CN113332385A - Preparation method of arenobufagin hard-hardness-softening liver-softening tablet - Google Patents
Preparation method of arenobufagin hard-hardness-softening liver-softening tablet Download PDFInfo
- Publication number
- CN113332385A CN113332385A CN202110640582.XA CN202110640582A CN113332385A CN 113332385 A CN113332385 A CN 113332385A CN 202110640582 A CN202110640582 A CN 202110640582A CN 113332385 A CN113332385 A CN 113332385A
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- parts
- tablet
- arenobufagin
- softening
- materials
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Abstract
The invention discloses a preparation method of a arenobufagin tablet for softening hard masses and softening liver, which has the technical scheme that: the method comprises the following steps: s1, selecting materials; s2, cleaning; s3, powdering; s4, heating and stirring; s5, dispersing materials; s6, preheating before pressing: adding excipient, disintegrant and adhesive into the S5 material, mixing, and heating to 50-60 deg.C; s7, tabletting: transferring the materials in the reaction kettle to a traditional Chinese medicine pressing decoction piece tablet press, and pressing the materials into tablets by using the traditional Chinese medicine pressing decoction piece tablet press; s8, coating preparation: attaching a coating on the surface of the tablet prepared in the step S7; the arenobufagin hard mass softening liver tablet adopts arenobufagin, dendrobium officinale, berberis poiretii schneid, muskroot-like semiaquilegia root, gardenia jasminoides, oriental wormwood, angelica sinensis, rhizoma alismatis, rehmannia glutinosa, gentiana macrophylla, leech and other components with good effects of protecting liver and protecting liver, has obvious effect and has certain treatment effect on cirrhosis.
Description
Technical Field
The invention relates to the field of medicines, and in particular relates to a preparation method of a arenobufagin tablet for softening hard masses and softening liver.
Background
With the development of society and the progress of living standard of people, the welfare of scientific and technological development in daily life brings more convenience to people, but simultaneously, the living rhythm of modern people is greatly accelerated, and the irregularity of living habits of people in diet, work and rest time and the like causes the problems of obesity, inappetence, fatty liver, insomnia, rough skin and the like of more and more people in the society, and also causes the reduction of the immunity of the people, wherein most of the reasons are the reduction of the liver function.
The prior Chinese patent with publication number CN111345388A discloses a method for preparing a tablet candy with liver-protecting, spleen-invigorating and anti-tumor effects and a preparation device thereof, which comprises the following steps: step S1, preparing materials; step S2, micronizing the main material; step S3, low-temperature extraction; step S4, processing the main material; step S5, micronizing the auxiliary materials; step S6, mixing; step S7, tabletting; step S8, coating; and step S9, subpackaging.
The manufacturing method of the tablet candy with the effects of protecting liver, tonifying spleen and resisting tumors has some disadvantages, such as: the capability of protecting and nourishing the liver is limited, and the production process is difficult and complex.
Disclosure of Invention
In view of the problems mentioned in the background art, the invention aims to provide a preparation method of a arenobufagin tablet for softening hard masses and softening liver, so as to solve the problems mentioned in the background art.
The technical purpose of the invention is realized by the following technical scheme:
a preparation method of a arenobufagin tablet for softening hard masses and softening liver comprises the following steps:
s1, selecting materials: selecting the following raw materials by weight for later use, 5-10 parts of arenobufagin, 10-14 parts of dendrobium officinale, 5-10 parts of berchemia lineata willd, 15-20 parts of muskroot-like semiaquilegia root, 4-8 parts of liquorice, 6-10 parts of gardenia jasminoides, 2-4 parts of oriental wormwood, 18-24 parts of isatis root, 5-8 parts of polygonatum odoratum, 4-10 parts of glossy privet fruit, 3-8 parts of angelica sinensis, 4-10 parts of radix paeoniae alba, 10-15 parts of salvia miltiorrhiza, 4-10 parts of astragalus membranaceus, 6-12 parts of codonopsis pilosula, 4-8 parts of rhizoma alismatis, 4-8 parts of rhizoma polygonati, 2-5 parts of rehmannia glutinosa, 3-6 parts of gentiana macrophylla, 5-10 parts of desmodium, 10-15 parts of excipient, 5-10 parts of disintegrating agent and 14-16 parts of adhesive;
s2, cleaning: mixing herba Dendrobii, herba Damnacanthi, radix Semiaquilegiae, Glycyrrhrizae radix, fructus Gardeniae, herba Artemisiae Scopariae, radix Isatidis, rhizoma Polygonati Odorati, fructus Ligustri Lucidi, radix Angelicae sinensis, radix Paeoniae alba, Saviae Miltiorrhizae radix, radix astragali, and radix Codonopsis uniformly, adding into a cleaning container, washing with 1/1000 quality light saline water;
s3, powdering: draining the water of the material cleaned in the step S2, adding the material into a stirrer for powder grinding operation, wherein the rotating speed of a powder grinding machine is controlled to be 2000r/min during powder grinding, and the material is ground into particles with the fineness of 5-10 meshes;
s4, heating and stirring: adding the S3 pulverized particles into a reaction kettle, adding clear water accounting for 50-60% of the mass ratio of the materials, heating the reaction kettle to 70-80 ℃, preserving the heat for 2 hours, and continuously stirring during heating;
s5, dispersing materials: grinding arenobufagin, rhizoma alismatis, rhizoma polygonati, rehmannia, gentiana macrophylla and leech to particles with the fineness of 10-15 meshes by using a grinding machine, filling the particles into a reaction kettle in S4, and uniformly dispersing the particles at the rotating speed of 2000-2500r/min by using an electric stirrer for 30-50 min;
s6, preheating before pressing: adding excipient, disintegrant and adhesive into the S5 material, mixing, and heating to 50-60 deg.C;
s7, tabletting: transferring the materials in the reaction kettle to a traditional Chinese medicine pressing decoction piece tablet press, and pressing the materials into tablets by using the traditional Chinese medicine pressing decoction piece tablet press;
s8, coating preparation: a coating was attached to the surface of the tablet prepared in S7.
Preferably, when the S1 is selected, the following raw materials are selected by weight for standby, 8 parts of arenobufagin, 12 parts of dendrobium officinale, 8 parts of berberis poiretii schneid, 17 parts of muskroot-like semiaquilegia root, 6 parts of liquorice, 8 parts of gardenia jasminoides, 3 parts of oriental wormwood, 22 parts of isatis root, 6 parts of polygonatum odoratum, 7 parts of glossy privet fruit, 5 parts of angelica, 6 parts of white paeony root, 12 parts of salvia miltiorrhiza, 8 parts of astragalus membranaceus, 8 parts of codonopsis pilosula, 6 parts of rhizoma alismatis, 6 parts of rhizoma polygonati, 3 parts of rehmannia glutinosa, 5 parts of gentiana macrophylla, 8 parts of leech, 13 parts of excipient, 8 parts of disintegrant and 15 parts of adhesive.
Preferably, when preheating is carried out before S6 is pressed, the excipient added into the material of S5 is one or a mixture of more of acacia, syrup and lanolin.
Preferably, when preheating is carried out before S6 pressing, the disintegrant added into the material of S5 is one or a mixture of citric acid, tartaric acid, sodium carboxymethyl starch and polyvinylpyrrolidone.
Preferably, when preheated before pressing in S6, the binder added to the material in S5 is one or more of sodium carboxymethyl cellulose, PVP, HPC, HPMC, MC, and EC.
Preferably, when the S4 is heated and stirred, the S3 powdered particles are added into the reaction kettle, and simultaneously, a mixture of vitamin C and microorganism D which accounts for 3-5% of the mass ratio of the materials is added, wherein the mass ratio of the vitamin C to the microorganism D is 2: 1.
preferably, when S7 is tabletted, the mesh size of the adopted die is 8-12mm, and after tabletting, drying is carried out at the temperature of 50-60 ℃ by using drying equipment.
Preferably, in the step of coating at S8, the coating composition is added after spraying the aqueous coating solution, and a coating film is formed in a vibrating screen.
Preferably, the coating aqueous solution is a 1% glucose solution, and the coating composition is prepared from the following components in percentage by mass: 1 alginate mixed with pectin.
In summary, the invention mainly has the following beneficial effects:
the arenobufagin hard mass softening and liver softening tablet adopts arenobufagin, dendrobium officinale, berberis poiretii schneid, muskroot-like semiaquilegia root, gardenia, oriental wormwood, angelica sinensis, rhizoma alismatis, rehmannia, gentiana macrophylla, leech and other components with good effects of protecting the liver and protecting the liver, has obvious effect and has certain treatment effect on liver cirrhosis.
The arenobufagin hard-softening and liver-softening tablet can be prepared into tablets with stable performance by means of material selection, cleaning, powdering, heating and stirring, material dispersion, preheating before pressing, tabletting, coating preparation and the like, and the arenobufagin hard-softening and liver-softening tablet is simple in preparation process, low in cost, suitable for large-scale industrial preparation and has a remarkable application prospect.
Drawings
FIG. 1 is a process diagram of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Referring to fig. 1, a method for preparing a arenobufagin tablet for softening hard masses and softening liver comprises the following steps:
s1, selecting materials: selecting the following raw materials by weight for later use, 5 parts of arenobufagin, 10 parts of dendrobium officinale, 5 parts of berberis thunbergii, 20 parts of muskroot-like semiaquilegia root, 4 parts of liquorice, 6 parts of cape jasmine fruit, 4 parts of oriental wormwood, 18 parts of isatis root, 8 parts of polygonatum odoratum, 4 parts of glossy privet fruit, 3 parts of Chinese angelica, 4 parts of white paeony root, 15 parts of salvia miltiorrhiza, 4 parts of astragalus mongholicus, 6 parts of codonopsis pilosula, 4 parts of rhizoma alismatis, 4 parts of rhizoma polygonati, 2 parts of rehmannia, 3 parts of gentiana macrophylla, 10 parts of desmodium, 10 parts of excipient, 5 parts of disintegrant and 16 parts of adhesive;
s2, cleaning: mixing herba Dendrobii, herba Damnacanthi, radix Semiaquilegiae, Glycyrrhrizae radix, fructus Gardeniae, herba Artemisiae Scopariae, radix Isatidis, rhizoma Polygonati Odorati, fructus Ligustri Lucidi, radix Angelicae sinensis, radix Paeoniae alba, Saviae Miltiorrhizae radix, radix astragali, and radix Codonopsis uniformly, adding into a cleaning container, washing with 1/1000 quality light saline water;
s3, powdering: draining the water of the material cleaned in the step S2, adding the material into a stirrer for powder grinding operation, wherein the rotating speed of a powder grinding machine is controlled to be 2000r/min during powder grinding, and the material is ground into particles with the fineness of 5 meshes;
s4, heating and stirring: adding the S3 pulverized particles into a reaction kettle, adding clear water accounting for 50-60% of the mass ratio of the materials, heating the temperature in the reaction kettle to 70 ℃, preserving the temperature for 2 hours, and continuously stirring during heating;
s5, dispersing materials: grinding arenobufagin, rhizoma alismatis, rhizoma polygonati, rehmannia, gentiana macrophylla and leech to particles with the fineness of 10 meshes by using a grinding machine, filling the particles into a reaction kettle in S4, and uniformly dispersing the particles at the rotating speed of 2000r/min by using an electric stirrer for 30 min;
s6, preheating before pressing: adding excipient, disintegrant and adhesive into the S5 material, mixing uniformly, and heating the material to 50 ℃;
s7, tabletting: transferring the materials in the reaction kettle to a traditional Chinese medicine pressing decoction piece tablet press, and pressing the materials into tablets by using the traditional Chinese medicine pressing decoction piece tablet press;
s8, coating preparation: a coating was attached to the surface of the tablet prepared in S7.
Wherein, when preheating is carried out before S6 is pressed, the excipient added into the material of S5 is Arabic gum.
Wherein, when preheating before S6 pressing, citric acid is added as disintegrant into S5 material.
Wherein, when preheating before S6 pressing, the adhesive added into the material of S5 is sodium carboxymethyl cellulose.
Wherein, when S4 is heated and stirred, S3 powdered particles are added into a reaction kettle, and simultaneously, a mixture of vitamin C and microorganism D which occupies 3% of the mass ratio of the materials is added, wherein the mass ratio of the vitamin C to the microorganism D is 2: 1.
wherein, when S7 preforming, the sieve mesh aperture of the mould that adopts is 8mm, utilizes drying equipment to dry at 50 ℃ after the preforming.
Wherein, when S8 is used for preparing coating, the coating aqueous solution is sprayed, then the coating composition is added, and the coating film is prepared in a vibrating screen.
Wherein the coating aqueous solution is a glucose solution with the mass ratio of 1%, and the coating composition is a glucose solution with the mass ratio of 2: 1 alginate mixed with pectin.
The arenobufagin hard mass softening and liver softening tablet adopts arenobufagin, dendrobium officinale, berberis thunbergii, muskroot-like semiaquilegia root, gardenia jasminoides, oriental wormwood, angelica sinensis, rhizoma alismatis, rehmannia glutinosa, large-leaved gentian, leech and other components with good effects of protecting the liver, has obvious effect and has certain treatment effect on liver cirrhosis. The arenobufagin hard-softening liver-softening tablet can be prepared into tablets with stable performance by means of material selection, cleaning, powdering, heating and stirring, material dispersion, preheating before pressing, tabletting, coating preparation and the like, and the preparation method is simple in generation process, low in cost, suitable for large-scale industrial generation and has a remarkable application prospect.
Example 2
Referring to fig. 1, a method for preparing a arenobufagin tablet for softening hard masses and softening liver comprises the following steps:
s1, selecting materials: selecting the following raw materials by weight for later use, namely 7 parts of arenobufagin, 11 parts of dendrobium officinale, 6 parts of berberis thunbergii, 15 parts of muskroot-like semiaquilegia root, 5 parts of liquorice, 10 parts of cape jasmine fruit, 2 parts of oriental wormwood, 18 parts of isatis root, 5 parts of polygonatum odoratum, 4 parts of glossy privet fruit, 3 parts of Chinese angelica, 4 parts of white paeony root, 12 parts of salvia miltiorrhiza, 6 parts of astragalus mongholicus, 8 parts of codonopsis pilosula, 5 parts of rhizoma alismatis, 5 parts of rhizoma polygonati, 2 parts of rehmannia root, 4 parts of gentiana macrophylla, 6 parts of desmodium, 12 parts of excipient, 7 parts of disintegrant and 15 parts of adhesive;
s2, cleaning: mixing herba Dendrobii, herba Damnacanthi, radix Semiaquilegiae, Glycyrrhrizae radix, fructus Gardeniae, herba Artemisiae Scopariae, radix Isatidis, rhizoma Polygonati Odorati, fructus Ligustri Lucidi, radix Angelicae sinensis, radix Paeoniae alba, Saviae Miltiorrhizae radix, radix astragali, and radix Codonopsis uniformly, adding into a cleaning container, washing with 1/1000 quality light saline water;
s3, powdering: draining the water of the material cleaned in the step S2, adding the material into a stirrer for powder grinding operation, wherein the rotating speed of a powder grinding machine is controlled to be 2000r/min during powder grinding, and the material is ground into particles with the fineness of 8 meshes;
s4, heating and stirring: adding the S3 pulverized particles into a reaction kettle, adding clear water accounting for 54% of the mass ratio of the materials, heating the reaction kettle to 75 ℃, keeping the temperature for 2 hours, and continuously stirring during heating;
s5, dispersing materials: grinding arenobufagin, rhizoma alismatis, rhizoma polygonati, rehmannia, gentiana macrophylla and leech to particles with the fineness of 12 meshes by using a grinding machine, filling the particles into a reaction kettle in S4, and uniformly dispersing the particles at the rotating speed of 2200r/min by using an electric stirrer for 30 min;
s6, preheating before pressing: adding excipient, disintegrant and adhesive into the S5 material, mixing uniformly, and heating the material to 52 ℃;
s7, tabletting: transferring the materials in the reaction kettle to a traditional Chinese medicine pressing decoction piece tablet press, and pressing the materials into tablets by using the traditional Chinese medicine pressing decoction piece tablet press;
s8, coating preparation: a coating was attached to the surface of the tablet prepared in S7.
Wherein, when preheating is carried out before S6 compression, the excipient added into the material of S5 is syrup.
Wherein, when preheating before S6 pressing, the disintegrant added into the material of S5 is tartaric acid.
Wherein, when preheating before S6 pressing, PVP is added as the binding agent into the material of S5.
Wherein, when S4 is heated and stirred, S3 powdered particles are added into a reaction kettle, and simultaneously, a mixture of vitamin C and microorganism D which occupies 5% of the mass ratio of the materials is added, wherein the mass ratio of the vitamin C to the microorganism D is 2: 1.
wherein, when S7 tabletting, the mesh diameter of the adopted mould is 11mm, and drying is carried out at 50 ℃ by using drying equipment after tabletting.
Wherein, when S8 is used for preparing coating, the coating aqueous solution is sprayed, then the coating composition is added, and the coating film is prepared in a vibrating screen.
Wherein the coating aqueous solution is a glucose solution with the mass ratio of 1%, and the coating composition is a glucose solution with the mass ratio of 2: 1 alginate mixed with pectin.
Example 3
Referring to fig. 1, a method for preparing a arenobufagin tablet for softening hard masses and softening liver comprises the following steps:
s1, selecting materials: selecting the following raw materials by weight for later use, 10 parts of arenobufagin, 12 parts of dendrobium officinale, 9 parts of berberis thunbergii, 18 parts of muskroot-like semiaquilegia root, 7 parts of liquorice, 8 parts of gardenia, 4 parts of oriental wormwood, 23 parts of isatis root, 7 parts of polygonatum odoratum, 8 parts of glossy privet fruit, 6 parts of Chinese angelica, 8 parts of white paeony root, 13 parts of salvia miltiorrhiza, 4 parts of astragalus mongholicus, 6 parts of codonopsis pilosula, 4 parts of rhizoma alismatis, 4 parts of rhizoma polygonati, 2 parts of rehmannia, 3 parts of gentiana macrophylla, 5 parts of desmodium, 11 parts of excipient, 7 parts of disintegrant and 14 parts of adhesive;
s2, cleaning: mixing herba Dendrobii, herba Damnacanthi, radix Semiaquilegiae, Glycyrrhrizae radix, fructus Gardeniae, herba Artemisiae Scopariae, radix Isatidis, rhizoma Polygonati Odorati, fructus Ligustri Lucidi, radix Angelicae sinensis, radix Paeoniae alba, Saviae Miltiorrhizae radix, radix astragali, and radix Codonopsis uniformly, adding into a cleaning container, washing with 1/1000 quality light saline water;
s3, powdering: draining the water of the material cleaned in the step S2, adding the material into a stirrer for powder grinding operation, wherein the rotating speed of a powder grinding machine is controlled to be 2000r/min during powder grinding, and the material is ground into particles with the fineness of 10 meshes;
s4, heating and stirring: adding the S3 pulverized particles into a reaction kettle, adding clear water accounting for 60% of the mass of the materials, heating the reaction kettle to 80 ℃, preserving the temperature for 2 hours, and continuously stirring during heating;
s5, dispersing materials: grinding arenobufagin, rhizoma alismatis, rhizoma polygonati, rehmannia, gentiana macrophylla and leech to particles with the fineness of 15 meshes by using a grinding machine, filling the particles into a reaction kettle in S4, and uniformly dispersing the particles at the rotating speed of 2500r/min by using an electric stirrer for 50 min;
s6, preheating before pressing: adding excipient, disintegrant and adhesive into the S5 material, mixing uniformly, and heating the material to 58 ℃;
s7, tabletting: transferring the materials in the reaction kettle to a traditional Chinese medicine pressing decoction piece tablet press, and pressing the materials into tablets by using the traditional Chinese medicine pressing decoction piece tablet press;
s8, coating preparation: a coating was attached to the surface of the tablet prepared in S7.
Wherein when preheating is carried out before S6 is pressed, the mass ratio of the acacia gum to the syrup added into the material S5 is 1: 2, or a mixture thereof.
When preheating is carried out before S6 is pressed, the mass ratio of citric acid to tartaric acid of the disintegrant added into the material S5 is 1: 1.
Wherein, when preheating before S6 pressing, the adhesive added into the material of S5 is sodium carboxymethyl cellulose.
Wherein, when S4 is heated and stirred, S3 powdered particles are added into a reaction kettle, and simultaneously, a mixture of vitamin C and microorganism D which occupies 4% of the mass ratio of the materials is added, wherein the mass ratio of the vitamin C to the microorganism D is 2: 1.
wherein, when S7 tabletting, the mesh size of the adopted mould is 12mm, and drying is carried out at the temperature of 60 ℃ by using drying equipment after tabletting.
Wherein, when S8 is used for preparing coating, the coating aqueous solution is sprayed, then the coating composition is added, and the coating film is prepared in a vibrating screen.
Wherein the coating aqueous solution is a glucose solution with the mass ratio of 1%, and the coating composition is a glucose solution with the mass ratio of 2: 1 alginate mixed with pectin.
Example 4
Referring to fig. 1, a method for preparing a arenobufagin tablet for softening hard masses and softening liver comprises the following steps:
s1, selecting materials: selecting the following raw materials by weight for later use, 10 parts of arenobufagin, 14 parts of dendrobium officinale, 10 parts of berberis thunbergii, 20 parts of muskroot-like semiaquilegia root, 8 parts of liquorice, 10 parts of cape jasmine fruit, 4 parts of oriental wormwood, 24 parts of isatis root, 8 parts of polygonatum odoratum, 10 parts of glossy privet fruit, 8 parts of Chinese angelica, 10 parts of white paeony root, 15 parts of salvia miltiorrhiza, 10 parts of astragalus membranaceus, 6 parts of codonopsis pilosula, 4 parts of oriental waterplantain rhizome, 4 parts of rhizoma polygonati, 5 parts of rehmannia root, 4 parts of gentiana macrophylla, 5 parts of desmodium;
s2, cleaning: mixing herba Dendrobii, herba Damnacanthi, radix Semiaquilegiae, Glycyrrhrizae radix, fructus Gardeniae, herba Artemisiae Scopariae, radix Isatidis, rhizoma Polygonati Odorati, fructus Ligustri Lucidi, radix Angelicae sinensis, radix Paeoniae alba, Saviae Miltiorrhizae radix, radix astragali, and radix Codonopsis uniformly, adding into a cleaning container, washing with 1/1000 quality light saline water;
s3, powdering: draining the water of the material cleaned in the step S2, adding the material into a stirrer for powder grinding operation, wherein the rotating speed of a powder grinding machine is controlled to be 2000r/min during powder grinding, and the material is ground into particles with the fineness of 6 meshes;
s4, heating and stirring: adding the S3 pulverized particles into a reaction kettle, adding clear water accounting for 52% of the mass of the materials, heating the reaction kettle to 74 ℃, preserving the temperature for 2 hours, and continuously stirring during heating;
s5, dispersing materials: grinding arenobufagin, rhizoma alismatis, rhizoma polygonati, rehmannia, gentiana macrophylla and leech to particles with the fineness of 13 meshes by using a grinding machine, filling the particles into a reaction kettle in S4, and uniformly dispersing the particles at the rotating speed of 2100r/min by using an electric stirrer for 40 min;
s6, preheating before pressing: adding excipient, disintegrant and adhesive into the S5 material, mixing uniformly, and heating the material to 56 ℃;
s7, tabletting: transferring the materials in the reaction kettle to a traditional Chinese medicine pressing decoction piece tablet press, and pressing the materials into tablets by using the traditional Chinese medicine pressing decoction piece tablet press;
s8, coating preparation: a coating was attached to the surface of the tablet prepared in S7.
Wherein, when preheating before S6 pressing, the excipient added into the material of S5 is lanolin.
Wherein, when preheating before S6 pressing, the disintegrant added into the material of S5 is sodium carboxymethyl starch.
Wherein, when preheating before S6 pressing, the adhesive added into the material of S5 is sodium carboxymethyl cellulose.
Wherein, when S4 is heated and stirred, S3 powdered particles are added into a reaction kettle, and simultaneously, a mixture of vitamin C and microorganism D which occupies 5% of the mass ratio of the materials is added, wherein the mass ratio of the vitamin C to the microorganism D is 2: 1.
wherein, when S7 tabletting, the mesh size of the adopted mould is 12mm, and drying is carried out at the temperature of 60 ℃ by using drying equipment after tabletting.
Wherein, when S8 is used for preparing coating, the coating aqueous solution is sprayed, then the coating composition is added, and the coating film is prepared in a vibrating screen.
Wherein the coating aqueous solution is a glucose solution with the mass ratio of 1%, and the coating composition is a glucose solution with the mass ratio of 2: 1 alginate mixed with pectin.
To test the difference of the present tablet compared to the reference mentioned in the background, the following method comparisons were made:
the experimental method comprises the following steps:
firstly, trial eating by a patient:
50 liver cirrhosis volunteers were selected to eat the tablets of the comparison document, the example 1, the example 2, the example 3 and the example 4 respectively, the administration period was 2 weeks, and through detection, the recovery effect of liver cirrhosis after taking the tablets manufactured by the example 1, the example 2, the example 3 and the example 4 is better than that of the tablets generated by taking the comparison document, and the effect of the example 2 is the best;
secondly, measuring sulfite:
according to the national standard GB/T5009.34: the tablets of the comparative document, example 1, example 2, example 3 and example 4 were subjected to sulfite detection by chromatography, and the detection results showed that the tablets of the comparative document, example 1, example 2, example 3 and example 4 had a sulfite content ratio of 3: 2.6: 2.1: 2.9: 2.2; the sulfite content was the lowest in example 2.
Thirdly, detecting the total arsenic content:
according to the national standard GB/T5009.11: the total arsenic content of the tablets of the comparative document, example 1, example 2, example 3 and example 4 was measured by a chromatograph, and the results of the measurement were that the total arsenic content ratio of the tablets of the comparative document, example 1, example 2, example 3 and example 4 was 1: 0.77: 0.68: 0.94: 0.88; example 2 the total arsenic content was the lowest.
Fourthly, detecting the copper content:
according to the national standard GB/T5009.13: the tablets of the comparative document, example 1, example 2, example 3 and example 4 were subjected to copper content detection by chromatography, and the detection results showed that the tablets of the comparative document, example 1, example 2, example 3 and example 4 had a copper content ratio of 1: 0.88: 0.81: 0.91: 0.93; the copper content was the lowest in example 4.
The analysis shows that: the standards of example 2, example 3 and example 4 are superior to those of the comparison document, and example 2 is the best example.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. A preparation method of a arenobufagin tablet for softening hard masses and softening liver is characterized by comprising the following steps:
s1, selecting materials: selecting the following raw materials by weight for later use, 5-10 parts of arenobufagin, 10-14 parts of dendrobium officinale, 5-10 parts of berchemia lineata willd, 15-20 parts of muskroot-like semiaquilegia root, 4-8 parts of liquorice, 6-10 parts of gardenia jasminoides, 2-4 parts of oriental wormwood, 18-24 parts of isatis root, 5-8 parts of polygonatum odoratum, 4-10 parts of glossy privet fruit, 3-8 parts of angelica sinensis, 4-10 parts of radix paeoniae alba, 10-15 parts of salvia miltiorrhiza, 4-10 parts of astragalus membranaceus, 6-12 parts of codonopsis pilosula, 4-8 parts of rhizoma alismatis, 4-8 parts of rhizoma polygonati, 2-5 parts of rehmannia glutinosa, 3-6 parts of gentiana macrophylla, 5-10 parts of desmodium, 10-15 parts of excipient, 5-10 parts of disintegrating agent and 14-16 parts of adhesive;
s2, cleaning: mixing herba Dendrobii, herba Damnacanthi, radix Semiaquilegiae, Glycyrrhrizae radix, fructus Gardeniae, herba Artemisiae Scopariae, radix Isatidis, rhizoma Polygonati Odorati, fructus Ligustri Lucidi, radix Angelicae sinensis, radix Paeoniae alba, Saviae Miltiorrhizae radix, radix astragali, and radix Codonopsis uniformly, adding into a cleaning container, washing with 1/1000 quality light saline water;
s3, powdering: draining the water of the material cleaned in the step S2, adding the material into a stirrer for powder grinding operation, wherein the rotating speed of a powder grinding machine is controlled to be 2000r/min during powder grinding, and the material is ground into particles with the fineness of 5-10 meshes;
s4, heating and stirring: adding the S3 pulverized particles into a reaction kettle, adding clear water accounting for 50-60% of the mass ratio of the materials, heating the reaction kettle to 70-80 ℃, preserving the heat for 2 hours, and continuously stirring during heating;
s5, dispersing materials: grinding arenobufagin, rhizoma alismatis, rhizoma polygonati, rehmannia, gentiana macrophylla and leech to particles with the fineness of 10-15 meshes by using a grinding machine, filling the particles into a reaction kettle in S4, and uniformly dispersing the particles at the rotating speed of 2000-2500r/min by using an electric stirrer for 30-50 min;
s6, preheating before pressing: adding excipient, disintegrant and adhesive into the S5 material, mixing, and heating to 50-60 deg.C;
s7, tabletting: transferring the materials in the reaction kettle to a traditional Chinese medicine pressing decoction piece tablet press, and pressing the materials into tablets by using the traditional Chinese medicine pressing decoction piece tablet press;
s8, coating preparation: a coating was attached to the surface of the tablet prepared in S7.
2. The preparation method of the arenobufagin tablet for softening hard masses and softening liver according to claim 1, wherein the tablet comprises the following components: s1 is prepared by selecting the following raw materials by weight for later use, 8 parts of arenobufagin, 12 parts of dendrobium officinale, 8 parts of berberis poiretii schneid, 17 parts of muskroot-like semiaquilegia root, 6 parts of liquorice, 8 parts of gardenia jasminoides, 3 parts of oriental wormwood, 22 parts of isatis root, 6 parts of polygonatum odoratum, 7 parts of glossy privet fruit, 5 parts of angelica, 6 parts of white paeony root, 12 parts of salvia miltiorrhiza, 8 parts of astragalus mongholicus, 8 parts of codonopsis pilosula, 6 parts of rhizoma alismatis, 6 parts of rhizoma polygonati, 3 parts of rehmannia glutinosa, 5 parts of large-leaved gentian, 8 parts of leech, 13 parts of excipient, 8 parts of disintegrating agent and 15 parts of adhesive.
3. The preparation method of the arenobufagin tablet for softening hard masses and softening liver according to claim 1, wherein the tablet comprises the following components: when the S6 is preheated before compression, the excipient added into the material of S5 is one or a mixture of more of acacia, syrup and lanolin.
4. The preparation method of the arenobufagin tablet for softening hard masses and softening liver according to claim 1, wherein the tablet comprises the following components: when preheating is carried out before S6 pressing, the disintegrant added into the material of S5 is one or a mixture of more of citric acid, tartaric acid, sodium carboxymethyl starch and polyvinylpyrrolidone.
5. The preparation method of the arenobufagin tablet for softening hard masses and softening liver according to claim 1, wherein the tablet comprises the following components: when the material is preheated before being pressed in S6, the binder added into the material in S5 is one or more of sodium carboxymethyl cellulose, PVP, HPC, HPMC, MC and EC.
6. The preparation method of the arenobufagin tablet for softening hard masses and softening liver according to claim 1, wherein the tablet comprises the following components: when the S4 is heated and stirred, the S3 powdered particles are added into a reaction kettle, and simultaneously, a mixture of vitamin C and microorganism D which accounts for 3-5% of the mass ratio of the materials is added, wherein the mass ratio of the vitamin C to the microorganism D is 2: 1.
7. the preparation method of the arenobufagin tablet for softening hard masses and softening liver according to claim 1, wherein the tablet comprises the following components: when S7 is tabletted, the mesh opening of the adopted mould is 8-12mm, and after tabletting, drying is carried out by using drying equipment at the temperature of 50-60 ℃.
8. The preparation method of the arenobufagin tablet for softening hard masses and softening liver according to claim 1, wherein the tablet comprises the following components: in the step S8, when the coating is prepared, the coating aqueous solution is sprayed, and then the coating composition is added to prepare the coating film in a vibrating screen.
9. The method for preparing the arenobufagin tablet for softening hard masses and soothing liver according to claim 8, wherein the method comprises the following steps: the coating aqueous solution is a glucose solution with the mass ratio of 1%, and the coating composition is prepared from the following components in mass ratio of 2: 1 alginate mixed with pectin.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176113A (en) * | 1996-09-09 | 1998-03-18 | 徐向田 | Compound bufonin of bufo gargarizans |
| CN102940775A (en) * | 2012-10-18 | 2013-02-27 | 王荣 | Traditional Chinese medicine used for preventing and treating liver and gall diseases, and preparation method and application thereof |
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- 2021-06-09 CN CN202110640582.XA patent/CN113332385A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176113A (en) * | 1996-09-09 | 1998-03-18 | 徐向田 | Compound bufonin of bufo gargarizans |
| CN102940775A (en) * | 2012-10-18 | 2013-02-27 | 王荣 | Traditional Chinese medicine used for preventing and treating liver and gall diseases, and preparation method and application thereof |
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Application publication date: 20210903 |