CN113286614A - 用于治疗癌症的pd-1拮抗剂、atr抑制剂和铂化物质的组合 - Google Patents

用于治疗癌症的pd-1拮抗剂、atr抑制剂和铂化物质的组合 Download PDF

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Publication number
CN113286614A
CN113286614A CN201980077396.0A CN201980077396A CN113286614A CN 113286614 A CN113286614 A CN 113286614A CN 201980077396 A CN201980077396 A CN 201980077396A CN 113286614 A CN113286614 A CN 113286614A
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cancer
substance
antagonist
compound
treatment
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Chinese (zh)
Inventor
M·阿利姆扎诺夫
P·苏拉尔
F·岑克
H·达门
A·齐默尔曼
A·施罗德
K·塔贾利梅尔
M·法尔克
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Merck Patent GmbH
Pfizer Inc
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Merck Patent GmbH
Pfizer Inc
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6866—Interferon
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201980077396.0A 2018-09-26 2019-09-26 用于治疗癌症的pd-1拮抗剂、atr抑制剂和铂化物质的组合 Pending CN113286614A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862736699P 2018-09-26 2018-09-26
US62/736,699 2018-09-26
PCT/EP2019/076116 WO2020064971A1 (en) 2018-09-26 2019-09-26 Combination of a pd-1 antagonist, an atr inhibitor and a platinating agent for the treatment of cancer

Publications (1)

Publication Number Publication Date
CN113286614A true CN113286614A (zh) 2021-08-20

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US (1) US12227577B2 (https=)
EP (1) EP3856251B1 (https=)
JP (1) JP2022502399A (https=)
KR (1) KR20210066837A (https=)
CN (1) CN113286614A (https=)
AU (1) AU2019346012A1 (https=)
BR (1) BR112021004935A2 (https=)
CA (1) CA3114024A1 (https=)
ES (1) ES3009674T3 (https=)
IL (1) IL281670A (https=)
MX (1) MX2021003263A (https=)
WO (1) WO2020064971A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN120884711A (zh) * 2025-09-29 2025-11-04 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） 一种逆转卵巢癌顺铂耐药的药物制剂及其制备方法

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Publication number Priority date Publication date Assignee Title
BR112022022634A2 (pt) * 2020-05-11 2022-12-13 Astrazeneca Ab Inibidores de atr para o tratamento de câncer
WO2024164089A1 (en) * 2023-02-09 2024-08-15 Repare Therapeutics Inc. Use of atr inhibitors in the treatment of cancers with high tumor mutational burden
WO2025233224A1 (en) * 2024-05-09 2025-11-13 F. Hoffmann-La Roche Ag Use of atr inhibitors in combination with anti-pd(l)1 therapy

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CN103987405A (zh) * 2011-11-28 2014-08-13 默克专利股份公司 抗pd-l1抗体及其用途

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