CN113260368B - 抗gpc3嵌合抗原受体(car)与反式共刺激分子的组合及其治疗用途 - Google Patents

抗gpc3嵌合抗原受体(car)与反式共刺激分子的组合及其治疗用途 Download PDF

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CN113260368B
CN113260368B CN201980087101.8A CN201980087101A CN113260368B CN 113260368 B CN113260368 B CN 113260368B CN 201980087101 A CN201980087101 A CN 201980087101A CN 113260368 B CN113260368 B CN 113260368B
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cell
gly gly
car
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CN113260368A (zh
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K.麦金尼斯
C.威尔逊
B.赫林
G.莫茨
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Shudian Biotechnology Co
Sotio Ltd
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Sotio Ltd
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CN201980087101.8A 2018-11-07 2019-11-07 抗gpc3嵌合抗原受体(car)与反式共刺激分子的组合及其治疗用途 Expired - Fee Related CN113260368B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862756683P 2018-11-07 2018-11-07
US62/756,683 2018-11-07
PCT/US2019/060287 WO2020097346A1 (en) 2018-11-07 2019-11-07 ANTI-GPC3 CHIMERIC ANTIGEN RECEPTORS (CARs) IN COMBINATION WITH TRANS CO-STIMULATORY MOLECULES AND THERAPEUTIC USES THEREOF

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CN113260368A CN113260368A (zh) 2021-08-13
CN113260368B true CN113260368B (zh) 2023-08-29

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US (1) US20220054545A1 (enExample)
EP (1) EP3876950A4 (enExample)
JP (1) JP2022512958A (enExample)
CN (1) CN113260368B (enExample)
AU (1) AU2019374828A1 (enExample)
CA (1) CA3118889A1 (enExample)
WO (1) WO2020097346A1 (enExample)

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WO2018124766A2 (ko) 2016-12-28 2018-07-05 주식회사 녹십자랩셀 키메라 항원 수용체 및 이를 발현하는 자연 살해 세포
US11649294B2 (en) 2017-11-14 2023-05-16 GC Cell Corporation Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
CN110468105B (zh) * 2018-05-09 2024-03-22 恺兴生命科技(上海)有限公司 表达il-18r结合蛋白的免疫效应细胞
WO2020037066A1 (en) 2018-08-14 2020-02-20 Unum Therapeutics Inc. Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof
AU2020437669A1 (en) * 2020-03-26 2022-09-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services CD28H domain-containing chimeric antigen receptors and methods of use
CN113754778A (zh) * 2020-06-05 2021-12-07 上海交通大学 靶向cldn18.2的嵌合抗原受体及其用途
CN114057890A (zh) * 2020-07-31 2022-02-18 南京北恒生物科技有限公司 新型共刺激结构域及其用途
CN112159818B (zh) * 2020-08-20 2023-02-21 山东兴瑞生物科技有限公司 用于治疗hcc的核酸、其制备方法、具有该核酸的car-t细胞及细胞的制备方法
US20240041924A1 (en) * 2020-09-29 2024-02-08 Nanjing Legend Biotech Co., Ltd. T cell and antigen-presenting cell engagers and uses thereof
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
US20240277841A2 (en) * 2020-12-11 2024-08-22 Purdue Research Foundation Human chimeric antigen receptor neutrophils, compositions, kits and methods of use
EP4271798A1 (en) 2020-12-30 2023-11-08 CRISPR Therapeutics AG Compositions and methods for differentiating stem cells into nk cells
EP4319794A4 (en) * 2021-04-08 2025-03-12 Artiva Biotherapeutics, Inc. CHIMERIC ANTIGEN RECEPTOR COMPRISING AN ANTI-CD19 ANTIBODY OR AN ANTIGEN-BINDING FRAGMENT THEREOF AND NATURAL KILLER CELLS COMPRISING SAME
CA3217252A1 (en) * 2021-04-19 2022-10-27 Nanjing Legend Biotech Co., Ltd. Chimeric cytokine receptors and uses thereof in cellular therapies
CN117615786A (zh) * 2021-05-07 2024-02-27 森蒂生物科学公司 嵌合抗原受体及其使用方法
WO2023036043A1 (zh) * 2021-09-09 2023-03-16 广东东阳光药业有限公司 抗癌结合分子及其应用
CA3237201A1 (en) 2021-11-16 2023-05-25 Sotio Biotech Inc. Treatment of myxoid/round cell liposarcoma patients
CN116426483B (zh) * 2021-12-30 2024-02-23 南京紫珑生物科技有限公司 Cd258蛋白在免疫治疗中的应用
WO2024015995A2 (en) * 2022-07-15 2024-01-18 Albert Einstein College Of Medicine Chimeric antigen receptors comprising a tmigd2 costimulatory domain and associated methods of using the same
CN117304343B (zh) * 2023-10-11 2024-05-07 北京景达生物科技有限公司 Gpc3靶向的car-nk细胞的制备及其应用
CN117247466B (zh) * 2023-11-20 2025-01-24 北京艺妙神州医药科技有限公司 抗磷脂酰肌醇蛋白聚糖3的嵌合抗原受体及其用途
AU2024415858A1 (en) * 2023-12-27 2026-07-16 Obsidian Therapeutics, Inc. Compositions and methods for tunable regulation of il15 and light
WO2025191139A1 (en) * 2024-03-15 2025-09-18 Avidicure Ip B.V. Conjugates of her2-specific antigen binding proteins and cytokines

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US20160340406A1 (en) * 2014-01-21 2016-11-24 Novartis Ag Enhanced antigen presenting ability of rna car t cells by co-introduction of costimulatory molecules
US20170281683A1 (en) * 2014-09-26 2017-10-05 Baylor College Of Medicine Glypican-3 specific chimeric antigen receptors for adoptive immunotherapy

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Patent Citations (2)

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US20160340406A1 (en) * 2014-01-21 2016-11-24 Novartis Ag Enhanced antigen presenting ability of rna car t cells by co-introduction of costimulatory molecules
US20170281683A1 (en) * 2014-09-26 2017-10-05 Baylor College Of Medicine Glypican-3 specific chimeric antigen receptors for adoptive immunotherapy

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CA3118889A1 (en) 2020-05-14
JP2022512958A (ja) 2022-02-07
WO2020097346A1 (en) 2020-05-14
US20220054545A1 (en) 2022-02-24
EP3876950A1 (en) 2021-09-15
EP3876950A4 (en) 2022-11-30
CN113260368A (zh) 2021-08-13
AU2019374828A1 (en) 2021-05-27

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