CN220827384U - Circulating tumor cell detection device - Google Patents
Circulating tumor cell detection device Download PDFInfo
- Publication number
- CN220827384U CN220827384U CN202322583084.3U CN202322583084U CN220827384U CN 220827384 U CN220827384 U CN 220827384U CN 202322583084 U CN202322583084 U CN 202322583084U CN 220827384 U CN220827384 U CN 220827384U
- Authority
- CN
- China
- Prior art keywords
- base
- tumor cell
- circulating tumor
- positioning frame
- rotating box
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 title claims abstract description 31
- 238000001514 detection method Methods 0.000 title claims abstract description 28
- 210000004881 tumor cell Anatomy 0.000 claims abstract description 19
- 230000001681 protective effect Effects 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 abstract description 13
- 239000012535 impurity Substances 0.000 abstract description 4
- 239000000428 dust Substances 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 206010027476 Metastases Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model relates to the field of detection devices, in particular to a circulating tumor cell detection device which comprises a base, a fixing frame, a microscope device, an ocular lens, a conveying mechanism and the like. According to the utility model, the conveying mechanism is arranged on the base, the worm is driven to rotate through the handle, the worm is matched with the worm wheel rim to drive the rotating box to horizontally rotate on the base, and the rotating box drives the positioning frame and the cell sample in the positioning frame to convey when rotating, so that the cell sample is conveyed to the position under the microscope device for detection, the cell sample which is not detected is protected by the protection plate, the influence of external dust and impurities on cells is reduced, the accuracy of detecting tumor cell samples is improved, and the practicability of the detection device is improved.
Description
Technical Field
The utility model relates to the field of detection devices, in particular to a circulating tumor cell detection device.
Background
Malignant tumor is transferred to other organs of the body through blood transmission, tumor metastasis is a main cause of death of a tumor patient, tumor cells invade surrounding tissues of primary tumor cells, enter blood and lymphatic system to form circulating tumor cells (the circulating tumor cells are called CTC for short, the tumor cells entering human peripheral blood are usually called circulating tumor cells), and are transferred to remote tissues and ooze out, so that the method is suitable for new microenvironment, and finally seeding, proliferation, field planting and formation of metastasis are carried out, therefore, CTC in blood is found early, the method has important guiding effects on prognosis judgment, curative effect evaluation and personalized treatment of the patient, and the detection device is used for detecting the blood of the patient to be an effective means for timely finding the tumor cells, thereby facilitating subsequent treatment according to detection results.
The prior patent: the utility model provides a lung cancer circulation tumor cell detection device of CN211921521U, through second slider and the second spout that sets up, cooperation rolling disc for the second slider can slide in the second spout, thereby makes the staff can rotate the rolling disc, thereby adjusts the position of putting the thing groove, and the medical personnel of being convenient for observe different cells in the different thing grooves of putting, has improved the convenience of staff when using.
This current patent can be convenient for detect the observation to different cell samples, improves the convenience, and owing to be provided with a plurality of cell samples, the cell sample that does not detect is placed for exposing the mode, and the environment of partial inspector or detection is difficult to obtain the guarantee, if appear dust impurity drop down in to the cell sample then influence the accuracy of testing result easily, has reduced detection device's practicality.
Disclosure of Invention
Therefore, in order to solve the above-mentioned drawbacks, the present utility model provides a circulating tumor cell detection device to solve the above-mentioned technical problems.
In order to achieve the above purpose, the present utility model adopts the following technical scheme: the circulating tumor cell detection device comprises a base, a fixing frame arranged at the rear end of the top of the base, a microscope device arranged at the top of the inner side of the fixing frame, an ocular lens arranged at the top of the fixing frame and connected with the microscope device, and a conveying mechanism arranged on the base and used for guiding a tumor cell sample, wherein the conveying mechanism comprises a rotating box movably embedded into the front end of the top of the base, a worm wheel ring fixedly sleeved outside the rotating box and a worm meshed with the worm wheel ring;
The top of the inner side of the rotating box is provided with a protective cover for sealing a tumor cell sample, and the bottom of the inner side of the rotating box is fixedly embedded with a positioning frame;
The worm is movably connected with the inner side of the base, and passes through the front end of the inner side of the base and then is connected with the handle.
Preferably, the bottom of the inner side of the rotating box is embedded with more than two positioning frames, and the positioning frames are distributed in an equidistant annular mode, wherein the positioning frame at the rearmost end is opposite to the microscope device.
Preferably, the top of the inner side of the positioning frame is outwards expanded.
Preferably, the protection cover comprises a protection plate movably embedded into the top of the inner side of the rotating box and positioned above the positioning frame, a first opening and a second opening formed in the side surface of the protection plate, and two connecting rods mounted at the rear end of the top of the protection plate, wherein the first opening is positioned under the microscope device, and one end of each connecting rod, far away from the protection plate, is connected with the base.
Preferably, the inner diameters of the first opening and the second opening are larger than the outer diameter of the positioning frame.
Preferably, an electric push rod is installed on the inner side of the base, and a piston rod of the electric push rod is upwards arranged to face the second opening.
Preferably, the bottom of the rotating box and the bottom of the positioning frame are provided with perforations, and the inner diameter of each perforation is larger than the outer diameter of a piston rod at the top of the electric push rod.
Preferably, a distance is arranged between the bottom end surface of the protection plate and the top end surface of the positioning frame, and the distance is 0.1 cm-0.5 cm.
The utility model has the beneficial effects that:
according to the utility model, the conveying mechanism is arranged on the base, the worm is driven to rotate through the handle, the worm is matched with the worm wheel rim to drive the rotating box to horizontally rotate on the base, and the rotating box drives the positioning frame and the cell sample in the positioning frame to convey when rotating, so that the cell sample is conveyed to the position under the microscope device for detection, the cell sample which is not detected is protected by the protection plate, the influence of external dust and impurities on cells is reduced, the accuracy of detecting tumor cell samples is improved, and the practicability of the detection device is improved.
Drawings
FIG. 1 is a schematic diagram of the structure of the present utility model;
FIG. 2 is a schematic elevational cross-sectional view of the conveyor mechanism of the present utility model;
FIG. 3 is a schematic view of the protective cover structure of the present utility model;
Fig. 4 is a schematic view of a connection structure of a protection plate of the present utility model.
Wherein: the microscope comprises a base-1, a fixing frame-2, a microscope device-3, an eyepiece-4, a conveying mechanism-5, a rotating box-51, a worm wheel ring-52, a worm-53, a handle-54, a positioning frame-55, an electric push rod-56, a protective cover-57, a protective plate-571, a first opening-572, a second opening-573 and a connecting rod-574.
Detailed Description
In order to further explain the technical scheme of the utility model, the following is explained in detail through specific examples.
As shown in fig. 1, the utility model provides a circulating tumor cell detection device, which comprises a base 1, a fixing frame 2 arranged at the rear end of the top of the base 1, a microscope device 3 arranged at the top of the inner side of the fixing frame 2, and an ocular lens 4 arranged at the top of the fixing frame 2 and connected with the microscope device 3, wherein the ocular lens 4 is matched with the microscope device 3 to observe and detect a tumor cell sample.
As shown in fig. 2, the embodiment further includes a conveying mechanism 5 disposed on the base 1 and used for guiding a tumor cell sample, where the conveying mechanism 5 includes a rotating box 51 with a circular structure movably embedded in the front end of the top of the base 1, the rotating box 51 can horizontally rotate along the top of the inner side of the base 1, so that the rotating box 51 rotates to drive the tumor cell sample to horizontally rotate to the bottom of the microscope device 3 for observation and detection, a worm wheel ring 52 fixedly sleeved outside the rotating box 51, and a worm 53 meshed with the worm wheel ring 52;
The top of the inner side of the rotating box 51 is provided with a protective cover 57 for sealing the tumor cell sample, the bottom of the inner side of the rotating box 51 is fixedly embedded with a positioning frame 55, and the upper end part of the positioning frame 55 is of an open structure and is used for providing positioning for a vessel for containing the tumor cell sample;
The worm 53 is rotationally connected with the inner side of the base 1, and the worm 53 horizontally passes through the front end of the inner side of the base 1 and is connected with the middle part of the rear end face of the handle 54;
wherein, more than two positioning frames 55 are embedded in the bottom of the inner side of the rotating box 51, and each positioning frame 55 is distributed in an equidistant annular shape, wherein the positioning frame 55 at the rearmost end is opposite to the microscope device 3, so that a plurality of groups of tumor cell samples can be conveniently positioned through the positioning frames 55, and the convenience of detection is improved;
in this embodiment, the top of the inner side of the positioning frame 55 is outwardly expanded, so as to facilitate the taking of a tumor cell sample in the positioning frame 55.
As shown in fig. 3 and 4, the protection cover 57 in this embodiment includes a circular protection plate 571 movably inserted into the top of the inner side of the rotation box 51 and located above the positioning frame 55, a first opening 572 and a second opening 573 which are horizontally rotated along the protection plate 571 when the rotation box 51 horizontally rotates and are opened on the side surface of the protection plate 571, and two connection rods 574 having a U-shaped structure and mounted on the rear end of the top of the protection plate 571, wherein the first opening 572 is located under the microscope device 3, and one end of the connection rod 574 far from the protection plate 571 is locked and fixed on the base 1;
Wherein, the inner diameters of the first opening 572 and the second opening 573 are larger than the outer diameter of the positioning frame 55, so that a vessel for taking tumor cell samples in the first opening 572 and the second opening 573 is convenient;
An electric push rod 56 is arranged on the inner side of the base 1, and a piston rod of the electric push rod 56 is upwards arranged to face the second opening 573, so that a tumor cell sample vessel can be conveniently upwards ejected into the second opening 573 through the electric push rod 56;
Perforations are formed at the bottoms of the rotating box 51 and the positioning frame 55, and the inner diameter of each perforation is larger than the outer diameter of a piston rod at the top of the electric push rod 56;
the bottom end surface of the protection plate 571 and the top end surface of the positioning frame 55 are provided with a distance of 0.3cm, so that friction between the protection plate 571 and the positioning frame 55 is reduced, and impurities are reduced from falling into a circulating tumor cell sample in the positioning frame 55;
the protection plate 571 is made of transparent plastic material, and the protection plate 571 can be made of common plastic material according to actual needs;
When the device is used, a vessel with a circulating tumor cell sample passes through the second opening 573 and is placed into the positioning frame 55, the rotating handle 54 drives the worm 53 to rotate, the worm 53 drives the rotating box 51 to rotate through the matching worm wheel ring 52, the rotating box 51 drives the positioning frame 55 and the circulating tumor cell sample vessel to rotate, another circulating tumor cell sample is placed into the positioning frame 55 after the next positioning frame 55 is aligned with the second opening 573, and the circulating tumor cell sample is circulated until the circulating tumor cell sample is aligned with the first opening 572, and at the moment, the circulating tumor cell sample in the positioning frame 55 can be observed and detected through the observation eyepiece 4 matched with the microscope device 3;
When the detection is finished, the handle 54 is continuously rotated to drive the next positioning frame 55 and the circulating tumor cell sample in the positioning frame 55 to rotate under the microscope device 3 for observation and detection, and when the detected circulating tumor cell sample rotates to the second opening 573, the circulating tumor cell sample vessel in the positioning frame 55 can be ejected upwards into the second opening 573 by controlling the electric push rod 56, then the circulating tumor cell sample vessel can be taken out, and a worker can also take the circulating tumor cell sample vessel in the positioning frame 55 after the hand passes through the second opening 573, so that the detection of the circulating tumor cell sample is completed.
The foregoing is merely a preferred example of the present utility model, and the present utility model is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present utility model has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model should be included in the protection scope of the present utility model.
Claims (8)
1. The circulating tumor cell detection device comprises a base, a fixing frame arranged at the rear end of the top of the base, a microscope device arranged at the top of the inner side of the fixing frame, and an ocular lens arranged at the top of the fixing frame and connected with the microscope device;
The method is characterized in that: the device comprises a base, a worm wheel ring, a worm rod and a driving mechanism, wherein the base is provided with a worm wheel ring, the worm wheel ring is fixedly sleeved outside the rotating box, and the worm wheel ring is fixedly sleeved outside the rotating box;
The top of the inner side of the rotating box is provided with a protective cover for sealing a tumor cell sample, and the bottom of the inner side of the rotating box is fixedly embedded with a positioning frame;
The worm is movably connected with the inner side of the base, and passes through the front end of the inner side of the base and then is connected with the handle.
2. The circulating tumor cell detection apparatus of claim 1, wherein: the bottom of the inner side of the rotating box is embedded with more than two positioning frames, and the positioning frames are distributed in an equidistant annular mode, wherein the positioning frame at the rearmost end is opposite to the microscope device.
3. The circulating tumor cell detection apparatus of claim 1, wherein: the top of the inner side of the positioning frame is outwards expanded.
4. The circulating tumor cell detection apparatus of claim 1, wherein: the protection cover comprises a protection plate movably embedded into the top of the inner side of the rotating box and positioned above the positioning frame, a first opening and a second opening which are formed in the side surface of the protection plate, and two connecting rods arranged at the rear end of the top of the protection plate, wherein the first opening is positioned under the microscope device, and one end of each connecting rod, far away from the protection plate, is connected with the base.
5. The device for detecting circulating tumor cells of claim 4, wherein: the inner diameters of the first opening and the second opening are both larger than the outer diameter of the positioning frame.
6. The device for detecting circulating tumor cells of claim 4, wherein: an electric push rod is arranged on the inner side of the base, and a piston rod of the electric push rod is upwards arranged to be opposite to the second opening.
7. The circulating tumor cell detection apparatus of claim 6, wherein: perforations are formed in the bottoms of the rotating box and the positioning frame, and the inner diameter of each perforation is larger than the outer diameter of a piston rod at the top of the electric push rod.
8. The device for detecting circulating tumor cells of claim 4, wherein: the bottom end face of the protection plate and the top end face of the positioning frame are provided with a distance of 0.1 cm-0.5 cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322583084.3U CN220827384U (en) | 2023-09-22 | 2023-09-22 | Circulating tumor cell detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322583084.3U CN220827384U (en) | 2023-09-22 | 2023-09-22 | Circulating tumor cell detection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220827384U true CN220827384U (en) | 2024-04-23 |
Family
ID=90722327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322583084.3U Active CN220827384U (en) | 2023-09-22 | 2023-09-22 | Circulating tumor cell detection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220827384U (en) |
-
2023
- 2023-09-22 CN CN202322583084.3U patent/CN220827384U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Mertz et al. | The learning curve for EUS-guided FNA of pancreatic cancer | |
| EP1736095A1 (en) | Speculum | |
| CN209465063U (en) | A kind of clinical examination performance test platform | |
| US6409970B1 (en) | Biopsy collection system | |
| CN220827384U (en) | Circulating tumor cell detection device | |
| CN110431088A (en) | For distributing the box, distributor and external member of bell for stethoscope | |
| CN212074866U (en) | Special urine sampling equipment of urological department | |
| CN108225838A (en) | One kind renovates closed gastric juice sampler | |
| CN206204272U (en) | A kind of novel microbial nucleic acid detecting cassette | |
| CN113252565B (en) | AI artificial intelligence-based lung cancer circulating tumor cell detection device | |
| CN214751087U (en) | Medical tumor detection equipment | |
| CN210279224U (en) | Inspection rack for medical inspection | |
| CN113876366A (en) | Tumor sampling device | |
| CN219557374U (en) | Sample sampling device for medical detection | |
| CN218445172U (en) | Mobile detection platform for aquatic seedling culture | |
| CN217536021U (en) | Kit for identifying exosome differential expression of pancreatic cancer metastasis patient | |
| CN213200654U (en) | Site investigation information collecting equipment | |
| CN219957365U (en) | Novel manual interpretation instrument | |
| CN215404191U (en) | Cell contrast device for tumor single cell detection and analysis | |
| CN211002277U (en) | Medical science inspection is with living fungus cultivation verifying attachment | |
| CN216021150U (en) | Breathe sputum sampling device for internal medicine | |
| CN213787484U (en) | Protective device for image radiology department | |
| CN215780167U (en) | Test sample processing device | |
| CN214002770U (en) | Pathological section helicobacter pylori rapid detection kit | |
| CN212710836U (en) | Urological department sample light-resistant save set |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |