CN113367264A - Full-nutrient peony pistil effervescent tablet - Google Patents
Full-nutrient peony pistil effervescent tablet Download PDFInfo
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- CN113367264A CN113367264A CN202110593306.2A CN202110593306A CN113367264A CN 113367264 A CN113367264 A CN 113367264A CN 202110593306 A CN202110593306 A CN 202110593306A CN 113367264 A CN113367264 A CN 113367264A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
A full-nutrition peony pistil effervescent tablet comprises the following substances in parts by weight: 13.2 parts of peony stamen extract, 2.7 parts of aspartame and 51 parts of disintegrant, wherein 27.8 parts of acid source, 23.2 parts of alkali source, 27.1 parts of lactose, 60006 parts of PEG and a proper amount of wetting agent and adhesive. The peony pistil total nutrient extract effervescent tablet prepared from the peony pistil avoids resource waste of the peony pistil, develops a portable solid beverage with comprehensive and rich nutrition for people, and has great social value and wide development prospect. Therefore, the peony pistil total-nutrient extract effervescent tablet solid beverage which is convenient to carry and drink immediately after being mixed with water is developed by taking peony pistils as raw materials, optimizing the optimal auxiliary material proportion through a single-factor test and a Box-Behnken response method through the peony pistil total-nutrient extract obtained by processes of normal-temperature water extraction, vacuum concentration, ceramic membrane filtration, freeze drying, microwave sterilization and the like.
Description
Technical Field
The invention belongs to the field of peony pistil products, and particularly relates to a full-nutrition peony pistil effervescent tablet.
Background
Peony is once honored as 'plant gold', peony stamen is the essence of essence, and nutrition is extremely rich, also is called 'micro nutrition treasury' and is an excellent health product. At present, because of the lack of technical experience, peony pistils are not developed and utilized on a large scale, only unopened peony pistils are dried and utilized by the traditional tea making process, and some pistils with defective long phases and poor quality phases in the making process can be directly eliminated, so that the cost is greatly increased; the opened peony pistil is discarded, so that great resource waste is caused, the traditional peony pistil tea only selects unopened peony pistil, the yield of the traditional peony pistil tea is far lower than that of the opened peony pistil compared with the opened peony pistil, the product cost is increased in a phase-changing manner, the supply of market products is influenced, the requirements on raw materials of the full-nutrition peony pistil effervescent tablet are not high, and the unopened, opened and poor-quality peony pistil can be used as the raw materials, so that the development of the product expands the application range of the peony pistil.
Disclosure of Invention
The invention provides a full-nutrition peony pistil effervescent tablet, which is used for solving the defects in the prior art.
The invention is realized by the following technical scheme:
a full-nutrition peony pistil effervescent tablet comprises the following substances in parts by weight:
13.2 parts of peony stamen extract, 27.1 parts of aspartame, 2.7 parts of lactose and 51 parts of disintegrant, wherein 27.8 parts of acid source, 23.2 parts of alkali source, 60006 parts of PEG and a proper amount of wetting agent and adhesive.
The total nutrient peony pistil effervescent tablet comprises an acid source and an alkali source, wherein the weight ratio of the acid source to the alkali source is 1.2: 1.
the full-nutrition peony pistil effervescent tablet is characterized in that the acid source is tartaric acid: citric acid was added as 1:1, and mixing the components in a mass ratio of 1.
The full-nutrient peony pistil effervescent tablet is characterized in that the alkali source is sodium bicarbonate.
The full-nutrition peony pistil effervescent tablet is characterized in that aspartame and lactose are sweeteners.
The full-nutrition peony pistil effervescent tablet is characterized in that the wetting agent is 80% ethanol.
The full-nutrition peony pistil effervescent tablet is characterized in that the adhesive is 8% polyvinylpyrrolidone water solution.
The preparation method of the full-nutrition peony pistil effervescent tablet comprises the following steps:
the method comprises the following steps: a peony pistil full-nutrition effervescent tablet is characterized in that: the composition comprises the following substances in parts by weight: 13.2 parts of peony stamen extract, 27.1 parts of aspartame, 2.7 parts of lactose and 51 parts of disintegrant, wherein 27.8 parts of acid source, 23.2 parts of alkali source, 60006 parts of PEG and a proper amount of wetting agent and adhesive are used;
step two: mixing one half of the peony pistil extract, aspartame and lactose with an acid source, a wetting agent and an adhesive, and granulating to obtain acid source granules;
step three: taking the residual peony pistil extract, aspartame and lactose in half weight, adding an alkali source, a wetting agent and an adhesive, mixing and granulating to obtain alkali source granules;
step four: drying the acid source particles obtained in the step two and the alkali source particles obtained in the step three at 50-60 ℃ for 40 min;
step five: and D, crushing the dried acid source particles and alkali source particles, adding PEG6000, fully mixing and tabletting to obtain the full-nutrition peony pistil effervescent tablet.
The fully-nutritional peony pistil effervescent tablet is characterized in that the acid source particles and the alkali source particles dried in the fifth step are crushed and then sieved by a 14-mesh sieve.
The full-nutrient peony pistil effervescent tablet is described above.
The invention has the advantages that: the invention prepares the peony pistil into the full-nutrition peony pistil effervescent tablet, which not only avoids the resource waste of the peony pistil, but also develops a solid beverage which is convenient to carry and has comprehensive and rich nutrition for people, and has larger social value and wide development prospect. Therefore, the research takes peony pistil as a raw material, and the full-nutrition peony pistil extract obtained by the processes of warm water extraction, vacuum concentration, ceramic membrane filtration, freeze drying, microwave sterilization and the like develops the portable and ready-to-drink full-nutrition peony pistil effervescent tablet solid beverage through single factors and Box-Behnken response surfaces; the invention adopts a single-factor test and a Box-Behnken response surface test to optimize the addition amount of the peony pistil, the acid-base ratio of a disintegrant, the addition amount of the disintegrant and the addition amount of a sweetener, and scores the peony pistil according to the appearance, the soup color and the taste by taking the friability, the average tablet weight, the disintegration time limit and the PH as quality indexes. The result shows that the optimized preparation process has good repeatability and stable product quality, and meets the quality requirement of 2020 edition Chinese pharmacopoeia.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a graph showing the effect of the peony pistil extract of the present invention interacting with the amount of disintegrant added on sensory scores;
FIG. 2 is a graph of the effect of peony pistil extract on sensory score interaction with sweetener addition levels
Figure 3 is a graph of an analysis of the effect of disintegrant interaction with sweetener add-on sensory score according to the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1 Performance testing
Determination of disintegration time of peony pistil effervescent tablet
Taking 1 tablet, placing in 250ml beaker (containing 200ml water with temperature of 20 deg.C + -5 deg.C), i.e. many bubbles are released, when the gas around the tablet or fragment stops escaping, the tablet should be dissolved or dispersed in water without aggregated particles remaining. Unless otherwise specified, 6 tablets were examined in the same way, and each tablet should disintegrate within 5 minutes. If 1 tablet can not be completely disintegrated, 6 tablets should be taken for retesting, and all the results are in accordance with the regulations.
Determination of weight difference of peony pistil effervescent tablets
The inspection method comprises the steps of taking 20 test samples, accurately weighing the total weight, obtaining the average tablet weight, accurately weighing the weight of each tablet, comparing the weight of each tablet with the average tablet weight (the weight of each tablet is compared with the weight of the marked tablet for tablets without content measurement or traditional Chinese medicine tablets with marked tablet weight), and according to the specification in a table, exceeding the weight difference limit by not more than 2 tablets and not more than 1 tablet exceeding the limit by 1 time.
Determination of friability of peony pistil effervescent tablets
Determination of friability: taking several tablets with weight of 0.65g or less to make total weight of about 6.5 g; taking 10 tablets when the weight of the tablets is more than 0.65 g. The powder falling off the tablets was blown off with a blower, precisely weighed, placed in a cylinder and rotated 100 times. Taking out, removing powder by the same method, precisely weighing, reducing weight loss not to exceed 1%, and not detecting fracture, crack and crushed sheet. The test is generally carried out only 1 time. If the weight loss exceeds 1%, the weight loss should be measured again 2 times, and the average weight loss of 3 times should not exceed 1%, and no fracture, crack or crushed piece should be detected.
Determination of PH value of peony pistil effervescent tablet
This product, 5 tablets, was dispersed in 100mL of fresh distilled water at 20 ℃ to perform pH measurement, and the pH was measured in parallel 6 times and averaged.
Sensory evaluation of peony pistil effervescent tablets
10 professional students are selected to score the peony pistil effervescent tablets, the scoring standards are evaluated according to the table 1, and the scores are shown in the table 1 according to appearance, soup color and taste. Sensory score ═ appearance score × 0.33+ soup color score × 0.33+ taste score × 0.33.
TABLE 1 evaluation criteria for sensory evaluation of peony pistil effervescent tablets
Example 2 peony pistil effervescent tablet Single factor experiment
Determination of acid-base ratio of effervescent disintegrant
Citric acid is easy to absorb moisture when meeting water in the air, and is easy to be adhered during tabletting. Tartaric acid is not hygroscopic, but tastes less palatable than citric acid. Therefore, the weight ratio of tartaric acid to citric acid is 1: the mixed acid of 1 is used as an acid source, which can reduce the moisture absorption and absorption phenomena of the effervescent tablet in the air and can improve the taste of the effervescent tablet. Therefore, under the conditions that 10 parts of peony pistil extract, 1.5 parts of aspartame, 1.06 parts of PEG60006 parts, 27.5 parts of lactose and 50 parts of fixed effervescent disintegrant are adopted, single-factor experiments are carried out with acid-base ratios of 1.4:1, 1.2:1, 1:1, 1:1.2 and 1: 1.4.
TABLE 2 disintegrant acid to base ratio test results
As can be seen from the analysis of Table 2, the disintegration time of the peony stamen effervescent tablet is reduced and the acidity is gradually increased with the increase of the amount of the acid source. When the acid source and the alkali source are 1.2:1, the pH is acidic, the taste is sour and sweet, and the effervescent tablet conforms to the popular taste, so that the acid-alkali ratio of the peony pistil effervescent tablet is determined to be 1.2: 1. the disintegration time limit, friability and weight difference of the tablet all accord with the quality regulation of 2020 edition of Chinese pharmacopoeia.
Determination of the amount of effervescent disintegrant added
Under the conditions that the peony pistil extract is 10 parts, the aspartame is 1.5 parts, the PEG6000 is 6 parts, the acid-base ratio of the effervescent disintegrant is 1.2:1, and the lactose is 27.5 parts, the adding amount of the effervescent disintegrant is 40 parts, 45 parts, 50 parts, 55 parts and 60 parts, and single-factor experiments are carried out.
Table 3 disintegrant addition amount test results
As can be seen from the analysis of Table 3, the disintegration time decreased with the increase in the amount of the disintegrant, but the pH did not change significantly. When the addition amount of the disintegrant is between 45 and 55 parts, the disintegration time of the peony pistil effervescent tablet is short, so from the viewpoint of enterprise benefit, 45, 50 and 55 parts of the addition amount of the disintegrant is selected for response surface analysis. The disintegration time limit, friability and weight difference of the tablet all accord with the quality regulation of 2020 edition of Chinese pharmacopoeia.
Determination of the amount of peony pistil added
1.5 parts of aspartame, 6 parts of PEG6000, 1.2 parts of effervescent disintegrant acid-base ratio: 1, the addition amount of the effervescent disintegrant is 50 parts, and the addition amount of the lactose is 27.5 parts. 5 parts, 7.5 parts, 10 parts, 12.5 parts and 15 parts of peony stamen extract are selected for carrying out single-factor experiments.
TABLE 4 peony pistil addition test results
As can be seen from the analysis in Table 4, the color of soup increases with the increase of the amount of the peony pistil, and the color of soup is preferably between 10 parts and 15 parts. The taste of the effervescent tablet is most moderate when the effervescent tablet is 12.5 parts, and the fragrance of the effervescent tablet is stronger when the effervescent tablet is 10 to 12.5 parts. Therefore, 10%, 12.5% and 15% of the peony pistil addition amount is selected for response surface analysis. The friability and the weight difference of the tablets both accord with the quality regulation of 2020 edition of Chinese pharmacopoeia.
Determination of sweetener addition
In the selection of the sweetener, the aspartame has high sweetness which is 50 times that of the white granulated sugar (the sweetness of the aspartame used in the research is 50 times that of the white granulated sugar), but the aspartame does not participate in general sugar metabolism and is not degraded by microorganisms, so that the aspartame is suitable for diabetics, does not produce decayed teeth and has better taste than the general sweetener. Under the conditions that the peony stamen extract is 15 parts, the acid-base ratio of the effervescent disintegrant is 1.2:1, the addition amount of the effervescent disintegrant is 50 parts, the PEG6000 part is 6 parts, and the lactose part is 27.5 parts. The addition amount of aspartame is selected from 0.5 part, 1.0 part, 1.5 parts, 2.0 parts and 2.5 parts for single-factor experiments.
Table 5 sweetener add-on test results
Table 5 shows that the sweetness of the effervescent tablet increases with the increase of the amount of the sweetener, and the sweetness of the peony pistil effervescent tablet is suitable when the amount of the sweetener is 2.5 parts, so that 2 parts, 2.5 parts, and 3 parts of the amount of the sweetener are selected for response surface analysis. The friability and the weight difference of the tablets both accord with the quality regulation of 2020 edition of Chinese pharmacopoeia.
Example 3 peony pistil effervescent tablet Box-Behnken response surface test results and analysis
Box-Behnken response surface test design
The formulas of the peony pistil addition amount (a), the disintegrant addition amount (B), and the sweetener addition amount (C) were optimized by Box-Behnken response surface test according to the test factor levels of table 6. The appearance, color and taste of the peony pistil effervescent tablets were scored according to table 1 by sensory evaluation criteria.
TABLE 6 level of response surface test factors of peony stamen effervescent tablets
Response surface analysis of peony pistil effervescent tablets
Design-Expert 12 software is used for obtaining a response surface Design scheme, the peony pistil effervescent tablets are evaluated, sensory evaluation data are shown in a table 7, and a regression model variance analysis is carried out to obtain a table 8. (in the table, the number of,***the difference is extremely obvious when P is less than 0.001;**p is less than 0.01, and the difference height is obvious;*representing that P is less than 0.05, the difference is significant)
TABLE 7Box-Behnken test design and results
TABLE 8 regression model analysis of variance
Regression fitting analysis is carried out on table 8, and a quadratic polynomial regression equation of 3 factors of A (peony pistil adding amount), B (disintegrant adding amount), C (sweetener adding amount) and R (sensory score) is obtained through fitting: : r-95.42 +5.12A +1.54B +1.59C-1.07AB +2.43AC +2.05BC-10.91a2-5.03B2-3.79C2
Through analysis of variance, the F value of the regression equation model is 28.42, and P is less than 0.05, which shows that the fitting model has higher significance, and the smaller the P value in the model is, which shows that the fitting equation is more consistent with the actual situation. Wherein the mismatching term P value is 0.0646, the fitting is not obvious and accords with an experimental expected value, and the fitting equation can well analyze the experimental result. Overall coefficient of determination R of the fitting equation20.9734, the fitting equation can accurately predict the actual result of the experiment, and the reliability is high. Therefore, the fitting equation can well reflect the real situation. By analyzing the F values in the table 8, the main and secondary sequences influencing the sensory score factors of the peony pistil effervescent tablet can be deduced as follows: a (peony pistil adding amount) > C (sweetener adding amount) > B (disintegrant adding amount).
Peony pistil effervescent tablet response surface curve analysis
The curve of the three-dimensional response surface graph is larger, the interaction between the two factors is more obvious, the contour graph is elliptic, the interaction between the two factors is obvious, and the interaction is more obvious when the longer semiaxis of the ellipse is longer. While a circle indicates that the interaction of the two factors is not significant.
As can be seen from the analysis of the three-dimensional response surface chart in fig. 1, as a (peony pistil addition amount) and B (disintegrant addition amount) increase, the sensory score also increases, and as a and B reach the peak values, the sensory score also decreases. The contour line graph shows that the change along the contour line of the A (peony pistil addition) axis is dense, and the influence of the response value of the peony pistil addition to the disintegrant addition is obvious. And the contour lines are in an oval shape, which shows that the interaction between the two factors A and B is remarkable.
Analysis of the three-dimensional map of FIG. 2 shows that as A (peony pistil addition) and C (sweetener addition) increase, the sensory score also increases, and as A and B reach their peaks, the sensory score also decreases. The contour line graph shows that the change of contour lines along the A (peony pistil addition) axis is dense, and the influence of the response value of the peony pistil addition to the sweetener addition is obvious. And the contour lines are in an oval shape, which shows that the A and C factors have obvious interaction.
As can be seen from the analysis of the three-dimensional corresponding graph in fig. 3, as B (zero disintegrant addition) and C (sweetener addition) increase, the sensory score also increases, and as B and C reach the peak, the sensory score also decreases. The contour line graph shows that the change along the contour line of the C (sweetener addition amount) axis is dense, and the response value of the sweetener addition amount to the disintegrant addition amount is significantly influenced. And the contour lines are in an oval shape, which shows that the two factors B and C have obvious interaction.
Through the curve analysis of the response surface of the peony pistil effervescent tablet, the primary and secondary sequence of factors influencing the sensory score of the peony pistil effervescent tablet can be obtained as follows: a (peony pistil adding amount) > C (sweetener adding amount) > B (disintegrant adding amount).
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (8)
1. A peony pistil full-nutrition effervescent tablet is characterized in that: the composition comprises the following substances in parts by weight:
13.2 parts of peony stamen extract, 27.1 parts of aspartame, 2.7 parts of lactose and 51 parts of disintegrant, wherein 27.8 parts of acid source, 23.2 parts of alkali source, 60006 parts of PEG and a proper amount of wetting agent and adhesive.
2. The full nutrient peony pistil effervescent tablet of claim 1, wherein: the disintegrating agent comprises an acid source and an alkali source, wherein the weight ratio of the acid source to the alkali source is 1.2: 1.
3. the full nutrient peony pistil effervescent tablet of claim 2, wherein: the acid source is tartaric acid: citric acid was added as 1:1, and mixing the components in a mass ratio of 1.
4. The full nutrient peony pistil effervescent tablet of claim 2, wherein: the alkali source is sodium bicarbonate.
5. The full nutrient peony pistil effervescent tablet of claim 1, wherein: the wetting agent is 80% ethanol.
6. The full nutrient peony pistil effervescent tablet of claim 1, wherein: the adhesive is 8% polyvinylpyrrolidone water solution.
7. The full nutrient peony pistil effervescent tablet of claim 1, wherein: the preparation method comprises the following steps:
the method comprises the following steps: accurately weighing the peony stamen extract, aspartame, lactose, an acid source, an alkali source and PEG6000, measuring a proper amount of adhesive and a wetting agent for later use;
step two: taking a half weight of the peony pistil extract, aspartame and lactose, adding an acid source, a proper amount of wetting agent and adhesive, mixing and granulating to obtain acid source granules;
step three: taking the residual peony pistil extract, aspartame and lactose in half of the weight, adding an alkali source, a proper amount of wetting agent and adhesive, mixing and granulating to obtain alkali source granules;
step four: drying the acid source particles obtained in the step two and the alkali source particles obtained in the step three at 50-60 ℃ for 40 min;
step five: and D, crushing the dried acid source particles and alkali source particles, adding PEG6000, fully mixing and tabletting to obtain the full-nutrition peony pistil effervescent tablet.
8. The effervescent tablet of peony pistil as claimed in claim 6, wherein: and fifthly, crushing the dried acid source particles and alkali source particles, and sieving the crushed particles with a 14-mesh sieve.
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| CN202110593306.2A CN113367264A (en) | 2021-05-28 | 2021-05-28 | Full-nutrient peony pistil effervescent tablet |
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| CN202110593306.2A CN113367264A (en) | 2021-05-28 | 2021-05-28 | Full-nutrient peony pistil effervescent tablet |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114376226A (en) * | 2022-01-24 | 2022-04-22 | 中国科学院植物研究所 | Peony flavone extract and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104041908A (en) * | 2014-07-02 | 2014-09-17 | 菏泽尧舜牡丹生物科技有限公司 | Preparation method of peony pollen effervescent tablet |
| CN109123536A (en) * | 2018-09-05 | 2019-01-04 | 河南科技大学 | A kind of peony bud jelly and preparation method thereof |
| CN109619584A (en) * | 2019-01-17 | 2019-04-16 | 安徽怀善堂国药有限公司 | A kind of lycium ruthenicum effervescent tablet and preparation method thereof |
-
2021
- 2021-05-28 CN CN202110593306.2A patent/CN113367264A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104041908A (en) * | 2014-07-02 | 2014-09-17 | 菏泽尧舜牡丹生物科技有限公司 | Preparation method of peony pollen effervescent tablet |
| CN109123536A (en) * | 2018-09-05 | 2019-01-04 | 河南科技大学 | A kind of peony bud jelly and preparation method thereof |
| CN109619584A (en) * | 2019-01-17 | 2019-04-16 | 安徽怀善堂国药有限公司 | A kind of lycium ruthenicum effervescent tablet and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114376226A (en) * | 2022-01-24 | 2022-04-22 | 中国科学院植物研究所 | Peony flavone extract and preparation method and application thereof |
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