CN113304356B

CN113304356B - Fixed-point puncture drug delivery device for stem cell exosomes and application method

Info

Publication number: CN113304356B
Application number: CN202110625328.2A
Authority: CN
Inventors: 徐晓; 段莉; 徐丽梅
Original assignee: Shenzhen Second Peoples Hospital
Current assignee: Shenzhen Second Peoples Hospital
Priority date: 2021-06-04
Filing date: 2021-06-04
Publication date: 2022-01-18
Anticipated expiration: 2041-06-04
Also published as: CN113304356A

Abstract

The invention relates to the technical field of medical supplies, in particular to a fixed-point puncture drug delivery device for a preparation of a stem cell exosome, which comprises a cylinder body, wherein one end of the cylinder body is in threaded connection with a cover body, a power body penetrates through the cylinder body, one end of the power body is fixedly connected with a rubber disc, one end of the rubber disc, which is back to the power body, is in contact with a first spring, a corrugated pipe is sleeved on the power body in the cylinder body, one end of the cover body is fixedly connected with a needle tube, a positioning tube is fixedly connected in the cover body, one end of the needle tube extends into the positioning tube, the invention also discloses a use method of the preparation fixed-point puncture administration device for the stem cell exosomes, the structural design of the invention realizes the effect of continuous administration, and a doctor can continuously inject the stem cell exosomes in the administration device to a specified position by repeatedly pressing the power body, and meanwhile, the main speed can be controlled, thereby avoiding discomfort brought to a human body by excessively fast administration.

Description

Fixed-point puncture drug delivery device for stem cell exosomes and application method

Technical Field

The invention relates to the technical field of medical supplies, in particular to a fixed-point puncture drug delivery device for a preparation of a stem cell exosome and a using method.

Background

The preparation fixed point puncture of stem cell exosome among the prior art process of dosing needs to use the ware of dosing, and ordinary cylinder ware function singleness of dosing is carried out the improved design to the ware of dosing, improves its stable accuse ability of flowing and accurate measurement ability, is the problem that individual needs were solved.

If the fixed-point puncture drug delivery device can be invented, the injection speed can be controlled in the process of injecting the liquid medicine, the information of the injection amount can be fed back in real time, the problem can be solved, and the preparation fixed-point puncture drug delivery device of the stem cell exosome and the using method are provided.

Disclosure of Invention

The invention aims to provide a preparation fixed-point puncture administration device of a stem cell exosome and a using method thereof, so as to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

a preparation fixed-point puncture medicine feeder for a stem cell exosome comprises a barrel, wherein one end of the barrel is in threaded connection with a cover body, a power body penetrates through the barrel, one end of the power body is fixedly connected with a rubber disc, one end of the rubber disc, which is back to the power body, is in contact with a first spring, a corrugated pipe is sleeved on the power body in the barrel, one end of the cover body is fixedly connected with a needle pipe, a positioning cylinder is fixedly connected in the cover body, one end of the needle pipe extends into the positioning cylinder, a one-way valve is arranged in the positioning cylinder, a U-shaped pipe is fixedly connected to one side of the barrel, an external threaded pipe is communicated to one side of the U-shaped pipe, the U-shaped pipe is provided with the one-way valve, a mesh disc is arranged between the barrel and the cover body, a plurality of uniformly distributed clamps are annularly arranged on one side of the mesh disc, a filtering circular cloth is padded between the clamps and the mesh disc, and an L-shaped guide rod is fixedly connected to one side of the power body, the other side of the power body is connected with a detection device in a transmission manner, the detection device comprises a power device and a measuring column, one side of the power device is connected with the measuring column in a transmission manner, the other side of the power device is connected with an inner rod in a transmission manner, the power device is arranged in a circular plate cavity formed in the barrel body, the measuring column is arranged in a prismatic cavity formed in the barrel body, the circular plate cavity is communicated with the prismatic cavity, the power device comprises an outer ring, an inner column and a tooth unit, the middle part of the outer ring is sleeved with the inner column, the outer ring of the outer ring is provided with a plurality of uniformly distributed tooth units, one side wall of the inner rod is provided with a plurality of uniformly distributed power grooves, the plurality of tooth units are meshed and connected with the plurality of power grooves, the inner column comprises a positioning circular plate, a second spring, a clamping column and a pneumatic device, the positioning circular plate is provided with a through hole, and the positioning circular plate is provided with the second spring and the clamping column, two ends of the second spring are respectively contacted with a clamping column, one side of each clamping column is contacted with a plurality of pneumatic devices which are uniformly distributed, a branch pipe cavity and a main pipe cavity are arranged in the positioning circular plate, one end of each branch pipe cavity extends into a through hole of the positioning circular plate, each pneumatic device is arranged in a cylindrical groove formed in the positioning circular plate, the main pipe cavity is communicated with the cylindrical groove where the pneumatic device is located, two control valves are arranged in the main pipe cavity, an external straight pipe is embedded in the positioning circular plate, one end of the external straight pipe extends into the main pipe cavity, one end of the main pipe cavity is communicated with the external straight pipe, the other end of the main pipe cavity extends to the middle part of the through hole of the positioning circular plate, each pneumatic device comprises a piston column, an inner guide column and a third spring, the piston column is in the shape that one end of the cylinder is integrally connected with a cylinder body, a cylindrical groove is formed in the middle part of the piston column, and the inner guide column is movably sleeved in the cylindrical groove of the piston column, the movable sleeve is sleeved with a third spring on the inner guide pillar, the piston pillar is movably sleeved in a cylindrical groove formed in the positioning circular plate, one end of the piston pillar extends into the double grooves, one end of the inner guide pillar is fixed on the positioning circular plate, one end of the third spring is in contact with the piston pillar, the other end of the third spring is in contact with the bottom surface of the cylindrical groove in the positioning circular plate, the control valve comprises a ventilation disc, a sealing ball and a sealing cylinder, one end of the sealing ball is provided with the sealing cylinder, the other end of the sealing ball is provided with the ventilation disc, the sealing cylinder and the ventilation disc are fixed on the inner wall of the main tube cavity, the ventilation disc is in a circular plate shape, through holes which are uniformly distributed are formed in the circular plate body, and the sealing cylinder is provided with L-shaped tube cavities which are uniformly distributed.

Preferably, the mesh disc is fixed on the cover body, the rubber disc and the first spring are arranged in the inner cavity of the cylinder body, the cylinder body is in a cylindrical shell shape with one open end, an internal thread is arranged at the open end of the cylinder body, the cover body is in a cone-shaped body with one end integrally connected with the circular plate shell, the bottom end of one side of the circular plate shell of the cover body is open, an external thread is arranged at the open end, a rubber ring is padded at the butt joint of the cylinder body and the cover body, the power body comprises a press handle disc, an inner rod and a supporting disc, one end of the inner rod is integrally connected with the press handle disc, the other end of the inner rod is integrally connected with the supporting disc, one end of the corrugated pipe is fixed on the cylinder body, the other end of the corrugated pipe is fixed on the supporting disc, the supporting disc is fixedly connected with the rubber disc, one end of the first spring is in contact with the rubber disc, the other end of the first spring is in contact with a plurality of blocking blocks which are uniformly and annularly arranged, and the blocking blocks are fixed on the wall of the inner cavity of the cylinder body, two cross columns which are symmetrically distributed are fixedly connected to the cylinder body.

Preferably, the tooth unit comprises a positioning block, a first spring piece and a prism tooth, the prism tooth is prism-shaped, one end of the cylinder is provided with a bevel face, the bevel face end of the prism tooth extends into the power groove, one side wall of the prism tooth is provided with a sliding groove, the sliding groove of the prism tooth is internally provided with the positioning block and the first spring piece, the outer ring is annular plate-shaped, the outer side wall of the outer ring is annularly provided with a plurality of uniformly distributed control column grooves, the inner side wall of the outer ring is annularly provided with a plurality of uniformly distributed cambered surface clamping grooves, one end of the clamping column extends into the cambered surface clamping grooves, the tooth unit is arranged in the control column grooves, the positioning block is fixed on the outer ring, one end of the positioning block is contacted with the first wavy plate-shaped spring piece, the clamping column is cylindrical, one end of the cylinder is spherical, one side wall of the clamping column is provided with a plurality of uniformly distributed double grooves, each double groove comprises two adjacent connected cambered surface grooves, the measuring column is in a prism shape, a plurality of tooth sockets which are uniformly distributed are formed in one side wall of the column body, and part of prism teeth are meshed and connected with the tooth sockets on the measuring column.

Preferably, the check valve includes sealed crown plate, support pin, spring four, control lever, screens dish and baffle, the baffle shape is equipped with a contraceptive ring for plectane and plate body and is equipped with a contraceptive ring and be equipped with a plurality of evenly distributed's through-hole, one side of baffle is provided with annular platelike sealed crown plate, and the middle part of sealed crown plate is provided with the control lever, and the vertical fixation has the support pin on the control lever, supports pin one end and fixes on sealed crown plate, the one end of control lever extends to the cylinder chamber of seting up on the baffle in, is provided with spring four and screens dish in the cylinder chamber of baffle, the tip at the control lever is fixed to the screens dish, and spring four cover is on the control lever, and the one end and the screens dish contact of spring four, and the other end top of spring is on the inner wall in baffle cylinder chamber, and the through-hole of seting up on the baffle is run through to the control lever.

Preferably, anchor clamps include splint, side otic placode, spring leaf two, arc and back shaft, the splint shape is prismatic one side body coupling drum, and prismatic one side body coupling of splint has a plurality of evenly distributed's triangle piece, and prismatic opposite side body coupling semicircle post, and the back shaft has been cup jointed in the activity of the drum middle part of splint, and one side fixedly connected with arc of back shaft, the one end contact of arc has wave platelike spring leaf two, and arc and spring leaf two set up in the arc groove of seting up on the drum inner chamber wall of splint, the both sides of splint respectively are provided with a side otic placode, and the side otic placode is fixed on the lid, and the back shaft tip is fixed on the side otic placode.

Compared with the prior art, the invention has the beneficial effects that:

1. the structure design of the invention realizes the effect of continuous administration, and doctors can continuously inject the stem cell exudate in the administration device into the appointed position by repeatedly pressing the power body, and meanwhile, the main speed can be controlled, thereby avoiding discomfort brought to human bodies by too fast administration;

2. the device is through the cooperation design of power device and measuring post, and the distance that stretches out to the barrel outside through measuring the post feeds back to dose information, sets up a series of exquisite control parts among the power device, realizes automatic pneumatic pressurized effect, and the functional stability is powerful.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic view of the structure at A in FIG. 1;

FIG. 3 is a schematic view of the structure at B in FIG. 1;

FIG. 4 is a schematic view of the structure of FIG. 1 at C;

FIG. 5 is a schematic view of the structure of FIG. 1 at D;

FIG. 6 is a schematic diagram of an explosive structure according to the present invention;

FIG. 7 is a schematic view of the structure at E in FIG. 6;

FIG. 8 is a schematic view of the structure at F in FIG. 6;

FIG. 9 is a schematic view of the power plant;

FIG. 10 is a schematic view of an inner column structure;

FIG. 11 is a schematic view of the structure of FIG. 9 at G;

FIG. 12 is a schematic view of the pneumatic device;

FIG. 13 is a schematic view of a control valve configuration;

FIG. 14 is a schematic view of a check valve;

fig. 15 is a schematic view of a structure of the jig.

In the figure: the device comprises a cylinder body 1, a cover body 2, a power body 3, a rubber disc 4, a first spring 5, a corrugated pipe 6, a needle tube 7, a positioning cylinder 8, a one-way valve 9, a U-shaped pipe 10, an external threaded pipe 11, a mesh disc 12, a clamp 13, a filter circular cloth 14, an L-shaped guide rod 15, a detection device 16, a power device 17, a measurement column 18, a power groove 19, an outer ring 20, an inner column 21, a tooth unit 22, a positioning circular plate 23, a second spring 24, a clamping column 25, a pneumatic device 26, a branch pipe cavity 27, a main pipe cavity 28, a control valve 29, an external straight pipe 30, a transverse column 31, an interception block 32, a double groove 33, a rubber ring 34, a handle disc 301, an inner rod 302, a supporting disc 303, a positioning block 221, a first spring leaf 222, a prism tooth 223, a control column groove 201, a cambered surface clamping groove 202, a piston 261, an inner guide column 262, a third spring 263, a ventilation disc 291, a sealing ball 292, a sealing cylinder 293, a sealing ring plate 901, a supporting thin rod 902, a four spring 903, The control rod 904, the clamping disc 905, the partition plate 906, the clamping plate 131, the side lug plate 132, the second spring piece 133, the arc-shaped plate 134 and the support shaft 135.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments obtained by those skilled in the art without creative efforts based on the technical solutions of the present invention belong to the protection scope of the present invention.

Referring to fig. 1 to 15, the present invention provides a technical solution: a preparation fixed-point puncture medicine feeder for stem cell exosomes comprises a barrel body 1, one end of the barrel body 1 is in threaded connection with a cover body 2, a power body 3 penetrates through the barrel body 1, one end of the power body 3 is fixedly connected with a rubber disc 4, one end of the rubber disc 4, which is back to the power body 3, is in contact with a spring I5, a corrugated pipe 6 is sleeved on the power body 3 in the barrel body 1, one end of the cover body 2 is fixedly connected with a needle pipe 7, a positioning cylinder 8 is fixedly connected in the cover body 2, one end of the needle pipe 7 extends into the positioning cylinder 8, a one-way valve 9 is arranged in the positioning cylinder 8, a U-shaped pipe 10 is fixedly connected to one side of the barrel body 1, an external threaded pipe 11 is communicated to one side of the U-shaped pipe 10, the one-way valve 9 is arranged in the U-shaped pipe 10, a mesh disc 12 is arranged between the barrel body 1 and the cover body 2, a plurality of evenly distributed clamps 13 are annularly arranged on one side of the mesh disc 12, and a filtering circular cloth 14 is arranged between the clamps 13 and the mesh disc 12, one side of the power body 3 is fixedly connected with an L-shaped guide rod 15, and the other side of the power body 3 is connected with a detection device 16 in a transmission manner.

The mesh disc 12 is fixed on the cover body 2, the rubber disc 4 and the first spring 5 are arranged in the inner cavity of the cylinder body 1, the cylinder body 1 is in a cylindrical shell body with one open end, the open end of the cylinder body 1 is provided with an internal thread, the cover body 2 is in a cone body with one end integrally connected with the circular plate shell body, one side bottom surface end of the circular plate shell body of the cover body 2 is open, the open end is provided with an external thread, a rubber ring 34 is padded at the butt joint of the cylinder body 1 and the cover body 2, the power body 3 comprises a press handle disc 301, an inner rod 302 and a support disc 303, one end of the inner rod 302 is integrally connected with the press handle disc 301, the other end of the inner rod 302 is integrally connected with the support disc 303, one end of the corrugated pipe 6 is fixed on the cylinder body 1, the other end of the corrugated pipe 6 is fixed on the support disc 303, the support disc 303 is fixedly connected with the rubber disc 4, one end of the first spring 5 is contacted with the rubber disc 4, the other end of the first spring 5 is contacted with a plurality of uniformly and annularly arranged blocking blocks 32, the interception block 32 is fixed on the inner cavity wall of the cylinder body 1, and two cross columns 31 which are symmetrically distributed are fixedly connected on the cylinder body 1.

Detection device 16 includes power device 17 and measures post 18, one side transmission of power device 17 is connected with measures post 18, power device 17's opposite side and interior pole 302 transmission are connected, power device 17 sets up in the disc chamber of seting up on barrel 1, measure in the prism chamber of post 18 setting seting up on barrel 1, and disc chamber and prism chamber intercommunication, power device 17 includes outer loop 20, interior post 21 and tooth unit 22, the middle part cover of outer loop 20 has interior post 21, the outside ring of outer loop 20 is equipped with a plurality of evenly distributed's tooth unit 22, set up a plurality of evenly distributed's power groove 19 on the lateral wall of interior pole 302, and a plurality of tooth unit 22 and a plurality of power groove 19 meshing connection.

The inner column 21 comprises a positioning circular plate 23, a second spring 24, a clamping column 25 and a pneumatic device 26, wherein the positioning circular plate 23 is provided with a through hole, the second spring 24 and the clamping column 25 are arranged in the through hole of the positioning circular plate 23, two ends of the second spring 24 are respectively contacted with the clamping column 25, one side of the clamping column 25 is contacted with a plurality of pneumatic devices 26 which are uniformly distributed, a branch pipe cavity 27 and a main pipe cavity 28 are arranged in the positioning circular plate 23, one end of the branch pipe cavity 27 extends into the through hole of the positioning circular plate 23, the pneumatic device 26 is arranged in a cylindrical groove formed in the positioning circular plate 23, the main pipe cavity 28 is communicated with the cylindrical groove where the pneumatic device 26 is located, two control valves 29 are arranged in the main pipe cavity 28, an external straight pipe 30 is embedded in the positioning circular plate 23, one end of the external straight pipe 30 extends into the main pipe cavity 28, one end of the main pipe cavity 28 is communicated with the external straight pipe 30, and the other end of the main pipe cavity 28 extends to the middle of a through hole of the positioning circular plate 23.

The tooth unit 22 comprises a positioning block 221, a first spring piece 222 and a prismatic tooth 223, the prismatic tooth 223 is prismatic, one end of a cylinder is provided with a beveled surface, the beveled surface end of the prismatic tooth 223 extends into the power groove 19, one side wall of the prismatic tooth 223 is provided with a sliding groove, the positioning block 221 and the first spring piece 222 are arranged in the sliding groove of the prismatic tooth 223, the outer ring 20 is annular plate-shaped, the outer side wall of the outer ring 20 is provided with a plurality of uniformly distributed control column grooves 201 in a surrounding manner, the inner side wall of the outer ring 20 is provided with a plurality of uniformly distributed cambered clamping grooves 202 in a surrounding manner, one end of the clamping column 25 extends into the cambered clamping grooves 202, the tooth unit 22 is arranged in the control column grooves 201, the positioning block 221 is fixed on the outer ring 20, one end of the positioning block 221 is contacted with the first spring piece 222 which is wavy plate-shaped, the clamping column 25 is cylindrical, one end of the cylinder is spherical, one side wall of the clamping column 25 is provided with a plurality of uniformly distributed double grooves 33, the double grooves 33 comprise two adjacent connected arc grooves, the measuring column 18 is in a prism shape, a plurality of uniformly distributed tooth sockets are formed in one side wall of the column body, and part of prism teeth 223 are in meshed connection with the tooth sockets on the measuring column 18.

The pneumatic device 26 comprises a piston column 261, an inner guide column 262 and a spring three 263, wherein the piston column 261 is in the shape of a hemisphere integrally connected with one end of a cylinder, a cylinder groove is formed in the middle of the piston column 261, the inner guide column 262 is movably sleeved in the cylinder groove of the piston column 261, the spring three 263 is movably sleeved on the inner guide column 262, the piston column 261 is movably sleeved in the cylinder groove formed in the positioning circular plate 23, one end of the piston column 261 extends into the double groove 33, one end of the inner guide column 262 is fixed on the positioning circular plate 23, one end of the spring three 263 is contacted with the piston column 261, the other end of the spring three 263 is contacted with the bottom surface of the cylinder groove on the positioning circular plate 23, as understood by referring to fig. 11 and fig. 12, one side of the clamping column 25 is contacted with a plurality of piston columns 261 which are uniformly distributed, the movement of the piston column 261 causes the air flow movement in the positioning circular plate 23, specifically, the process that the piston column 261 is separated from the clamping column 25, the air in the cylinder groove is extruded, the gas flow is injected into the main lumen 28 through the branch lumen 27, and when moving in the reverse direction, the gas in the main lumen 28 is adsorbed into the cylindrical groove in which the pneumatic device 26 is located through the branch lumen 27.

The control valve 29 includes a ventilation disk 291, a sealing ball 292, and a sealing cylinder 293, one end of the sealing ball 292 is provided with the sealing cylinder 293, the other end of the sealing ball 292 is provided with the ventilation disk 291, the sealing cylinder 293 and the ventilation disk 291 are fixed on the inner wall of the main tube cavity 28, the ventilation disk 291 is shaped as a circular plate and is provided with a plurality of through holes uniformly distributed on the plate body, the sealing cylinder 293 is annularly provided with a plurality of L-shaped tube cavities uniformly distributed, as can be understood with reference to fig. 11 and 13, one end of each L-shaped tube cavity extends to the inner wall of the sealing cylinder 293, the other end extends to the bottom surface of the sealing cylinder 293 facing the sealing ball 292, a certain distance is maintained between the ventilation disk 291 and the sealing cylinder 293 to ensure that the sealing ball 292 can move within a certain range, when the sealing ball 292 is attached to the sealing cylinder 293, the middle hole of the sealing cylinder 293 is blocked, so that the air flow can only slowly permeate through the plurality of L-shaped tube cavities, and the air flow impacts the sealing ball 292 from the direction of the sealing cylinder 293, a gap is formed between the sealing ball 292 and the sealing cylinder 293, so that the air flow can rapidly flow through the gap, and the control valve 29 has a bidirectional flow control effect.

The check valve 9 comprises a sealing ring plate 901, a supporting thin rod 902, a spring four 903, a control rod 904, a clamping disc 905 and a partition plate 906, wherein the partition plate 906 is in a circular plate shape, a plurality of through holes are uniformly distributed on the plate body in an encircling manner, the sealing ring plate 901 in an annular plate shape is arranged on one side of the partition plate 906, the control rod 904 is arranged in the middle of the sealing ring plate 901, the supporting thin rod 902 is vertically fixed on the control rod 904, one end of the supporting thin rod 902 is fixed on the sealing ring plate 901, one end of the control rod 904 extends into a cylindrical cavity formed in the partition plate 906, the spring four 903 and the clamping disc 905 are arranged in the cylindrical cavity of the partition plate 906, the clamping disc 905 is fixed at the end part of the control rod 904, the spring four 903 is sleeved on the control rod 904, one end of the spring four 904 is in contact with the clamping disc 905, the other end of the spring four 903 is abutted against the inner wall of the cylindrical cavity of the partition plate 906, the control rod 904 penetrates through the through holes formed in the partition plate 906, the position relation of each part on the check valve 9 is understood by referring to figure 14, the sealing ring plate 901 is just used for sealing the through hole on the partition plate 906, after the sealing ring plate 901 is far away from the partition plate 906, the air flow passing through the through hole on the partition plate 906 can pass through the periphery of the sealing ring plate 901 or pass through the middle hole of the sealing ring plate 901, as understood by referring to fig. 1, 4 and 5, two one-way valves 9 are arranged on the medicine feeder, one is positioned in a U-shaped pipe 10, the other is positioned in a positioning cylinder 8 and is used for guiding the liquid to flow in a one-way mode, the liquid in the U-shaped pipe 10 is injected into the cylinder body 1 in a one-way mode and then is injected into the needle tube 7 through the positioning cylinder 8, two end parts of the U-shaped pipe 10 extend into the cylinder body 1, the rubber disc 4 is positioned between the two end parts, one end of an external threaded pipe 11 is connected with the external pipeline, the external pipeline is connected with a stem cell exosome storage mechanism in the prior art, the rubber disc 4 is close to the rubber disc 4, and the liquid in the cylinder body 1 and the cover body 2 are injected into the needle tube 7, conversely, the rubber disc 4 is away from the process, the liquid in the U-shaped pipe 10 is sucked into the cylinder body 1 and the cover body 2, the two ends of the U-shaped pipe 10 extend into the cylinder body 1, the fluid pressure is reduced, the movement situation of the rubber disc 4 is restrained, namely the rubber disc 4 falls in the figure 1, and if the cavity above the rubber disc 4 is sealed, the suction force is generated to restrain the falling of the rubber disc 4.

The clamp 13 comprises a clamp plate 131, side ear plates 132, two spring pieces 133, an arc plate 134 and a support shaft 135, wherein the clamp plate 131 is in a shape that one side of a prism is integrally connected with a cylinder, one side of the prism of the clamp plate 131 is integrally connected with a plurality of evenly distributed triangular blocks, the other side of the prism is integrally connected with a semi-ring column, the support shaft 135 is movably sleeved in the middle of the cylinder of the clamp plate 131, one side of the support shaft 135 is fixedly connected with the arc plate 134, one end of the arc plate 134 is contacted with the two spring pieces 133 in a wave plate shape, the arc plate 134 and the two spring pieces 133 are arranged in an arc plate groove formed in the inner cavity wall of the cylinder of the clamp plate 131, two sides of the clamp plate 131 are respectively provided with one side ear plate 132, the side ear plates 132 are fixed on the cover body 2, the end part of the support shaft 135 is fixed on the side ear plates 132, as can be understood by referring to figures 4 and 15, the triangular blocks on the clamp plate 131 are sunk into the filter circular cloth 14 to fix the edge of the filter circular cloth 14, in addition, the semi-ring column design on the clamping plate 131 facilitates the manual pulling up of the clamping plate 131, thereby facilitating the replacement process of the filter circular cloth 14.

The working principle is as follows: the doctor manually controls the medicine feeder, one end of the needle tube 7 is aligned to a designated position, the thumb presses the press handle disc 301, the index finger and the middle finger reversely hook the cross column 31, the thumb moves to approach the index finger process to enable the power body 3 to be inserted into the tube body 1, the power body 3 drives the rubber disc 4, the rubber disc 4 moves to approach the cover body 2, medicine liquid in the inner cavities of the tube body 1 and the cover body 2 is injected into the needle tube 7 and then is discharged to the designated position through the needle tube 7, the medicine liquid refers to liquid containing stem cell exosomes, then no pressure is applied, the spring I5 rebounds to push the rubber disc 4 to return to the initial position, backflow phenomenon does not occur in the needle tube 7 in the process, because when the fluid passes through the positioning tube 8, the fluid jacks up the sealing ring plate 901 on the one-way valve 9 and then passes through the through hole on the clapboard 906, and after the fluid passes through, the spring IV 903 rebounds to push the sealing ring plate 901 to seal and block the clapboard 906 in time, avoiding the backflow of fluid, the rubber disc 4 is away from the cover body 2, the fluid in the U-shaped tube 10 can be sucked into the inner cavities of the tube body 1 and the cover body 2, the circulation is carried out, the power body 3 is repeatedly pressed to enable the liquid passing through the doser to be stably discharged outside, the detection device 16 is designed to play a role in recording the dosing amount, the moving speed of the power body 3 is inhibited, namely the impact force of the discharged liquid medicine is controlled, the efficient absorption of the liquid medicine by a human body is ensured, specifically, the reciprocating motion of the inner rod 302 is realized due to the unidirectional rotation of the power device 17, the power device 17 drives the measuring column 18 to move, one end of the measuring column 18 extends out of the tube body 1, the dosing amount information of the doser is fed back by the finally extending distance, referring to the figure that the cover body 2 is immediately, the tooth grooves on the inner rod 302 and the measuring column 18 are designed in a reverse direction, and the tooth grooves are provided with inclined surface parts, so that the inner rod 302 falls to drive the power device 17, the power device 17 rotates to drive the measuring column 18 to rise, conversely, the inner rod 302 rises to not drive the power device 17, because the arc-shaped clamping groove 202 and the clamping column 25 are clamped with each other at the moment, the outer ring 20 is forced to rotate, so that the inner rod 302 rises to force the prism teeth 223 to retract into the control column groove 201, on the other hand, the measuring column 18 is required to be reset and retracted into the barrel 1, and the measuring column 18 is manually pressed back, the same principle can not cause the rotation of the power device 17, and the falling of the inner rod 302 drives the power device 17 because the straight inner wall of the tooth groove on the inner rod 302 is pressed against the straight side wall of the prism teeth 223, so that the clamping state of the clamping column 25 is directly broken, so that the power device 17 has a transmission effect, and when the power device 17 transmits, the inner column 21 has an effect of controlling the speed, specifically, the staggered rotation between the outer ring 20 and the positioning circular plate 23 causes the reciprocating swing of the clamping column 25, the double grooves 33 shift the pneumatic device 26, the reciprocating swing of the pneumatic device 26 is caused, the pneumatic device 26 retracts into the cylindrical groove of the positioning circular plate 23, the airflow in the cylindrical groove is squeezed into the main pipe cavity 28, the airflow is injected into the cavity where the second spring 24 is located under the guidance of the control valve 29, the pneumatic device 26 moves reversely, the air is required to be supplemented into the cylindrical groove of the positioning circular plate 23, the outside air is absorbed into the main pipe cavity 28 through the external straight pipe 30 and then supplemented into the cylindrical groove where the pneumatic device 26 is located, so that when the second spring 24 supports the clamping column 25, the clamping column 25 is supported by air pressure, the clamping effect of the clamping column 25 is enhanced, if the outer ring 20 rotates too fast, the movement of the pneumatic device 26 is finally caused to be too fast, namely, the airflow is supplemented into the through hole of the positioning circular plate 23 rapidly, the L-shaped pipe cavity on the sealing cylinder 293 has the effect of backflow, but the speed of the backflow is lower than the speed of the airflow injected into the through hole in the main pipe cavity 28, the clamping position of the clamping position column 25 is strengthened, conversely, the clamping position column 25 moves slowly, the air injection flow speed is lower than the return flow speed, and the clamping position of the clamping position column 25 cannot be strengthened, so that the automatic clamping position adjustment of the clamping position column 25 is realized, namely, a mechanism for inhibiting the rotating speed of the power device 17 occurs when the rotating speed of the power device 17 is too high.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A preparation fixed-point puncture administration device for stem cell exosomes comprises a cylinder body (1), and is characterized in that: a cover body (2) is connected to one end of the barrel body (1) in a threaded manner, a power body (3) penetrates through the barrel body (1), a rubber disc (4) is fixedly connected to one end of the power body (3), a first spring (5) is contacted with one end, back to the power body (3), of the rubber disc (4), a corrugated pipe (6) is sleeved on the power body (3) in the barrel body (1), a needle tube (7) is fixedly connected to one end of the cover body (2), a positioning tube (8) is fixedly connected to the cover body (2), one end of the needle tube (7) extends into the positioning tube (8), a one-way valve (9) is arranged in the positioning tube (8), a U-shaped tube (10) is fixedly connected to one side of the barrel body (1), an external threaded tube (11) is communicated with one side of the U-shaped tube (10), the one-way valve (9) is arranged in the U-shaped tube (10), and a mesh disc (12) is arranged between the barrel body (1) and the cover body (2), one side of the mesh plate (12) is annularly provided with a plurality of evenly distributed clamps (13), a filter circular cloth (14) is padded between the clamps (13) and the mesh plate (12), one side of the power body (3) is fixedly connected with an L-shaped guide rod (15), the other side of the power body (3) is in transmission connection with a detection device (16), the detection device (16) comprises a power device (17) and a measuring column (18), one side of the power device (17) is in transmission connection with the measuring column (18), the other side of the power device (17) is in transmission connection with an inner rod (302), the power device (17) is arranged in a circular plate cavity arranged on the cylinder body (1), the measuring column (18) is arranged in a prism cavity arranged on the cylinder body (1), the circular plate cavity is communicated with the prism cavity, the power device (17) comprises an outer ring (20), an inner column (21) and a tooth unit (22), an inner column (21) is sleeved in the middle of the outer ring (20), a plurality of uniformly distributed tooth units (22) are arranged on the outer ring of the outer ring (20), a plurality of uniformly distributed power grooves (19) are formed in one side wall of the inner rod (302), the tooth units (22) are meshed with the power grooves (19), the inner column (21) comprises a positioning circular plate (23), a second spring (24), a clamping column (25) and a pneumatic device (26), a through hole is formed in the positioning circular plate (23), the second spring (24) and the clamping column (25) are arranged in the through hole of the positioning circular plate (23), the clamping column (25) is respectively contacted with two ends of the second spring (24), a plurality of uniformly distributed pneumatic devices (26) are contacted with one side of the clamping column (25), a branch tube cavity (27) and a main tube cavity (28) are formed in the positioning circular plate (23), one end of the branch tube cavity (27) extends into the through hole of the positioning circular plate (23), the pneumatic device (26) is arranged in a cylindrical groove formed in a positioning circular plate (23), a main pipe cavity (28) is communicated with the cylindrical groove where the pneumatic device (26) is located, two control valves (29) are arranged in the main pipe cavity (28), an external straight pipe (30) is embedded in the positioning circular plate (23), one end of the external straight pipe (30) extends into the main pipe cavity (28), one end of the main pipe cavity (28) is communicated with the external straight pipe (30), the other end of the main pipe cavity (28) extends to the middle of a through hole of the positioning circular plate (23), the pneumatic device (26) comprises a piston column (261), an inner guide column (262) and a spring III (263), the piston column (261) is in a shape that one end of the cylinder is integrally connected, the cylindrical groove is formed in the middle of the piston column (261), the inner guide column (262) is movably sleeved in the cylindrical groove of the piston column (261), the spring III (263) is movably sleeved on the inner guide column (262), the piston column (261) is movably sleeved in a cylindrical groove formed on the positioning circular plate (23), one end of the piston column (261) extends into the double groove (33), one end of the inner guide column (262) is fixed on the positioning circular plate (23), one end of the spring III (263) is contacted with the piston column (261), the other end of the spring III (263) is contacted with the bottom surface of the cylindrical groove on the positioning circular plate (23), the control valve (29) comprises a gas permeable disc (291), a sealing ball (292) and a sealing barrel (293), one end of the sealing ball (292) is provided with a sealing cylinder (293), the other end of the sealing ball (292) is provided with a ventilation disc (291), the sealing cylinder (293) and the ventilation disc (291) are fixed on the inner wall of the main tube cavity (28), the shape of the ventilation disc (291) is a circular plate, a plurality of through holes are uniformly distributed in the plate body, and a plurality of uniformly distributed L-shaped tube cavities are annularly arranged on the sealing barrel (293).

2. The fixed-point puncture applicator for stem cell exosomes according to claim 1, characterized in that: the mesh plate (12) is fixed on the cover body (2), the rubber plate (4) and the first spring (5) are arranged in an inner cavity of the cylinder body (1), the cylinder body (1) is in a cylindrical shell shape with one open end, an internal thread is arranged at the open end of the cylinder body (1), the cover body (2) is in a conical body shape with one end integrally connected with the circular plate shell, one side bottom end of the circular plate shell of the cover body (2) is open, an external thread is arranged at the open end, a rubber ring (34) is padded at the butt joint of the cylinder body (1) and the cover body (2), the power body (3) comprises a press handle plate (301), an inner rod (302) and a support plate (303), one end of the inner rod (302) is integrally connected with the press handle plate (301), the other end of the inner rod (302) is integrally connected with the support plate (303), one end of the corrugated pipe (6) is fixed on the cylinder body (1), and the other end of the corrugated pipe (6) is fixed on the support plate (303), the supporting plate (303) is fixedly connected with the rubber disc (4), one end of the first spring (5) is in contact with the rubber disc (4), the other end of the first spring (5) is in contact with a plurality of blocking blocks (32) which are uniformly and annularly arranged, the blocking blocks (32) are fixed on the wall of an inner cavity of the cylinder body (1), and the cylinder body (1) is fixedly connected with two cross columns (31) which are symmetrically distributed.

3. The fixed-point puncture applicator for stem cell exosomes according to claim 1, characterized in that: the tooth unit (22) comprises a positioning block (221), a first spring piece (222) and prism teeth (223), the prism teeth (223) are prism-shaped, one end of a cylinder is provided with a beveled surface, the beveled surface end of the prism teeth (223) extends into the power groove (19), one side wall of the prism teeth (223) is provided with a sliding groove, the sliding groove of the prism teeth (223) is internally provided with the positioning block (221) and the first spring piece (222), the outer ring (20) is annular plate-shaped, the outer side wall of the outer ring (20) is annularly provided with a plurality of uniformly distributed control column grooves (201), the inner side wall of the outer ring (20) is annularly provided with a plurality of uniformly distributed cambered surface clamping grooves (202), one end of each clamping column (25) extends into the cambered surface clamping groove (202), the tooth unit (22) is arranged in the control column groove (201), the positioning block (221) is fixed on the outer ring (20), one end of the positioning block (221) is contacted with the first wavy plate-shaped spring piece (222), position clamping post (25) shape is the cylinder and cylinder one end is the sphere form, offers a plurality of evenly distributed's double flute (33) on the lateral wall of position clamping post (25), and double flute (33) include the cambered surface recess of two adjacent connections, measures post (18) shape and offers a plurality of evenly distributed's tooth's socket for prismatic and cylinder on the lateral wall, and some prism tooth (223) and the tooth's socket meshing on measuring post (18) are connected.

4. The fixed-point puncture applicator for stem cell exosomes according to claim 1, characterized in that: the check valve (9) comprises a sealing ring plate (901), a supporting thin rod (902), a spring four (903), a control rod (904), a clamping disc (905) and a partition plate (906), wherein the partition plate (906) is in a circular plate shape, a plurality of uniformly distributed through holes are annularly arranged on the plate body, the sealing ring plate (901) in an annular plate shape is arranged on one side of the partition plate (906), the control rod (904) is arranged in the middle of the sealing ring plate (901), the supporting thin rod (902) is vertically fixed on the control rod (904), one end of the supporting thin rod (902) is fixed on the sealing ring plate (901), one end of the control rod (904) extends into a cylindrical cavity formed in the partition plate (906), the spring four (903) and the clamping disc (905) are arranged in the cylindrical cavity of the partition plate (906), the clamping disc (905) is fixed at the end of the control rod (904), and the spring four (903) is sleeved on the control rod (904), one end of the spring IV (903) is in contact with the clamping disc (905), the other end of the spring IV (903) abuts against the inner wall of the cylindrical cavity of the partition plate (906), and the control rod (904) penetrates through a through hole formed in the partition plate (906).

5. The fixed-point puncture applicator for stem cell exosomes according to claim 1, characterized in that: the clamp (13) comprises a clamping plate (131), a side ear plate (132), a second spring piece (133), an arc-shaped plate (134) and a supporting shaft (135), the clamp plate (131) is in a shape that one side of a prism is integrally connected with a cylinder, one side of the prism of the clamp plate (131) is integrally connected with a plurality of evenly distributed triangular blocks, the other side of the prism is integrally connected with the semicircular column, the middle part of the cylinder of the clamping plate (131) is movably sleeved with the supporting shaft (135), one side of the supporting shaft (135) is fixedly connected with an arc-shaped plate (134), one end of the arc-shaped plate (134) is contacted with a second wavy plate spring leaf (133), the arc-shaped plate (134) and the second wavy plate spring leaf (133) are arranged in an arc-shaped plate groove formed in the wall of the inner cavity of the cylinder of the clamping plate (131), two sides of the clamping plate (131) are respectively provided with a side ear plate (132), the side ear plates (132) are fixed on the cover body (2), and the end part of the supporting shaft (135) is fixed on the side ear plates (132).