CN1133728A - Tonic infusion of Schisandra fruit for liver - Google Patents
Tonic infusion of Schisandra fruit for liver Download PDFInfo
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- CN1133728A CN1133728A CN 96100786 CN96100786A CN1133728A CN 1133728 A CN1133728 A CN 1133728A CN 96100786 CN96100786 CN 96100786 CN 96100786 A CN96100786 A CN 96100786A CN 1133728 A CN1133728 A CN 1133728A
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Abstract
An instant particles for curing hepatitis B with high curative effect and low cost is prepared from giant knotweed rhizome, gynostemma pentaphyllum, patrinia herb, mulberry and liquorice root.
Description
The present invention relates to a kind of tonic infusion of Schisandra fruit for liver for the treatment of hepatitis B and preparation method thereof.
In recent years, the quantity of hepatitis is growing on and on, there are nearly 200,000,000 HBV carriers in the whole world, wherein 1～2%HBSAg positive patient is CHB (chb) and HCC (hepatocarcinoma), 20～70% CAH (chronic active hepatitis) state of an illness in 2～7 years increases the weight of, case fatality rate in its 5 years is up to 25～50%, and what make that the clinician has a headache most is the treatment problem of hepatitis B.Although the medicine of treatment hepatitis B is a lot of on the market, still there is not a kind of specific drug for the treatment of hepatitis B.At home, the control of Chinese medicine pick is just at the early-stage, develops oleanolic acid tablet, cucurbitacin sheet, glycyrrhizin tablet, YIGANNING CHONGJI, compound recipe Ganoderma applanatum (Pers. Ex Wallr) Pat. sheet, compound liver-benepitino remedy in succession, the spirit difficult to understand or the like of going out, but curative effect is still very dissatisfied.Abroad, Locarninis proposition HBV infects optimal therapeutic scheme and should comprise (1) antiviral performance, (2) antigen-binding energy, (3) immunomodulating performance, (4) liver protection effect, the medicine of relevant treatment hepatitis B is many, regrettably still do not have a kind of medicine so far and come out, and cost an arm and a leg with above-mentioned four kinds of performances.
Purpose of the present invention is exactly to develop a kind of new drug that can treat hepatitis B, and this medicament had both had the above four kinds of performance, and medicine source abundance again, low price, and convenient oral, characteristics such as have no side effect.The tonic infusion of Schisandra fruit for liver of treatment hepatitis B provided by the invention only is made into by Chinese medicine of the five flavours, and prescription is simple, and is evident in efficacy.
The tonic infusion of Schisandra fruit for liver of treatment hepatitis B of the present invention comprises:
Rhizoma Polygoni Cuspidati 20～100g Herb Gynostemmae Pentaphylli 15～80g Patrinia scabiosaefolia Fisch grass 10～70g
Fructus Mori 10～70g Radix Glycyrrhizae 5～50g
Can comprise in addition in the general Chinese medicine electuary and poke the excipient that adds, cane sugar powder etc., its addition is similar to general Chinese medicine electuary.
To not reach effect of the present invention if be lower than the low limit value of prescription, be higher than the ceiling value electuary the toxigenicity side effect.
Tonic infusion of Schisandra fruit for liver preferred version of the present invention is:
Rhizoma Polygoni Cuspidati 25～80g Herb Gynostemmae Pentaphylli 15～70g Patrinia scabiosaefolia Fisch grass 12～60g
Fructus Mori 10～50g Radix Glycyrrhizae 5～30g.
The preparation method of above-mentioned tonic infusion of Schisandra fruit for liver is: former medicated powder is pulverized in proportion be coarse powder, pack in the heating container, adding the steaming decocting boils 1-2 time, each water yield is 4～6 times of former medicated powder amount, decocting time is 1 hour, decoction liquor merges filters, filtrate decompression is condensed into extractum, adds 2 times of amount 80% alcoholic solution in extractum, stirs, leaves standstill 24 hours, filter, ethanol in the reclaim under reduced pressure filtrate, gained magma low-temperature evaporation again gets extractum, adds figuration powder and cane sugar powder in extractum, granulation, drying, packing promptly gets the tonic infusion of Schisandra fruit for liver finished product.
In the prescription of the present invention, nontoxic, the dampness removing of Rhizoma Polygoni Cuspidati bitter cold, the merit of the blood stasis expelling of invigorating blood circulation is thought the master, Herba Patriniae works hard, is slightly cold, nontoxic, and the merit of heat-clearing and toxic substances removing, blood stasis expelling detumescence is arranged, and is for auxilliary; Nontoxic, the heat-clearing and toxic substances removing of gynostemma pentaphyllum bitter cold, tonification liver, kidney; Fructus Mori property is sweet to be slightly cold, the moon of nontoxic, liver nourishing lung and enrich blood and think and help; Sweet flat, the invigorating the spleen and replenishing QI of Radix Glycyrrhizae, the mediation property of medicine, and separate hundred poison for making.
Liver body the moon (store blood) and with the sun (catharsis).Liver being bold and firm viscera happiness is cloudy gentle and dislike dryly, and the happiness bar reaches and dislikes depression, and the pathological change of liver is: YIN often being in shortage, YANG often being in excess, thus hepatopathy frequent fever disease, empty person's deficiency of YIN and yang hyperactivity, real person's the moon is had a surplus and the fire inflammation, or dampness-heat in the liver and gallbladder, the fire-transformation removing toxic substances.Kidney belongs to water and is the mother of liver, the lung belonging to metal and be the source of unboiled water, the moon of nourishing the lung and kidney is basis of the liver benefiting, liver-yin needs the biochemistry (the spleen being in charge of dampness, main fortuneization) of spleen, the biochemistry of spleen needs the catharsis of liver, the few power of hepatopathy and catharsis then can cause the retention of water-damp of spleen, and fortuneization is unable, suppress the normal catharsis of liver and cause depression of liver-QI, so hepatopathy is related to liver, spleen, lung, kidney, four dirty, clinical show as dampness-heat in the liver and gallbladder, qi stagnation blood stasis more, deficiency of spleen-QI and stomach-QI, the hepatic and renal YIN deficiency four types, and hepatitis B four types have both for many, are the weight difference.Tonic infusion of Schisandra fruit for liver is drafted according to the dialectical theory of motherland's medical science, based on liver heat removing through pyretic toxicity, note controlling the medicine for treatment of hepatic disease spleen, control the medicine for treatment of hepatic disease kidney, treating the liver must be enriched blood, nourished blood, the theory of activating blood circulation to dissipate blood stasis, and the sweet cold of its property of medicine is gentle, YIN nourishing and do not stagnate evil, dampness removing and non-impairment of YIN are changed silt and are not just hindered, heat clearing away and non-impairment of YANG (melancholy of the no bitter cold impairment of the spleen), all medicine combinations, complement each other, to promoting immunity, eliminate virus eventually, reach the purpose of anti-hepatitis B surface antigen, the treatment, the medicine source that are applicable to various viral hepatitis are wide, and low price is beneficial to popularization.
Pharmacodynamic test of active extract of the present invention: tonic infusion of Schisandra fruit for liver is to the protective effect of experimental hepatic injury
1 experiment material
1.1 animal Wistar rat weighs 180～220g, the male and female dual-purpose.
2.2 medicine and reagent tonic infusion of Schisandra fruit for liver, lot number 921108; The positive control drug YIGANNING CHONGJI is provided by Jiuzhitang Pharmaceutical Factory, lot number 910803; Carbon tetrachloride provides (import packing) by Guangzhou Medical Depot chemical reagents corporation.
2 methods
2.1 method is got 32 of Wistar rats, male and female half and half.Be divided into normal control group (normal saline), hepatic injury group, tonic infusion of Schisandra fruit for liver group (4g/kg) and YIGANNING CHONGJI group (4.7g/kg) at random.Test the 1st, 5 day subcutaneous injection of carbon tetrachloride 5ml/kg, cause liver injury model.And in experiment the 1st～6 day by the group difference, the subcutaneous injection medicine and etc. dosage normal saline (5ml/kg).Test and put to death animal on the 7th day, get serum and survey glutamate pyruvate transaminase (SGPT), serum towards albumen, albumin and globulin.Get hepatic tissue simultaneously and be fixed in 10% formalin solution, routine paraffin wax embedded section, HE dyeing.Other gets the part hepatic tissue and is fixed in the Canoy liquid, and the green group of first rather dyes and shows RNA, and PAS dyeing shows glycogen, carries out histochemistry and observes.
2.2 the date processing mean takes statistics to learn with t check and rank test and handles so that X ± S is represented.P=0.05 is the statistically significant level.
3 results
3.1 to the rising (comparing P＜0.01 with the carbon tetrachloride hepatic injury group) that tonic infusion of Schisandra fruit for liver can obviously reduce the serum SGPT due to the carbon tetrachloride that influences of SGPT, it reduces the amplitude and YIGANNING CHONGJI suitable (P＞0.05) of SGPT.Each group (n=8) SGPT (u) value: carbon tetrachloride 161 ± 63, tonic infusion of Schisandra fruit for liver 53 ± 16, proheparin electuary 60 ± 21, blank 33 ± 9.3.2 to the influence of serum albumin, tonic infusion of Schisandra fruit for liver does not have obvious influence (all P＞0.05) to the Rats with Acute Liver Injury serum albumin.(table 1)
Table 1 total serum protein, albumin, globulin value (g/L, X ± S, n=8)
| Group | Total protein | Albumin | Globulin |
| Carbon tetrachloride tonic infusion of Schisandra fruit for liver YIGANNING CHONGJI blank | 64±6 60±4 57±4 67±4 | 26±5 24±2 21±3 27±2 | 38±4 36±4 36±4 39±4 |
3.3 the rank test that influences to the hepatic tissue chemistry shows, tonic infusion of Schisandra fruit for liver can obviously alleviate hepatocellular cloudy swelling, steatosis and inflammatory reaction (all P＜0.05), and make that RNA and glycogen obviously increase (P＜0.05) in the hepatic tissue, and do not see that nucleus becomes big, engrain and karyokinesis resembles (the hepatic injury group is obvious), do not have significance (P＞0.05) with YIGANNING CHONGJI group comparing difference.(table 2)
Table 2 medicine is to Rats with Acute Liver Injury and histochemical influence (n=8)
| Group | Cloudy swelling | Steatosis | Downright bad | Inflammatory reaction | ??RNA | Glycogen |
| ?????+ ?-?+ ?????+ | ?+???????+ ???????+ ?+?-?+???+ ???????+ ?+???????+ | ????-?+?+ | ????????+ ??????+ ??-?+???+?- ??????+ ????????+ | ?????+ ?±?+???- ?????+ | ????????+ ??????+ ??±?+???+ ??????+ ????????+ | |
| Hepatic injury group YIGANNING CHONGJI tonic infusion of Schisandra fruit for liver | ?0?0?3 ?0?3?5 ?0?0?7 | ?5?0?3?2?3 ?0?0?4?2?2 ?1?1?3?4?0 | ????0?6?2 ????4?3?1 ????1?6?1 | ??0?0?4?4?4 ??0?5?3?0?1 ??0?6?2?0?0 | ?2?2?0?7 ?2?3?2?2 ?3?3?2?4 | ??1?0?0?0 ??1?2?2?1 ??0?1?2?1 |
4, discuss
Tonic infusion of Schisandra fruit for liver has obvious protective effect to acute liver injury.It can make serum SGPT significantly reduce, and alleviates hepatocyte cloudy swelling, steatosis and inflammatory reaction etc., makes RNA and glycogen increase in the hepatic tissue simultaneously.It is generally acknowledged that carbon tetrachloride produces free radical in the reduction activation of hepatomicrosome internal diameter, the destruction by lipid peroxide makes hepatocyte impaired, causes serum transaminase to increase.According to theory of Chinese medical science, hepatitis B is to be main pathogenesis with damp-heat accumulation.And tonic infusion of Schisandra fruit for liver has expelling wind and removing dampness, and the effects such as YIN nourishing, invigorating the spleen and replenishing QI of enriching blood are so have certain curative effect to hepatitis.But it does not have obvious influence to the serum albumin of acute liver injury, may be short relevant with administration time.Tonic infusion of Schisandra fruit for liver is suitable to the curative effect and the YIGANNING CHONGJI of experimental hepatic injury.
The safe animal acute toxicity test of five tastes liver of the present invention
The Kunming that 1 animal is provided by the institute for drug control, Hunan Province is healthy mice, body weight 18-22 gram, and male and female are various.Fasting before the experiment, 24 ℃ of room temperatures, animal feed is conventional piece material.
2 route of administration, dosage and grouping
(1) oral administration gavage group LD50 measures: press animal body weight, sex, be divided into five groups at random, 10 every group.
Tonic infusion of Schisandra fruit for liver, lot number is 921005, medicine is prepared with normal saline.
Dosage I organizes 30g/kg;
II organizes 22.5g/kg;
III organizes 16.875g/kg;
IV organizes 12.65g/kg;
V organizes 9.48g/kg.
Disposable gastric infusion, the administration volume is 0.3ml/10g, observes a week continuously after the administration, observes behavior symptom and the death condition of animal.
Experimental result: five tastes liver is safe to behind the mouse stomach, and animal activity reduces in rarely seen several minutes, promptly returns to the preceding situation of administration subsequently; Animal activity, appetite, hair color are all normal, none animal dead in seven days.
(2) the safe lumbar injection LD50 of five tastes liver measures: press animal body weight, sex, divide 4 groups at random, every group of 5 mices.On the basis of prerun, 4 dosage groups are set, animal dead number in seven days after the accumulative total administration.
Calculate: use the Kou Shi improved method and calculate
| Group | Dosage g/kg | ?n | ?r | ?P | ?P 2 |
| I group II group III group IV group | ??4.5 ??3.37 ??2.53 ??1.90 | ?5 ?5 ?5 ?5 | ?5 ?3 ?1 ?0 | ?1 ?0.6 ?0.2 ?0 | ?1 ?0.36 ?0.04 ?0 |
LD50＝3.09g/kg
The 95% credible 2.58～3.69g/kg that is limited to of LD50.
3 results are by oral and two kinds of route of administration experiments of lumbar injection, and visible tonic infusion of Schisandra fruit for liver toxicity is very low, belongs to nontoxic substantially scope.
Claims (3)
1, a kind of tonic infusion of Schisandra fruit for liver for the treatment of hepatitis B comprises:
Rhizoma Polygoni Cuspidati 20～100g Herb Gynostemmae Pentaphylli 15～80g Patrinia scabiosaefolia Fisch grass 10～70g
Fructus Mori 10～70g Radix Glycyrrhizae 5～50g
2, tonic infusion of Schisandra fruit for liver according to claim 1, wherein:
Rhizoma Polygoni Cuspidati 25～80g Herb Gynostemmae Pentaphylli 15～70g Patrinia scabiosaefolia Fisch grass 12～60g
Fructus Mori 10～50g Radix Glycyrrhizae 5～30g
3, the method for preparing the described tonic infusion of Schisandra fruit for liver of claim 1 comprises former medicated powder is ground into coarse powder in proportion, is 4～6 times of former medicated powder amount, decocting time is 1 hour, and decoction liquor merges filters, and filtrate decompression is condensed into extractum, in extractum, add 2 times of amount 80% alcoholic solution, stir, left standstill 24 hours, filter, ethanol in the reclaim under reduced pressure filtrate, gained magma low-temperature evaporation again gets extractum, adds figuration powder and cane sugar powder in extractum, granulation, drying, packing gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96100786 CN1133728A (en) | 1996-02-07 | 1996-02-07 | Tonic infusion of Schisandra fruit for liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96100786 CN1133728A (en) | 1996-02-07 | 1996-02-07 | Tonic infusion of Schisandra fruit for liver |
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| Publication Number | Publication Date |
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| CN1133728A true CN1133728A (en) | 1996-10-23 |
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| CN 96100786 Pending CN1133728A (en) | 1996-02-07 | 1996-02-07 | Tonic infusion of Schisandra fruit for liver |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083700C (en) * | 1999-03-01 | 2002-05-01 | 施友彬 | Shiganbao capsula as one kind of nutritious food |
| CN104127536A (en) * | 2013-10-21 | 2014-11-05 | 金秀瑶族自治县瑶医医院 | Liver-clearing, cholagogic and detoxifying electuary and preparation method thereof |
-
1996
- 1996-02-07 CN CN 96100786 patent/CN1133728A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083700C (en) * | 1999-03-01 | 2002-05-01 | 施友彬 | Shiganbao capsula as one kind of nutritious food |
| CN104127536A (en) * | 2013-10-21 | 2014-11-05 | 金秀瑶族自治县瑶医医院 | Liver-clearing, cholagogic and detoxifying electuary and preparation method thereof |
| CN104127536B (en) * | 2013-10-21 | 2016-03-23 | 金秀瑶族自治县瑶医医院 | Liver heat removing function of gallbladder promoting removing toxic substances electuary and preparation method thereof |
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