CN113365622A - 使用2，3-二氢异吲哚-1-酮化合物的组合疗法及用于治疗具有各种突变的患者的方法 - Google Patents

使用2，3-二氢异吲哚-1-酮化合物的组合疗法及用于治疗具有各种突变的患者的方法 Download PDF

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Publication number
CN113365622A
CN113365622A CN201980090539.1A CN201980090539A CN113365622A CN 113365622 A CN113365622 A CN 113365622A CN 201980090539 A CN201980090539 A CN 201980090539A CN 113365622 A CN113365622 A CN 113365622A
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leukemia
mutation
compound
cancer
cell
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CN201980090539.1A
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Chinese (zh)
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W·赖斯
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Aptose Biosciences Inc
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Aptose Biosciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980090539.1A 2018-11-30 2019-12-02 使用2，3-二氢异吲哚-1-酮化合物的组合疗法及用于治疗具有各种突变的患者的方法 Pending CN113365622A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862773686P 2018-11-30 2018-11-30
US62/773,686 2018-11-30
PCT/US2019/063993 WO2020113216A1 (en) 2018-11-30 2019-12-02 Combination therapy with 2,3-dihydro-isoindole-1-one compounds and methods for treating patients with various mutations

Publications (1)

Publication Number Publication Date
CN113365622A true CN113365622A (zh) 2021-09-07

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Family Applications (1)

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CN201980090539.1A Pending CN113365622A (zh) 2018-11-30 2019-12-02 使用2，3-二氢异吲哚-1-酮化合物的组合疗法及用于治疗具有各种突变的患者的方法

Country Status (8)

Country Link
US (1) US20200171001A1 (https=)
EP (1) EP3886840A4 (https=)
JP (1) JP2022509257A (https=)
KR (1) KR20210150353A (https=)
CN (1) CN113365622A (https=)
AU (1) AU2019387508A1 (https=)
CA (1) CA3133376A1 (https=)
WO (1) WO2020113216A1 (https=)

Families Citing this family (1)

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Publication number Priority date Publication date Assignee Title
PY2125608A (es) * 2020-04-01 2021-12-28 Fmc Corp Atropisómeros de derivados de piridazinona como herbicidas

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012047017A2 (ko) * 2010-10-05 2012-04-12 크리스탈지노믹스(주) 2,3-디히드로-이소인돌-1-온 유도체 및 이를 포함하는 조성물
CN104995184A (zh) * 2012-12-28 2015-10-21 晶体基因技术株式会社 作为btk激酶抑制剂的2,3-二氢异吲哚-1-酮诱导体与含此类的药学组合物
WO2018081830A1 (en) * 2016-10-31 2018-05-03 Oregon Health & Science University Combinations of agents to treat hematological malignancies
US20180207164A1 (en) * 2015-08-03 2018-07-26 Gilead Sciences, Inc. Combination therapies for treating cancers
WO2018156578A1 (en) * 2017-02-21 2018-08-30 Aptose Biosciences Inc. Methods for treating patients with hematologic malignancies

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Publication number Priority date Publication date Assignee Title
EP2971079A1 (en) * 2013-03-12 2016-01-20 Novartis AG Markers for isocitrate dehydrogenase inhibitors
EP2983670A4 (en) * 2013-04-08 2017-03-08 Pharmacyclics LLC Ibrutinib combination therapy
ES2905915T3 (es) * 2015-12-04 2022-04-12 Servier Lab Procedimientos de tratamiento de neoplasias malignas
JP6961879B2 (ja) * 2015-12-30 2021-11-05 レ ラボラトワール セルヴィエ ソシエテ・パール・アクシオンス・サンプリフィエ 変異体イソクエン酸デヒドロゲナーゼを包含する腫瘍の処置
CA3029851A1 (en) * 2016-07-29 2018-02-01 Oncternal Therapeutics, Inc. Uses of indoline compounds such as tk216 for the treatment of cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012047017A2 (ko) * 2010-10-05 2012-04-12 크리스탈지노믹스(주) 2,3-디히드로-이소인돌-1-온 유도체 및 이를 포함하는 조성물
CN104995184A (zh) * 2012-12-28 2015-10-21 晶体基因技术株式会社 作为btk激酶抑制剂的2,3-二氢异吲哚-1-酮诱导体与含此类的药学组合物
US20180207164A1 (en) * 2015-08-03 2018-07-26 Gilead Sciences, Inc. Combination therapies for treating cancers
WO2018081830A1 (en) * 2016-10-31 2018-05-03 Oregon Health & Science University Combinations of agents to treat hematological malignancies
WO2018156578A1 (en) * 2017-02-21 2018-08-30 Aptose Biosciences Inc. Methods for treating patients with hematologic malignancies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
程井军: "《中国肿瘤临床年鉴 2012》", 中国协和医科大学出版社, pages: 220 - 178 *

Also Published As

Publication number Publication date
WO2020113216A1 (en) 2020-06-04
EP3886840A4 (en) 2022-08-24
EP3886840A1 (en) 2021-10-06
US20200171001A1 (en) 2020-06-04
JP2022509257A (ja) 2022-01-20
CA3133376A1 (en) 2020-06-04
AU2019387508A1 (en) 2021-06-10
KR20210150353A (ko) 2021-12-10

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