CN113330312B - 评估生物样品中与分子效应相关的分子变化的方法 - Google Patents

评估生物样品中与分子效应相关的分子变化的方法 Download PDF

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CN113330312B
CN113330312B CN202080010118.6A CN202080010118A CN113330312B CN 113330312 B CN113330312 B CN 113330312B CN 202080010118 A CN202080010118 A CN 202080010118A CN 113330312 B CN113330312 B CN 113330312B
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roi
molecule
biological sample
molecular
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CN113330312A (zh
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乔纳森·斯陶贝尔
里马·艾特-贝尔卡塞姆
大卫·博内尔
法比安·帕默拉尔德
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Imabiotech
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10004—Still image; Photographic image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30096—Tumor; Lesion

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202080010118.6A 2019-01-22 2020-01-21 评估生物样品中与分子效应相关的分子变化的方法 Active CN113330312B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19305081 2019-01-22
EP19305081.2 2019-01-22
PCT/EP2020/051388 WO2020152151A1 (en) 2019-01-22 2020-01-21 Method for evaluating molecular changes related to a molecule effect in a biological sample

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CN113330312B true CN113330312B (zh) 2025-03-21

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US (1) US20220137027A1 (enExample)
EP (1) EP3914911A1 (enExample)
JP (1) JP2022517827A (enExample)
CN (1) CN113330312B (enExample)
CA (1) CA3125695A1 (enExample)
WO (1) WO2020152151A1 (enExample)

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CN115541692A (zh) * 2022-10-20 2022-12-30 中国科学院兰州化学物理研究所 一种同时分析小扁豆萌发过程中多种脂类成分空间分布变化的质谱成像方法
WO2024185286A1 (ja) * 2023-03-07 2024-09-12 株式会社島津製作所 イメージング質量分析を用いた解析方法
CN117740919A (zh) * 2023-11-27 2024-03-22 中国科学院深圳先进技术研究院 一种肿瘤类器官空间成像表征方法

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AU2009258038A1 (en) * 2008-03-14 2009-12-17 Eastern Virginia Medical School Imaging mass spectrometry for improved prostate cancer diagnostics
CN101975818B (zh) * 2010-04-29 2012-12-26 中国计量科学研究院 特征物质的检测系统及方法
FR2973112B1 (fr) * 2011-03-21 2018-05-25 Imabiotech Procede de detection et de quantification d'une molecule cible dans un echantillon
US20150262329A1 (en) * 2012-10-03 2015-09-17 KONINKLIJKE PHILIPS N.V. a corporation Combined sample examinations
WO2014078374A2 (en) * 2012-11-13 2014-05-22 Presage Biosciences, Inc. Methods for multiplexed drug evaluation
CA2899994C (en) * 2013-02-25 2022-08-30 Imabiotech Method to evaluate the tissue targeting of a molecule of interest
CA2947650C (en) * 2014-05-29 2021-04-27 Spring Bioscience Corporation Anti- indoleamine 2,3-dioxygenase 1 antibodies and diagnostic uses thereof
GB201413162D0 (en) * 2014-07-24 2014-09-10 Immusmol Sas Prediction of cancer treatment based on determination of enzymes or metabolites of the kynurenine pathway
FR3025317B1 (fr) * 2014-08-26 2022-09-23 Imabiotech Methode de caracterisation d'un echantillon par imagerie par spectrometrie de masse
CA3182538C (en) * 2015-06-11 2026-05-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Educatio Systems and methods for finding regions of interest in hematoxylin and eosin (h&e) stained tissue images and quantifying intratumor cellular spatial heterogeneity in multiplexed/hyperplexed fluorescence tissue images
WO2017049403A1 (en) * 2015-09-22 2017-03-30 University Health Network System and method for optimized mass spectrometry analysis
US10609324B2 (en) * 2016-07-18 2020-03-31 Snap Inc. Real time painting of a video stream
CN107424156B (zh) * 2017-06-28 2019-12-06 北京航空航天大学 基于仿仓鸮眼视觉注意的无人机自主编队精准测量方法

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"Evaluation of non-supervised MALDI mass spectrometry imaging combined with microproteomics for glioma grade III classification";Emilie Le Rhun 等;《Biochimica et Biophysica Acta》;20171231;第1865卷;875–890 *

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US20220137027A1 (en) 2022-05-05
WO2020152151A1 (en) 2020-07-30
CA3125695A1 (en) 2020-07-30
CN113330312A (zh) 2021-08-31
JP2022517827A (ja) 2022-03-10
EP3914911A1 (en) 2021-12-01

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