CN113368008A - 去角质化妆品组合物 - Google Patents
去角质化妆品组合物 Download PDFInfo
- Publication number
- CN113368008A CN113368008A CN202110261852.6A CN202110261852A CN113368008A CN 113368008 A CN113368008 A CN 113368008A CN 202110261852 A CN202110261852 A CN 202110261852A CN 113368008 A CN113368008 A CN 113368008A
- Authority
- CN
- China
- Prior art keywords
- cosmetic composition
- exfoliating
- exfoliating cosmetic
- mass
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 116
- 239000002537 cosmetic Substances 0.000 title claims abstract description 100
- 229920001195 polyisoprene Polymers 0.000 claims abstract description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 239000002562 thickening agent Substances 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 239000004909 Moisturizer Substances 0.000 claims description 5
- 230000001333 moisturizer Effects 0.000 claims description 5
- 239000002699 waste material Substances 0.000 abstract description 18
- 230000007794 irritation Effects 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 10
- -1 polyoxypropylene Polymers 0.000 description 27
- 239000003795 chemical substances by application Substances 0.000 description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 17
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 16
- 239000002244 precipitate Substances 0.000 description 16
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 15
- 238000011156 evaluation Methods 0.000 description 15
- 235000014113 dietary fatty acids Nutrition 0.000 description 14
- 239000000194 fatty acid Substances 0.000 description 14
- 229930195729 fatty acid Natural products 0.000 description 14
- 229920000642 polymer Polymers 0.000 description 14
- 239000003921 oil Substances 0.000 description 13
- 235000019198 oils Nutrition 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 12
- 229920002125 Sokalan® Polymers 0.000 description 8
- 239000002253 acid Substances 0.000 description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 8
- 239000000499 gel Substances 0.000 description 8
- 235000011187 glycerol Nutrition 0.000 description 8
- 239000000839 emulsion Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 6
- 239000004166 Lanolin Substances 0.000 description 6
- 229960001631 carbomer Drugs 0.000 description 6
- 230000008021 deposition Effects 0.000 description 6
- 150000004665 fatty acids Chemical class 0.000 description 6
- 125000005456 glyceride group Chemical group 0.000 description 6
- 235000019388 lanolin Nutrition 0.000 description 6
- 229940039717 lanolin Drugs 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 108010076876 Keratins Proteins 0.000 description 5
- 102000011782 Keratins Human genes 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 5
- 239000004359 castor oil Substances 0.000 description 5
- 235000019438 castor oil Nutrition 0.000 description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- 229920000832 Cutin Polymers 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 239000003925 fat Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 239000012188 paraffin wax Substances 0.000 description 4
- 229920001451 polypropylene glycol Polymers 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 235000015278 beef Nutrition 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 239000003973 paint Substances 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 229940058015 1,3-butylene glycol Drugs 0.000 description 2
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 239000002612 dispersion medium Substances 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 239000010696 ester oil Substances 0.000 description 2
- CYKDLUMZOVATFT-UHFFFAOYSA-N ethenyl acetate;prop-2-enoic acid Chemical compound OC(=O)C=C.CC(=O)OC=C CYKDLUMZOVATFT-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 229940094522 laponite Drugs 0.000 description 2
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 150000003432 sterols Chemical class 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- 235000019871 vegetable fat Nutrition 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- BJDAUCLANVMIOB-UHFFFAOYSA-N (3-decanoyloxy-2,2-dimethylpropyl) decanoate Chemical compound CCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCC BJDAUCLANVMIOB-UHFFFAOYSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- ZWVMLYRJXORSEP-UHFFFAOYSA-N 1,2,6-Hexanetriol Chemical compound OCCCCC(O)CO ZWVMLYRJXORSEP-UHFFFAOYSA-N 0.000 description 1
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 1
- LGEZTMRIZWCDLW-UHFFFAOYSA-N 14-methylpentadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C LGEZTMRIZWCDLW-UHFFFAOYSA-N 0.000 description 1
- ABEXEQSGABRUHS-UHFFFAOYSA-N 16-methylheptadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C ABEXEQSGABRUHS-UHFFFAOYSA-N 0.000 description 1
- RNNHLXAEVKCLDG-UHFFFAOYSA-N 2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane Chemical compound C[Si]1(C)O[SiH2]O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 RNNHLXAEVKCLDG-UHFFFAOYSA-N 0.000 description 1
- RKJGFHYCZPZJPE-UHFFFAOYSA-N 2,2-bis(16-methylheptadecanoyloxymethyl)butyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C RKJGFHYCZPZJPE-UHFFFAOYSA-N 0.000 description 1
- QOOJEEZYYXGPAO-UHFFFAOYSA-N 2,2-bis(2-ethylhexanoyloxymethyl)butyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(CC)(COC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC QOOJEEZYYXGPAO-UHFFFAOYSA-N 0.000 description 1
- XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- SFAAOBGYWOUHLU-UHFFFAOYSA-N 2-ethylhexyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC SFAAOBGYWOUHLU-UHFFFAOYSA-N 0.000 description 1
- KKDLMTFRMQVLMO-UHFFFAOYSA-N 2-heptylundecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CCCCCCC)CCCCCCCCC KKDLMTFRMQVLMO-UHFFFAOYSA-N 0.000 description 1
- JVXJFNLEXLGQIO-UHFFFAOYSA-N 2-hexyldecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CCCCCC)CCCCCCCC JVXJFNLEXLGQIO-UHFFFAOYSA-N 0.000 description 1
- GECRRQVLQHRVNH-MRCUWXFGSA-N 2-octyldodecyl (z)-octadec-9-enoate Chemical compound CCCCCCCCCCC(CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC GECRRQVLQHRVNH-MRCUWXFGSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 description 1
- ZQXRINMCMHCYBD-UHFFFAOYSA-N 4-(2-ethylhexoxy)-4-oxobutanoic acid Chemical compound CCCCC(CC)COC(=O)CCC(O)=O ZQXRINMCMHCYBD-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- MVJSIAIXMFGVSA-UHFFFAOYSA-N 6-(2-hexyldecoxy)-6-oxohexanoic acid Chemical compound CCCCCCCCC(CCCCCC)COC(=O)CCCCC(O)=O MVJSIAIXMFGVSA-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 235000003930 Aegle marmelos Nutrition 0.000 description 1
- 244000058084 Aegle marmelos Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000011632 Caseins Human genes 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 235000017788 Cydonia oblonga Nutrition 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- RDOFJDLLWVCMRU-UHFFFAOYSA-N Diisobutyl adipate Chemical compound CC(C)COC(=O)CCCCC(=O)OCC(C)C RDOFJDLLWVCMRU-UHFFFAOYSA-N 0.000 description 1
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- 229940124091 Keratolytic Drugs 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 241000199919 Phaeophyceae Species 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 235000019774 Rice Bran oil Nutrition 0.000 description 1
- 235000000539 Rosa canina Nutrition 0.000 description 1
- 240000008530 Rosa canina Species 0.000 description 1
- 235000010337 Rosa dumalis Nutrition 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
- XKMYWNHZAQUEPY-YZGJEOKZSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] 12-hydroxyoctadecanoate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCCCCCC(O)CCCCCC)C1 XKMYWNHZAQUEPY-YZGJEOKZSA-N 0.000 description 1
- DRRMRHKHTQRWMB-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-bis(2-ethylhexanoyloxymethyl)propyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(COC(=O)C(CC)CCCC)(COC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DRRMRHKHTQRWMB-UHFFFAOYSA-N 0.000 description 1
- GORMSINSWZJIKL-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-dimethylpropyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(C)(C)COC(=O)C(CC)CCCC GORMSINSWZJIKL-UHFFFAOYSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- 125000004442 acylamino group Chemical group 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- HGKOWIQVWAQWDS-UHFFFAOYSA-N bis(16-methylheptadecyl) 2-hydroxybutanedioate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CC(O)C(=O)OCCCCCCCCCCCCCCCC(C)C HGKOWIQVWAQWDS-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 1
- 239000010495 camellia oil Substances 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229940072104 cholesteryl hydroxystearate Drugs 0.000 description 1
- 239000002734 clay mineral Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
- 229940031769 diisobutyl adipate Drugs 0.000 description 1
- 229940031569 diisopropyl sebacate Drugs 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 150000002339 glycosphingolipids Chemical class 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- DWMMZQMXUWUJME-UHFFFAOYSA-N hexadecyl octanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCC DWMMZQMXUWUJME-UHFFFAOYSA-N 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- 229940078545 isocetyl stearate Drugs 0.000 description 1
- 229940100554 isononyl isononanoate Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 229940060384 isostearyl isostearate Drugs 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 229940099367 lanolin alcohols Drugs 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 229940114937 microcrystalline wax Drugs 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 239000003345 natural gas Substances 0.000 description 1
- 239000010697 neat foot oil Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000120 polyethyl acrylate Polymers 0.000 description 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 229920001522 polyglycol ester Polymers 0.000 description 1
- 239000002952 polymeric resin Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 229940074113 rosa multiflora fruit extract Drugs 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000012438 synthetic essential oil Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229940118594 trimethylolpropane triisostearate Drugs 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
本发明提供一种去角质化妆品组合物，其对肌肤的刺激小、去除皮肤废物的作用优异。提供一种含有聚异戊二烯的去角质化妆品组合物。
Description
技术领域
本发明涉及去角质化妆品组合物。
背景技术
以往的去角质化妆品，通过溶解在水中的高分子树脂在肌肤上干燥时形成去角质膜来去除角质。或者，将含有酸的低pH的凝胶涂布在肌肤上，从而pH上升，剂形发生变化而形成去角质膜，由此去除角质。
在肌肤上干燥时形成去角质膜这样的类型的去角质化妆品存在如下问题：在浴室等湿度高的场所或水的存在下难以形成去角质膜，或者形成去角质膜花费时间。另外，低pH凝胶类型的去角质化妆品由于pH低，因此存在对肌肤的刺激强的问题。
作为应对，专利文献1公开了一种对肌肤的刺激性小的去角质化妆品。专利文献1的去角质化妆品组合物是用于去除不需要的皮肤成分的去角质化妆品组合物，其特征在于，含有析出性粘合剂和挥发性油剂，所述析出性粘合剂由粘合性固体成分和分散该粘合性固体成分的挥发性的分散介质构成，在上述分散介质挥发时粘合性固体成分析出。吸附、去除皮肤的废物的粘合性固体成分为选自包含具有乙烯基结构的化合物作为单体的聚合物、共聚物和它们的盐中的1种或2种以上。
专利文献2公开了含有聚乙烯醇1～10质量％、聚氧丙烯聚甘油醚10～30质量％和丙烯酸系水溶性高分子0.1～5质量％的剥落剂(peeling agent)。该剥落剂的pH为中性附近，通过以特定的比例配合聚乙烯醇、聚氧丙烯聚甘油醚和丙烯酸系水溶性高分子，实现了清洁性、湿润感和涂擦时间的缩短。
现有技术文献
专利文献
专利文献1：日本特开2001-139426
专利文献2：日本特开2004-359627
发明内容
发明要解决的问题
本发明要解决的课题在于提供对肌肤的刺激小、去除皮肤废物的作用优异的去角质化妆品组合物。
用于解决问题的技术方案
本发明人为了解决上述课题而进行了深入研究，结果，令人惊讶地发现，当将聚异戊二烯配合在去角质化妆品组合物中时，能够有效地去除角质，从而完成了本发明。
本发明包含以下所述的实施方式。
项1.一种去角质化妆品组合物，其含有聚异戊二烯。
项2.根据项1所述的去角质化妆品组合物，其pH为4～9。
项3.根据项1或2所述的去角质化妆品组合物，其中，聚异戊二烯的含量为0.01～50质量％。
项4.根据项1～3中任一项所述的去角质化妆品组合物，其含有50质量％以上的水。
项5.根据项1～4中任一项所述的去角质化妆品组合物，其含有0.01～20质量％的聚异戊二烯、0.01～10质量％的增稠剂和0.01～50质量％的润湿剂。
项6.聚异戊二烯的用于制造去角质化妆品组合物的用途。
发明效果
本发明的去角质化妆品组合物可以在对皮肤的刺激小的情况下去除皮肤废物。本发明的去角质化妆品组合物即使在水分的存在下也起到去除皮肤废物的作用，也可以用于被水润湿的肌肤。
具体实施方式
以下，说明本发明的实施方式。
在本说明书中，“去角质化妆品组合物”是指含有固体物质的化妆品组合物，是指涂布于皮肤并利用基于该固体物质的擦拭来去除皮肤废物的化妆品。
在本说明书中，“皮肤废物”包含老化的角质、过量分泌的脂质、角栓等。
本发明的去角质化妆品组合物含有聚异戊二烯。
聚异戊二烯是具有-CH2-C(CH3)＝CH-CH2-结构作为重复单元的聚合物。聚异戊二烯可以是仅异戊二烯聚合而成的均聚物，也可以是异戊二烯与其他不饱和有机化合物的共聚物即copolymer。作为其他不饱和有机化合物，可举出丁烯、苯乙烯等不饱和烃。或者，聚异戊二烯的一部分双键可以通过氢化而单键化。从获得的容易性方面考虑，聚异戊二烯优选为异戊二烯的均聚物。
聚异戊二烯的分子量没有特别限定，以数均分子量计优选为300～100000的范围内，更优选为1000～100000的范围内，进一步优选为5000～60000的范围内。聚异戊二烯的单体的聚合度优选为5～1500的范围内，优选为15～1500的范围内，优选为70～900的范围内。
聚异戊二烯的含量没有特别限定，从皮肤废物的去除效果的方面出发，相对于去角质化妆品组合物总量优选为0.01～50质量％，更优选为0.1～30质量％，进一步优选为1～20质量％。
本发明的去角质化妆品组合物可以进一步含有水。在含有水的情况下，水的含量可以根据聚异戊二烯和其他成分的含量适当设定。水的含量没有特别限定，相对于去角质化妆品组合物总量优选为20～99质量％，更优选为50～97质量％，进一步优选为70～95质量％。在一个特定的优选实施方式中，去角质化妆品组合物含有50质量％以上的水。
为了提高使用后的湿润感，本发明的去角质化妆品组合物可以进一步含有油剂。作为油剂，例如可举出天然动植物油脂类、半合成油脂、烃油、高级脂肪酸、酯油、甘油酯油、硅油(silicone oil)等。作为上述天然动植物油脂类和半合成油脂，例如可举出鳄梨油、亚麻籽油、杏仁油、橄榄油、巴西棕榈蜡、小烛树蜡、牛脂、牛脚脂、牛骨脂、氢化牛脂、小麦胚芽油、芝麻油、米胚芽油、米糠油、红花油、大豆油、山茶油、月见草油、玉米油、菜籽油、马脂、棕榈油、棕榈仁油、蓖麻油、氢化蓖麻油、葵花籽油、霍霍巴油、澳洲坚果油、蜂蜡、貂油、棉籽油、椰子油、氢化椰子油、花生油、羊毛脂、液态羊毛脂、还原羊毛脂、羊毛脂醇、羊毛脂脂肪酸异丙酯、POE羊毛脂醇醚、羊毛脂脂肪酸聚乙二醇酯、POE氢化羊毛脂醇酯等。作为上述烃油，例如可举出角鲨烷、角鲨烯、纯地蜡、石蜡(paraffin)、固体石蜡(paraffin wax)、液体石蜡、微晶蜡、凡士林等。作为上述高级脂肪酸，例如可举出月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、山萮酸、十一碳烯酸、油酸、亚油酸、亚麻酸、异硬脂酸、12-羟基硬脂酸等。作为上述酯油，例如可举出异壬酸异壬酯、己二酸二异丁酯、己二酸2-己基癸酯、己二酸二-2-庚基十一烷基酯、异硬脂酸异硬脂酯、三羟甲基丙烷三异硬脂酸酯、2-乙基己酸鲸蜡酯、二-2-乙基己酸新戊二醇酯、三羟甲基丙烷三(乙基己酸)酯(Trimethylolpropane Tris(2-ethylhexanoate)、四-2-乙基己酸季戊四醇酯、辛酸鲸蜡酯、油酸油酯、油酸辛基十二烷基酯、油酸癸酯、二癸酸新戊二醇酯、琥珀酸2-乙基己酯、硬脂酸异鲸蜡酯、硬脂酸丁酯、癸二酸二异丙酯、乳酸鲸蜡酯、乳酸肉豆蔻酯、棕榈酸2-乙基己酯、棕榈酸2-己基癸酯、棕榈酸2-庚基十一烷基酯、胆甾醇羟基硬脂酸酯(Cholesteryl Hydroxystearate)、苹果酸二异硬脂酯等。作为上述甘油酯油，例如可举出三异辛酸甘油酯、三异硬脂酸甘油酯、三异棕榈酸甘油酯、三2-乙基己酸甘油酯、三肉豆蔻酸甘油酯等。作为上述硅油，例如可举出二甲基聚硅氧烷、甲基苯基聚硅氧烷、甲基氢聚硅氧烷、十甲基环五硅氧烷、八甲基环五硅氧烷、十二甲基环六硅氧烷、硬脂氧基硅酮等高级烷氧基改性硅酮、烷基改性硅酮、高级脂肪酸酯改性硅酮、高级脂肪酸醚改性硅酮、动植物的精油类、合成精油等。上述油剂可以单独使用，也可以混合使用2种以上。
油剂的配合浓度没有特别限定，相对于去角质组合物总量优选配合0.01～40质量％，优选配合0.1～30质量％，进一步优选配合1～20质量％。
为了制剂的稳定化，本发明的去角质化妆品组合物可以进一步含有增稠剂。作为增稠剂，可举出有机增稠剂和无机增稠剂，作为有机增稠剂，可举出天然的有机增稠剂、半合成的有机增稠剂、合成的有机增稠剂。可举出如下的例子。作为天然的有机增稠剂，例如可举出黄原胶、阿拉伯树胶、黄蓍胶、半乳聚糖、瓜尔胶、角豆胶、刺梧桐胶、角叉菜胶、果胶、琼脂、榅桲籽(Marmelo)、海藻胶体(褐藻提取物)、淀粉(大米、玉米、马铃薯、小麦)、甘草酸等植物性高分子、胶原蛋白、酪蛋白、白蛋白、明胶等动物系高分子。作为半合成的有机增稠剂，例如可举出羧甲基淀粉、甲基羟丙基淀粉等淀粉系高分子、甲基纤维素、硝基纤维素、乙基纤维素、甲基羟丙基纤维素、羟乙基纤维素、纤维素硫酸钠、羟丙基甲基纤维素、羟丙基纤维素、羧甲基纤维素钠(CMC)、结晶纤维素、纤维素粉末等纤维素系高分子、海藻酸钠、海藻酸丙二醇酯等海藻酸系高分子。作为合成的有机增稠剂，例如可举出聚乙烯醇、聚乙烯基甲基醚、聚乙烯基吡咯烷酮、羧基乙烯基聚合物(卡波姆)、烷基改性羧基乙烯基聚合物等乙烯基系高分子、聚乙二醇1500、4000、6000等聚氧乙烯系高分子、聚氧乙烯聚氧丙烯共聚物共聚类高分子、聚丙烯酸钠、聚丙烯酸乙酯、聚丙烯酰胺等丙烯酸系高分子、聚乙烯亚胺、阳离子聚合物、交联型N,N-二甲基丙烯酰胺-2-丙烯酰胺-2-甲基丙烷磺酸钠共聚物等。作为无机增稠剂，例如可举出膨润土、硅酸AlMg(Veegum)、锂皂石(Laponite)、锂蒙脱石、硅酸酐等。作为增稠剂，可以从这些中适当选择使用1种或2种以上。
增稠剂的配合浓度没有特别限定，相对于去角质组合物总量优选为0.01～10质量％，更优选为0.01～7质量％，进一步优选为0.01～5质量％。
为了保持皮肤中的水分，本发明的去角质化妆品组合物可以进一步含有润湿剂。作为润湿剂，可举出多元醇，例如甘油、丙二醇、二丙二醇、聚丙二醇、聚乙二醇、山梨糖醇、羟丙基山梨糖醇、己二醇、1,3-丁二醇、神经酰胺类、鞘糖脂类、野蔷薇果提取物(RosaMultiflora Fruit Extract)、1,2,6-己三醇、乙氧基化甘油、丙氧基化甘油或其混合物。另外，可举出蛋白质、粘多糖、胶原蛋白、弹性蛋白、角蛋白等润湿剂。
润湿剂的配合浓度没有特别限定，相对于去角质组合物总量优选为0.01～80质量％，更优选为0.1～50质量％，进一步优选为1～20质量％。
本发明的去角质化妆品组合物可以进一步含有表面活性剂。作为表面活性剂，例如可举出非离子表面活性剂、阴离子表面活性剂、阳离子表面活性剂、两性表面活性剂等。作为表面活性剂，例如可举出烷基葡糖苷、丙二醇脂肪酸酯、甘油脂肪酸酯、POE甘油脂肪酸酯、聚甘油脂肪酸酯、山梨糖醇酐脂肪酸酯、POE山梨糖醇酐脂肪酸酯、POE山梨糖醇脂肪酸酯、POE蓖麻油、POE氢化蓖麻油、POE甾醇、POE氢化甾醇、聚乙二醇脂肪酸酯、POE烷基醚、POE聚氧丙烯烷基醚、POE羊毛脂、POE羊毛脂醇、POE蜂蜡衍生物、POE烷基胺、POE脂肪酸酰胺、POE烷基醚磷酸、POE烷基醚磷酸盐、C12～C20烷基醚羧酸盐、C12～C20高级脂肪酸酯的磺酸盐(例如磺基琥珀酸二辛酯钠、月桂基磺基乙酸钠等)、C12～C20烷基磷酸盐、C12～C20烷基硫酸盐、酰基氨基酸盐等。
为了调节pH，本发明的去角质化妆品组合物可以进一步含有中和剂。作为中和剂，例如可举出三乙醇胺、单乙醇胺等烷醇胺、氨、氢氧化钠、氢氧化钾等无机碱、精氨酸等碱性氨基酸等。
本发明的去角质化妆品组合物可以进一步含有防腐剂。作为防腐剂，例如可举出苯甲酸盐、感光素、对羟基苯甲酸酯类、苯氧基乙醇、水杨酸、山梨酸、异丙基甲基苯酚等。
除了上述成分之外，本发明的去角质化妆品组合物可以根据目标物性，在不损害本发明的特性的范围内含有化妆品技术领域中通常使用的用于制剂化的添加物。作为这样的添加物，例如可举出磨砂剂、硫、水果酸、抗氧化剂、金属螯合剂、香料、紫外线吸收剂、血液循环促进剂、各种提取液、无机和有机颜料、无机和粘土矿物、色素、清凉剂、止汗剂、皮肤赋活化剂等。
这样的添加物的配合浓度没有特别限定，优选0.001～10质量％，优选0.01～5质量％。
本发明的去角质化妆品组合物优选pH为4～9，更优选pH为5～9，进一步优选pH为6～8。在本发明的去角质化妆品组合物中，聚异戊二烯这一化学稳定的聚合物本身起到去除皮肤废物的作用。因此，即使在中性附近的pH下也能够有效地去除角质。另外，当pH为4～9时，与为了去除皮肤废物而使用酸的化妆品相比，对肌肤的刺激小。
在本发明的去角质化妆品组合物中，聚异戊二烯起到去除皮肤废物的作用。因此，如果涂布去角质化妆品组合物并摩擦皮肤，则皮肤废物迅速析出，能够在短时间内去除皮肤废物。因此，即使是被水润湿的肌肤，也能够使用去角质化妆品组合物。另外，由于本发明的去角质化妆品组合物的去除皮肤废物的作用优异，因此去除彩妆化妆品污渍的性能也优异。而且，本发明的去角质化妆品组合物由于pH为中性附近，因此对肌肤的刺激性小。
本发明的去角质化妆品组合物可以用于面部或全身。
本发明的优选的特定实施方式的去角质化妆品组合物含有0.01～20质量％的聚异戊二烯、0.01～10质量％的增稠剂和0.01～50质量％的润湿剂。因此，能够用于被水润湿的肌肤，对肌肤的刺激性小，且去除皮肤废物的作用优异。
本发明的更优选的特定实施方式的去角质化妆品组合物含有0.01～20质量％的聚异戊二烯、0.01～10质量％的增稠剂和0.01～50质量％的润湿剂，pH为4～9。因此，能够用于被水润湿的肌肤，对肌肤的刺激性小，且去除皮肤废物的作用优异。
本发明的另一优选的特定实施方式的去角质化妆品组合物含有0.01～20质量％的聚异戊二烯、0.01～10质量％的增稠剂和0.01～50质量％的润湿剂，水的含量为50～97质量％。因此，能够用于被水润湿的肌肤，对肌肤的刺激性小，且去除皮肤废物的作用优异。
本发明的又一优选的特定实施方式的去角质化妆品组合物含有0.01～20质量％的聚异戊二烯、0.01～10质量％的增稠剂和0.01～50质量％的润湿剂，水的含量为50～97质量％，pH为4～9。因此，能够用于被水润湿的肌肤，对肌肤的刺激性小，且去除皮肤废物的作用优异。
关于本发明的去角质化妆品组合物的形态，只要是能够涂布于皮肤，则可以为任意的剂型，优选可举出化妆水、凝胶、乳液、乳霜等。或者，也可以将本发明的去角质化妆品与丙烷、丁烷等天然气体、氮气、二氧化碳、二甲基醚等喷出剂一起混合，作为气溶胶填充于密封容器。
本发明的去角质化妆品组合物的制造方法没有特别限定，只要以成为规定的组成的方式混合各成分即可。混合时可以根据需要进行加热。本发明的优选制造方法包括：将油剂溶解后，向其中投入预先分散、溶解的水溶性成分，根据目标剂型适当搅拌、乳化后，投入聚异戊二烯，适当搅拌、乳化。无论投入聚异戊二烯的阶段如何，均可以在油剂溶解后投入，投入分散、溶解的水溶性剂之后进行搅拌、乳化。可以在任何阶段调整pH，可以根据目的随时投入其他成分。
以下列举实施例更具体地说明本发明，但本发明不限定于这些实施例。
【实施例】
试验例1含有聚异戊二烯的去角质化妆品组合物的制造和评价
1.去角质化妆品组合物的制造
实施例1
向在70～80℃下分散的甘油、卡波姆、纯化水中加入氢氧化钾进行中和，制作基剂的水性凝胶。以成为最终组合物的10质量％的方式向其中投入VINYSOL 3700(聚异戊二烯的树脂乳液，大同化成工业株式会社，聚异戊二烯含量63～72重量％)，进行搅拌，得到实施例1的去角质化妆品组合物。
实施例2
除了将实施例1的VINYSOL 3700变更为VINYSOL 3701C(聚异戊二烯的树脂乳液，大同化成工业株式会社，聚异戊二烯含量52～60重量％)以外，通过与实施例1相同的方法得到实施例2的去角质化妆品组合物。
实施例3
除了将实施例1的VINYSOL 3700变更为SEPOREX IR100-H(聚异戊二烯的树脂乳液，住友精化株式会社，聚异戊二烯含量66重量％)以外，通过与实施例1相同的方法得到实施例3的去角质化妆品组合物。
比较例1
除了将实施例1的VINYSOL 3700变更为DAITOSOL5000AD(丙烯酸共聚物的乳液，大东化成工业株式会社，聚合物含量50重量％)以外，通过与实施例1相同的方法得到比较例1的去角质化妆品组合物。
比较例2
除了将实施例1的VINYSOL 3700变更为VINYSOL 2140L(乙酸乙烯酯-丙烯酸共聚物，大同化成工业株式会社，聚合物含量45～50重量％)以外，通过与实施例1相同的方法得到比较例2的去角质化妆品组合物。
比较例3
除了将实施例1的VINYSOL 3700变更为VINYSOL 2140LH(乙酸乙烯酯-丙烯酸共聚物，大同化成工业株式会社，聚合物含量45～50重量％)以外，通过与实施例1相同的方法得到比较例3的去角质化妆品组合物。
比较例4
除了将实施例1的VINYSOL 3700变更为DOWSIL HMW 2220NON-IONIC EMULSION(Dow Corporate公司，二乙烯基聚二甲基硅氧烷-聚二甲基硅氧烷共聚物)以外，通过与实施例1相同的方法，得到比较例4的去角质化妆品组合物。
将实施例1～3和比较例1～4的去角质化妆品组合物的组成示于表1。
2.评价
对实施例1～3和比较例1～4的去角质化妆品组合物进行以下评价。
＜析出性＞
在规定条件下(20℃，湿度50％)下，将所得到的各去角质化妆品组合物0.5g取至用流水润湿2秒钟的手背，使用食指、中指进行涂擦，按照下述评价项目进行析出性的评价。
◎：涂擦后，在10秒以内出现析出物。
○：涂擦后，在20秒以内出现析出物。
×：涂擦后，即使经过20秒以上也不出现析出物。
＜去污性的评价＞
在规定条件(20℃，湿度50％)下，在人工皮肤(株式会社Beaulax：BIOSKINplates)上涂布普通的粉底，涂擦所得到的各去角质剂组合物约0.15g，按照下述评价基准评价去污性。
○：污垢被去除。
×：污垢几乎未被去除。
＜结果＞
在实施例1～3的去角质化妆品组合物中，迅速产生析出物，并且能够在不带来刺激感的情况下，析出物高效地卷入老化的角质，同时将其去除。实施例1～3的去角质化妆品组合物在pH为中性附近这一点上，没有刺激而优异。
比较例1的去角质化妆品组合物的析出性和去污性良好，但比较例2和3的去角质化妆品组合物的析出性和去污性均差。
【表1】
表1
试验例2聚异戊二烯含量的影响
1.去角质化妆品组合物的制造
实施例4
向在70～80℃下分散的甘油、卡波姆、纯化水中加入氢氧化钾进行中和，制作基剂的水性凝胶。将VINYSOL 3701C以成为最终组合物的0.5质量％的方式投入其中，进行搅拌，得到实施例4的去角质化妆品组合物。
实施例5
除了将实施例4的VINYSOL 3701C的配合量从最终浓度0.5质量％变更为最终浓度30质量％以外，通过与实施例4相同的方法得到实施例5的去角质化妆品组合物。
实施例6
除了将实施例4的VINYSOL 3701C变更为SEPOREX IR100-H以外，通过与实施例4相同的方法得到实施例6的去角质化妆品组合物。
实施例7
除了将实施例6的SEPOREX IR100-H的配合量从最终浓度0.5质量％变更为最终浓度30质量％以外，通过与实施例6相同的方法得到实施例7的去角质化妆品组合物。
将实施例4～7的去角质化妆品组合物的组成示于表2。
2.评价
对实施例4～7的去角质化妆品组合物进行以下评价。
＜析出性＞
在规定条件下(20℃，湿度50％)下，将所得到的各去角质化妆品组合物0.5g取至用流水润湿2秒钟的手背，使用食指、中指进行涂擦，按照下述评价项目进行析出性的评价。
◎：涂擦后，在10秒以内出现析出物。
○：涂擦后，在20秒以内出现析出物。
×：涂擦后，即使经过20秒以上也不出现析出物。
＜结果＞
在实施例4～7的去角质化妆品组合物中，迅速产生析出物，并且能够在不带来刺激感的情况下，析出物高效地卷入老化的角质，同时将其去除。实施例4～7的去角质化妆品组合物在pH为中性附近的这一点上，没有刺激而优异。
【表2】
表2
| 成分 | 聚合物成分 | 实施例4 | 实施例5 | 实施例6 | 实施例7 |
| VINYSOL 3701C | 聚异戊二烯 | 0.50 | 30.00 | ||
| SEPOREX IR100-H | 丙烯酸共聚物 | 0.50 | 30.00 | ||
| 氢氧化钾 | 适量 | 适量 | 适量 | 适量 | |
| 甘油 | 10 | 10 | 10.00 | 10.00 | |
| 卡波姆 | 0.5 | 0.5 | 0.50 | 0.50 | |
| 纯化水 | 余量 | 余量 | 余量 | 余量 | |
| 总质量％ | 100 | 100 | 100.00 | 100.00 | |
| 析出性 | ○ | ◎ | ○ | ◎ | |
| pH | 5.47 | 5.09 | 5.69 | 8.96 |
试验例3不同剂形的去角质化妆品组合物的制造和评价
1.去角质化妆品组合物的制造
实施例8化妆水的制造
在70～80℃下溶解PEG-60氢化蓖麻油、生育酚乙酸酯、聚二甲基硅氧烷(溶解物A)，在70～80℃下溶解甘油、1，3-丁二醇和防腐剂(溶解物B)，分散卡波姆和纯化水(分散物C)，溶解氢氧化钾和水(溶解物D)，在溶解物A中投入溶解物A和分散物C，向其中加入溶解物D进行中和，制作了基剂的水性凝胶。冷却后，将VINYSOL 3701C(E)以成为最终组合物的10质量％的方式投入其中，进行搅拌，得到实施例8的去角质化妆品组合物。
实施例9凝胶的制造
除了将实施例8的卡波姆的量变更为最终浓度为0.5质量％以外，通过与实施例8相同的方法得到实施例9的去角质化妆品组合物。
实施例10乳液的制造
除了如表3所示那样变更溶解物A、B、C、D、E的各成分和配合量以外，通过与实施例8相同的方法得到实施例10的去角质化妆品组合物。
实施例11乳霜的制造
除了如表3所示那样变更溶解物A、B、C、D、E的各成分和配合量以外，通过与实施例8相同的方法得到实施例11的去角质化妆品组合物。
将实施例8～11的去角质化妆品组合物的组成示于表3。
2.评价
对实施例8～11的去角质化妆品组合物进行以下评价。
＜析出性＞
在规定条件下(20℃，湿度50％)下，将所得到的各去角质化妆品组合物0.5g取至用流水润湿2秒的手背，使用食指、中指进行涂擦，按照下述评价项目进行析出性的评价。
◎：涂擦后，在10秒以内出现析出物。
○：涂擦后，在20秒以内出现析出物。
×：涂擦后，即使经过20秒以上也不出现析出物。
＜去污性的评价＞
在规定条件(20℃，湿度50％)下，在人工皮肤(株式会社Beaulax：BIOSKINplates)上涂布普通的粉底，涂擦得到的各去角质剂组合物约0.15g，按照下述评价基准评价去污性。
○：污垢被去除。
×：污垢几乎未被去除。
＜结果＞
在实施例8的化妆水、实施例9的凝胶、实施例10的乳液和实施例11的乳霜中的任一种剂形中，本发明的去角质化妆品组合物迅速产生析出物，并且能够在不带来刺激感的情况下，析出物高效地卷入老化的角质，同时将其去除。另外，实施例8～11的去角质化妆品组合物的去污性也良好。
【表3】
表3
Claims (6)
1.一种去角质化妆品组合物，其含有聚异戊二烯。
2.根据权利要求1所述的去角质化妆品组合物，其中，所述去角质化妆品组合物pH为4～9。
3.根据权利要求1或2所述的去角质化妆品组合物，其中，聚异戊二烯的含量为0.01质量％～50质量％。
4.根据权利要求1、2中任一项所述的去角质化妆品组合物，其中，所述去角质化妆品组合物含有50质量％以上的水。
5.根据权利要求1或2所述的去角质化妆品组合物，其中，所述去角质化妆品组合物含有0.01质量％～20质量％的聚异戊二烯、0.01质量％～10质量％的增稠剂和0.01质量％～50质量％的润湿剂。
6.聚异戊二烯的用于制造去角质化妆品组合物的用途。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020040483A JP2021143127A (ja) | 2020-03-10 | 2020-03-10 | ゴマージュ化粧料組成物 |
| JP2020-040483 | 2020-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113368008A true CN113368008A (zh) | 2021-09-10 |
Family
ID=77569702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110261852.6A Pending CN113368008A (zh) | 2020-03-10 | 2021-03-10 | 去角质化妆品组合物 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2021143127A (zh) |
| CN (1) | CN113368008A (zh) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01261318A (ja) * | 1988-04-12 | 1989-10-18 | Iwase Kosufua Kk | パック化粧料 |
| US5369130A (en) * | 1992-01-27 | 1994-11-29 | Alcare Co., Ltd. | Paste composition for skin barrier |
| US6471983B1 (en) * | 2000-08-18 | 2002-10-29 | Stockhausen Gmbh & Co. Kg | Skin application agents |
| US20040191197A1 (en) * | 2003-03-04 | 2004-09-30 | Intercos S.P.A. | Cosmetic composition containing polyisoprene |
| CN101057815A (zh) * | 2006-04-18 | 2007-10-24 | 株式会社资生堂 | 皮肤化妆品 |
| CN101917964A (zh) * | 2007-11-13 | 2010-12-15 | 株式会社资生堂 | 皮肤化妆品 |
| CN102946850A (zh) * | 2010-06-17 | 2013-02-27 | 株式会社资生堂 | 皮肤改善皮肤化妆品 |
-
2020
- 2020-03-10 JP JP2020040483A patent/JP2021143127A/ja active Pending
-
2021
- 2021-03-10 CN CN202110261852.6A patent/CN113368008A/zh active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01261318A (ja) * | 1988-04-12 | 1989-10-18 | Iwase Kosufua Kk | パック化粧料 |
| US5369130A (en) * | 1992-01-27 | 1994-11-29 | Alcare Co., Ltd. | Paste composition for skin barrier |
| US6471983B1 (en) * | 2000-08-18 | 2002-10-29 | Stockhausen Gmbh & Co. Kg | Skin application agents |
| US20040191197A1 (en) * | 2003-03-04 | 2004-09-30 | Intercos S.P.A. | Cosmetic composition containing polyisoprene |
| CN101057815A (zh) * | 2006-04-18 | 2007-10-24 | 株式会社资生堂 | 皮肤化妆品 |
| CN101917964A (zh) * | 2007-11-13 | 2010-12-15 | 株式会社资生堂 | 皮肤化妆品 |
| CN102946850A (zh) * | 2010-06-17 | 2013-02-27 | 株式会社资生堂 | 皮肤改善皮肤化妆品 |
Non-Patent Citations (1)
| Title |
|---|
| 广州天生丽质生物科技有限公司: "朵拉朵尚澄糖护唇磨砂膏", Retrieved from the Internet <URL:https://hzpba.nmpa.gov.cn/gccx/chakanHis.html?prodId=20190513080533s0dsp&gb=G> * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021143127A (ja) | 2021-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100424504B1 (ko) | 친수성 증점 화합물 및 증점 공중합체를 함유한 유제, 상기 유제를 함유한 조성물 및 이의 용도 | |
| CN102596151B (zh) | O/w乳化组合物的制备方法 | |
| TW510801B (en) | Skin toning formulation | |
| DE69817647T4 (de) | Feine Dispersion von Wachs, kosmetisches Haarpflegemittel und Glasierungsmittel | |
| US5039516A (en) | Sunscreen preparation | |
| CN102946850A (zh) | 皮肤改善皮肤化妆品 | |
| KR20150108611A (ko) | 자가 발포 기능을 갖는 클렌징용 마스크시트형 화장료 및 그 제조 방법 | |
| JP4160463B2 (ja) | 皮膚外用剤 | |
| JP2014101344A (ja) | 化粧料 | |
| JP2008290973A (ja) | 泡沫状整髪用化粧料 | |
| JPH09278644A (ja) | 水中油型乳化化粧料 | |
| JP3444366B2 (ja) | 乳化組成物 | |
| AU625678B2 (en) | Cosmetic preparation containing stable oil in water emulsion of 2-hydroxyethyl methacrylate homopolymer | |
| JP2006321769A (ja) | 高含水油中水型乳化化粧料 | |
| JP2003095883A (ja) | 毛髪脱色・脱染剤組成物 | |
| CN113368008A (zh) | 去角质化妆品组合物 | |
| KR102557085B1 (ko) | 오일 겔화제를 포함하는 수중유형 화장료 조성물 및 이의 제조방법 | |
| JPH11263721A (ja) | 水中油型ゴマージュ化粧料 | |
| JP2002145733A (ja) | 固形状油中水型乳化化粧料 | |
| JP5063206B2 (ja) | ゲル状整髪料 | |
| JP3441387B2 (ja) | 保湿剤及び皮膚化粧料並びに入浴剤 | |
| KR101338503B1 (ko) | 비중조절제를 포함하는 화장료 조성물 | |
| WO2004039339A1 (ja) | 風合い・油分散性に優れた化粧料 | |
| JP2008266275A (ja) | 水中油型化粧料 | |
| JP4090947B2 (ja) | ピーリング剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |