CN113252565B - AI artificial intelligence-based lung cancer circulating tumor cell detection device - Google Patents
AI artificial intelligence-based lung cancer circulating tumor cell detection device Download PDFInfo
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- CN113252565B CN113252565B CN202110596921.9A CN202110596921A CN113252565B CN 113252565 B CN113252565 B CN 113252565B CN 202110596921 A CN202110596921 A CN 202110596921A CN 113252565 B CN113252565 B CN 113252565B
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- 238000001514 detection method Methods 0.000 title claims abstract description 41
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 title claims description 14
- 206010058467 Lung neoplasm malignant Diseases 0.000 title claims description 11
- 201000005202 lung cancer Diseases 0.000 title claims description 11
- 208000020816 lung neoplasm Diseases 0.000 title claims description 11
- 238000013473 artificial intelligence Methods 0.000 title claims description 10
- 230000007246 mechanism Effects 0.000 claims description 14
- 238000005286 illumination Methods 0.000 claims description 12
- 238000003745 diagnosis Methods 0.000 claims description 8
- 230000003028 elevating effect Effects 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 206010066054 Dysmorphism Diseases 0.000 claims 4
- 125000003003 spiro group Chemical group 0.000 claims 1
- 230000003287 optical effect Effects 0.000 abstract description 13
- 210000004369 blood Anatomy 0.000 abstract description 9
- 239000008280 blood Substances 0.000 abstract description 9
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 210000004881 tumor cell Anatomy 0.000 description 5
- 206010027476 Metastases Diseases 0.000 description 4
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- 238000000034 method Methods 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
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- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 230000008782 phagocytosis Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
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Abstract
Compared with the prior art, the invention reasonably designs the optical filter and the backlight light source, so that a plurality of groups of blood samples can be continuously detected, the working principle is perfected, the detection efficiency is improved, the upper side of the lighting lamp holder is provided with the elastic leak-proof ring which can be attached to the object placing disc at any time under the condition that the object placing disc rotates, and the light source of the lighting lamp for a microscope mainly penetrates through the optical filter plate, so that the blood sample can be conveniently observed better.
Description
Technical Field
The invention relates to the technical field of circulating tumor cell detection, in particular to a lung cancer circulating tumor cell detection device based on AI artificial intelligence.
Background
Circulating Tumor Cells (CTCs) are a collective term for various types of tumor cells existing in peripheral blood, most CTCs undergo apoptosis or phagocytosis after entering peripheral blood due to shedding from solid tumor lesions (primary foci, metastasis) by spontaneous or diagnosis and treatment operations, and a small number can escape and develop into metastasis to increase the death risk of malignant tumor patients. Malignant tumors are all transferred to other organs of the body through blood transmission, and tumor metastasis is a major cause of death in tumor patients. Tumor cells invade the surrounding tissues of the primary tumor cells, enter the blood and lymphatic system to form circulating tumor cells CTC, are transferred to the remote tissues, ooze out again, adapt to new microenvironments, and finally are sown, proliferated, colonized and form a metastasis. Therefore, the CTC in blood is found early, and the method has important guiding effects on prognosis judgment, curative effect evaluation and personalized treatment of patients.
Patent No. cn202020343045.X discloses a lung cancer circulating tumor cell detection device, comprising a base plate, the left central fixedly connected with bracing piece of bottom plate, bracing piece surface sliding connection has the movable block, the central fixedly connected with roof at bracing piece top, the central fixedly connected with rotation axis on movable block right side, the central fixedly connected with thing board on rotation axis right side, the central fixedly connected with detector of thing inboard wall, the central fixedly connected with eyepiece at detector top, the central fixedly connected with fixed disk at bottom plate top, the central rotation at fixed disk top is connected with the rolling disc, push rod and movable plate through setting up for the transfer line can promote push rod and movable plate upward movement when upward movement, will put the culture dish in the thing groove and follow the thing inslot ejection of putting, the staff of being convenient for takes out the culture dish from putting the thing inslot, the convenience of staff when using has been improved.
Although the device improves the detection efficiency, the device utilizes a detector, namely a microscope, but the optical filter and the backlight light source are not reasonably designed, so that the detection cannot be effectively implemented. In addition, the existing detection equipment relies on manual judgment of the illness state, is not only hard to operate, but also easy to cause judgment errors, and delays the timely discovery of the illness state.
Therefore, the invention designs a lung cancer circulating tumor cell detection device based on AI artificial intelligence to solve the problems.
Disclosure of Invention
The invention aims to provide an AI artificial intelligence-based lung cancer circulating tumor cell detection device so as to solve the problems in the background technology.
In order to achieve the above purpose, the present invention provides the following technical solutions: the utility model provides a lung cancer circulation tumor cell detection device based on AI artificial intelligence, includes the bottom plate, bottom plate top left side is provided with the host computer, bottom plate top right side is provided with the detection room, run through on the roof of detection room and install elevating system, elevating system's downside expansion end rigid coupling has the microscope, detection room detects the middle part and is equipped with the operation mouth, the light screen is gone up to the operation mouth, the microscope is close to detection room inner chamber left side, detection room bottom central authorities are equipped with the brace table, the brace table top is rotated and is installed and put the thing dish, the brace table inner chamber is provided with first motor, the output shaft of first motor puts the rotation center pin of thing dish, put and offered on the thing groove, it has a plurality of to put the thing groove to be annular distribution, the microscope is located the annular distribution route of putting the thing groove, it is provided with the light filter to put the thing inslot, the brace table left side is provided with the illumination lamp stand, the illumination lamp stand is located the microscope under, illumination lamp stand is provided with the illumination lamp.
Preferably, the lifting mechanism comprises an outer tube, an inner tube is inserted at the bottom end of the lifting mechanism in a limiting mode, a threaded rod is rotatably installed in the middle of the top wall of the inner cavity of the outer tube, the top end of the threaded rod is connected with a second motor, and the bottom end of the threaded rod is in threaded connection with the top end of the inner tube.
Preferably, the lighting lamp holder comprises a cylinder seat, a lighting lamp for a microscope is arranged in the cylinder seat, a light leakage prevention ring is movably inserted into the ring surface at the top end of the cylinder seat, and a reset spring is arranged at the bottom end of the light leakage prevention ring.
Preferably, the optical filter is connected with the object placing groove through a special-shaped ring seat, the special-shaped ring seat is rotationally connected with the inner wall of the object placing groove, the optical filter is clamped and arranged in a groove at the top end of the special-shaped ring seat, a cavity is arranged in the object placing disc and close to the object placing groove, a fine adjustment mechanism is arranged in the cavity, and the special-shaped ring seat is connected in a driving mode through the fine adjustment mechanism.
Preferably, the special-shaped ring seat comprises a ring body, a supporting ring is arranged in the middle of the inner side of the ring body, a limiting convex ring is arranged at the lower part of the outer wall of the ring body, the limiting convex ring is rotationally connected with the inner wall of the storage groove, and teeth are arranged on the outer ring surface of the limiting convex ring
Preferably, the fine adjustment mechanism comprises a third motor, wherein a gear is connected to an output shaft of the third motor, and the gear is meshed with the connecting teeth.
Preferably, the microscope is connected with a host, and the host performs disease diagnosis on a detection picture displayed by the microscope in combination with historical big data in the hospital system, and records the disease diagnosis in the hospital system as historical data.
Preferably, a plurality of groups of ultraviolet sterilizing lamp bands are arranged on the side wall of the inner cavity of the detection chamber.
Compared with the prior art, the invention has the beneficial effects that:
compared with the prior art, the invention reasonably designs the optical filter and the backlight light source, so that a plurality of groups of blood samples can be continuously detected, the working principle is perfected, and the detection efficiency is improved;
the elastic leak-proof ring is arranged on the upper side of the lighting lamp holder and can be attached to the object placing disc at any time under the condition that the object placing disc rotates, so that a light source of a lighting lamp for a microscope mainly passes through the light filtering plate, and a blood sample can be observed better;
the special-shaped ring seat is matched with the fine adjustment mechanism, and the optical filter plate and the blood sample on the optical filter plate can be driven to rotate and finely adjust in the detection process, so that a cleaned display picture is obtained, and the purpose of accurate detection is achieved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is a top view of the tray of the present invention;
FIG. 3 is a schematic view of a lifting mechanism according to the present invention;
FIG. 4 is a three-dimensional view of a lighting socket of the present invention;
FIG. 5 is a three-dimensional view of a contoured ring seat of the present invention;
FIG. 6 is an enlarged schematic view of the invention at A.
Description of the embodiments
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Examples
Referring to fig. 1 and 2, the present invention provides a technical solution: the utility model provides a lung cancer circulation tumour cell detection device based on AI artificial intelligence, is including bottom plate 1, its characterized in that: the left side of bottom plate 1 top is provided with host computer 2, bottom plate 1 top right side is provided with detection room 3, the roof of detection room 3 is gone up and is run through and install elevating system 4, elevating system 4's downside active end rigid coupling has microscope 5, detection room 3 detects the middle part and is equipped with operation mouth 6, light screen 7 on the operation mouth 6, microscope 5 is close to detection room 3 inner chamber left side, detection room 3 bottom central authorities are equipped with brace table 8, thing dish 9 is installed in the rotation of brace table 8 top, brace table 8 inner chamber is provided with first motor 10, the output shaft of first motor 10 is connected with the rotation center pin of putting thing dish 9, put and set up on the thing dish 9 and put thing groove 11, put thing groove 11 and have a plurality ofly, all put thing groove 11 and be annular distribution, microscope 5 is located and put the annular distribution route of thing groove 11, be provided with light filter 12 in putting thing groove 11, brace table 8 left side is provided with illumination lamp stand 13, illumination lamp stand 13 is located microscope 5 under, be provided with illumination light 14 in the lamp stand 13.
The microscope 5 is connected with the host computer 2, the host computer 2 performs disease diagnosis on a detection picture displayed by the microscope 5 by combining historical big data in a hospital system, and meanwhile, the disease diagnosis is recorded in the hospital system as historical data.
Wherein, a plurality of groups of ultraviolet sterilizing lamp belts 19 are arranged on the side wall of the inner cavity of the detecting chamber 3.
Working principle: when the device works, the light shielding plate 7 is opened, a pretreated blood sample slide is placed on the optical filter 12, then the light shielding plate 7 is covered, the switch is started to detect, the microscope uses the illuminating lamp 14 to emit light, the slide is illuminated by the optical filter 12, the microscope 5 detects the slide at the lower side, the detection picture is displayed on the host computer 2 in real time, and in the process, the lifting mechanism 4 adjusts the height position of the microscope 5 to obtain a cleaned picture;
after detecting a group of slides, the first motor 10 is intermittently started to enable the next group of slides to move to the detection position, the previous steps are continued to detect, the host computer 2 performs disease diagnosis on the detection picture displayed by the microscope 5 in combination with the historical big data in the hospital system, and meanwhile, the disease diagnosis is recorded in the hospital system as historical data.
Examples
Compared with the first embodiment, the following improvements are provided: the lifting mechanism 4 comprises an outer tube 41, an inner tube 44 is inserted at the bottom end of the lifting mechanism 4 in a limiting mode, a threaded rod 42 is rotatably installed in the middle of the top wall of the inner cavity of the outer tube 41, a second motor 43 is connected to the top end of the threaded rod 42, and the bottom end of the threaded rod 42 is in threaded connection with the top end of the inner tube 44.
When the microscope works, the second motor 43 is started to drive the threaded rod 42 to rotate, and the threaded rod 42 drives the inner tube 44 to ascend or descend, so that the function of adjusting the height position of the microscope 5 is achieved.
Examples
Compared with the first embodiment, the following improvements are provided: the lighting lamp holder 13 comprises a cylinder holder 131, wherein a microscope lighting lamp 14 is arranged in the cylinder holder 131, a light leakage prevention ring 132 is movably inserted into the ring surface at the top end of the cylinder holder 131, and a reset spring 133 is arranged at the bottom end of the light leakage prevention ring 132.
During operation, under the action of the return spring 133, no matter how the object placing disc 9 rotates, the anti-leakage ring 132 can well contact the bottom surface of the object placing disc, so that the illuminating lamp 14 for the microscope emits light to pass through the light filtering plate 12 as much as possible, and a good observation effect is obtained.
Examples
Compared with the first embodiment, the following improvements are provided: the optical filter 12 is connected with the storage groove 11 through a special-shaped ring seat 15, the special-shaped ring seat 15 is rotationally connected with the inner wall of the storage groove 11, the optical filter 12 is clamped and connected in a groove at the top end of the special-shaped ring seat 15, a cavity 16 is arranged at a position, close to the storage groove 11, in the storage disc 9, a fine adjustment mechanism is arranged in the cavity 16, and the fine adjustment mechanism is in driving connection with the special-shaped ring seat 15.
The special-shaped ring seat 15 comprises a ring body 151, a supporting ring 152 is arranged in the middle of the inner side of the ring body 151, a limiting convex ring 153 is arranged at the lower part of the outer wall of the ring body 151, the limiting convex ring 153 is rotationally connected with the inner wall of the storage groove 11, and teeth 154 are arranged on the outer ring surface of the limiting convex ring 153;
the fine adjustment mechanism comprises a third motor 17, a gear 18 is connected to an output shaft of the third motor 17, and the gear 18 is meshed with the connecting teeth 154.
In the detection process, the best observation picture can not be obtained simply through the lifting of the microscope, and the definition of the observation picture can be further improved only by matching the slide glass with the rotation fine adjustment.
When the scheme works, the third motor 17 drives the special-shaped ring seat 15 to rotate slowly through the gear 18, and drives the optical filter 12, namely the glass slide, to be finely adjusted until the obtained detection picture is clear and reliable.
In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the invention disclosed above are intended only to assist in the explanation of the invention. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise form disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best understand and utilize the invention. The invention is limited only by the claims and the full scope and equivalents thereof.
Claims (3)
1. Lung cancer circulating tumor cell detection device based on AI artificial intelligence, including bottom plate (1), its characterized in that: the utility model discloses a device for detecting objects, including bottom plate (1), detection room (3) are provided with on the left side of bottom plate (1) top, detect and install elevating system (4) on the roof of room (3), elevating system (4) are including outer tube (41), elevating system bottom spacing is inserted and is equipped with inner tube (44), threaded rod (42) are installed in the rotation of outer tube (41) inner chamber roof middle part, threaded rod (42) top is connected with second motor (43), threaded rod (42) bottom spiro union runs through the top of inner tube (44), microscope (5) are fixed with in the downside expansion end of elevating system (4), detect room (3) and detect middle part and be equipped with operation mouth (6), light screen (7) on operation mouth (6), microscope (5) are close to detection room (3) inner chamber left side, detect room (3) bottom central authorities are equipped with brace table (8), brace table (8) top rotation installs thing dish (9), brace table (8) inner chamber are provided with first motor (10), the top of first motor (11) are put thing groove (11) on the output shaft (10), all thing groove (11) are the annular distribution, microscope (5) are located the annular distribution route of putting thing groove (11) directly over, be provided with light filter (12) in putting thing groove (11), be connected through dysmorphism ring seat (15) between light filter (12) and the thing groove (11), dysmorphism ring seat (15) include ring body (151), the inboard middle part of ring body (151) is equipped with carrier ring (152), the outer wall lower part of ring body (151) is equipped with spacing bulge loop (153), spacing bulge loop (153) are connected with the rotation of thing groove (11) inner wall, be equipped with tooth (154) on the outer anchor ring of spacing bulge loop (153), dysmorphism ring seat (15) are connected with the rotation of thing groove (11) inner wall, light filter (12) joint is installed in dysmorphism ring seat (15) top recess, the position that is close to putting thing groove (11) in thing dish (9) is equipped with cavity (16), be equipped with fine setting motor (16) in cavity (16), motor fine setting, including third gear (17) fine setting mechanism, third gear (17) are connected with on the light fixture (8) the support table (18), the utility model provides a microscope illumination lamp socket (13) is including tube holder (131), establish microscope illumination lamp (14) in tube holder (131), movable on tube holder (131) top anchor ring is gone up and is inserted and is equipped with leak protection light ring (132), leak protection light ring (132) bottom is provided with reset spring (133), illumination lamp socket (13) are located under microscope (5), be provided with microscope illumination lamp (14) in illumination lamp socket (13).
2. The AI-artificial-intelligence-based lung cancer circulating tumor cell detection device according to claim 1, wherein: the microscope (5) is connected with the host machine (2), the host machine (2) is combined with the historical big data in the hospital system to diagnose the illness state of the detection picture displayed by the microscope (5), and meanwhile, the illness state diagnosis is recorded in the hospital system and used as the historical data.
3. The AI-artificial-intelligence-based lung cancer circulating tumor cell detection device according to claim 1, wherein: a plurality of groups of ultraviolet sterilizing lamp bands (19) are arranged on the side wall of the inner cavity of the detection chamber (3).
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| CN209589847U (en) * | 2019-01-24 | 2019-11-05 | 吉林大学第一医院 | A kind of lung cancer circulating tumor cell detection device |
| CN111148573A (en) * | 2017-05-24 | 2020-05-12 | 西北大学 | Apparatus and method for rapid sample processing and analysis |
| CN111208148A (en) * | 2020-02-21 | 2020-05-29 | 凌云光技术集团有限责任公司 | Dig hole screen light leak defect detecting system |
| CN211921521U (en) * | 2020-03-18 | 2020-11-13 | 云南省肿瘤医院(昆明医科大学第三附属医院) | Lung cancer circulating tumor cell detection device |
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| JP5484879B2 (en) * | 2009-12-11 | 2014-05-07 | オリンパス株式会社 | Super-resolution microscope |
| JP6086366B2 (en) * | 2013-04-05 | 2017-03-01 | 国立研究開発法人理化学研究所 | Microscope, focusing device, fluid holding device, and optical unit |
| CN103574519A (en) * | 2013-10-11 | 2014-02-12 | 深圳炫庆能源科技有限公司 | LED (light emitting diode) remote omni |
| CN207832652U (en) * | 2017-12-06 | 2018-09-07 | 杲莉芬 | A kind of Novel medical clinical laboratory microscope |
| CN207488145U (en) * | 2017-12-06 | 2018-06-12 | 吉林大学 | A kind of neoplastic hematologic disorder detection device |
| CN110907412A (en) * | 2018-09-14 | 2020-03-24 | 益善生物技术股份有限公司 | Detection system and analysis detection method for circulating tumor cells |
| CN109834668A (en) * | 2019-03-26 | 2019-06-04 | 珠海罗西尼表业有限公司 | Rolling clamp |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111148573A (en) * | 2017-05-24 | 2020-05-12 | 西北大学 | Apparatus and method for rapid sample processing and analysis |
| CN209589847U (en) * | 2019-01-24 | 2019-11-05 | 吉林大学第一医院 | A kind of lung cancer circulating tumor cell detection device |
| CN111208148A (en) * | 2020-02-21 | 2020-05-29 | 凌云光技术集团有限责任公司 | Dig hole screen light leak defect detecting system |
| CN211921521U (en) * | 2020-03-18 | 2020-11-13 | 云南省肿瘤医院(昆明医科大学第三附属医院) | Lung cancer circulating tumor cell detection device |
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