CN113349988A - Tissue engineering bone for repairing jaw cleft palate defect and preparation method thereof - Google Patents
Tissue engineering bone for repairing jaw cleft palate defect and preparation method thereof Download PDFInfo
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- CN113349988A CN113349988A CN202110603628.0A CN202110603628A CN113349988A CN 113349988 A CN113349988 A CN 113349988A CN 202110603628 A CN202110603628 A CN 202110603628A CN 113349988 A CN113349988 A CN 113349988A
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- bone
- cleft palate
- maxillofacial
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2803—Bones for mandibular reconstruction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/30769—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth madreporic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
Abstract
The invention discloses a tissue engineering bone for repairing jaw facial cleft palate defects and a preparation method thereof. The double-layer degradable tissue engineering bone manufactured by the invention is completely matched with cleft palate defect of a patient, can accurately recover the original palate structure and function of the patient, avoids a series of problems of supply area trauma, deformity, scar, pain and the like caused by current autologous bone transplantation and inevitable defects of limited sources and the like, and simultaneously does not influence the normal growth and development of the jaw bone because the tissue engineering bone is degradable.
Description
Technical Field
The invention belongs to the technical field of oral medical instruments, and particularly relates to a tissue engineering bone for repairing jaw facial cleft palate defects and a preparation method thereof.
Background
Cleft palate is a common congenital deformity of the oromaxillofacial region of a newborn, which not only affects the appearance of a patient, but also affects the shapes and functions of multiple organs of the oromaxillofacial region of the patient, including appearance deformity, maxillofacial development deformity, dental and jaw system deformity, voice dysfunction, hearing disorder, psychological disorder and the like, and is a disease seriously harming the physical and psychological health of an infant patient.
The repair of defects caused by cleft palate is a continuing problem in dentistry due to the complex anatomic and physiological environment of the oromaxillofacial region. The clinical treatment method for repairing cleft palate is mainly to close the gap through an operation, keep and extend the length of the soft palate and restore the physiological function of the soft palate.
Cleft palate can be divided into incomplete cleft palate and complete cleft palate, the cleft palate completely splits from the uvula to the incisor orifice and leans outwards to directly support the alveolar process, often accompanied by alveolar process. At present, most scholars consider that the alveolar burst defect accompanied by cleft palate is repaired by carrying out secondary bone grafting in the mixed dentition stage, so that the influence on the growth and development of the maxilla can be reduced. The ilium cancellous bone is used as a bone grafting supply source, the operation is convenient and easy, the bone source is rich, the method is the first choice for autologous bone implantation, but a series of problems of supply area trauma, deformity, scar, pain and the like exist, and the source is limited and the like.
The tissue engineering bone provides a new method for repairing the bone defect of cleft palate. The tissue engineering bone as a bone transplantation substitute material can be used for replacing autologous bone for transplantation and repair of defects, thereby avoiding the occurrence of deformity of a bone supply area, reducing the pain of a patient and enabling the repair and reconstruction of the defects of palate and physiological function. The rapid development of tissue engineering provides a new idea for restoration and reconstruction of cleft palate, but because the oral maxillofacial region has the problems of specific anatomical structure, biomechanical conduction under physiological conditions and the like, the current tissue engineering bone aiming at cleft palate defect is developed less.
Disclosure of Invention
The present invention overcomes at least one of the deficiencies of the prior art described above,
the invention aims to provide a tissue engineering bone for repairing maxillofacial cleft palate defects, which comprises a double-layer bracket and hydrogel, wherein the hydrogel fills pores of the bracket.
Further, the scaffold is of a double-layer porous structure.
Further, the lower layer of the bracket is in contact with the soft tissues of the oral cavity.
Further, the pores in the lower layer of the scaffold resemble the denser compact bone of the human palate.
Further, the pores of the lower layer of the scaffold were 50 μm.
Further, the superior pores of the scaffold are similar to the more porous cancellous bone of the human palate.
Further, the pore size of the upper layer of the scaffold is 450 microns.
Further, the thickness of the lower layer of the support is consistent with the thickness of the compact bone part of the bone near the cleft palate defect of the patient.
Further, the total thickness and the size of the double-layer bracket of the bracket are consistent with the depth and the range of cleft palate defects of a patient.
Further, the hydrogel comprises 3% by mass of desferrioxamine powder and 10% by mass of methyl methacrylate hydrogel powder, the desferrioxamine powder and the methyl methacrylate hydrogel powder are premixed and then added with physiological saline to form DFO-GelMA premixed liquid, and the premixed liquid is injected into the stent and then cured by ultraviolet light to form the hydrogel.
Another object of the present invention is to provide a method for preparing a tissue engineering bone for maxillofacial cleft palate defect repair, comprising the steps of:
s1, processing a CT scanning image of a jaw of a cleft palate patient, reconstructing a jaw bone defect model of an affected side, and designing a hard palate bionic tissue scaffold according to the jaw bone defect;
s2, integrally printing a double-layer support by using beta-tricalcium phosphate powder through a photocuring 3D printing technology;
and S3, pouring the hydrogel premix solution into a bracket, and then carrying out ultraviolet curing to obtain the double-layer degradable tissue engineering bone for repairing the maxillofacial cleft palate defect.
Compared with the background art, the invention has the beneficial effects that:
(1) the double-layer degradable tissue engineering bone for repairing the palatoschisis defect of the maxillofacial region is completely matched with the palatoschisis defect of the affected side of a patient, and the original palatoschisis structure and function of the patient can be accurately recovered. Avoids a series of problems of injury, deformity, scar, pain and the like of a supply area, a source of the problems is limited and the like inevitable defects caused by the existing autologous bone transplantation. The tissue engineering bone has a double-layer porous structure similar to a dense layer and a loose layer of a normal palatal bone, can play a role in supporting soft tissues, is beneficial to keeping the length of the soft palate and exerting functions, provides a normal anatomical bone structure for reattaching ectopic muscles separated from fracture edges, and achieves a better biomechanical conduction effect.
(2) The main component of the degradable tissue engineering bone is beta-tricalcium phosphate which is a biodegradable and bioabsorbable active material, ions of degradation products Ca2+, PO 45-and the like can enter body fluid to promote the formation of new bones, so that the degradable tissue engineering bone becomes an ideal hard tissue repairing material for cleft palate, and the normal growth and development of bones are not influenced because the material is degradable. The hydrogel is composed of Desferrioxamine (DFO) -modified methyl methacrylate hydrogel (GelMA), and has effects of promoting angiogenesis and bone regeneration.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a longitudinal section of the present invention;
FIG. 3 is a schematic structural diagram of another embodiment of the present invention;
FIG. 4 is a longitudinal sectional view of another embodiment of the present invention;
FIG. 5 is a schematic view of cleft palate defect
Wherein, 1, double-layer porous support; 2. pore structure of the infused hydrogel; 3. the upper layer of the double-layer porous bracket; 4. a double-layer porous support lower layer; 5. cleft palate defect.
Detailed Description
The drawings are for illustrative purposes only and are not to be construed as limiting the patent; it will be understood by those skilled in the art that certain well-known structures and descriptions thereof may be omitted. Except for special notes, all the medicines used in the invention are purchased from the market.
A double-layer degradable tissue engineering bone for repairing the jaw-face cleft palate defect comprises a double-layer porous scaffold and hydrogel, wherein the hydrogel fills pores of the scaffold. The upper layer of the double-layer porous scaffold has pores of 450 microns, and the lower layer has pores of 50 microns. The hydrogel comprises 3 mass percent of desferrioxamine powder and 10 mass percent of methyl methacrylate hydrogel powder, and the balance is physiological saline; and premixing the two, adding physiological saline with corresponding mass fraction to form DFO-GelMA premixed solution, injecting the premixed solution into the beta-tricalcium phosphate stent, and curing by using ultraviolet light. The double-layer support is designed according to the shape of the defective hard palate, beta-tricalcium phosphate powder is used, and the double-layer support is integrally printed by a photocuring 3D printing (DLP) technology.
A preparation method of a double-layer degradable tissue engineering bone for maxillofacial cleft palate defect repair comprises the following steps:
s1, processing a CT scanning image of a jaw of a cleft palate patient, reconstructing a jaw bone defect model of an affected side, and designing a hard palate bionic tissue scaffold according to the jaw bone defect;
s2, integrally printing the beta-tricalcium phosphate double-layer support by a photocuring 3D printing (DLP) technology;
s3, pouring the hydrogel premix liquid as described in claim 3 into a support, and carrying out ultraviolet curing to obtain the double-layer degradable tissue engineering bone for repairing maxillofacial cleft palate defect.
Step S2 is to suspend the β -tricalcium phosphate powder in an organic matrix consisting of acrylate and methacrylate, lithium phenyl-2, 4, 6-trimethylbenzoylphosphonate (free radical photoinitiator) for use. Inputting the designed double-layer porous scaffold into a 3D printer in an STL format, and printing the beta-tricalcium phosphate scaffold.
Example 1:
as shown in fig. 1, the present embodiment provides a double-layer degradable tissue engineering bone structure for repairing cleft palate of maxillofacial region, comprising a porous scaffold 1 for double-layer, a porous structure 2 filled with hydrogel; the basic bracket is designed according to the shape of the hard palate, is integrally printed by beta-tricalcium phosphate material through a photocuring 3D printing (DLP) technology, is used for restoring the defective shape of the jaw and ensuring the mechanical strength, and is degradable, so that the normal growth and development of bones are not influenced; the hydrogel is composed of Desferrioxamine (DFO) -modified methyl methacrylate hydrogel (GelMA), and has effects of promoting angiogenesis and bone regeneration.
Example 2:
a preparation method of the double-layer degradable tissue engineering bone for repairing the cleft palate of the maxillofacial region in the embodiment 1 is provided, and the preparation method specifically comprises the following steps:
the first step is as follows: importing the image parameters of the palate anatomical structure obtained by CT scanning into computer Mimics15.01 software, and segmenting data of normal compact sclerotic bone near a palate defect and trabecular bone of inner cancellous bone by applying GeomagicStudio2013 software;
the second step is that: designing a double-layer pore structure of the tissue engineering bone scaffold for filling the palate defect, wherein the pores at the upper layer 3 of the double-layer porous scaffold are 450 microns and are similar to a human bone trabecula structure, so that the bone regeneration is facilitated; the lower layer 4 of the double-layer porous bracket is in contact with soft tissues and is designed to be a denser layer, and the pores are 50 microns, so that epithelial tissues are prevented from growing in early.
The third step: beta-tricalcium phosphate powder is suspended in an organic matrix consisting of acrylate and methacrylate, lithium phenyl-2, 4, 6-trimethylbenzoylphosphonate (free radical photoinitiator) for further use.
The fourth step: inputting the designed double-layer scaffold into a 3D printer in an STL format, and printing a finished product of the beta-tricalcium phosphate bionic bone scaffold (figure 2).
The fifth step: and (3) pouring a Deferoxamine (DFO) -modified methyl methacrylate hydrogel (GelMA) premix into the pore structure 2 of the beta-tricalcium phosphate scaffold, curing by ultraviolet light to obtain a double-layer degradable tissue engineering bone (figure 1), and transplanting the double-layer degradable tissue engineering bone to the cleft palate defect part 5 (figure 5) of the patient to complete the repair of the cleft palate defect.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by using the contents of the present specification and the accompanying drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. A tissue engineering bone for repairing maxillofacial cleft palate defect is characterized in that: comprises a double-layer bracket and hydrogel, wherein the hydrogel fills the bracket pores.
2. The tissue engineered bone for maxillofacial cleft palate defect repair of claim 1, wherein: the pores in the lower layer of the scaffold resemble the denser cortical bone of the human palate.
3. The tissue engineered bone for maxillofacial cleft palate defect repair of claim 1, wherein: the pores of the lower layer of the scaffold were 50 microns.
4. The tissue engineered bone for maxillofacial cleft palate defect repair of claim 1, wherein: the superior pores of the scaffold are similar to the looser cancellous bone of the human palate.
5. The tissue engineered bone for maxillofacial cleft palate defect repair of claim 1, wherein: the pore size of the upper layer of the scaffold was 450 microns.
6. The tissue engineered bone for maxillofacial cleft palate defect repair of claim 1, wherein: the thickness of the lower layer of the bracket is consistent with the thickness of the compact bone part of the bone near the cleft palate defect of the patient.
7. The tissue engineered bone for maxillofacial cleft palate defect repair of claim 1, wherein: the total thickness and the size of the double-layer bracket of the bracket are consistent with the depth and the range of cleft palate defects of a patient.
8. The tissue engineered bone for maxillofacial cleft palate defect repair of claim 1, wherein: the hydrogel comprises 3% of desferrioxamine powder and 10% of methyl methacrylate hydrogel powder in mass fraction, the desferrioxamine powder and the methyl methacrylate hydrogel powder are premixed and then added with physiological saline to form DFO-GelMA premixed liquid, and the premixed liquid is injected into the stent and then cured by ultraviolet light to form the DFO-GelMA premixed liquid.
9. A preparation method of a tissue engineering bone for repairing maxillofacial cleft palate defect is characterized by comprising the following steps:
s1, processing a CT scanning image of a jaw of a cleft palate patient, reconstructing a jaw bone defect model of an affected side, and designing a hard palate bionic tissue scaffold according to the jaw bone defect;
s2, integrally printing a double-layer support by using beta-tricalcium phosphate powder through a photocuring 3D printing technology;
s3, pouring the hydrogel premix liquid as described in claim 8 into a support, and carrying out ultraviolet curing to obtain the double-layer degradable tissue engineering bone for repairing maxillofacial cleft palate defect.
10. The method of claim 9, wherein step S2 is performed by suspending the β -tricalcium phosphate powder in an organic matrix comprising acrylate and methacrylate esters and a free radical photoinitiator.
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| CN202110603628.0A CN113349988A (en) | 2021-05-31 | 2021-05-31 | Tissue engineering bone for repairing jaw cleft palate defect and preparation method thereof |
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| CN202110603628.0A CN113349988A (en) | 2021-05-31 | 2021-05-31 | Tissue engineering bone for repairing jaw cleft palate defect and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114569789A (en) * | 2022-03-23 | 2022-06-03 | 宁波市医疗中心李惠利医院 | Preparation method and application of BPN-DFO gel scaffold |
| CN114870092A (en) * | 2022-05-20 | 2022-08-09 | 广州骊贝生物科技有限公司 | Bone substitute complex and preparation method and application thereof |
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Cited By (3)
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| CN114870092A (en) * | 2022-05-20 | 2022-08-09 | 广州骊贝生物科技有限公司 | Bone substitute complex and preparation method and application thereof |
| CN114870092B (en) * | 2022-05-20 | 2023-08-22 | 广州骊贝生物科技有限公司 | Bone substitute complex, preparation method and application thereof |
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Application publication date: 20210907 |