CN113383016A - 结合人IL-1β的抗体、其制备方法和用途 - Google Patents
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Abstract
本发明公开了一种全新结构的可结合人IL‑1β的抗体或其抗原结合片段，其具有良好的阻断IL‑1β与其受体相结合，从而下调IL‑1β活性的生物学功能，可应用于制备治疗IL‑1β过表达介导的免疫类疾病(例如关节炎、骨质疏松、肿瘤坏死因子受体相关周期性综合症等)的药物，具有良好的临床应用前景。
Description
PCT国内申请，说明书已公开。
Claims (16)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811322002 | 2018-11-07 | ||
| CN2018113220027 | 2018-11-07 | ||
| PCT/CN2019/115230 WO2020093957A1 (zh) | 2018-11-07 | 2019-11-04 | 结合人IL-1β的抗体、其制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113383016A true CN113383016A (zh) | 2021-09-10 |
| CN113383016B CN113383016B (zh) | 2022-09-13 |
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| CN201980064671.5A Active CN113383016B (zh) | 2018-11-07 | 2019-11-04 | 结合人IL-1β的抗体、其制备方法和用途 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11976115B2 (zh) |
| EP (1) | EP3878867A4 (zh) |
| JP (1) | JP7256266B2 (zh) |
| CN (1) | CN113383016B (zh) |
| WO (1) | WO2020093957A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117126278A (zh) * | 2023-10-26 | 2023-11-28 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种单克隆抗体及其应用 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113855807A (zh) * | 2021-10-25 | 2021-12-31 | 孙良丹 | 一种试剂在制备治疗/抑制银屑病药物中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995001997A1 (en) * | 1993-07-09 | 1995-01-19 | Smithkline Beecham Corporation | RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN |
| CN104341501A (zh) * | 2013-07-29 | 2015-02-11 | 上海睿智化学研究有限公司 | 抗IL-1β人源化单克隆抗体及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0020685D0 (en) | 2000-08-22 | 2000-10-11 | Novartis Ag | Organic compounds |
| GB0303337D0 (en) * | 2003-02-13 | 2003-03-19 | Celltech R&D Ltd | Biological products |
| AU2006208286A1 (en) * | 2005-01-26 | 2006-08-03 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
| RU2013115927A (ru) * | 2010-09-10 | 2014-10-20 | Апексиджен, Инк. | АНТИТЕЛА ПРОТИВ ИЛ-1β И СПОСОБЫ ПРИМЕНЕНИЯ |
| US20150017157A1 (en) * | 2011-12-19 | 2015-01-15 | Xoma (Us) Llc | Methods for treating acne |
| WO2016008851A1 (en) * | 2014-07-14 | 2016-01-21 | Boehringer Ingelheim International Gmbh | Anti-il-1b antibodies |
| CN106928354B (zh) * | 2017-04-25 | 2020-07-17 | 长春金赛药业有限责任公司 | 抗IL-1β单克隆抗体及其应用 |
-
2019
- 2019-11-04 US US17/292,384 patent/US11976115B2/en active Active
- 2019-11-04 CN CN201980064671.5A patent/CN113383016B/zh active Active
- 2019-11-04 JP JP2021523978A patent/JP7256266B2/ja active Active
- 2019-11-04 EP EP19882764.4A patent/EP3878867A4/en active Pending
- 2019-11-04 WO PCT/CN2019/115230 patent/WO2020093957A1/zh unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995001997A1 (en) * | 1993-07-09 | 1995-01-19 | Smithkline Beecham Corporation | RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN |
| CN104341501A (zh) * | 2013-07-29 | 2015-02-11 | 上海睿智化学研究有限公司 | 抗IL-1β人源化单克隆抗体及其制备方法和应用 |
Non-Patent Citations (2)
| Title |
|---|
| ABHIJIT CHAKRABORTY: "Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1β monoclonal antibody", 《CLINICAL PHARMACOKINETICS》 * |
| 刘佳佳等: "重组人IL-1β分子的克隆表达及其单克隆抗体的制备", 《苏州大学学报(医学版)》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117126278A (zh) * | 2023-10-26 | 2023-11-28 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种单克隆抗体及其应用 |
| CN117126278B (zh) * | 2023-10-26 | 2024-01-05 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种单克隆抗体及其应用 |
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| US11976115B2 (en) | 2024-05-07 |
| JP2022506561A (ja) | 2022-01-17 |
| JP7256266B2 (ja) | 2023-04-11 |
| EP3878867A1 (en) | 2021-09-15 |
| EP3878867A4 (en) | 2022-07-06 |
| CN113383016B (zh) | 2022-09-13 |
| WO2020093957A1 (zh) | 2020-05-14 |
| US20220064282A1 (en) | 2022-03-03 |
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