CN113365406A - Low-temperature plasma generating device and application - Google Patents
Low-temperature plasma generating device and application Download PDFInfo
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- H—ELECTRICITY
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- H05H1/24—Generating plasma
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H1/00—Generating plasma; Handling plasma
- H05H1/24—Generating plasma
- H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
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Abstract
The invention discloses a low-temperature plasma generating device and application thereof, which mainly comprise a high-voltage power supply system, a pair of electrodes, at least one transmission piece and at least one working medium. The high-voltage power supply system can be a high-voltage power supply or a transformer and is used for providing a high-voltage electric field; the electrode pairs are respectively and electrically connected with two sides of the output end of the high-voltage power supply system and used for loading a high-voltage electric field. The transmission piece is used for transmitting the high-voltage electric field and inducing the working medium to discharge. The working medium is discharged in an electron avalanche process under the action of a high-voltage electric field, so that at least one nano active substance of superfine particles with the particle size of 0-1000 nm, nitrogen-containing free radicals and oxygen-containing free radicals is obtained. The low-temperature plasma generating device can continuously work for a long time, is stable in work, safe, effective and small in size, and can be applied to various medical instruments and health care and physical purposes.
Description
Technical Field
The invention relates to the field of medical equipment and health care theory, in particular to a low-temperature plasma generating device and application.
Background
The traditional medicine is generally administered by intravenous injection or oral administration. However, the traditional drug therapy is not only expensive, but also low in drug utilization rate, extremely limited in therapeutic effect and great in systemic side effect. Because of their high activity, high permeability and low side effects, nano-drugs are becoming the focus of current medical research as a new drug delivery method or drug carrier.
Studies have shown that the size of the aerodynamic diameter directly affects the absorption effect and the site of deposition of drug particles, with particles having an aerodynamic diameter greater than 10 microns being deposited mainly in the mouth, particles of 5-10 microns being deposited mainly in the throat and bronchi, and particles of 0-5 microns being deposited mainly in the lungs. In particular, the ability of the drug to enter lung cancer cells is enhanced 8-9 times compared to 3-5 micron particles when the aerodynamic diameter of the drug is 1-300 nanometers. The conventional low-temperature plasma generating device has two main defects:
the conventional low-temperature plasma generating device has two main defects:
(1) the stable operation cannot be continued: particularly, for a working medium (such as water vapor and the like) which is difficult to discharge, the operation is unstable and often stops, so that low-temperature plasma cannot be continuously and stably generated.
(2) Multiple working media cannot be processed simultaneously: generally, only one working medium or a mixture of a plurality of working media can be processed, but different working media cannot be processed at a plurality of positions simultaneously, so that the flexibility and the diversity of the application are limited.
In view of the above, the present invention provides a novel low temperature plasma generating device and its application.
Disclosure of Invention
The invention aims to provide a low-temperature plasma generating device, which utilizes a high-voltage electric field ionization mode, leads a working medium to undergo electron avalanche process discharge under the action of a high-voltage electric field between a first electrode and a second electrode, or between the first electrode and a transmission piece, or between the second electrode and the transmission piece or between two adjacent transmission pieces so as to obtain at least one nano active substance of ultra-fine particles with the particle size of 0-1000 nanometers, nitrogen-containing free radicals and oxygen-containing free radicals, intelligently adjusts the components and the concentration of the nano active substance according to different purposes, and can be used for medical instruments such as skin disease and wound care, beauty treatment and anti-aging, alopecia prevention and hair growth, oral care, respiratory disease prevention and treatment, tumor treatment and the like.
In order to solve the technical problems, the following technical scheme is adopted:
a low-temperature plasma generating device comprises a high-voltage power supply system and an electrode pair, wherein the electrode pair comprises a first electrode and a second electrode, one side of the output end of the high-voltage power supply system is electrically connected with the end part of the first electrode, the other side of the output end of the high-voltage power supply system is electrically connected with the end part of the second electrode, and the first electrode and the second electrode are oppositely arranged and are not in contact with each other;
the first electrode and the second electrode are used for loading a high-voltage electric field under the action of a high-voltage power supply system;
the low-temperature plasma generating device also comprises at least one transmission piece and a working medium, wherein the working medium is subjected to electron avalanche process discharge under the action of a high-voltage electric field so as to obtain at least one nano active substance in the superfine particles with the particle size of 0-1000 nm, nitrogen-containing free radicals and oxygen-containing free radicals;
the working medium is arranged between the first electrode and the second electrode, or between the first electrode and the transmission member, or between the second electrode and the transmission member, or between adjacent transmission members;
the transmission piece is used for transmitting the high-voltage electric field and inducing the working medium to discharge.
Furthermore, the low-temperature plasma generating device also comprises a blocking medium which is a medium with a high dielectric constant and is used for preventing the electrode pair from discharging outside the working medium area, stabilizing a high-voltage electric field and generating uniform ionization.
Further, the blocking medium is arranged between the first electrode and the second electrode, or between the first electrode and the transmission member, or between the second electrode and the transmission member, or between two adjacent transmission members.
Further, the blocking medium penetrates through the first electrode and the second electrode, or penetrates through the first electrode and the transmission member, or penetrates through the second electrode and the transmission member, or penetrates through two adjacent transmission members.
The intelligent sensor is used for detecting the concentration of at least one nano active substance in the superfine particles, the nitrogen-containing free radicals and the oxygen-containing free radicals with the particle size of 0-1000 nanometers and intelligently adjusting the working parameters of the high-voltage power supply system and the components and the dosage of the working medium.
Further, the nano active substance is low-temperature plasma with electron density of 107～1023/cm3。
Further, the working medium is one or more of hyaluronic acid, collagen, water vapor, hydrogen, methane, oxygen, nitrogen, air, rare gas, essential oil, physiological saline or medicine.
Further, during the electron avalanche process, the electrode pair and the pass element are electrically connected by a partially ionized operating medium or a broken down blocking medium.
Further, during the electron avalanche process, the electrode pair and the transmission member are connected in series or in parallel through the partially ionized working medium or the broken-down blocking medium.
Further, the blocking medium and the working medium can be the same medium or different mediums.
Further, the high-voltage power supply system is a high-voltage power supply or a transformer, and the output high voltage of the high-voltage power supply system is direct current or alternating current high voltage.
Further, the output high voltage of the high-voltage power supply system is pulse high voltage.
Use of a low-temperature plasma generating device for obtaining at least one nano active substance of ultra-fine particles, nitrogen-containing radicals and oxygen-containing radicals with particle size of 0-1000 nm and electron density of 107～1023/cm3。
Due to the adoption of the technical scheme, the method has the following beneficial effects:
the invention relates to a low-temperature plasma generating device which mainly comprises a high-voltage power supply system, a pair of electrodes, at least one transmission piece and at least one working medium. The high-voltage power supply system can be a high-voltage power supply or a transformer and is used for providing a high-voltage electric field; the electrode pairs are respectively and electrically connected with two sides of the output end of the high-voltage power supply system and used for loading a high-voltage electric field. The transmission piece is used for transmitting the high-voltage electric field and inducing the working medium to discharge. The working medium is discharged in an electron avalanche process under the action of a high-voltage electric field, so that at least one nano active substance of superfine particles with the particle size of 0-1000 nm, nitrogen-containing free radicals and oxygen-containing free radicals is obtained.
The blocking medium is placed between the pair of electrodes, preferably a high dielectric constant medium, to stabilize the high voltage electric field and produce uniform ionization.
The intelligent sensor is used for detecting the concentration of at least one nano active substance in the ultra-fine particles, nitrogen-containing free radicals and oxygen-containing free radicals with the particle size of 0-1000 nanometers, and intelligently adjusting the working parameters of the transformer and the components and the dosage of the working medium, so that the components and the concentration of the nano active substance are adjusted, and different purposes and requirements are met.
The output high voltage of the high-voltage power supply system is direct current or alternating current high voltage, preferably pulse high voltage, and the working temperature is reduced and the biocompatibility is improved while the nano-drug is efficiently manufactured.
The invention can simultaneously have a plurality of working media by arranging the transmission piece, so that the low-temperature plasma generating device can not only simultaneously process a plurality of working media to meet various treatment requirements, but also can be started to discharge in advance by the working media easy to discharge. In addition, the transmission piece can be used for transmitting a high-voltage electric field and inducing the discharge of the working medium, and also can induce the discharge of the working medium (such as water vapor and the like) which is difficult to discharge, thereby reducing the discharge difficulty and maintaining the working stability.
The low-temperature plasma generating device can continuously work for a long time, is stable in work, safe, effective and small in size, and can be applied to various medical instruments and health care and physical purposes.
Drawings
The invention will be further described with reference to the accompanying drawings in which:
FIG. 1 is a schematic configuration diagram of a low-temperature plasma generating apparatus according to embodiment 1 of the present invention;
FIG. 2 is a schematic structural view of a low-temperature plasma generating apparatus according to embodiment 2 of the present invention;
FIG. 3 is a schematic structural view of a low-temperature plasma generating apparatus according to embodiment 3 of the present invention;
FIG. 4 is a schematic structural view of a low-temperature plasma generating apparatus according to embodiment 4 of the present invention;
FIG. 5 is a schematic structural view of a low-temperature plasma generating apparatus according to embodiment 5 of the present invention;
FIG. 6 is a graph showing the concentration of ultra-fine particles having a partial particle size (11.5-64.9 nm) generated by a low-temperature plasma generating apparatus according to the present invention;
FIG. 7 is a graph of the spectrum of hydroxyl radicals (ESR tester) produced by a low temperature plasma generating apparatus in accordance with the practice of the present invention;
FIG. 8 is a graph of NO concentration produced by a low temperature plasma generating device in accordance with an embodiment of the present invention;
FIG. 9 is a graph showing the effect of alleviating atopic eczema;
FIG. 10 is a graph showing the effect of inhibiting tumor cells.
In the figure: 1-a high-voltage power supply system, 11-a transformer primary side I, 12-a transformer primary side II, 13-a first electrode, 14-a second electrode, 2-a transmission part, 2A-a first transmission part, 2B-a second transmission part, 2C-a third transmission part, 3-a blocking medium, 4-a working medium, 41-a working medium I, 42-a working medium II, 43-a working medium III, 44-a working medium IV.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to the accompanying drawings and examples. It should be understood, however, that the description herein of specific embodiments is only intended to illustrate the invention and not to limit the scope of the invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
A low-temperature plasma generating device comprises a high-voltage power supply system 1 and an electrode pair, wherein the electrode pair comprises a first electrode 13 and a second electrode 14, one side of the output end of the high-voltage power supply system 1 is electrically connected with the end part of the first electrode 13, the other side of the output end of the high-voltage power supply system 1 is electrically connected with the end part of the second electrode 14, and the first electrode 13 and the second electrode 14 are oppositely arranged and are not in contact with each other;
the first electrode 13 and the second electrode 14 are used for loading a high-voltage electric field under the action of the high-voltage power supply system 1;
the low-temperature plasma generating device also comprises at least one transmission piece and a working medium 4, wherein the working medium 4 is subjected to electron avalanche process discharge under the action of a high-voltage electric field so as to obtain at least one nano active substance of superfine particles with the particle size of 0-1000 nm, nitrogen-containing free radicals and oxygen-containing free radicals;
the working medium 4 is arranged between the first electrode 13 and the second electrode 14, or between the first electrode 13 and a transmission member, or between the second electrode 14 and a transmission member, or between adjacent transmission members;
the transmission piece 2 is used for transmitting a high-voltage electric field and inducing the working medium 4 to discharge. The transmission members are conductive substances, and at least one of the transmission members 2 and the electrode pair are not in contact with each other, and the transmission members and the working medium 4 are in contact with each other.
The electrode pair of the device is different from the electrode pair of the prior art, the electrode pair of the prior art is generally placed in a relatively closed environment, and the electrode pair of the device can be placed in an open environment or a relatively closed environment to achieve the same effect.
Further, the low-temperature plasma generating device also comprises a blocking medium 3, wherein the blocking medium 3 is a medium with a high dielectric constant and is used for preventing the electrode pair from discharging outside the working medium 4 area, stabilizing a high-voltage electric field and generating uniform ionization.
Further, the blocking medium 3 is disposed between the first electrode 13 and the second electrode 14, or between the first electrode 13 and the transmission member 2, or between the second electrode 14 and the transmission member 2, or between two adjacent transmission members 2.
Further, the blocking medium 3 is disposed through the first electrode 13 and the second electrode 14, or disposed through the first electrode 13 and the transmission member 2, or disposed through the second electrode 14 and the transmission member 2, or disposed through two adjacent transmission members 2.
Further, the device comprises an intelligent sensor, wherein the intelligent sensor is used for detecting the concentration of at least one nano active substance in the superfine particles, the nitrogen-containing free radicals and the oxygen-containing free radicals with the particle size of 0-1000 nanometers, and intelligently adjusting the working parameters of the high-voltage power supply system 1 and the components and the dosage of the working medium 4.
Further, the nano active substance is low-temperature plasma with electron density of 107～1023/cm3. The generated low-temperature plasma can be directly used as a nano-drug, and can be used for medical purposes, such as skin disease and wound care, beauty treatment and anti-aging, alopecia prevention and hair growth, oral care, respiratory disease prevention and treatment, tumor treatment and the like by taking the nano active substance as a carrier and adding other drugs.
Further, the working medium 4 is one or more of hyaluronic acid, collagen, water vapor, hydrogen, methane, oxygen, nitrogen, air, rare gas, essential oil, physiological saline or medicine.
Further, during the electron avalanche process, the electrode pair and the transmission member 2 are electrically connected through the partially ionized operating medium 4 or the broken-down blocking medium 3.
Further, during the electron avalanche process, the electrode pair and the transmission member 2 are connected in series or in parallel through the partially ionized working medium 4 or the broken-down blocking medium 3.
Further, the blocking medium 3 and the working medium 4 may be the same medium or different mediums.
Further, the high-voltage power supply system 1 is a high-voltage power supply or a transformer, and the output high voltage of the high-voltage power supply system is a direct-current high voltage or an alternating-current high voltage.
Further, the output high voltage of the high-voltage power supply system is pulse high voltage.
Example 1
As shown in fig. 1, in order to set 1 transmission element 2, when the high voltage power supply system 1 is a transformer, one side of the transformer is a low voltage input end, the low voltage input end is a primary side i 11 of the transformer and a primary side ii 12 of the transformer, the other side of the transformer is a high voltage output end, the high voltage output end is a secondary side i of the transformer and a secondary side ii of the transformer, and the first electrode 13 and the second electrode 14 are electrically connected to the secondary side i of the transformer and the secondary side ii of the transformer respectively for loading a high voltage electric field.
The transmission pieces 2 are respectively arranged opposite to the first electrodes 13 at intervals and used for transmitting a high-voltage electric field and loading the working medium I41 and the working medium II 42; the working medium I41 is arranged between the first electrode 13 and the transmission piece 2, and the working medium II 42 is arranged between the second electrode 14 and the transmission piece 2, and discharges through an electron avalanche process under the action of a high-voltage electric field so as to obtain at least one nano active substance of superfine particles with the particle size of 0-1000 nm, nitrogen-containing free radicals and oxygen-containing free radicals; a blocking dielectric 3 is also provided, said blocking dielectric 3 being placed between the second electrode 14 and the transmission member 2 or being arranged through the second electrode 14 and the transmission member 2. The blocking medium 3 is preferably a high-dielectric-constant medium, which serves on the one hand to prevent discharges outside the region of the operating media i 41 and ii 42 and on the other hand to stabilize the high-voltage electric field and to generate uniform ionization.
In the present embodiment, the transmission member 2 and the first electrode 13 are not in contact with each other, and the transmission member 2 is in contact with the working medium i 41 and the working medium ii 42, respectively.
The low-temperature plasma generating device further comprises an intelligent sensor (not shown in the figure), wherein the intelligent sensor is used for detecting the concentration of at least one nano active substance in the superfine particles, the nitrogen-containing free radicals and the oxygen-containing free radicals with the particle size of 0-1000 nanometers, and intelligently adjusting the working parameters of the transformer and the components and the dosage of the working medium 4.
The nano active substance is low-temperature plasmaElectron density of 107～1023/cm3。
The working medium 4 is one or more of hyaluronic acid, collagen, water vapor, hydrogen, methane, oxygen, nitrogen, air, rare gas, essential oil, physiological saline or medicine.
The blocking medium 3 and the working medium 4 may be the same medium, such as air, in which case a part of the working medium 4 is ionized by discharging through electron avalanche process, and another part is not ionized and is in a dielectric state, and is used as the blocking medium 3.
The blocking medium 3 and the working medium 4 may be different mediums, and in this case, the blocking medium 3 may be disposed on the outer periphery of any one of the first electrode 13, the second electrode 14, and the transmission member 2 (e.g., disposed through the second electrode 14 and the transmission member 2), or disposed between any two of the electrode pair and the transmission member 2 (e.g., between the second electrode 14 and the transmission member 2). In this embodiment, the blocking medium 3 is disposed through the second electrode 14 and the transmitting member 2, and at this time, the blocking medium 3 also plays a role of fixing the electrode pair and the transmitting member 2, so as to further ensure the stability of the electric field.
In the electron avalanche process, the first electrode 13, the second electrode 14 and the transmission member 2 are electrically connected through the partially ionized working medium I41 and the partially ionized working medium II 42, or the broken-down blocking medium 3. The first electrode 13, the second electrode 14 and the transmission piece 2 are connected in series or in parallel through the partially ionized working medium I41 and the partially ionized working medium II 42 or the punctured barrier medium 3.
The electrode pair (13, 14) is any combination of needle-shaped, rod-shaped, strip-shaped, sheet-shaped, annular, planar and the like. In the present embodiment, the first electrode 13 and the second electrode 14 are both configured to be needle-shaped, so as to maintain the local accumulation of the high voltage electric field, and to more easily induce the electron avalanche process of the working medium i 41 and the working medium ii 42 to discharge.
The high-voltage power supply system can be an electromagnetic transformer or a piezoelectric transformer, the output high voltage of the high-voltage power supply system is direct current or alternating current high voltage, preferably pulse high voltage, and the working temperature is reduced and the biocompatibility of the nano-drug is improved while the nano-drug is efficiently manufactured.
Because 2 working media I41 and II 42 exist, the low-temperature plasma generating device can simultaneously process different working media 4 so as to meet different treatment requirements and act on different treatment targets.
Example 2
As shown in fig. 2, the difference from embodiment 1 is that: the present embodiment is provided with 2 transfer elements 2. In the present embodiment, the 2 transmitting members 2 are respectively called a first transmitting member 2A and a second transmitting member 2B.
2 transmission pieces 2 can also process 2 working media 4 simultaneously, and 2 working media 4 are respectively working media I41 and working media II 42.
The 2 transmission parts 2 are oppositely arranged at intervals with a certain distance, wherein a first transmission part 2A is connected with a first electrode 13, a second transmission part 2B is connected with a second electrode 14 through a working medium II 42, the working medium I41 is arranged between the first transmission part 2A and the second transmission part 2B, and under the action of a high-voltage electric field, the electric discharge is carried out through an electron avalanche process so as to obtain at least one nano active substance in superfine particles with the particle size of 0-1000 nanometers, nitrogen-containing free radicals and oxygen-containing free radicals; a blocking dielectric 3 is also provided, said blocking dielectric 3 being placed between the first electrode 13 and the transmission member 2 or being arranged through the first electrode 13 and the transmission member 2. The blocking medium 3 is preferably a high-dielectric-constant medium, which serves on the one hand to prevent discharges outside the region of the operating media i 41 and ii 42 and on the other hand to stabilize the high-voltage electric field and to generate uniform ionization.
In this embodiment, the blocking medium 3 penetrates 2 transmission members 2, and at this time, the blocking medium 3 also plays a role in fixing the electrode pair and the transmission members 2, so as to further ensure the stability of the electric field.
In the present embodiment, the first transmission member 2A and the first electrode 13 are in contact with each other, the second transmission member 2B and the second electrode 14 are not in contact with each other, the working medium i 41 is in contact between the first transmission member 2A and the second transmission member 2B, and the second transmission member 2B and the working medium ii 42 are in contact with each other.
In the case of the example 3, the following examples are given,
as a modification to embodiment 2, fig. 3 is different from embodiment 2 in that: on the basis of 2 transmission pieces 2, 3 working media 4 can be processed simultaneously, and the 3 working media 4 are respectively a working medium I41, a working medium II 42 and a working medium III 43.
In the present embodiment, the 2 transmitting members 2 are respectively called a first transmitting member 2A and a second transmitting member 2B.
The 2 transmission parts 2 are oppositely arranged at intervals, wherein the first transmission part 2A is connected with the first electrode 13 through a working medium II 42; the second transmission piece 2B is connected with the second electrode 14 through a working medium III 43, the working medium I41 is arranged between the first transmission piece 2A and the second transmission piece 2B, and discharges through an electron avalanche process under the action of a high-voltage electric field so as to obtain at least one nano active substance in the superfine particles, the nitrogen-containing free radicals and the oxygen-containing free radicals with the particle size of 0-1000 nm; a blocking dielectric 3 is also provided, said blocking dielectric 3 being placed between the second electrode 14 and the transmission member 2 or being arranged through the second electrode 14 and the transmission member 2. The blocking medium 3 is preferably a high-dielectric-constant medium, which serves on the one hand to prevent discharges outside the region of the operating media i 41 and ii 42 and on the other hand to stabilize the high-voltage electric field and to generate uniform ionization.
In this embodiment, the blocking medium 3 penetrates 2 transmission members 2, and at this time, the blocking medium 3 also plays a role in fixing the electrode pair and the transmission members 2, so as to further ensure the stability of the electric field.
In the present embodiment, the first transmission member 2A and the first electrode 13 are not in contact with each other, the second transmission member 2B and the second electrode 14 are not in contact with each other, the working medium i 41 is in contact between the first transmission member 2A and the second transmission member 2B, the first transmission member 2A and the working medium ii 42 are in contact with each other, and the second transmission member 2B and the working medium iii 43 are in contact with each other.
Example 4
As shown in fig. 4, the difference from the embodiments 1 and 2 is that: in order to set 3 transfer members 2, 2 working mediums 4 can be processed simultaneously, and the 2 working mediums 4 are respectively a working medium I41 and a working medium II 42.
In the present embodiment, the 3 transmitting members 2 are respectively called a first transmitting member 2A, a second transmitting member 2B, and a third transmitting member 2C.
The first transmission piece 2A and the second transmission piece 2B are oppositely arranged at a certain distance, wherein the first transmission piece 2A is electrically connected with the first electrode 13; the second transmission part 2B is connected with a third transmission part 2C through a working medium II 42, the third transmission part 2C is electrically connected with the second electrode 14, and a working medium I41 is arranged between the first transmission part 2A and the second transmission part 2B and discharges through an electron avalanche process under the action of a high-voltage electric field so as to obtain at least one nano active substance in the superfine particles, nitrogen-containing free radicals and oxygen-containing free radicals with the particle size of 0-1000 nm; a blocking dielectric 3 is also provided, said blocking dielectric 3 being placed between the second electrode 14 and the transmission member 2 or being arranged through the second electrode 14 and the transmission member 2. The blocking medium 3 is preferably a high-dielectric-constant medium, which serves on the one hand to prevent discharges outside the region of the operating media i 41 and ii 42 and on the other hand to stabilize the high-voltage electric field and to generate uniform ionization.
In this embodiment, the blocking medium 3 penetrates through the first transmission member 2A and the second transmission member 2B, and at this time, the blocking medium 3 also plays a role in fixing the electrode pair and the transmission member 2, so as to further ensure the stability of the electric field.
In this embodiment, the first transmission member 2A and the first electrode 13 are in contact with each other, the second transmission member 2B and the second electrode 14 are not in contact with each other, the third transmission member 2C and the second electrode 14 are in contact with each other,
working medium I41 is in contact between the first transmission member 2A and the second transmission member 2B, and working medium II 42 is in contact between the second transmission member 2B and the third transmission member 2C.
Example 5
As a modification of the fourth embodiment, as shown in fig. 5, in the case of providing 3 transfer members 2, 4 working media 4 can be processed simultaneously, and the 4 working media 4 are respectively a working medium i 41, a working medium ii 42, a working medium iii 43, and a working medium iv 44.
In the present embodiment, the 3 transmitting members 2 are respectively called a first transmitting member 2A, a second transmitting member 2B, and a third transmitting member 2C.
The first transmission piece 2A and the second transmission piece 2B are oppositely arranged at a certain distance, wherein the first transmission piece 2A is connected with the first electrode 13 through a working medium II 42; the second transmission part 2B is connected with a third transmission part 2C through a working medium III 43, the third transmission part 2C is connected with a second electrode 14 through a working medium IV 44, a working medium I41 is arranged between the first transmission part 2A and the second transmission part 2B, and under the action of a high-voltage electric field, the working medium I is subjected to electron avalanche process to discharge so as to obtain at least one nano active substance of ultrafine particles with the particle size of 0-1000 nm, nitrogen-containing free radicals and oxygen-containing free radicals; a blocking dielectric 3 is also provided, said blocking dielectric 3 being placed between the second electrode 14 and the transmission member 2 or being arranged through the second electrode 14 and the transmission member 2. The blocking medium 3 is preferably a high-dielectric-constant medium, which serves on the one hand to prevent discharges outside the region of the operating media i 41 and ii 42 and on the other hand to stabilize the high-voltage electric field and to generate uniform ionization.
In this embodiment, the blocking medium 3 penetrates through the first transmission member 2A and the second transmission member 2B, and at this time, the blocking medium 3 also plays a role in fixing the electrode pair and the transmission member 2, so as to further ensure the stability of the electric field.
In this embodiment, the first transmission member 2A and the first electrode 13 are not in contact with each other, the second transmission member 2B and the second electrode 14 are not in contact with each other, the third transmission member 2C and the second electrode 14 are not in contact with each other,
working medium I41 is in contact between the first transmission piece 2A and the second transmission piece 2B, working medium II 42 is in contact between the first transmission piece 2A and the first electrode 13, working medium III 43 is in contact between the second transmission piece 2B and the third transmission piece 2C, and working medium IV 44 is in contact between the second electrode 14 and the third transmission piece 2C.
Specific experimental data are shown in table 1:
TABLE 1 Experimental data sheet for low temperature plasma generator (ambient temperature 25 deg.C, relative humidity 55%)
As can be seen from Table 1 and FIGS. 6-8: the low-temperature plasma generator of the embodiment produces a large amount of nano active materials such as ultra-fine particles with a particle size of 0-1000 nm, nitrogen-containing radicals and oxygen-containing radicals, and can produce a large amount of oxygen-containing radicals (such as hydroxyl groups) and nitrogen-containing radicals (such as nitric oxide) with a concentration of 15-42ppm or more, and can be used for medical purposes. In addition, under the same conditions, the embodiment adopts pulse high voltage, so that the temperature of the working medium 4 can be reduced and the biocompatibility of the working medium can be improved while the nano-drug is efficiently manufactured.
Use of a nano-active material containing at least one of an ultrafine particle having a particle diameter of 0 to 1000 nm, a nitrogen-containing radical and an oxygen-containing radical, in which at least one of an ultrafine particle having a particle diameter of 0 to 1000 nm, a nitrogen-containing radical and an oxygen-containing radical is obtained by using a low-temperature plasma generator as described in any of examples 1 to 5, and the nano-active material has an electron density of 107～1023/cm3It can be used as medical apparatus for caring skin diseases and wounds, caring skin, resisting aging, preventing alopecia and promoting hair growth, caring oral cavity, preventing and treating respiratory diseases, and treating tumor.
Taking a method for relieving skin diseases as an example, the working medium 4 is provided to generate at least one nano active substance of ultrafine particles with the particle size of 0-1000 nm, nitrogen-containing free radicals and oxygen-containing free radicals through the discharge in the electron avalanche process, the nano active substance acts on the skin, the oxygenation effect and hemoglobin index of the skin are increased, the activation of mast cells and eosinophilic granulocytes is inhibited, the expression and generation of IL-6 and TNF-alpha are inhibited, the activation of NF-kappa B is inhibited, and allergic dermatitis is improved. For example, allergic eczema is shown in fig. 9. Before treatment, M2 type macrophages have obvious infiltration, the horny layer is thicker, and the horny layer becomes thinner obviously after treatment by the nano active substances. Before treatment, the glands of M2 type macrophages are enlarged, and after treatment, the glands of M2 type macrophages become obviously smaller. Therefore, after the nanometer active substance acts on the skin, the activation of mast cells and eosinophils is inhibited, the stratum corneum is thinned and recovered to be normal, the parakeratosis is inhibited, and the allergic eczema is improved.
Taking a method for inhibiting tumor cells as an example, by providing a working medium 4, discharging in an electron avalanche process to generate a nano active substance containing at least one of ultrafine particles with the particle size of 0-1000 nm, nitrogen-containing free radicals and oxygen-containing free radicals, and acting on the tumor cells, as shown in fig. 10, taking lung cancer cells as an example, after the nano drug acts for 16 minutes, the lung cancer cells are completely inhibited, macrophages, T cells or NK cells are activated, immunogenic cell death of the tumor cells is induced, specific and protective immune responses are systematically triggered, and iron death of the tumor cells is induced.
The above is only a specific embodiment of the present invention, but the technical features of the present invention are not limited thereto. Any simple changes, equivalent substitutions or modifications made on the basis of the present invention to solve the same technical problems and achieve the same technical effects are all covered in the protection scope of the present invention.
Claims (13)
1. A low-temperature plasma generating device comprises a high-voltage power supply system and an electrode pair, wherein the electrode pair comprises a first electrode and a second electrode, one side of the output end of the high-voltage power supply system is electrically connected with the end part of the first electrode, the other side of the output end of the high-voltage power supply system is electrically connected with the end part of the second electrode, and the low-temperature plasma generating device is characterized in that: the first electrode and the second electrode are oppositely arranged and are not in contact with each other;
the first electrode and the second electrode are used for loading a high-voltage electric field under the action of a high-voltage power supply system;
the low-temperature plasma generating device also comprises at least one transmission piece and a working medium, wherein the working medium is subjected to electron avalanche process discharge under the action of a high-voltage electric field so as to obtain at least one nano active substance in the superfine particles with the particle size of 0-1000 nm, nitrogen-containing free radicals and oxygen-containing free radicals;
the working medium is arranged between the first electrode and the second electrode, or between the first electrode and the transmission piece, or between the second electrode and the transmission piece, or between two adjacent transmission pieces;
the transmission piece is used for transmitting the high-voltage electric field and inducing the working medium to discharge.
2. A low-temperature plasma generating apparatus according to claim 1, wherein: the low-temperature plasma generating device also comprises a blocking medium which is a medium with high dielectric constant and is used for preventing the electrode pair from discharging outside the working medium area, stabilizing a high-voltage electric field and generating uniform ionization.
3. A low-temperature plasma generating apparatus according to claim 2, wherein: the blocking medium is arranged between the first electrode and the second electrode, or between the first electrode and the transmission member, or between the second electrode and the transmission member, or between two adjacent transmission members.
4. A low-temperature plasma generating apparatus according to claim 2, wherein: the blocking medium penetrates through the first electrode and the second electrode, or penetrates through the first electrode and the transmission piece, or penetrates through the second electrode and the transmission piece, or penetrates through two adjacent transmission pieces.
5. A low-temperature plasma generating apparatus according to any one of claims 1 to 4, wherein: the intelligent sensor is used for detecting the concentration of at least one nano active substance in the ultra-fine particles, the nitrogen-containing free radicals and the oxygen-containing free radicals with the particle size of 0-1000 nanometers and intelligently adjusting the working parameters of the high-voltage power supply system and the components and the dosage of the working medium.
6. A low-temperature plasma generating apparatus according to any one of claims 1 to 4, wherein: the sodiumThe rice active substance is low temperature plasma with electron density of 107～1023/cm3。
7. A low-temperature plasma generating apparatus according to any one of claims 1 to 4, wherein: the working medium is one or more of hyaluronic acid, collagen, water vapor, hydrogen, methane, oxygen, nitrogen, air, rare gas, essential oil, normal saline or medicine.
8. A low-temperature plasma generating apparatus according to any one of claims 2 to 4, wherein: in an electron avalanche process, the electrode pair and the transmission member are electrically connected by a partially ionized operating medium or a broken down blocking medium.
9. A low-temperature plasma generating apparatus according to any one of claims 2 to 4, wherein: in the electron avalanche process, the electrode pair and the transmission member are connected in series or in parallel through a partially ionized working medium or a broken-down blocking medium.
10. A low-temperature plasma generating apparatus according to any one of claims 2 to 4, wherein: the blocking medium and the working medium can be the same medium or different mediums.
11. A low-temperature plasma generating apparatus according to any one of claims 1 to 4, wherein: the high-voltage power supply system is a high-voltage power supply or a transformer, and the output high voltage of the high-voltage power supply system is direct-current high voltage or alternating-current high voltage.
12. A low-temperature plasma generating apparatus according to any one of claims 1 to 4, wherein: the output high voltage of the high-voltage power supply system is pulse high voltage.
13. Low-temperature plasma generating deviceUse, characterized in that: using the low-temperature plasma generating device to obtain at least one nano active substance of ultra-fine particles, nitrogen-containing free radicals and oxygen-containing free radicals with the particle size of 0-1000 nm, wherein the electron density of the nano active substance is
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