CN113330113A - Pdcd-1归巢核酸内切酶变体 - Google Patents

Pdcd-1归巢核酸内切酶变体 Download PDF

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Publication number
CN113330113A
CN113330113A CN201980090012.9A CN201980090012A CN113330113A CN 113330113 A CN113330113 A CN 113330113A CN 201980090012 A CN201980090012 A CN 201980090012A CN 113330113 A CN113330113 A CN 113330113A
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Chinese (zh)
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乔丹·贾儒尔
凯尔·哈文斯
贾斯迪普·曼恩
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Regeneron Pharmaceuticals Inc
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Bluebird Bio Inc
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N5/0636—T lymphocytes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
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    • C07K2319/00—Fusion polypeptide
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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CN201980090012.9A 2018-12-10 2019-12-09 Pdcd-1归巢核酸内切酶变体 Pending CN113330113A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862777471P 2018-12-10 2018-12-10
US62/777,471 2018-12-10
PCT/US2019/065223 WO2020123375A1 (en) 2018-12-10 2019-12-09 Pdcd-1 homing endonuclease variants

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CN113330113A true CN113330113A (zh) 2021-08-31

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US (1) US12577547B2 (https=)
EP (1) EP3893886A4 (https=)
JP (2) JP7732893B2 (https=)
KR (1) KR20210102299A (https=)
CN (1) CN113330113A (https=)
AU (1) AU2019395334B2 (https=)
CA (1) CA3122094A1 (https=)
IL (2) IL283724B1 (https=)
WO (1) WO2020123375A1 (https=)

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KR102451510B1 (ko) 2016-09-08 2022-10-07 2세븐티 바이오, 인코포레이티드 Pd-1 호밍 엔도뉴클레아제 변이체, 조성물 및 사용 방법
JP2022513750A (ja) 2018-12-10 2022-02-09 ２セブンティ バイオ インコーポレイテッド ホーミングエンドヌクレアーゼバリアント
IL283724B1 (en) 2018-12-10 2026-02-01 Genetix Biotherapeutics Inc pdcd-1 homing endonuclease variants

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Publication number Priority date Publication date Assignee Title
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EP3893886A4 (en) 2022-09-28
IL283724B1 (en) 2026-02-01
JP7732893B2 (ja) 2025-09-02
WO2020123375A1 (en) 2020-06-18
KR20210102299A (ko) 2021-08-19
IL325732A (en) 2026-03-01
AU2019395334B2 (en) 2026-04-23
IL283724A (en) 2021-07-29
CA3122094A1 (en) 2020-06-18
US12577547B2 (en) 2026-03-17
EP3893886A1 (en) 2021-10-20
JP2022510481A (ja) 2022-01-26
JP2025139593A (ja) 2025-09-26
US20220177860A1 (en) 2022-06-09
AU2019395334A1 (en) 2021-06-24

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