerals: the drying device comprises a drying device body 1, a device cavity 2, a device shell 3, a discharge hole 4, a feed inlet 5, a guide plate 6, a flow dispersing plate 7, a drying agent 8, a first baffle plate 9, a second baffle plate 10, a heating layer 11 and a heat preservation layer 12.
Detailed Description
For the purpose of more clearly illustrating the present invention and more clearly understanding the technical features, objects and advantages of the present invention, the technical solutions of the present invention will now be described in detail below, but are not to be construed as limiting the implementable scope of the present invention.
The molecular sieve is firstly crushed into 120-mesh micron-sized particles, and then the micron-sized particles react under the conditions of seleno-L-cysteine and bismuth chloride, the seleno-L-cysteine and the bismuth chloride can gradually grow into bismuth selenide under the reaction of a hot solvent, the bismuth selenide is in an orthorhombic hexahedral crystal structure and can vertically grow along the surface of the molecular sieve, the bismuth selenide is uniformly arranged on the surface of the molecular sieve, and the specific surface area of the molecular sieve is greatly increased; and then, grinding the zirconium basic carbonate and the bismuth selenide/molecular sieve powder by a planetary ball mill to enable the zirconium basic carbonate to be coated on the surface of the bismuth selenide/molecular sieve powder, then pressing the powder into a spherical shape, and reacting at the high temperature of 545-585 ℃, wherein the zirconium basic carbonate in the pressed forming product can be gradually decomposed to generate a zirconium oxide crystal in sufficient time, the zirconium oxide crystal can be fixed on the surface and in the pore diameter of the bismuth selenide/molecular sieve, and meanwhile, carbon dioxide gas is separated out in the decomposition process based on the zirconium basic carbonate, so that a porous zirconium oxide crystal structure is formed on the surface of the bismuth selenide/molecular sieve, and the specific surface area of the whole material is increased to a greater extent.
The invention is further described with reference to the following examples.
Example 1
The utility model provides a high-efficient continuous medicine drying device, as shown in figure 1, including drying device body 1, drying device body 1 includes device cavity 2 and sets up the device casing 3 on device cavity 2 surface, the last port position of device cavity 2 is provided with discharge gate 4, the lower port position of device cavity 2 is provided with feed inlet 5, the inside one side that is close to discharge gate 4 of device cavity 2 is provided with guide plate 6, the inside one side that is close to feed inlet 5 of device cavity 2 is provided with scattered flow plate 7, it is provided with drier 8 to fill between guide plate 6 and the scattered flow plate 7.
A plurality of groups of first baffles 9 and second baffles 10 are arranged between the guide plate 6 and the flow dispersing plate 7, the first baffles 9 are arranged on the left side of the inner wall of the device cavity 2, the second baffles 10 are arranged on the right side of the inner wall of the device cavity 2, and the first baffles 9 and the second baffles 10 are arranged in a staggered mode at equal intervals.
A heating layer 11 and a heat preservation layer 12 are arranged between the device cavity 2 and the device shell 3, wherein the heating layer 11 is arranged close to the device cavity 2, and the heat preservation layer 12 is arranged close to the device shell 3.
The heat-insulating layer 12 is filled with a heat-insulating material, which is mineral wool.
The guide plate 6 and the flow dispersing plate 7 are both prepared from ceramic materials. The flow dispersing plate 7 is a plate with various pore sizes and directions, and the flow guide plate 6 is a plate with uniform pore sizes and the same direction.
The flow dispersing plate 7 is used for dispersing the gas entering from the inlet 5 to form a turbulent gas flow, and the flow guide plate 6 is used for guiding the turbulent gas flow to form a more uniform and stable gas flow.
The first baffle 9 and the second baffle 10 are both made of heat-conducting materials.
When the device is used, gas or volatile medicines are fed from the feeding hole 5, heating equipment in the heating layer 11 is started when necessary (the medicines can be gasified by heating if necessary), after the heating equipment is started to a proper temperature, the gas is dispersed into the drying agent 8 through the flow dispersing plates 7 with different pore sizes and directions, then is gradually dispersed to the flow guide plate 6 through the drying of the drying agent 8, and the dried gas is discharged through the discharge hole 4.
Wherein, the drying agent 8 is a modified molecular sieve, and the preparation method of the modified molecular sieve comprises the following steps:
s1, weighing a 5A molecular sieve, crushing into powder, and sieving with a 120-mesh sieve to obtain micron-sized molecular sieve powder; weighing sodium polyacrylate and a sodium hydroxide solution, mixing, and fully mixing until the sodium polyacrylate and the sodium hydroxide are dissolved to obtain a sodium polyacrylate solution; wherein the mass ratio of the sodium polyacrylate to the sodium hydroxide solution is 1.5:10, and the concentration of the sodium hydroxide solution is 0.1 mol/L;
s2, weighing seleno-L-cysteine and bismuth chloride, mixing, adding the mixture into N, N-dimethylformamide, fully stirring until the mixture is completely dissolved, adding micron-sized molecular sieve powder, performing ultrasound to form uniform mixed liquid, placing the mixture into a reaction kettle for reaction, setting the temperature of the reaction kettle to be 120-150 ℃, setting the reaction time to be 10-15 h, centrifuging, taking down a lower-layer solid, and washing and drying to obtain bismuth selenide/molecular sieve powder; wherein the mass ratio of the seleno-L-cysteine to the bismuth chloride to the N, N-dimethylformamide is 5.2:1:13.5, and the mass ratio of the micron-sized molecular sieve powder to the N, N-dimethylformamide is 1: 15;
s3, weighing basic zirconium carbonate powder, mixing the basic zirconium carbonate powder with bismuth selenide/molecular sieve powder, performing ball milling treatment in a planetary ball mill for 0.5-1 h, dropwise adding a sodium polyacrylate solution, and performing ball milling treatment again for 0.2-0.5 h to obtain a ball-milled mixture; wherein the mass ratio of the zirconium basic carbonate powder, the bismuth selenide/molecular sieve powder and the sodium polyacrylate solution is 1:0.42: 3.8;
s4, performing compression molding on the ball-milled mixture, then placing the ball-milled mixture into a high-temperature reaction furnace for high-temperature treatment, cooling the ball-milled mixture to room temperature along with the furnace, and collecting a solid obtained after the high-temperature treatment, namely the modified molecular sieve; wherein the temperature of the high-temperature reaction furnace is set to 565 ℃, the reaction time is set to 10h, and the temperature rise speed is 3 ℃/min.
Example 2
The utility model provides a high-efficient continuous medicine drying device, as shown in figure 1, including drying device body 1, drying device body 1 includes device cavity 2 and sets up the device casing 3 on device cavity 2 surface, the last port position of device cavity 2 is provided with discharge gate 4, the lower port position of device cavity 2 is provided with feed inlet 5, the inside one side that is close to discharge gate 4 of device cavity 2 is provided with guide plate 6, the inside one side that is close to feed inlet 5 of device cavity 2 is provided with scattered flow plate 7, it is provided with drier 8 to fill between guide plate 6 and the scattered flow plate 7.
A plurality of groups of first baffles 9 and second baffles 10 are arranged between the guide plate 6 and the flow dispersing plate 7, the first baffles 9 are arranged on the left side of the inner wall of the device cavity 2, the second baffles 10 are arranged on the right side of the inner wall of the device cavity 2, and the first baffles 9 and the second baffles 10 are arranged in a staggered mode at equal intervals.
A heating layer 11 and a heat preservation layer 12 are arranged between the device cavity 2 and the device shell 3, wherein the heating layer 11 is arranged close to the device cavity 2, and the heat preservation layer 12 is arranged close to the device shell 3.
The heat-insulating layer 12 is filled with a heat-insulating material, and the heat-insulating material is glass wool.
The guide plate 6 and the flow dispersing plate 7 are both prepared from ceramic materials. The flow dispersing plate 7 is a plate with various pore sizes and directions, and the flow guide plate 6 is a plate with uniform pore sizes and the same direction.
The flow dispersing plate 7 is used for dispersing the gas entering from the inlet 5 to form a turbulent gas flow, and the flow guide plate 6 is used for guiding the turbulent gas flow to form a more uniform and stable gas flow.
The first baffle 9 and the second baffle 10 are both made of heat-conducting materials.
The drying agent 8 is a modified molecular sieve, and the preparation method of the modified molecular sieve comprises the following steps:
s1, weighing a 4A molecular sieve, crushing into powder, and sieving with a 120-mesh sieve to obtain micron-sized molecular sieve powder; weighing sodium polyacrylate and a sodium hydroxide solution, mixing, and fully mixing until the sodium polyacrylate and the sodium hydroxide are dissolved to obtain a sodium polyacrylate solution; wherein the mass ratio of the sodium polyacrylate to the sodium hydroxide solution is 1.2:10, and the concentration of the sodium hydroxide solution is 0.1 mol/L;
s2, weighing seleno-L-cysteine and bismuth chloride, mixing, adding the mixture into N, N-dimethylformamide, fully stirring until the mixture is completely dissolved, adding micron-sized molecular sieve powder, performing ultrasound to form uniform mixed liquid, placing the mixture into a reaction kettle for reaction, setting the temperature of the reaction kettle to be 120-150 ℃, setting the reaction time to be 10-15 h, centrifuging, taking down a lower-layer solid, and washing and drying to obtain bismuth selenide/molecular sieve powder; wherein the mass ratio of the seleno-L-cysteine to the bismuth chloride to the N, N-dimethylformamide is 4.6:1:12, and the mass ratio of the micron-sized molecular sieve powder to the N, N-dimethylformamide is 1: 13;
s3, weighing basic zirconium carbonate powder, mixing the basic zirconium carbonate powder with bismuth selenide/molecular sieve powder, performing ball milling treatment in a planetary ball mill for 0.5-1 h, dropwise adding a sodium polyacrylate solution, and performing ball milling treatment again for 0.2-0.5 h to obtain a ball-milled mixture; wherein the mass ratio of the zirconium basic carbonate powder, the bismuth selenide/molecular sieve powder and the sodium polyacrylate solution is 1:0.28: 3.2;
s4, performing compression molding on the ball-milled mixture, then placing the ball-milled mixture into a high-temperature reaction furnace for high-temperature treatment, cooling the ball-milled mixture to room temperature along with the furnace, and collecting a solid obtained after the high-temperature treatment, namely the modified molecular sieve; wherein the temperature of the high-temperature reaction furnace is set to be 545 ℃, the reaction time is set to be 8h, and the temperature rise speed is 2 ℃/min.
Example 3
The utility model provides a high-efficient continuous medicine drying device, as shown in figure 1, including drying device body 1, drying device body 1 includes device cavity 2 and sets up the device casing 3 on device cavity 2 surface, the last port position of device cavity 2 is provided with discharge gate 4, the lower port position of device cavity 2 is provided with feed inlet 5, the inside one side that is close to discharge gate 4 of device cavity 2 is provided with guide plate 6, the inside one side that is close to feed inlet 5 of device cavity 2 is provided with scattered flow plate 7, it is provided with drier 8 to fill between guide plate 6 and the scattered flow plate 7.
A plurality of groups of first baffles 9 and second baffles 10 are arranged between the guide plate 6 and the flow dispersing plate 7, the first baffles 9 are arranged on the left side of the inner wall of the device cavity 2, the second baffles 10 are arranged on the right side of the inner wall of the device cavity 2, and the first baffles 9 and the second baffles 10 are arranged in a staggered mode at equal intervals.
A heating layer 11 and a heat preservation layer 12 are arranged between the device cavity 2 and the device shell 3, wherein the heating layer 11 is arranged close to the device cavity 2, and the heat preservation layer 12 is arranged close to the device shell 3.
The heat-insulating layer 12 is filled with a heat-insulating material, and the heat-insulating material is aluminum silicate cotton.
The guide plate 6 and the flow dispersing plate 7 are both prepared from ceramic materials. The flow dispersing plate 7 is a plate with various pore sizes and directions, and the flow guide plate 6 is a plate with uniform pore sizes and the same direction.
The flow dispersing plate 7 is used for dispersing the gas entering from the inlet 5 to form a turbulent gas flow, and the flow guide plate 6 is used for guiding the turbulent gas flow to form a more uniform and stable gas flow.
The first baffle 9 and the second baffle 10 are both made of heat-conducting materials.
The drying agent 8 is a modified molecular sieve, and the preparation method of the modified molecular sieve comprises the following steps:
s1, weighing a 3A molecular sieve, crushing into powder, and sieving with a 120-mesh sieve to obtain micron-sized molecular sieve powder; weighing sodium polyacrylate and a sodium hydroxide solution, mixing, and fully mixing until the sodium polyacrylate and the sodium hydroxide are dissolved to obtain a sodium polyacrylate solution; wherein the mass ratio of the sodium polyacrylate to the sodium hydroxide solution is 1.8:10, and the concentration of the sodium hydroxide solution is 0.1 mol/L;
s2, weighing seleno-L-cysteine and bismuth chloride, mixing, adding the mixture into N, N-dimethylformamide, fully stirring until the mixture is completely dissolved, adding micron-sized molecular sieve powder, performing ultrasound to form uniform mixed liquid, placing the mixture into a reaction kettle for reaction, setting the temperature of the reaction kettle to be 120-150 ℃, setting the reaction time to be 10-15 h, centrifuging, taking down a lower-layer solid, and washing and drying to obtain bismuth selenide/molecular sieve powder; wherein the mass ratio of the seleno-L-cysteine to the bismuth chloride to the N, N-dimethylformamide is 5.8:1:15, and the mass ratio of the micron-sized molecular sieve powder to the N, N-dimethylformamide is 1: 17;
s3, weighing basic zirconium carbonate powder, mixing the basic zirconium carbonate powder with bismuth selenide/molecular sieve powder, performing ball milling treatment in a planetary ball mill for 0.5-1 h, dropwise adding a sodium polyacrylate solution, and performing ball milling treatment again for 0.2-0.5 h to obtain a ball-milled mixture; wherein the mass ratio of the zirconium basic carbonate powder, the bismuth selenide/molecular sieve powder and the sodium polyacrylate solution is 1:0.56: 4.8;
s4, performing compression molding on the ball-milled mixture, then placing the ball-milled mixture into a high-temperature reaction furnace for high-temperature treatment, cooling the ball-milled mixture to room temperature along with the furnace, and collecting a solid obtained after the high-temperature treatment, namely the modified molecular sieve; wherein the temperature of the high-temperature reaction furnace is set to 585 ℃, the reaction time is set to 12h, and the heating rate is 5 ℃/min.
Comparative example 1
A drying agent is a modified molecular sieve, and the preparation method of the modified molecular sieve comprises the following steps:
s1, weighing a 5A molecular sieve, crushing into powder, and sieving with a 120-mesh sieve to obtain micron-sized molecular sieve powder;
s2, weighing seleno-L-cysteine and bismuth chloride, mixing, adding the mixture into N, N-dimethylformamide, fully stirring until the mixture is completely dissolved, adding micron-sized molecular sieve powder, performing ultrasound to form uniform mixed liquid, placing the mixture into a reaction kettle for reaction, setting the temperature of the reaction kettle to be 120-150 ℃, setting the reaction time to be 10-15 h, centrifuging, taking down a lower-layer solid, and washing and drying to obtain bismuth selenide/molecular sieve powder; wherein the mass ratio of the seleno-L-cysteine to the bismuth chloride to the N, N-dimethylformamide is 5.2:1:13.5, and the mass ratio of the micron-sized molecular sieve powder to the N, N-dimethylformamide is 1: 15;
s3, pressing and forming the bismuth selenide/molecular sieve powder, then placing the bismuth selenide/molecular sieve powder into a high-temperature reaction furnace for high-temperature treatment, cooling the bismuth selenide/molecular sieve powder to room temperature along with the furnace, and collecting a solid obtained after the high-temperature treatment, namely the modified molecular sieve; wherein the temperature of the high-temperature reaction furnace is set to 565 ℃, the reaction time is set to 10h, and the temperature rise speed is 3 ℃/min.
Comparative example 2
A desiccant is 120 mesh 5A molecular sieve powder.
For more clearly explaining the content of the invention, the compression resistance experiment and the water absorption experiment of the drying agents prepared in the embodiments 1 to 3 and the comparative examples 1 to 2 are compared, the crushing resistance of the molecular sieve is detected according to the industry standard HG/T2783-.
The results are shown in Table 1.
TABLE 1 comparison of the Performance of different desiccants
As can be seen from Table 1, the drying agents prepared in the embodiments 1 to 3 of the present invention have good drying performance (no matter at high humidity and high temperature or at low humidity and low temperature) and high crushing resistance.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (9)
1. The utility model provides a high-efficient continuous medicine drying device, its characterized in that, includes the drying device body, the drying device body includes the device cavity and sets up the device casing on device cavity surface, and the last port position of device cavity is provided with the discharge gate, and the lower port position of device cavity is provided with the feed inlet, and the inside one side that is close to the discharge gate of device cavity is provided with the guide plate, and the inside one side that is close to the feed inlet of device cavity is provided with the board that looses, and the packing is provided with the drier between guide plate and the board.
2. An efficient and continuous medicine drying device as claimed in claim 1, wherein a plurality of sets of first baffle plates and second baffle plates are disposed between the flow guide plate and the flow dispersing plate, the first baffle plates are disposed on the left side of the inner wall of the cavity of the device, the second baffle plates are disposed on the right side of the inner wall of the cavity of the device, and the first baffle plates and the second baffle plates are staggered at equal intervals.
3. An efficient and continuous medicine drying device as claimed in claim 1, wherein a heating layer and an insulating layer are arranged between the device cavity and the device shell, wherein the heating layer is arranged close to the device cavity, and the insulating layer is arranged close to the device shell.
4. An efficient and continuous drug drying apparatus as in claim 3 wherein said insulation is filled with an insulation material which is at least one of glass wool, mineral wool, aluminum silicate wool and asbestos.
5. An efficient continuous pharmaceutical drying apparatus as defined in claim 1 wherein said baffle plate and said diffuser plate are both made of ceramic material.
6. An efficient continuous pharmaceutical drying apparatus as defined in claim 2 wherein said first baffle and said second baffle are both made of a thermally conductive material.
7. A high efficiency continuous pharmaceutical product drying apparatus as defined in claim 1 wherein said drying agent is a modified molecular sieve.
8. An efficient and continuous drug drying device as claimed in claim 7, wherein the modified molecular sieve is prepared by the following steps:
s1, weighing a molecular sieve, crushing the molecular sieve into powder, and sieving the powder with a 120-mesh sieve to obtain micron-sized molecular sieve powder; weighing sodium polyacrylate and a sodium hydroxide solution, mixing, and fully mixing until the sodium polyacrylate and the sodium hydroxide are dissolved to obtain a sodium polyacrylate solution; wherein the mass ratio of the sodium polyacrylate to the sodium hydroxide solution is 1.2-1.8: 10, and the concentration of the sodium hydroxide solution is 0.1 mol/L;
s2, weighing seleno-L-cysteine and bismuth chloride, mixing, adding the mixture into N, N-dimethylformamide, fully stirring until the mixture is completely dissolved, adding micron-sized molecular sieve powder, performing ultrasound to form uniform mixed liquid, placing the mixture into a reaction kettle for reaction, setting the temperature of the reaction kettle to be 120-150 ℃, setting the reaction time to be 10-15 h, centrifuging, taking down a lower-layer solid, and washing and drying to obtain bismuth selenide/molecular sieve powder; wherein the mass ratio of the seleno-L-cysteine to the bismuth chloride to the N, N-dimethylformamide is 4.6-5.8: 1: 12-15, and the mass ratio of the micron-sized molecular sieve powder to the N, N-dimethylformamide is 1: 13-17;
s3, weighing basic zirconium carbonate powder, mixing the basic zirconium carbonate powder with bismuth selenide/molecular sieve powder, performing ball milling treatment in a planetary ball mill for 0.5-1 h, dropwise adding a sodium polyacrylate solution, and performing ball milling treatment again for 0.2-0.5 h to obtain a ball-milled mixture; wherein the mass ratio of the zirconium basic carbonate powder, the bismuth selenide/molecular sieve powder and the sodium polyacrylate solution is 1: 0.28-0.56: 3.2-4.8;
s4, performing compression molding on the ball-milled mixture, then placing the ball-milled mixture into a high-temperature reaction furnace for high-temperature treatment, cooling the ball-milled mixture to room temperature along with the furnace, and collecting a solid obtained after the high-temperature treatment, namely the modified molecular sieve; wherein the temperature of the high-temperature reaction furnace is set to be 545-585 ℃, the reaction time is set to be 8-12 h, and the heating speed is 2-5 ℃/min.
9. An efficient continuous pharmaceutical product drying apparatus as defined in claim 8 wherein said molecular sieve is at least one of a 5A molecular sieve, a 4A molecular sieve and a 3A molecular sieve.
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