CN113253642B

CN113253642B - Control device for blood purification apparatus

Info

Publication number: CN113253642B
Application number: CN202110499706.7A
Authority: CN
Inventors: 董凡; 区子友; 郭瑶; 杨艳秋
Original assignee: Beijing Jafron Medical Equipment Co Ltd
Current assignee: Beijing Jafron Medical Equipment Co Ltd
Priority date: 2021-05-08
Filing date: 2021-05-08
Publication date: 2024-06-21
Anticipated expiration: 2041-05-08
Also published as: CN113253642A

Abstract

The present application relates to a control device for a blood purification apparatus. Comprising the following steps: the device comprises a main control circuit, a secondary control circuit, a first secondary control circuit, a second secondary control circuit, a third secondary control circuit and a detection device; the main control circuit is used for outputting a first control signal to a first input end of the first slave control circuit, outputting a second control signal to a first input end of the second slave control circuit and outputting a third control signal to a first input end of the third slave control circuit; the secondary control circuit is used as a new main control circuit when detecting that the main control circuit is in a dead state. The problems that single faults occur in the blood purifying equipment and the faults of the first slave control circuit, the second slave control circuit and the third slave control circuit are mutually interfered when the main control circuit is in a dead state are avoided.

Description

Control device for blood purification apparatus

Technical Field

The application relates to the technical field of medical equipment, in particular to a control device of blood purification equipment.

Background

The blood purifying equipment filters out specific substances in the blood after leading out the human blood, and then returns the purified blood to the human body so as to achieve the effect of treating diseases; the blood purifying device belongs to medical equipment, and compared with other general electronic equipment, in the use process, medical staff is required to carry out various complicated and standard operations on the blood purifying device so as to maintain the operation safety of the blood purifying device.

Typical blood purification equipment adopts centralized control's mode, and when the controller breaks down, blood purification equipment can get into trouble running state, has reduced blood purification equipment's security performance.

Disclosure of Invention

In view of the foregoing, it is desirable to provide a control device for a blood purification apparatus such that the operation of the blood purification apparatus is not affected when a controller fails.

A control device of a blood purification apparatus, comprising: the device comprises a main control circuit, a secondary control circuit, a first secondary control circuit, a second secondary control circuit, a third secondary control circuit and a detection device;

The detection end of the main control circuit is connected with the detection end of the secondary control circuit; the output end of the main control circuit and the output end of the secondary control circuit are connected with the first input end of the first slave control circuit, the first input end of the second slave control circuit and the first input end of the third slave control circuit;

The second input end of the first slave control circuit is connected with the first output end of the second slave control circuit; the second input end of the second slave control circuit is connected with the output end of the detection device, and the second output end of the second slave control circuit is connected with the input end of the detection device; the detection end of the detection device is connected with a transmission pipeline of the blood purification equipment;

The main control circuit is used for outputting a first control signal to a first input end of the first slave control circuit, outputting a second control signal to a first input end of the second slave control circuit and outputting a third control signal to a first input end of the third slave control circuit; the secondary control circuit is used for being used as a new main control circuit when the main control circuit is detected to be in a dead state;

The first slave control circuit is used for generating an alarm signal according to the first control signal or the pipeline fault signal; the second slave control circuit is used for generating a detection driving signal according to a second control signal; the detection device is used for detecting the flowing state of the liquid in the transmission pipeline according to the detection driving signal and generating a detection signal; the second slave control circuit is also used for generating a pipeline fault signal when judging that the liquid in the transmission pipeline is in an abnormal state according to the detection signal; the third slave control circuit is used for controlling the liquid flow rate and the liquid flow direction of the liquid in the transmission pipeline according to the third control signal.

In the control device of the blood purification equipment, when the main control circuit is in a dead state, the secondary control circuit is used as a new main control circuit, and a control signal is sent to the secondary control circuit connected with the main control circuit in the control device, so that the problem that the blood purification equipment has single fault when the main control circuit is in the dead state is avoided. In addition, the main control circuit, the secondary control circuit, the first secondary control circuit, the second secondary control circuit and the third secondary control circuit realize layered control, and any one of the first secondary control circuit, the second secondary control circuit and the third secondary control circuit connected with the main control circuit and the secondary control circuit in the control device fails and does not influence the normal operation of the functional modules connected with other normal secondary control circuits, so that the problem that the faults of the first secondary control circuit, the second secondary control circuit and the third secondary control circuit mutually interfere is avoided.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments or the conventional techniques of the present application, the drawings required for the descriptions of the embodiments or the conventional techniques will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present application, and other drawings may be obtained according to the drawings without inventive effort for those skilled in the art.

FIG. 1 is a schematic structural view of a control device of a blood purifying apparatus in embodiment 1;

FIG. 2 is a schematic structural view of a control device of the blood purifying apparatus in embodiment 2;

FIG. 3 is a schematic diagram of a bubble detection circuit according to an embodiment;

FIG. 4 is a schematic structural view of a control device of the blood purifying apparatus in embodiment 3;

FIG. 5 is a schematic view showing the structure of a control device of the blood purifying apparatus in embodiment 4;

FIG. 6 is a schematic structural view of a control device of the blood purifying apparatus in embodiment 5;

FIG. 7 is a schematic view showing the overall structure of a control device of the blood purifying apparatus in embodiment 6;

FIG. 8 is a block diagram of a fourth slave control circuit according to an embodiment;

FIG. 9 is a schematic diagram of controlling the curve between the temperature of the fluid replacement, the flow rate of the fluid replacement and the temperature difference in an embodiment.

Detailed Description

In order that the application may be readily understood, a more complete description of the application will be rendered by reference to the appended drawings. Embodiments of the application are illustrated in the accompanying drawings. This application may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

As shown in fig. 1, in one embodiment, there is provided a control device of a blood purification apparatus, comprising: a main control circuit 10, a sub control circuit 20, a first slave control circuit 30, a second slave control circuit 40, a third slave control circuit 50, and a detection device 60;

The detection end of the main control circuit 10 is connected with the detection end of the secondary control circuit 20; the output end of the main control circuit 10 and the output end of the secondary control circuit 20 are connected with the first input end of the first slave control circuit 30, the first input end of the second slave control circuit 40 and the first input end of the third slave control circuit 50;

A second input of the first slave control circuit 30 is connected to a first output of the second slave control circuit 40; a second input end of the second slave control circuit 40 is connected with an output end of the detection device 60, and a second output end of the second slave control circuit 40 is connected with an input end of the detection device 60; the detection end of the detection device 60 is connected with a transmission pipeline of the blood purification equipment;

the master control circuit 10 is configured to output a first control signal to a first input terminal of the first slave control circuit 30, output a second control signal to a first input terminal of the second slave control circuit 40, and output a third control signal to a first input terminal of the third slave control circuit 50;

the secondary control circuit 20 is used as a new main control circuit 10 when detecting that the main control circuit 10 is in a dead state;

the first slave control circuit 30 is configured to generate an alarm signal according to the first control signal or the pipeline fault signal; the second slave control circuit 40 is configured to generate a detection driving signal according to the second control signal; the detecting device 60 is used for detecting the flowing state of the liquid in the transmission pipeline according to the detection driving signal and generating a detection signal; the second slave control circuit 40 is further configured to generate a pipeline fault signal when it is determined that the liquid in the transmission pipeline is in an abnormal state according to the detection signal; the third slave control circuit 50 is configured to control the flow rate and flow direction of the liquid in the transmission line according to the third control signal.

In the above-described control device for a blood purification apparatus, when the main control circuit 10 is in a dead state, the sub-control circuit 20 serves as a new main control circuit 10, and transmits control signals (including a first control signal, a second control signal, and a third control signal) to the sub-control circuit connected to the main control circuit 10 in the control device, thereby avoiding a single failure of the blood purification apparatus when the main control circuit 10 is in a dead state. In addition, the main control circuit 10, the secondary control circuit 20, the first secondary control circuit 30, the second secondary control circuit 40 and the third secondary control circuit 50 realize layered control, and the failure of any one of the first secondary control circuit 30, the second secondary control circuit 40 and the third secondary control circuit 50 connected with the main control circuit 10 and the secondary control circuit 20 in the control device does not affect the normal operation of the functional modules connected with other normal secondary control circuits, so that the problem that the failures of the first secondary control circuit 30, the second secondary control circuit 40 and the third secondary control circuit 50 are mutually interfered is avoided.

In one embodiment, the secondary control circuit 20 sends a test signal to the primary control circuit 10 according to a preset period, and if the secondary control circuit 20 receives a feedback signal sent by the primary control circuit 10, it indicates that the primary control circuit 10 is dead (in a dead state), and the secondary control circuit 20 performs the operation of the primary control circuit 10 as a new primary control circuit 10.

In one embodiment, the secondary control circuit 20 detects whether the main control circuit 10 outputs the control signal in real time, and if the secondary control circuit 20 detects that the main control circuit 10 successfully outputs the control signal, it indicates that the main control circuit 10 is not halted; when the secondary control circuit 20 detects that the primary control circuit 10 does not output the control signal, it indicates that the primary control circuit 10 is in a dead state, and the secondary control circuit 20 immediately replaces the primary control circuit 10, that is, the secondary control circuit 20 serves as a new primary control circuit 10, and the secondary control circuit 20 performs centralized control on the first, second and third secondary control circuits 30, 40 and 50.

As shown in fig. 2, in one embodiment, the control device of the blood purification apparatus further includes: the blood purification device comprises a touch screen, an RS232 circuit positioned between the touch screen and a main control circuit 10, and an RS485 circuit positioned between the main control circuit 10 and a secondary control circuit 20, wherein the touch screen is used for receiving operation instructions of a user so as to respectively control the working states of the main control circuit 10 and the secondary control circuit 20, and further the main control circuit 10 outputs control signals according to the operation instructions of the user, and the user controls the working states of the blood purification device through the touch screen. When a user inputs an operation instruction through the touch screen, the touch screen transmits the operation instruction to the main control circuit 10 in the form of RS232 communication. The RS485 circuit is used for realizing a bidirectional RS485 communication function between the main control circuit 10 and the secondary control circuit 20; for example, after the main control circuit 10 and the secondary control circuit 20 are powered on successfully, the secondary control circuit 20 transmits a test signal to the main control circuit 10 in an RS485 communication manner, and if the secondary control circuit 20 receives a response signal output by the main control circuit 10, it indicates that the main control circuit 10 is not halted; in contrast, if the sub-control circuit 20 does not receive the response signal output from the main control circuit 10, it indicates that the main control circuit 10 has been halted, that is, if the main control circuit 10 is in the halted state, it does not mean that the main control circuit 10 cannot transmit a signal.

In one embodiment, the control means of the blood purification device further comprises alarm means 70 connected to the first slave control circuit 30, the first control signal comprising a signal generated by a factor that the blood purification device needs to alarm, e.g. a signal generated by an alarm command entered by a user on a touch screen.

In one embodiment, the control device of the blood purification apparatus further includes a first IO amount driving circuit connected to the main control circuit 10, the sub control circuit 20, and the second sub control circuit 40, respectively, and when the main control circuit 10 outputs the first control signal or the second sub control circuit 40 outputs the line fault signal, the first IO driving circuit transmits the received first control signal or the line fault signal to the first sub control circuit 30, so that the first sub control circuit 30 outputs the alarm signal, for example, when the alarm device 70 includes a speaker, the alarm signal includes a sound driving signal, and the speaker emits an alarm sound according to the sound driving signal to implement the alarm function of the blood purification apparatus. Specifically, the first slave control circuit 30 determines the alarm level of the blood purification apparatus according to the emergency degree of the signal source in the first control signal or the line fault signal, and further outputs different sound driving signals to control the alarm device to emit different alarm sounds (the sound intensity or the sound content are different), so that the user can distinguish the alarm sounds of various levels.

In one embodiment, the control device of the blood purifying apparatus further includes a potentiometer-type knob connected to the first slave control circuit 30, and when the speaker emits an alarm sound, the user outputs a knob signal through the potentiometer-type knob, and the first slave control circuit 30 outputs a volume adjustment signal according to the knob signal to adjust the volume of the alarm sound emitted from the speaker.

In one embodiment, the control device of the blood purification apparatus further includes an indicator light connected to the first slave control circuit 30, and when the first slave control circuit 30 controls the alarm device 70 to alarm, the first slave control circuit 30 simultaneously generates a corresponding light-emitting driving signal and sends the light-emitting driving signal to the indicator light through the second IO amount driving circuit, so that the indicator light emits an alarm light source to transmit light source alarm information to a user.

In one embodiment, the control device of the blood purifying apparatus further includes a switching value actuator connected to the main control circuit 10 and the sub-control circuit 20, respectively, the switching value actuator is used for adjusting a first blood level in the arterial kettle in the transmission line and a second blood level in the venous kettle in the transmission line according to a liquid level control signal output from the main control circuit 10, the arterial kettle and the venous kettle are used for buffering a blood flow rate and removing blood bubbles in the transmission line, and the liquid levels of the arterial kettle and the venous kettle are also directly reflecting a flowing state of blood in the transmission line, and the liquid levels of the arterial kettle and the venous kettle are also one of important parameters in the blood purifying process. Specifically, the switching value actuator can change the air pressure in the venous kettle and/or the arterial kettle by exhausting or increasing the air in the venous kettle and/or the arterial kettle so as to realize the liquid level regulating function in the venous kettle and/or the arterial kettle.

In one embodiment, a user inputs a liquid level adjusting instruction for controlling the liquid level of the venous kettle and/or the arterial kettle on the touch screen, the main control circuit 10 outputs a liquid level control signal for controlling the liquid level of the venous kettle and/or the arterial kettle according to the liquid level adjusting instruction, the first IO driving circuit performs format conversion on the received liquid level control signal and then transmits the liquid level control signal to the switching value actuator, and the switching value actuator adjusts and controls the liquid level of the venous kettle and/or the arterial kettle according to the received liquid level control signal, so that the liquid level of the venous kettle and/or the arterial kettle is always in a safe state, and the safety of blood flow in a transmission pipeline in the blood purification process is ensured.

In one embodiment, the control device of the blood purification device further comprises at least one stop valve, wherein the stop valve is arranged on the arterial line and/or the venous line and is used for controlling the opening or closing of the transmission line according to the opening or closing of the stop valve, so as to control the start or end of blood purification. Only when the stop valve is opened, the blood in the transmission pipeline can flow; the switching value actuator is also used for controlling the opening or closing of the shut-off valve. Specifically, a user inputs a switching instruction on the touch screen, the main control circuit 10 generates an on-off control signal according to the switching instruction, the first IO driving circuit performs format conversion on the on-off control signal and outputs the on-off control signal to the switching value executor, and the switching value executor controls the stop valve to be opened or closed according to the on-off control signal after format conversion so as to start or stop the blood purification process; for example, before the blood purification starts, a user inputs a switch instruction on the touch screen, the main control circuit 10 generates an on-off control signal according to the switch instruction, the first IO driving circuit performs format conversion on the on-off control signal and outputs the on-off control signal to the switching value executor, the switching value executor controls the stop valve to be opened according to the on-off control signal after format conversion, the transmission pipeline starts to be connected into blood, and the blood purification equipment starts to purify human blood. At the end of blood purification, the principle of the switching value actuator controlling the shut-off valve to be closed is the same.

In one embodiment, the control device of the blood purifying apparatus further includes a switching value sensor connected to the first IO driving circuit, the switching value sensor being configured to detect a second blood level in the venous kettle and a first blood level in the arterial kettle and generate a blood level detection signal; when blood exists in a transmission pipeline of the blood purifying device, the switching value sensor can detect the blood liquid level in the venous kettle or the arterial kettle to obtain a blood liquid level detection signal, the first IO driving circuit outputs the blood liquid level detection signal to the main control circuit 10, and the main control circuit 10 generates a liquid level control signal according to the blood liquid level detection signal and a preset blood liquid level signal to feed back and control the switching value actuator so as to adjust the blood liquid level of the venous kettle and/or the arterial kettle; i.e. the combination of the switching value sensor and the switching value actuator can realize the feedback control function of the blood level of the venous pot and/or the arterial pot so that the blood level of the venous pot and/or the arterial pot is maintained in a stable and safe state. Specifically, the main control circuit 10 compares the difference between the actual blood level (obtained according to the blood level detection signal) and the preset blood level (obtained according to the preset blood level signal) in the venous kettle or the arterial kettle, and then adjusts the switching value actuator according to the feedback of the difference, and the switching value actuator adjusts the blood level in the venous kettle or the arterial kettle in a feedback manner so that the blood level in the venous kettle or the arterial kettle is in a stable and safe state; the preset blood level signal may be stored in advance by the main control circuit 10, or may be input by the user on the touch screen.

When the transmission pipeline is in loose connection or the pipe wall is damaged, air bubbles can appear in the transmission pipeline, the life safety of a user can be influenced when the liquid with the air bubbles flows into a human body, in one embodiment, the control device of the blood purifying device further comprises an air bubble detection circuit connected with the first IO driving circuit, the air bubble detection circuit is used for detecting the air bubbles of blood in the transmission pipeline according to the air bubble detection control signal output by the main control circuit 10 and generating the air bubble detection signal, and the main control circuit 10 is used for sending a first control signal for performing air bubble fault alarm to the first slave control circuit 30 and sending a third control signal for controlling the liquid to stop flowing to the third slave control circuit 50 when judging that the air bubbles exist in the transmission pipeline according to the air bubble detection signal. Specifically, the main control circuit 10 outputs a bubble detection control signal to the bubble detection circuit through the first IO drive circuit, and the bubble detection circuit detects whether bubbles occur in the transmission pipeline according to the bubble detection control signal and generates a bubble detection signal; the bubble detection circuit outputs a bubble detection signal to the main control circuit 10, and if the main control circuit 10 determines that there is a bubble in the transmission line based on the bubble detection signal, the first control signal for performing bubble failure alarm is sent to the first slave control circuit 30, and the third control signal for controlling the flow of the liquid in the transmission line to stop the blood purification process is sent to the third slave control circuit 50, so that the blood purification process is terminated urgently.

In one embodiment, the bubble detection circuit comprises an ultrasonic transmitter, an ultrasonic receiver and an amplifier, wherein the transmission pipeline is positioned on the ultrasonic wave propagation optical path between the ultrasonic transmitter and the ultrasonic receiver; the ultrasonic transmitter is used for transmitting ultrasonic waves according to the bubble detection control signals output by the main control circuit 10, the ultrasonic receiver is used for receiving the ultrasonic waves after passing through the transmission pipeline and generating ultrasonic detection signals, and the amplifier is used for amplifying the ultrasonic detection signals to obtain bubble detection signals. Specifically, as shown in fig. 3, whether a bubble occurs in a transmission pipeline is detected by an ultrasonic detection mode, an ultrasonic transmitter transmits ultrasonic waves after receiving a bubble detection control signal output by a main control circuit 10, the ultrasonic waves pass through the transmission pipeline and are received by an ultrasonic receiver, the ultrasonic receiver generates ultrasonic detection signals according to the received ultrasonic waves, the generated ultrasonic detection signals are weak due to the fact that the ultrasonic waves received by the ultrasonic receiver are weak, an amplifier is connected with the ultrasonic receiver and amplifies the ultrasonic detection signals to obtain bubble detection signals, the main control circuit 10 acquires actual bubble quantity in the transmission pipeline according to the bubble detection signals, and when a difference value between the actual bubble quantity and a preset bubble quantity (the preset bubble quantity is usually 0) is larger than a safety threshold value, the existence of the bubble in the transmission pipeline is judged.

As shown in fig. 2, in one embodiment, the second slave control circuit 40 includes a blood leakage control circuit 102, the second control signal includes a blood leakage control signal, and the detection device 60 includes a blood leakage detection circuit 202; the blood leakage control circuit 102 is connected to the blood leakage detection circuit 202, and is configured to generate a blood leakage detection driving signal according to a blood leakage control signal output by the main control circuit 10, where the blood leakage detection circuit 202 is configured to detect a blood leakage state of the transmission line according to the blood leakage detection driving signal and generate a blood leakage detection signal, the blood leakage control circuit 102 is configured to generate a blood leakage failure signal when it is determined that the transmission line has a blood leakage phenomenon according to the blood leakage detection signal, the first slave control circuit 30 is configured to generate a blood leakage alarm signal according to the blood leakage failure signal, and the main control circuit 10 is configured to send a third control signal for controlling the flow of liquid to the third slave control circuit 50 according to the blood leakage failure signal. Specifically, in the operation process of the blood purification apparatus, blood exists in the transmission pipeline, when the blood leakage detection driving signal sent by the blood leakage control circuit 102 is received, the blood leakage detection circuit 202 starts to detect the blood leakage state of the transmission pipeline and generates a blood leakage detection signal, and transmits the blood leakage detection signal to the blood leakage control circuit 102, and the blood leakage control circuit 102 determines whether the blood leakage phenomenon exists in the transmission pipeline according to the received blood leakage detection signal. If the blood leakage control circuit 102 judges that the blood leakage phenomenon occurs in the transmission pipeline, a blood leakage fault signal is generated, the blood leakage fault signal is transmitted to the first slave control circuit 30 through the first IO value driving circuit, and the first slave control circuit 30 generates a blood leakage alarm signal according to the blood leakage fault signal to control the loudspeaker to send out an alarm sound. Meanwhile, the blood leakage control circuit 102 transmits a blood leakage fault signal to the main control circuit 10 through the first IO amount driving circuit, and the main control circuit 10 outputs a third control signal for controlling the flow of the liquid to stop to the third slave control circuit 50 according to the blood leakage fault signal, thereby automatically stopping the blood purification process.

In one embodiment, the blood leakage detecting circuit 202 adopts a light source detecting mode, firstly sends a detecting light source to the transmission pipeline, then receives the detecting light source after passing through the transmission pipeline and generates a blood leakage detecting signal according to the light intensity of the received detecting light source, and the blood leakage control circuit 102 judges whether the blood leakage phenomenon exists in the transmission pipeline according to the light intensity corresponding to the blood leakage detecting signal, and the working principle of the blood leakage detecting circuit 202 is similar to that of the bubble detecting circuit.

As shown in fig. 2, in one embodiment, the second slave control circuit 40 includes a blood drawing control circuit 104, the second control signal includes a blood drawing control signal, the detecting device 60 includes a blood drawing detection circuit 204, the blood drawing control circuit 104 is connected to the blood drawing detection circuit 204, and is configured to generate a blood drawing detection driving signal according to the blood drawing control signal output by the master control circuit 10, the blood drawing detection circuit 204 is configured to detect a blood drawing state of the transmission line according to the blood leakage detection driving signal and generate a blood drawing detection signal, the blood drawing control circuit 104 is configured to generate a blood drawing fault signal when it is determined that the transmission line has a blood drawing fault according to the blood drawing detection signal, the first slave control circuit 30 is configured to generate a blood drawing alarm signal according to the blood drawing fault signal, and the master control circuit 10 is configured to send a third control signal for controlling the flow of the liquid to stop to the third slave control circuit 50 according to the blood drawing fault signal. Specifically, at the initial stage of blood purification (that is, when the blood pump 304 starts to operate, blood starts to flow into the transmission line), the main control circuit 10 outputs a blood drawing control signal to the blood drawing control circuit 104 through the first IO driving circuit, the blood drawing control circuit 104 generates a blood drawing detection driving signal according to the blood drawing control signal, the blood drawing detection circuit 204 starts to detect the blood drawing state of the transmission line and generates a blood drawing detection signal after receiving the blood drawing detection driving signal, and transmits the blood drawing detection signal to the blood drawing control circuit 104, and the blood drawing control circuit 104 determines whether the transmission line draws blood normally according to the received blood drawing detection signal. If the blood drawing control circuit 104 judges that the transmission pipeline has the blood drawing fault, a blood drawing fault signal is generated, the blood drawing fault signal is transmitted to the first slave control circuit 30 through the first IO quantity driving circuit, the first slave control circuit 30 generates a blood drawing alarm signal according to the blood drawing fault signal, and the loudspeaker is controlled to send out an alarm sound, so that a user can acquire the blood drawing fault information in the pipeline in real time. Meanwhile, the blood drawing control circuit 104 transmits a blood drawing fault signal to the main control circuit 10 through the first IO amount driving circuit, and the main control circuit 10 outputs a third control signal for controlling the flow of liquid to stop to the third slave control circuit 50 according to the blood drawing fault signal, thereby automatically stopping the blood purifying process.

Since the transmission line of the blood purification device may have a "pre-flushing" step before starting the blood purification, the specific operation of the pre-flushing is: the injection water is conveyed into a conveying pipeline to exhaust air in the conveying pipeline and remove impurities in the conveying pipeline; when the pre-flushing is finished, water for injection may exist in the transmission pipeline; next, after formally starting the blood purification, the transmission pipeline starts to draw out blood from the human body, at this time, the blood drawing detection circuit 204 detects whether the blood in the transmission pipeline is drawn normally, namely, whether the liquid in the transmission pipeline is blood is detected, and if the blood drawing control circuit 104 judges that the liquid in the transmission pipeline is blood through the blood drawing detection signal, the blood drawing success of the blood purification equipment is indicated; in contrast, if the blood drawing control circuit 104 determines that the liquid in the transmission line is not blood (is water for injection) by the blood drawing detection signal, which indicates that the blood purification apparatus fails to draw blood, the blood drawing control circuit 104 outputs a blood drawing failure signal to stop the flow of the liquid in the transmission line (stop of the blood pump 304) and the speaker gives an alarm.

In one embodiment, the blood-drawing detection circuit 204 adopts a light source detection method, and the main principle is that: the absorption intensity of the light source by blood and other liquids (e.g., physiological saline) is different, and reference is specifically made to the description of the leak detection circuit 202.

As shown in fig. 2, in one embodiment, the second slave control circuit 40 includes a pressure control circuit 106, the second control signal includes a pressure control signal, the detecting device 60 includes a pressure detection circuit 206, the pressure control circuit 106 is connected to the pressure detection circuit 206, for generating a pressure detection driving signal according to the pressure control signal output by the master control circuit 10, the pressure detection circuit 206 is configured to detect the pressure in the transmission line according to the pressure detection driving signal and generate a pressure detection signal, the pressure control circuit 106 is configured to generate a pressure failure signal when it is determined that the pressure in the transmission line is in a failure state according to the pressure detection signal, the first slave control circuit 30 is configured to generate a pressure alarm signal according to the pressure failure signal, and the master control circuit 10 is configured to send a third control signal for controlling the flow of the liquid to stop to the third slave control circuit 50 according to the pressure failure signal. Specifically, the main control circuit 10 outputs a pressure control signal to the pressure control circuit 106 through the RS485 serial port, the pressure control circuit 106 generates a pressure detection driving signal according to the pressure control signal, the pressure detection circuit 206 starts to detect the pressure in the transmission pipeline and generates a pressure detection signal after receiving the pressure detection driving signal, and transmits the pressure detection signal to the pressure control circuit 106, and the pressure control circuit 106 determines whether the pressure in the transmission pipeline is in a fault state according to the received pressure detection signal. If the pressure control circuit 106 judges that the pressure in the transmission pipeline is in a fault state, a pressure fault signal is generated, the pressure fault signal is transmitted to the first slave control circuit 30 through the RS485 serial port, the first slave control circuit 30 generates a pressure alarm signal according to the pressure fault signal, and the loudspeaker is controlled to send out an alarm sound, so that a user can acquire the pressure fault information in the transmission pipeline in real time. Meanwhile, the pressure control circuit 106 transmits a pressure failure signal to the main control circuit 10 through the RS485 serial port, and the main control circuit 10 outputs a third control signal for controlling the flow of the liquid to stop to the third slave control circuit 50 according to the pressure failure signal, thereby automatically stopping the blood purification process.

Specifically, the pressure control circuit 106 obtains a pressure detection value in the transmission pipeline according to the pressure detection signal, the pressure control circuit 106 determines a difference between the pressure detection value and a preset pressure value (obtained according to the preset pressure signal), and if the difference exceeds a safety alarm value, the pressure control circuit 106 determines that the pressure in the transmission pipeline is in a fault state. The transmission pipeline includes: the arterial line is connected with arterial blood of a human body, the venous line can convey the purified blood to veins of the human body, the arterial line is connected with an arterial puncture needle, the arterial puncture needle is inserted into an artery of the human body to lead out the arterial blood of the human body, the venous line is connected with a venous puncture needle, and the venous puncture needle is inserted into veins of the human body to convey the purified blood to the veins of the human body; the pressure detection signal in the transmission pipeline can be used for judging whether the arterial puncture needle and the venous puncture needle are connected in the loop, for example, when the arterial puncture needle is not inserted into an artery of a human body, the pressure of the arterial pipeline is changed, and the actual connection state of the arterial puncture needle can be judged by detecting the pressure of the transmission pipeline. The pressure control circuit 106 may preset a pressure signal in advance; the user can also directly input a pressure setting instruction on the touch screen, then the main control circuit 10 outputs a preset pressure signal according to the pressure setting instruction, and outputs the preset pressure signal to the pressure control circuit 106 through the RS485 serial port, and the pressure control circuit 106 generates preset pressure according to the preset pressure signal.

In one embodiment, the pressure detection circuit 206 includes a first pressure sensor and a second pressure sensor, the pressure detection circuit 206 detecting both arterial side pressure on the arterial line side and venous side pressure on the venous line side, arterial side pressure by the first pressure sensor disposed on an arterial pitcher in the arterial line, venous side pressure by the second pressure sensor disposed on a venous pitcher in the venous line; the pressure detection circuit 206 can detect the arterial side pressure and the venous side pressure simultaneously to generate pressure detection signals, and the pressure control circuit 106 can judge whether the arterial side pressure and the venous side pressure are normal or not according to the obtained pressure detection signals and generate pressure fault signals when the arterial side pressure and/or the venous side pressure are in fault state; the judging thresholds of the arterial side pressure and the venous side pressure are different, that is, the pressure control circuit 106 judges whether the arterial side pressure is in a fault state according to the difference between the arterial side pressure detection value and the preset arterial pressure, and judges whether the venous side pressure is in a fault state according to the difference between the venous side pressure detection value and the preset venous pressure, and other pressure detection and alarm modes of the arterial line side and the venous line side are identical except that the preset pressure is different in size.

As shown in fig. 2, in one embodiment, the control device of the blood purification apparatus further comprises a blood pump device 208, the third slave control circuit 50 comprises a blood pump control circuit 108 connected to the blood pump device 208, and the third control signal comprises a blood pump 304 control signal;

the blood pump control circuit 108 is configured to generate a blood pump driving signal according to the blood pump control signal, and the blood pump device 208 is configured to control a blood flow rate and a blood flow direction of blood in the transmission line according to the blood pump driving signal.

In one embodiment, the blood pump device 208 is further configured to send a rotational speed feedback signal to the blood pump control circuit 108, and the blood pump control circuit 108 is further configured to generate a blood pump drive signal based on the blood pump control signal and the rotational speed feedback signal.

Specifically, the user inputs a desired first blood flow rate (for example, 30 ml/min) on the touch screen, the main control circuit 10 generates a blood pump control signal according to the first blood flow rate, the RS485 serial port transmits the blood pump control signal to the blood pump control circuit 108 in an RS485 communication manner, the blood pump control circuit 108 generates a blood pump driving signal for adjusting the rotation speed and the steering of the blood pump device 208 according to the blood pump control signal, and the blood pump control circuit 108 can feedback-control the blood pump device 208 according to the feedback information amount (rotation speed feedback signal) of the blood pump device 208 so that the blood pump device 208 can be maintained in a stable operation state according to the instruction of the user.

As shown in fig. 4, in one embodiment, the blood pump device 208 includes a blood pump 304, a blood pump drive circuit 302, and a blood pump rotational speed feedback circuit 306;

The blood pump driving circuit 302 is connected to the blood pump control circuit 108 and the blood pump 304, respectively; the blood pump rotational speed feedback circuit 306 is respectively connected with the blood pump 304 and the blood pump control circuit 108;

The blood pump control circuit 108 is used for generating a blood pump driving signal according to the blood pump control signal and the rotating speed feedback signal; the blood pump driving circuit 302 is used for adjusting the rotational speed and the steering direction of the blood pump 304 according to the blood pump driving signal; the blood pump 304 is used for controlling the blood flow speed and the blood flow direction in the transmission pipeline according to the rotation speed and the steering direction of the blood pump; the blood pump rotational speed feedback circuit 306 is configured to detect a rotational speed of the blood pump in the transmission line and generate a rotational speed feedback signal.

Specifically, when a user inputs a desired preset blood flow rate and a preset blood flow direction on the touch screen, the main control circuit 10 generates a blood pump control signal according to the preset blood flow rate, and outputs the blood pump control signal to the blood pump control circuit 108 in an RS485 communication manner through an RS485 serial port, the blood pump control circuit 108 obtains a preset rotation speed and a preset rotation direction of the blood pump 304 according to the blood pump control signal, and then generates a blood pump driving signal, and the blood pump driving circuit 302 drives the blood pump 304 to rotate according to the blood pump driving signal, so that blood in the transmission pipeline is conveyed at the blood flow rate desired by the user; the blood pump rotational speed feedback circuit 306 is configured to detect an actual rotational speed of the blood pump 304 and output a rotational speed feedback signal, the blood pump control circuit 108 is configured to obtain the actual rotational speed of the blood pump 304 according to the rotational speed feedback signal, compare a difference between the actual rotational speed and a preset rotational speed, and then feedback-control the blood pump driving circuit 302 according to the difference and a preset blood flow rate desired by a user, so as to dynamically adjust the rotational speed of the blood pump 304, thereby ensuring that the rotational speed of the blood pump 304 can be kept in a stable state, and the blood flow rate in a transmission pipeline in the blood purification device is kept in a stable level.

In one embodiment, the user may directly control the rotational speed and the rotational direction of the blood pump 304 through the touch screen, and the user may directly control the stopping or starting of the blood pump 304 through the touch screen; wherein the blood pump 304 is controlled to stop, that is, the rotation speed of the blood pump 304 is set to 0; the control of the blood pump 304 is started by setting the rotational speed of the blood pump 304 from 0 to any value.

As shown in fig. 4, in one embodiment, the blood pump device 208 further includes:

The blood pump detection module 308 is connected with the blood pump 304 and the blood pump control circuit 108 respectively, and is used for detecting the blood pump rotation speed and the blood pump steering direction of the blood pump 304 and generating a blood pump detection signal; the blood pump control circuit 108 is connected to the first slave control circuit 30;

The blood pump control circuit 108 is also configured to determine whether or not the blood pump 304 is abnormal based on the blood pump detection signal and the blood pump control signal, generate a blood pump driving signal for controlling the blood pump 304 to stop when it is determined that the blood pump 304 is abnormal, and send a blood pump failure signal to the first slave control circuit 30.

In one embodiment, the blood pump detection module 308 is a sensor module, specifically, when the blood pump driving circuit 302 drives the blood pump 304 to operate, the sensor module attached to the blood pump 304 will detect the actual rotation speed and the actual rotation direction of the blood pump 304 and generate a blood pump detection signal, and the sensor module transmits the blood pump detection signal to the blood pump control circuit 108, if the blood pump control circuit 108 obtains that the actual rotation speed of the blood pump 304 exceeds the preset safe rotation speed range or the rotation direction of the blood pump 304 does not rotate according to the preset rotation direction according to the detected blood pump detection signal, the blood pump control circuit 108 generates a blood pump fault signal; on the one hand, the blood pump control circuit 108 generates a blood pump driving signal according to the blood pump fault signal, and the blood pump driving circuit 302 controls the blood pump 304 to stop emergently according to the blood pump driving signal, so as to ensure the safety of the blood operation in the transmission pipeline of the blood purifying equipment; on the other hand, the blood pump control circuit 108 outputs the blood pump fault signal to the first slave control circuit 30 sequentially through the RS485 serial port and the IO driving circuit, and the first slave control circuit 30 generates a blood pump fault alarm signal according to the blood pump fault signal, so as to control the speaker to send an alarm sound, so as to remind the user that the operation of the blood pump 304 is in a fault state, and the user needs to perform timely processing.

In one embodiment, the blood pump detection module 308 includes a blood pump rotational speed feedback circuit 306.

As shown in fig. 5, in one embodiment, the third slave control circuit 50 includes a fluid replacement control circuit 110, the third control signal includes a fluid replacement control signal, and the control device of the blood purification apparatus further includes:

The blood purifying device is used for purifying the purified blood obtained after the blood in the transmission pipeline is purified;

and the fluid replacement unit is connected with the fluid replacement control circuit 110 and is used for receiving a fluid replacement driving signal generated by the fluid replacement control circuit 110 according to the fluid replacement control signal and controlling the flow rate and the flow direction of the fluid replacement filled in the purified blood according to the fluid replacement driving signal.

In one embodiment, the fluid infusion unit includes a fluid infusion device 212 and a heating device 210; the control device of the blood purification apparatus further includes a fourth slave control circuit 80;

The fourth slave control circuit 80 is connected to the master control circuit 10, the secondary control circuit 20, and the heating device 210, respectively, and the fourth slave control circuit 80 is configured to receive a heating control signal sent by the master control circuit 10, and generate a heating driving signal according to the heating control signal;

The fluid infusion device 212 is connected to the fluid infusion control circuit 110, and is configured to control a fluid infusion flow rate and a fluid infusion flow direction of the fluid infusion fluid in the fluid infusion pipeline in the transmission pipeline according to the fluid infusion driving signal;

The heating device 210 is installed on the surface of the fluid replacement pipeline, and is used for heating the fluid replacement according to the heating driving signal.

In one embodiment, the fluid infusion device 212 comprises a fluid infusion pump drive circuit, a fluid infusion pump, and a fluid infusion pump rotational speed feedback circuit;

The fluid infusion pump driving circuit is respectively connected with the fluid infusion pump control circuit and the fluid infusion pump; the liquid supplementing pump rotating speed feedback circuit is respectively connected with the liquid supplementing pump and the liquid supplementing pump control circuit;

The fluid replacement pump control circuit is used for generating a fluid replacement pump driving signal according to the fluid replacement control signal and the fluid replacement rotating speed feedback signal; the fluid infusion pump driving circuit is used for adjusting the fluid infusion pump rotating speed and the fluid infusion pump steering of the fluid infusion pump according to the fluid infusion driving signal; the fluid infusion pump is used for controlling the first flow rate and the first flow direction of the supplementing fluid in the fluid infusion pipeline according to the rotating speed and the steering direction of the fluid infusion pump; the fluid replacement pump rotating speed feedback circuit is used for detecting a first flow rate of the fluid replacement and generating a fluid replacement rotating speed feedback signal.

In one embodiment, the fluid replacement device 212 further includes a replacement fluid storage bag for storing a replacement fluid, where the replacement fluid is illustratively a replacement fluid, where the replacement fluid contains substances or therapeutic drugs required by a human body, and the fluid replacement device 212 controls the delivery of the replacement fluid in the fluid replacement line to the venous pot according to the fluid replacement driving signal, so that the replacement fluid and the purified blood together are delivered to the veins of the human body.

As shown in fig. 5, in one embodiment, the third slave control circuit 50 includes a slurry separation control circuit 112; the blood purification device includes: a plasma separator, a purification unit, a plasma separation device 214; the third control signal comprises a slurry separation control signal;

the plasma separator is used for separating the blood in the transmission pipeline into plasma and blood cells;

The purifying unit is used for purifying the blood plasma to obtain purified blood plasma;

The plasma separating control circuit 112 is connected to the plasma separating device 214, and is configured to receive the plasma separating control signal sent by the main control circuit 10, generate a plasma driving signal according to the plasma separating control signal, and the plasma separating device 214 is configured to control a plasma flow direction and a plasma velocity of plasma in the transmission pipeline according to the plasma driving signal; the heating device 210 is installed on the surface of the fluid replacement line, and is used for heating the first mixed liquid in the fluid replacement line, which is composed of the fluid replacement and the purified plasma, according to the heating driving signal. The fluid infusion pump is used for controlling the flow rate and the flow direction of the first mixed liquid in the fluid infusion pipeline according to the rotation speed and the steering direction of the fluid infusion pump; the fluid replacement pump rotating speed feedback circuit is used for detecting the flow rate of the first mixed fluid and generating a fluid replacement rotating speed feedback signal.

As shown in fig. 5, in one embodiment, the third slave control circuit 50 includes a discard control circuit 114; the blood purification device further includes: a discard device 216, a discard storage bag; the purification module comprises a component separator; the third control signal further comprises a liquid discarding control signal;

The component separator is used for purifying the blood plasma to obtain waste liquid and purified blood plasma;

the waste liquid control circuit 114 is connected to the waste liquid device 216, and is configured to receive the waste liquid control signal sent by the main control circuit 10, generate a waste liquid driving signal according to the waste liquid control signal, and the waste liquid device 216 is configured to control the waste liquid in the transmission pipeline to flow into the waste liquid storage bag according to the waste liquid driving signal.

Specifically, the functions of the slurry separation control circuit 112 and the slurry reject control circuit 114 are similar to those of the blood pump control circuit 108 described above, and the functions and constituent blocks of the slurry reject device 216 and the slurry separation device 214 are similar to those of the blood pump device 208 described above, and will not be described in detail here.

In one embodiment, the first control signal includes a first weight fault signal, the blood purifying device further includes an amplifying circuit connected to the main control circuit 10 and the secondary control circuit 20, and a liquid-discarding scale and a liquid-replacing scale connected to the amplifying circuit, respectively, the liquid-discarding scale is used for detecting the weight increase of the liquid-discarding storage bag and generating a first weight signal, the liquid-filling scale is used for detecting the weight decrease of the liquid-replacing storage bag and generating a second weight signal, the amplifying circuit amplifies the first weight signal and the detected second weight signal of the liquid-filling scale, and then outputs the amplified first weight signal and the amplified second weight signal to the main control circuit 10 through the AD expanding circuit, the main control circuit 10 is further used for judging whether the weight change of the liquid-discarding storage bag and/or the weight change of the liquid-replacing storage bag is in a fault state according to the first weight signal and the second weight signal, and generating the first weight fault signal when judging that the weight of the liquid-discarding storage bag and/or the liquid-replacing storage bag is in a fault state, the main control circuit 10 outputs the first weight fault signal to the first slave control circuit 30 through the first IO driving circuit and sends an alarm sound to the first slave control circuit 30 through the first slave control circuit 30; and the main control circuit 10 generates a slurry separating control signal for controlling the slurry separating device 214 to stop, a slurry discarding control signal for controlling the liquid discarding device 216 to stop, and a liquid supplementing control signal for controlling the liquid supplementing device 212 to stop according to the first weight fault signal so as to prevent the dual-mode plasma exchange from being in a fault state.

In one embodiment, the third slave control circuit 50 includes a filtrate control circuit 116; the blood purification device comprises a blood filter, a filtrate device 218, a filtrate storage bag, and the third control signal comprises a filtrate control signal;

The blood filter is used for filtering blood to obtain filtrate and purifying blood;

The filtrate control circuit 116 is connected to a filtrate device 218 for receiving the filtrate control signal sent by the main control circuit 10 and generating a filtrate drive signal according to the filtrate control signal, and the filtrate device 218 is used for controlling the filtrate in the transmission line to flow into the filtrate storage bag according to the filtrate drive signal.

As shown in fig. 6, in one embodiment, the heating device 210 includes a heating driving circuit 310, a heating body 312, and a first temperature sensor 314;

the heating driving circuit 310 is connected to the fourth slave control circuit 80 and the heating body 312, respectively, and is configured to generate a heating power signal according to the heating driving signal;

the heating body 312 is mounted on the surface of the fluid infusion line and is used for heating the fluid infusion in the fluid infusion line according to the heating power signal;

The first temperature sensor 314 is installed in the fluid infusion line, and is configured to detect a fluid infusion temperature of the fluid infusion in the heated fluid infusion line, and generate a temperature detection signal;

The fourth slave control circuit 80 is connected to the first temperature sensor 314 and the first slave control circuit 30, respectively, and is configured to determine whether the fluid replacement temperature is in an abnormal state based on the temperature detection signal and the heating control signal, generate a heating drive signal for controlling the heating body 312 to stop heating when it is determined that the fluid replacement temperature is abnormal, and send a temperature failure signal to the first slave control circuit 30.

In one embodiment, the control device of the blood purifying apparatus further includes a plasma break detector disposed on the transmission line between the plasma separator and the plasma separating device 214, and when the plasma separator separates the blood in the transmission line, the main control circuit 10 outputs a first plasma break detection signal, and converts the first plasma break detection signal into a first plasma break driving signal through the AD expansion and conversion circuit and outputs the first plasma break driving signal to the plasma break detector, where the plasma break detector is configured to detect whether a plasma break occurs in the transmission line according to the first plasma break driving signal; specifically, the plasma break detector detects whether plasma in the transmission pipeline breaks flow in real time, generates a first plasma break detection signal, the amplifying circuit amplifies the first plasma break detection signal and outputs the first plasma break detection signal to the main control circuit 10 through the AD expansion and conversion circuit, if the main control circuit 10 judges that the transmission pipeline breaks flow according to the first plasma break detection signal, the main control circuit 10 generates a first plasma break fault signal, and outputs the first plasma break fault signal to the first slave control circuit 30 through the first IO quantity driving circuit, and the first slave control circuit 30 controls the loudspeaker to send an alarm sound; and the main control circuit 10 outputs a first slurry breaking fault signal to the blood pump control circuit 108 and the slurry separation control circuit 112 through the RS485 serial port, the blood pump control circuit 108 controls the blood pump 304 to stop through the blood pump driving circuit 302 according to the first slurry breaking fault signal, and the slurry separation control circuit 112 controls the plasma to stop flowing through the slurry separation pump driving circuit in the slurry separation device 214 according to the first slurry breaking fault signal so as to prevent the blood purification device from being in a state of 'slurry breaking operation'.

In one embodiment, the control device of the blood purification device further comprises a fluid replacement cut-off detector arranged on the fluid replacement pipeline in the transmission pipeline between the fluid replacement pump and the replacement fluid storage bag, when the blood in the transmission pipeline is separated by the plasma separator, the main control circuit 10 outputs a first fluid replacement cut-off detection signal, and the first fluid replacement cut-off detection signal is converted into a first fluid replacement cut-off driving signal through the AD expansion and conversion circuit and is output to the fluid replacement cut-off detector, and the fluid replacement cut-off detector is used for detecting whether the replacement fluid in the fluid replacement pipeline is cut-off according to the first fluid replacement cut-off driving signal; specifically, the fluid replacement flow break detector detects whether the replacement fluid in the fluid replacement pipeline breaks flow in real time, generates a first fluid replacement flow break detection signal, amplifies the first fluid replacement flow break detection signal by the amplifying circuit, outputs the amplified first fluid replacement flow break detection signal to the main control circuit 10 through the AD expansion and conversion circuit, and if the main control circuit 10 judges that the fluid replacement pipeline breaks flow according to the first fluid replacement flow break detection signal, the main control circuit 10 generates a first fluid replacement flow break signal and outputs the first fluid replacement flow break signal to the first slave control circuit 30 through the first IO (input/output) quantity driving circuit, and the first slave control circuit 30 controls the loudspeaker to send an alarm; and the main control circuit 10 outputs a first fluid infusion cut-off fault signal to the blood pump control circuit 108 and the fluid infusion control circuit 110 through the RS485 serial port, the blood pump 304 control circuit 108 controls the blood pump 304 to stop through the blood pump driving circuit 302 according to the first fluid infusion cut-off fault signal, and the fluid infusion control circuit 110 controls the fluid infusion pump to stop through the fluid infusion pump driving circuit in the fluid infusion device 212 according to the first fluid infusion cut-off fault signal, so as to prevent the blood purification equipment from being in a 'cut-off running' state.

As shown in fig. 7, S1 is a plasma separator, S2 is a purifying unit, S3 is a plasma pot, a bubble detecting clamp is a bubble detecting circuit, a transmission pipeline includes an arterial pipeline, an arterial pot, a venous pot, and a venous pipeline, an FP pump is a slurry separating pump in the slurry separating device 214, an RP pump is a fluid supplementing pump, a DP pump is a fluid discarding pump in the fluid discarding device 216, W1 is a replacement fluid storage bag, and W2 is a fluid discarding storage bag. The replacement liquid storage bag stores the replacement liquid in advance, wherein the components of the replacement liquid can be prepared according to practical application.

When the first fluid replacement temperature (i.e., the heating temperature expected by the user) of the fluid replacement is set on the touch screen, the heating driving circuit 310 is used for controlling the heating temperature of the heating body 312, the heating body 312 only transmits heat to the pipe wall of the fluid replacement pipe, and the heat received by the fluid replacement in the fluid replacement pipe is not the expected temperature (the heat loss is reduced), so when the fluid replacement pipe is heated by the heating body 312, if the temperature of the heating body 312 is directly set to the first fluid replacement temperature, the actual temperature of the fluid replacement after heating and the expected first fluid replacement temperature have a temperature difference; thus in order to solve this temperature difference problem; before heating, the first temperature sensor 314 is used to detect the actual temperature of the heated replenishment liquid in real time, and then the temperature of the heating body 312 is calibrated.

As shown in fig. 8, in one embodiment, the fourth slave control circuit includes:

a setting module 402, configured to set a first temperature threshold and a second temperature threshold of a fluid replacement temperature corresponding to a fluid replacement, and a first rate threshold and a second rate threshold corresponding to a fluid replacement flow rate;

The calibration module 404 is configured to obtain a first calibration temperature of the corresponding heating body 312 according to the second temperature threshold and the second rate threshold, and a first calibration point formed by the second temperature threshold, the second rate threshold, and a first temperature difference between the first calibration temperature and the second temperature threshold; obtaining a second calibration temperature of the corresponding heating body 312 according to the second temperature threshold and the first speed threshold, and a second calibration point formed by the second temperature threshold, the first speed threshold, and a second temperature difference between the second calibration temperature and the second temperature threshold; obtaining a third calibration temperature of the corresponding heating body 312 according to the first temperature threshold and the second rate threshold, and a third calibration point formed by the first temperature threshold, the second rate threshold, and a third temperature difference between the third calibration temperature and the first temperature threshold; obtaining a fourth calibration temperature of the corresponding heating body 312 according to the first temperature threshold and the first speed threshold, and a fourth calibration point formed by the first temperature threshold, the first speed threshold, and a third temperature difference between the fourth calibration temperature and the first temperature threshold;

The curved surface generating module 406 establishes a coordinate system with the fluid infusion temperature as the X axis, the fluid infusion flow rate as the Y axis, and the temperature difference between the calibration temperature of the heating body 312 and the temperature threshold as the Z axis, and generates a control curved surface in the coordinate system with the first calibration point, the second calibration point, the third calibration point, and the fourth calibration point as endpoints;

The obtaining module 408 is configured to obtain a target fluid replacement temperature and a target fluid replacement flow rate of the replenishment fluid according to the heating control signal, and obtain a target calibration temperature corresponding to the target fluid replacement temperature according to the control curved surface;

An output module 410 for generating a heating drive signal based on the target calibration temperature.

In one embodiment, the surface generation module 406: and obtaining a first line segment formed by connecting the first calibration point with the second calibration point, a second line segment formed by connecting the third calibration point with the fourth calibration point, a third line segment formed by connecting the first calibration point with the third calibration point, a fourth line segment formed by connecting the second calibration point with the fourth calibration point and a control curved surface formed by encircling the first line segment, the second line segment, the third line segment and the fourth line segment according to the first calibration point, the second calibration point, the third calibration point and the fourth calibration point.

In one embodiment, the first temperature threshold is the highest temperature Tmax of the fluid replacement temperature, the first temperature threshold is the lowest temperature Tmin of the fluid replacement temperature, the first rate threshold is the maximum rate Vmax of the fluid replacement flow rate, and the second rate threshold is the minimum rate Vmin of the fluid replacement flow rate.

Before the user inputs the desired first fluid replacement temperature on the touch screen, we need to calibrate the heating temperature of the heating body 312 in advance; setting the position of the first temperature sensor 314 in the fluid infusion line as the target temperature measurement point, where the user desires the temperature of the fluid infusion detected by the target temperature measurement point to be the first fluid infusion temperature, the setting factors affecting the calibration temperature of the heating body 312 include: the first make-up temperature and the flow rate of the make-up fluid (and in addition to these two, there are many other factors such as the size of the tubing, the material of the tubing, the ambient temperature, the pipe diameter length between the target temperature measurement point and the heating body 312, etc.).

The fourth slave control circuit generates the heating driving signal according to the heating control signal, comprising: firstly, acquiring a target calibration temperature of a heating body 312 corresponding to a target fluid replacement temperature in a heating control signal; and secondly, generating a heating driving signal according to the target calibration temperature.

Specifically, in the first step, a first temperature threshold value, i.e., a maximum temperature value Tmax and a second temperature threshold value, i.e., a minimum temperature value Tmin, of the replenishing temperature corresponding to the replenishing liquid, and a first rate threshold value, i.e., a maximum rate Vmax and a second temperature threshold value, i.e., a minimum rate Vmin, of the replenishing flow rate corresponding to the replenishing liquid are set; wherein the target fluid replacement temperature is between the first temperature threshold and the second temperature threshold, and the target fluid replacement flow rate is between the first rate threshold and the second rate threshold. And secondly, traversing and combining the highest temperature Tmax and the lowest temperature Tmin with the maximum rate Vmax and the minimum rate Vmin to obtain A1 point (Tmin and Vmin), A2 point (Tmin and Vmax), A3 point (Tmax and Vmin) and A4 point (Tmax and Vmax) which are 4 two-dimensional points formed by the flow rate limit value of the target fluid infusion flow rate and the temperature limit value of the target fluid infusion temperature, wherein the highest temperature Tmax is 38 ℃, the lowest temperature Tmin is 35 ℃, the maximum rate Vmax is 83.3ml/min and the minimum rate Vmin is 16.7ml/min. At this time, the A1 point was (35 ℃,16.7 ml/min), the A2 point was (38 ℃,16.7 ml/min), the A3 point was (35 ℃,83.3 ml/min), and the A4 point was (38 ℃,83.3 ml/min). in the third step, the calibration temperature of the heating body 312 is obtained through a fourth slave control circuit, specifically, when the heating temperature of the heating body 312 is adjusted at the point A1 so that the flow rate of the fluid replacement is Vmin (16.7 ml/min), the actual fluid replacement temperature detected by the first temperature sensor 314 is Tmin (35 ℃), and at this time, the heating temperature of the heating body 312 is the first calibration temperature T1 (35.6 ℃), so as to obtain the heating temperatures of the heating body 312 corresponding to the point A2, the point A3 and the point A4, wherein the heating temperature corresponding to the point A2 is the second calibration temperature T2 (39.2 ℃), the heating temperature corresponding to the point A3 is the third calibration temperature T3 (48 ℃) the heating temperature corresponding to the A4 point is a fourth calibration temperature T4 (55 ℃), and the temperature difference delta T between each calibration temperature and the corresponding actual fluid replacement temperature, wherein the first temperature difference corresponding to the A1 point is delta T1-Tmin, the second temperature difference corresponding to the A2 point is delta T2-Tmin, the third temperature difference corresponding to the A3 point is delta T3-Tmax, the fourth temperature difference corresponding to the A4 point is delta T4-Tmax, the A1 point, the A2 point, the A3 point and the A4 point are updated to obtain A1 'points (Tmin, vm in, delta T1) and A2' points (Tmin, vmax, Δt2), A3 'point (Tmax, vmin, Δt3), A4' point (Tmax, vmax, Δt4) total 4 three-dimensional points. Fourth, a coordinate system is established by taking the fluid replacement temperature as the X axis, the fluid replacement flow rate as the Y axis and the temperature difference delta T as the Z axis, and then three-dimensional points A1 '(Tmin, vmin, delta T1), A2' (Tmin, vmax, delta T2), A3 '(Tmax, vmin, delta T3) and A4' (Tmax, vmax, delta T4) are taken as four vertexes to form a control curved surface S1, and the control curved surface is shown in fig. 9. And fifth, when the target fluid replacement flow rate (corresponding to the determination of the Y value) of the desired fluid replacement and the target fluid replacement temperature (corresponding to the determination of the X value) of the desired fluid replacement are input, the fourth slave control circuit obtains the Z value, namely the calibration temperature of the heating body 312, according to the X value, the Y value and the control area S1, and the fourth slave control circuit changes the power of the heating body 312 through the heating driving circuit 310 so that the temperature of the heating body 312 reaches the calibration temperature, thereby improving the heating precision of the fluid replacement.

After the temperature and the flow rate of the supplementary liquid expected by the user can be calibrated through the control curved surface S1 formed by 4 three-dimensional points (A1 ', A2', A3', A4'), the calibrated temperature of the calibrated heating body 312 is obtained, the number of the calibrated points of the temperature of the heating body 312 is greatly reduced, the calibration time is saved, meanwhile, the heating temperature of each heating body 312 can be calibrated by adopting the control curved surface, the higher temperature calibration consistency (equivalent to 'stepless speed regulation') is realized, and the problem that the temperature calibration error is larger due to the discontinuity of each calibrated point in the traditional technology is avoided.

In one embodiment, a three-dimensional control surface S1 is formed according to 4 three-dimensional points (A1 ', A2', A3', A4'), in which a straight line simulation (fitting is performed by using a straight line) can be used between A1 'and A2', the straight line is L1, and similarly, a curve between A3 'and A4' can also be replaced by a straight line L2 simulation, L2 and L1 are connected by innumerable straight lines (refer to a straight line L3), L3 is a movable line segment, the length of the movable line segment is variable, L1 is one of the "guide rails", L2 is the other of the "guide rails", L3 slides directly on the two guide rails to form the control surface forming surface S1, and the surface S1 is the control surface set by adopting the heating body 312 to control the fluid infusion flow rate corresponding to different targets and the calibration temperature of different targets.

The above examples illustrate only a few embodiments of the application, which are described in detail and are not to be construed as limiting the scope of the application. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the application, which are all within the scope of the application. Accordingly, the scope of protection of the present application is to be determined by the appended claims.

Claims

1. A control device for a blood purification apparatus, comprising: the device comprises a main control circuit, a secondary control circuit, a first secondary control circuit, a second secondary control circuit, a third secondary control circuit, a detection device, a liquid supplementing unit and a fourth secondary control circuit;

The detection end of the main control circuit is connected with the detection end of the secondary control circuit; the output end of the main control circuit and the output end of the secondary control circuit are connected with the first input end of the first secondary control circuit, the first input end of the second secondary control circuit and the first input end of the third secondary control circuit;

The main control circuit is used for outputting a first control signal to a first input end of the first slave control circuit, outputting a second control signal to a first input end of the second slave control circuit and outputting a third control signal to a first input end of the third slave control circuit;

The secondary control circuit is used for being used as a new main control circuit when the main control circuit is detected to be in a dead state;

The first slave control circuit is used for generating an alarm signal according to the first control signal or the pipeline fault signal; the second slave control circuit is used for generating a detection driving signal according to the second control signal; the detection device is used for detecting the flowing state of the liquid in the transmission pipeline according to the detection driving signal and generating a detection signal; the second slave control circuit is further used for generating the pipeline fault signal when judging that the liquid in the transmission pipeline is in an abnormal state according to the detection signal; the third slave control circuit is used for controlling the liquid flow rate and the liquid flow direction of the liquid in the transmission pipeline according to the third control signal;

The third slave control circuit comprises a fluid replacement control circuit, the third control signal comprises a fluid replacement control signal, the fluid replacement unit is connected with the fluid replacement control circuit and is used for receiving a fluid replacement driving signal generated by the fluid replacement control circuit according to the fluid replacement control signal and controlling the flow rate and the flow direction of the fluid replacement filled in purified blood according to the fluid replacement driving signal; the liquid supplementing unit comprises a heating device;

The fourth slave control circuit is respectively connected with the main control circuit, the secondary control circuit and the heating device, and is used for receiving a heating control signal sent by the main control circuit and generating a heating driving signal according to the heating control signal; the heating device is arranged on the surface of the fluid infusion pipeline and is used for heating the fluid infusion according to the heating driving signal;

the heating device comprises a heating driving circuit, a heating body and a first temperature sensor;

The heating driving circuit is respectively connected with the fourth slave control circuit and the heating body and is used for generating a heating power signal according to the heating driving signal;

The heating body is arranged on the surface of the fluid infusion pipeline and is used for heating the fluid infusion in the fluid infusion pipeline according to the heating power signal;

the first temperature sensor is arranged in the fluid infusion pipeline and is used for detecting the fluid infusion temperature of the fluid infusion in the heated fluid infusion pipeline and generating a temperature detection signal;

the fourth slave control circuit is respectively connected with the first temperature sensor and the first slave control circuit and is used for judging whether the fluid infusion temperature is in an abnormal state according to the temperature detection signal and the heating control signal, generating a heating driving signal for controlling the heating body to stop heating when judging that the fluid infusion temperature is abnormal, and sending a temperature fault signal to the first slave control circuit;

the fourth slave control circuit includes:

The setting module is used for setting a first temperature threshold value and a second temperature threshold value of the fluid replacement temperature corresponding to the fluid replacement, and a first speed threshold value and a second speed threshold value corresponding to the fluid replacement flow rate;

The calibration module is used for obtaining a first calibration temperature of the corresponding heating body according to the second temperature threshold value and the second rate threshold value, and a first calibration point formed by the second temperature threshold value, the second rate threshold value and a first temperature difference value between the first calibration temperature and the second temperature threshold value; obtaining a second calibration temperature of the corresponding heating body according to the second temperature threshold and the first speed threshold, and a second calibration point formed by the second temperature threshold, the first speed threshold, and a second temperature difference between the second calibration temperature and the second temperature threshold; obtaining a third calibration temperature of the corresponding heating body according to the first temperature threshold and the second rate threshold, and a third calibration point formed by the first temperature threshold, the second rate threshold, and a third temperature difference between the third calibration temperature and the first temperature threshold; obtaining a fourth calibration temperature of the corresponding heating body according to the first temperature threshold and the first speed threshold, and a fourth calibration point formed by the first temperature threshold, the first speed threshold, and a third temperature difference between the fourth calibration temperature and the first temperature threshold;

The curved surface generating module is used for establishing a coordinate system by taking the fluid infusion temperature as an X axis, the fluid infusion flow rate as a Y axis and the temperature difference between the calibration temperature of the heating body and the temperature threshold value as a Z axis, and generating a control curved surface by taking the first calibration point, the second calibration point, the third calibration point and the fourth calibration point as endpoints;

The acquisition module is used for obtaining the target fluid replacement temperature and the target fluid replacement flow rate of the supplementing fluid according to the heating control signal, and obtaining the target calibration temperature corresponding to the target fluid replacement temperature according to the control curved surface;

and the output module is used for generating a heating driving signal according to the target calibration temperature.

2. The control device of claim 1, further comprising a blood pump device, wherein the third slave control circuit comprises a blood pump control circuit coupled to the blood pump device, wherein the third control signal comprises a blood pump control signal;

The blood pump control circuit is used for generating a blood pump driving signal according to the blood pump control signal, and the blood pump device is used for controlling the blood flow speed and the blood flow direction of blood in the transmission pipeline according to the blood pump driving signal.

3. The control device according to claim 2, wherein the blood pump device includes a blood pump, a blood pump driving circuit, a blood pump rotational speed feedback circuit;

The blood pump driving circuit is respectively connected with the blood pump control circuit and the blood pump; the blood pump rotating speed feedback circuit is respectively connected with the blood pump and the blood pump control circuit;

The blood pump control circuit is used for generating a blood pump driving signal according to the blood pump control signal and the rotating speed feedback signal; the blood pump driving circuit is used for adjusting the blood pump rotating speed and the blood pump steering of the blood pump according to the blood pump driving signal; the blood pump is used for controlling the blood flow rate and the blood flow direction according to the blood pump rotating speed and the blood pump steering; the blood pump rotation speed feedback circuit is used for detecting the rotation speed of the blood pump and generating the rotation speed feedback signal.

4. A control device according to claim 3, wherein the blood pump device further comprises:

The blood pump detection module is respectively connected with the blood pump and the blood pump control circuit and is used for detecting the rotation speed of the blood pump and the steering direction of the blood pump and generating a blood pump detection signal; the blood pump control circuit is connected with the first slave control circuit;

The blood pump control circuit is also used for judging whether the blood pump is abnormal according to the blood pump detection signal and the blood pump control signal, generating a blood pump driving signal for controlling the blood pump to stop when the blood pump is judged to be abnormal, and sending a blood pump fault signal to the first slave control circuit.

5. The control device of claim 4, wherein the blood pump detection module includes the blood pump rotational speed feedback circuit.

6. The control device according to any one of claims 2 to 5, characterized in that the control device further comprises:

And the blood purifying device is used for purifying the purified blood obtained after the blood in the transmission pipeline is purified.

7. The control device of claim 1, wherein the fluid replacement unit further comprises a fluid replacement device;

The fluid infusion device is connected with the fluid infusion control circuit and is used for controlling the fluid infusion flow rate and the fluid infusion flow direction of the fluid infusion in the fluid infusion pipeline in the transmission pipeline according to the fluid infusion driving signal.

8. The control device of claim 7, wherein the third slave control circuit comprises a slurry separation control circuit; the blood purification device includes: a plasma separator, a purification unit and a plasma separating device; the third control signal comprises a slurry separation control signal;

The plasma separation control circuit is connected with the plasma separation device and is used for receiving the plasma separation control signal sent by the main control circuit and generating a plasma driving signal according to the plasma separation control signal, and the plasma separation device is used for controlling the plasma flow direction and the plasma velocity of plasma in the transmission pipeline according to the plasma driving signal; the heating device is arranged on the surface of the fluid infusion pipeline and is used for heating first mixed liquid which is formed by the fluid infusion and the purified blood plasma in the fluid infusion pipeline according to the heating driving signal.

9. The control device of claim 8, wherein the third slave control circuit comprises a reject control circuit; the blood purification device further includes: a liquid discarding device and a liquid discarding storage bag; the purification module comprises a component separator; the third control signal further comprises a liquid discarding control signal;

The liquid discarding control circuit is connected with the liquid discarding device and is used for receiving the liquid discarding control signal sent by the main control circuit and generating a liquid discarding driving signal according to the liquid discarding control signal, and the liquid discarding device is used for controlling the liquid discarding in the transmission pipeline to flow into the liquid discarding storage bag according to the liquid discarding driving signal;

wherein the third slave control circuit further comprises a filtrate control circuit; the blood purification device further comprises a blood filter, a filtrate device and a filtrate storage bag, and the third control signal further comprises a filtrate control signal;

The filtrate control circuit is connected with the filtrate device and is used for receiving the filtrate control signal sent by the main control circuit and generating a filtrate drive signal according to the filtrate control signal, and the filtrate device is used for controlling filtrate in the transmission pipeline to flow into the filtrate storage bag according to the filtrate drive signal.