CN113317784A - Micron-scale linear focusing scanning microspectrum optical coherence tomography system - Google Patents
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- 238000012014 optical coherence tomography Methods 0.000 title claims abstract description 23
- 238000002381 microspectrum Methods 0.000 title abstract description 7
- 238000003384 imaging method Methods 0.000 claims abstract description 21
- 238000001228 spectrum Methods 0.000 claims abstract description 13
- 230000003287 optical effect Effects 0.000 claims description 27
- 230000003595 spectral effect Effects 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 9
- 238000001634 microspectroscopy Methods 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 238000002310 reflectometry Methods 0.000 claims description 3
- 238000004621 scanning probe microscopy Methods 0.000 claims 1
- 238000005286 illumination Methods 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
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- 229910052760 oxygen Inorganic materials 0.000 description 2
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- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
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- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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Abstract
The invention discloses a micron-scale linear focusing scanning micro-spectrum optical coherence tomography system which comprises a light source light path, a reference arm light path, a sample arm light path, a spectrometer light path and a beam splitter. The first face of beam splitter communicates with each other with light source light path, and the second face of beam splitter communicates with each other with reference arm light path, and the third face of beam splitter communicates with each other with sample arm light path, and the fourth face of beam splitter communicates with each other with the spectrum appearance light path. The broadband illumination light source uses a spectrum in the range of 500-600 nm. The interference spectrum is modulated with the backscattering information of different depths of an imaging sample, and the depth information of the sample can be obtained by carrying out Fourier transform and further processing on the backscattering information. Through the line type illumination mode, the side-cut images of the tested sample can be parallelly acquired on the two-dimensional array camera. The system is mainly used in the field of three-dimensional microscopic imaging.
Description
Technical Field
The invention relates to a micron-scale linear focusing scanning microspectrum optical coherence tomography system, belonging to the technical field of three-dimensional microscopic imaging of biomedicine.
Background
Spectral Optical Coherence Tomography (SOCT) is a three-dimensional tomographic technique that can reconstruct an image in the depth direction by acquiring interference spectra and by fourier transform. Compared with other medical imaging methods, the OCT technology has the advantages of high resolution, non-contact, non-invasive measurement, low cost, simple system and the like. The core elements of the OCT system are a broadband illumination light source, a Michelson interferometer and a spectrometer. However, the conventional spectral optical coherence tomography has no imaging features and advantages and has limitations of low resolution and low imaging efficiency, so in order to be applied to the field of detecting blood oxygen concentration in blood and avoid the defects, a micron-scale linear focusing scanning micro-spectral optical coherence tomography is proposed.
Disclosure of Invention
The invention aims to provide a micron-scale linear focusing scanning micro-spectral optical coherence tomography system to overcome the defects that the traditional spectral optical coherence tomography technology has no imaging characteristics and advantages and has low resolution and imaging efficiency.
The technical problem solving scheme of the invention is as follows:
a micron-scale line-focused scanning micro-spectroscopic optical coherence tomography system, comprising: the optical system comprises a light source optical path, a reference arm optical path, a sample arm optical path, a spectrometer optical path and a beam splitter, wherein a first surface of the beam splitter is communicated with the light source optical path, a second surface of the beam splitter is communicated with the reference arm optical path, a third surface of the beam splitter is communicated with the sample arm optical path, and a fourth surface of the beam splitter is communicated with the spectrometer optical path.
Further, the light source optical path includes: the broadband light source comprises a broadband light source, a spectrum filter, a light beam expanding lens group and a cylindrical lens, wherein the wavelength range of the broadband light source is 500-600 nm, light emitted by the broadband light source firstly passes through the spectrum filter to filter the spectrum wavelength range and passes through 100 nm, secondly passes through the beam expanding lens group to expand light spots, and finally passes through the cylindrical lens to be focused and is emitted to the first surface of the beam splitter.
Further, the reference arm optical path includes: the light passes through the beam splitter and is divided into two beams by the beam splitter, wherein one beam of light is emitted from the second surface of the beam splitter, the power of the light is firstly adjusted by the neutral density filter, then the light is emitted to the microscope objective, and the light is emitted to the plane mirror after being focused by the microscope objective; after the light rays strike the plane mirror, the light rays are reflected back by the plane mirror and are reflected back to the second surface of the beam splitter.
Further, the sample arm optical path comprises: the scanning imaging device comprises a scanning galvanometer, a microscope objective and an object to be imaged, wherein light is divided into two beams by a beam splitter after passing through the beam splitter, the other beam of light is emitted from a third surface of the beam splitter, emitted to the scanning galvanometer, reflected by the scanning galvanometer, emitted to the microscope objective, focused by the microscope objective and emitted to the object to be imaged, and the light is emitted to different angles through the rotation of the scanning galvanometer, so that the scanning imaging of a sample is realized; after the light reaches the object to be imaged, the light is scattered inside the object, a part of the light is absorbed by the object, and the rest part of the light is reflected by the object and is reflected to the third surface of the beam splitter.
Further, the spectrometer optical path comprises: the light reflected by the reference mirror and the sample is converged by the beam splitter and is emitted from the fourth surface of the beam splitter, the light is emitted to the reflector, the light reflected by the reflector is condensed by light spots passing through the beam-shrinking lens group and then emitted to the grating, the light with different wavelengths is separated after passing through the grating, the separated light is emitted to the lens, the light is focused after passing through the lens, and a two-dimensional image with color distribution is displayed on the two-dimensional photosensitive array after the light is focused.
The method for imaging the two-dimensional image with color distribution on the horizontal plane by using the micron-scale linear focusing scanning microspectrum optical coherence tomography system comprises the following steps: on a horizontal plane, light rays pass through a cylindrical mirror to be kept parallel and enter a beam splitter, the light rays are emitted from the beam splitter and then strike a scanning vibrating mirror, then are reflected from the scanning vibrating mirror and irradiated on a microscope objective, and finally are focused on a sample plane through the microscope objective, after the light rays are reflected from the sample plane, the light rays return in a primary path in a sample arm, after passing through the microscope objective, the light rays are transmitted to a light beam shrinking lens group in parallel, then the light rays are emitted to the grating in parallel, the light rays with different wavelengths in the light ray bundle are emitted to different angles after being transmitted through the grating, then the light rays are respectively focused by the lens, and finally the light rays are all emitted to pixels in the horizontal direction of the two-dimensional photosensitive array, a colorful rainbow line is presented in the transverse direction, the rainbow line is the spectral distribution on any pixel point x, and the obtained spectrum is subjected to dispersion compensation and inverse Fourier transform to calculate the reflectivity information of the z axis.
The method for imaging the two-dimensional image with color distribution on the vertical plane by using the micron-scale linear focusing scanning microspectrum optical coherence tomography system comprises the following steps: on a vertical plane, light rays pass through a cylindrical mirror and then are focused on a beam splitter, then are divergently irradiated on a microscope objective through the beam splitter and multiple reflections, and then pass through the microscope objective and are irradiated on a sample plane in parallel; after the light is reflected from the sample surface, the light returns in a path in the sample arm, after passing through the microscope objective, the light is transmitted and diverged to the light beam shrinking lens group, the light is vertically diverged to irradiate on the grating, after passing through the grating, the light is irradiated to the lens, and the light is converged by the lens, finally the light presents a linear spot in the vertical direction of the two-dimensional array, and the linear spot records the object reflection information in the x direction; and combining the transverse spectral information to obtain the section (x and z directions) reflection information of the sample.
The beneficial effects of the invention are:
1. the micron-scale line type focusing scanning micro-spectrum optical coherence tomography system in the invention uses light in a visible light wave band, and the blood oxygen concentration in blood can be detected by using the light in the wave band.
2. The invention replaces the traditional point focusing mode for illumination by using a line focusing mode, replaces a one-dimensional linear array camera by using a two-dimensional photosensitive array, can image and acquire a section view of an object to be imaged, which is formed by the directions of x and z, and then can acquire the three-dimensional structure distribution of the object to be imaged only by unidirectional scanning in the direction of y, thereby improving the imaging efficiency.
3. The invention adopts a microscope objective lens on the sample arm and the reference arm respectively, thus being capable of acquiring the imaging details of a section diagram formed by the x direction and the z direction under the micron resolution, and being beneficial to analyzing the dynamic process of a plurality of blood vessel sections in the section, in particular the space-time flow condition of red blood cells in blood.
4. The sample arm optical path and the reference arm optical path are the same, so that the dispersion difference of the two optical paths is effectively reduced; in addition, the system is linear focusing imaging, the same light path can ensure the space consistency of two beams of light, and the finally formed interference fringe can realize two-dimensional section imaging under high resolution.
Drawings
Fig. 1 is a schematic structural diagram of a first embodiment of the present invention.
Fig. 2 is a schematic structural diagram of a second embodiment of the present invention.
Fig. 3 is a schematic structural diagram of a third embodiment of the present invention.
Detailed Description
The first embodiment is as follows:
referring to fig. 1, a micro-scale linear focused scanning micro-spectroscopy optical coherence tomography system comprises: the device comprises a light source light path, a reference arm light path, a sample arm light path and a spectrometer light path. The light source optical path includes: the device comprises a broadband light source 110, a spectral filter 120, light beam expanding lens groups (130, 140), a cylindrical mirror 150 and a first surface 160 of a beam splitter. The wavelength range of the broadband light source is 500-600 nm. In the light source optical path, the light emitted from the broadband light source 110 sequentially passes through the spectral filter 120, the light beam expanding lens group (130, 140), the cylindrical mirror 150, and the first surface 160 of the beam splitter in the order of the apparatus.
The reference arm optical path includes: a second surface 210 of the beam splitter, a neutral density filter 220, a microscope objective 230, and a plane mirror 240. The light emitted from the second surface 210 of the beam splitter sequentially passes through the instrument and sequentially comprises a neutral density filter 220, a microscope objective 230 and a plane mirror 240.
The sample arm optical path includes: a third surface 310 of the beam splitter, a scanning galvanometer 320, a microscope objective 330 and an object to be measured 340. The light emitted from the third surface 310 of the beam splitter sequentially passes through the scanning galvanometer 320, the microscope objective 330 and the object to be measured 340 in sequence.
The spectrometer optical path comprises: a fourth surface 410 of the beam splitter, a mirror 420, a light collection lens group (430, 440), a transmission grating 450, a lens 460, and a two-dimensional display array 470. The light emitted from the fourth surface 410 of the beam splitter sequentially passes through the instrument and sequentially comprises a reflector 420, light beam converging lens groups (430, 440), a transmission grating 450, a lens 460 and a two-dimensional display array 470.
Example two:
referring to fig. 2, this is an imaging principle optical path of a two-dimensional image of a color distribution presented on a two-dimensional photosensitive array on a horizontal plane, including: cylindrical mirror 150, beam splitter 160, microscope objective 330, light beam converging lens groups (430, 440), grating 450, lens 460 and two-dimensional photosensitive array 470. The light emitted by the cylindrical lens 150 group sequentially passes through the instrument and sequentially comprises a cylindrical lens 150, a beam splitter 160, a microscope objective 330, a light beam converging lens group (430, 440), a grating 450, a lens 460 and a two-dimensional photosensitive array 470. On a horizontal plane, light rays pass through a cylindrical mirror to be kept parallel and enter a beam splitter, the light rays are emitted from the beam splitter and then strike a scanning vibrating mirror, then are reflected from the scanning vibrating mirror and irradiated on a microscope objective, and finally are focused on a sample plane through the microscope objective, after the light rays are reflected from the sample plane, the light rays return in a primary path in a sample arm, after passing through the microscope objective, the light rays are transmitted to a light beam shrinking lens group in parallel, then the light rays are emitted to the grating in parallel, the light rays with different wavelengths in the light ray bundle are emitted to different angles after being transmitted through the grating, then the light rays are respectively focused by the lens, and finally the light rays are all emitted to pixels in the horizontal direction of the two-dimensional photosensitive array, a colorful rainbow line is presented in the transverse direction, the rainbow line is the spectral distribution on any pixel point x, and the obtained spectrum is subjected to dispersion compensation and inverse Fourier transform to calculate the reflectivity information of the z axis.
Example three:
referring to fig. 3, this is an imaging principle optical path of a two-dimensional image of a color distribution presented on a two-dimensional photosensitive array on a vertical plane, including: cylindrical mirror 150, beam splitter 160, microscope objective 330, light beam converging lens groups (430, 440), grating 450, lens 460 and two-dimensional photosensitive array 470. The light emitted by the cylindrical lens 150 group sequentially passes through the instrument and sequentially comprises a cylindrical lens 150, a beam splitter 160, a microscope objective 330, a light beam converging lens group (430, 440), a grating 450, a lens 460 and a two-dimensional photosensitive array 470. On a vertical plane, light rays pass through a cylindrical mirror and then are focused on a beam splitter, then are divergently irradiated on a microscope objective through the beam splitter and multiple reflections, and then pass through the microscope objective and are irradiated on a sample plane in parallel; after the light is reflected from the sample surface, the light returns in a path in the sample arm, after passing through the microscope objective, the light is transmitted and diverged to the light beam shrinking lens group, the light is vertically diverged to irradiate on the grating, after passing through the grating, the light is irradiated to the lens, and the light is converged by the lens, finally the light presents a linear spot in the vertical direction of the two-dimensional array, and the linear spot records the object reflection information in the x direction; and combining the transverse spectral information to obtain the section (x and z directions) reflection information of the sample.
Although the embodiments of the present invention have been described in detail, the present invention is not limited thereto, and the scope of the present invention is not to be construed as being limited thereto. It will be appreciated by those skilled in the art that various modifications, substitutions, and other embodiments can be made without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (7)
1. A micron-scale line-focused scanning micro-spectroscopic optical coherence tomography system, comprising: the spectrometer comprises a light source light path, a reference arm light path, a sample arm light path, a spectrometer light path and a beam splitter, and is characterized in that a first surface of the beam splitter is communicated with the light source light path, a second surface of the beam splitter is communicated with the reference arm light path, a third surface of the beam splitter is communicated with the sample arm light path, and a fourth surface of the beam splitter is communicated with the spectrometer light path.
2. The micro-scale line focus scanning micro-spectroscopy optical coherence tomography system of claim 1, wherein: the light source optical path includes: the broadband light source comprises a broadband light source, a spectrum filter, a light beam expanding lens group and a cylindrical lens, wherein the wavelength range of the broadband light source is 500-600 nm, light emitted by the broadband light source firstly passes through the spectrum filter to filter the spectrum wavelength range and passes through 100 nm, secondly passes through the beam expanding lens group to expand light spots, and finally passes through the cylindrical lens to be focused and is emitted to the first surface of the beam splitter.
3. The micro-scale line focus scanning micro-spectroscopy optical coherence tomography system of claim 1, wherein: the reference arm optical path includes: the light passes through the beam splitter and is divided into two beams by the beam splitter, wherein one beam of light is emitted from the second surface of the beam splitter, the power of the light is firstly adjusted by the neutral density filter, then the light is emitted to the microscope objective, and the light is emitted to the plane mirror after being focused by the microscope objective; after the light rays strike the plane mirror, the light rays are reflected back by the plane mirror and are reflected back to the second surface of the beam splitter.
4. The micro-scale line focus scanning micro-spectroscopy optical coherence tomography system of claim 1, wherein: the sample arm optical path includes: the scanning imaging device comprises a scanning galvanometer, a microscope objective and an object to be imaged, wherein light is divided into two beams by a beam splitter after passing through the beam splitter, the other beam of light is emitted from a third surface of the beam splitter, emitted to the scanning galvanometer, reflected by the scanning galvanometer, emitted to the microscope objective, focused by the microscope objective and emitted to the object to be imaged, and the light is emitted to different angles through the rotation of the scanning galvanometer, so that the scanning imaging of a sample is realized; after the light reaches the object to be imaged, the light is scattered inside the object, a part of the light is absorbed by the object, and the rest part of the light is reflected by the object and is reflected to the third surface of the beam splitter.
5. The micro-scale line focus scanning micro-spectroscopy optical coherence tomography system of claim 1, wherein: the spectrometer optical path includes: the light reflected by the reference mirror and the sample is converged by the beam splitter and is emitted from the fourth surface of the beam splitter, the light is emitted to the reflector, the light reflected by the reflector is condensed by light spots passing through the beam-shrinking lens group and then emitted to the grating, the light with different wavelengths is separated after passing through the grating, the separated light is emitted to the lens, the light is focused after passing through the lens, and a two-dimensional image with color distribution is displayed on the two-dimensional photosensitive array after the light is focused.
6. A method of imaging a two-dimensional image of a color distribution in a horizontal plane by a micro-scale line-focus scanning microscopy spectroscopic optical coherence tomography system as claimed in any one of claims 1 to 5, wherein: the method comprises the following steps: on a horizontal plane, light rays pass through a cylindrical mirror to be kept parallel and enter a beam splitter, the light rays are emitted from the beam splitter and then strike a scanning vibrating mirror, then are reflected from the scanning vibrating mirror and irradiated on a microscope objective, and finally are focused on a sample plane through the microscope objective, after the light rays are reflected from the sample plane, the light rays return in a primary path in a sample arm, after passing through the microscope objective, the light rays are transmitted to a light beam shrinking lens group in parallel, then the light rays are emitted to the grating in parallel, the light rays with different wavelengths in the light ray bundle are emitted to different angles after being transmitted through the grating, then the light rays are respectively focused by the lens, and finally the light rays are all emitted to pixels in the horizontal direction of the two-dimensional photosensitive array, a colorful rainbow line is presented in the transverse direction, the rainbow line is the spectral distribution on any pixel point x, and the obtained spectrum is subjected to dispersion compensation and inverse Fourier transform to calculate the reflectivity information of the z axis.
7. A method of imaging a two-dimensional image of a color distribution in a vertical plane by a micro-scale line-focus scanning micro-spectroscopic optical coherence tomography system as claimed in any one of claims 1 to 5, wherein: the method comprises the following steps: on a vertical plane, light rays pass through a cylindrical mirror and then are focused on a beam splitter, then are divergently irradiated on a microscope objective through the beam splitter and multiple reflections, and then pass through the microscope objective and are irradiated on a sample plane in parallel; after the light is reflected from the sample surface, the light returns in a path in the sample arm, after passing through the microscope objective, the light is transmitted and diverged to the light beam shrinking lens group, the light is vertically diverged to irradiate on the grating, after passing through the grating, the light is irradiated to the lens, and the light is converged by the lens, finally the light presents a linear spot in the vertical direction of the two-dimensional array, and the linear spot records the object reflection information in the x direction; and combining the transverse spectral information to obtain the section (x and z directions) reflection information of the sample.
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| CN114646613A (en) * | 2022-05-19 | 2022-06-21 | 剑桥大学南京科技创新中心有限公司 | Holographic dot matrix coherent imaging method and system |
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| CN114646613A (en) * | 2022-05-19 | 2022-06-21 | 剑桥大学南京科技创新中心有限公司 | Holographic dot matrix coherent imaging method and system |
| CN115791756A (en) * | 2022-11-24 | 2023-03-14 | 北京杏林睿光科技有限公司 | Laser-induced breakdown spectroscopy device for measuring full spectrum at one time |
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| CN117825279B (en) * | 2024-03-04 | 2024-06-07 | 江苏金视传奇科技有限公司 | Full-field sweep-frequency optical coherence tomography system capable of achieving parallel acquisition |
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