CN113244366A

CN113244366A - Traditional Chinese medicine composition for treating premature ejaculation and impotence and preparation method and application thereof

Info

Publication number: CN113244366A
Application number: CN202110737678.8A
Authority: CN
Inventors: 孙大林; 金保方; 蔡滨; 邓伟民; 张新东; 金亦涵; 朱树丽
Original assignee: Southeast University
Current assignee: Southeast University
Priority date: 2021-06-30
Filing date: 2021-06-30
Publication date: 2021-08-13

Abstract

The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for treating premature ejaculation and impotence and a preparation method and application thereof, and the following scheme is proposed, wherein the traditional Chinese medicine composition comprises the following extracts of raw materials in parts by weight: 5-50 parts of pinellia ternate, 5-50 parts of caulis bambusae in taeniam, 5-50 parts of fructus aurantii, 5-60 parts of pericarpium citri reticulatae, 10-50 parts of poria cocos, 5-50 parts of rhizoma acori graminei, 5-50 parts of polygala tenuifolia, 10-120 parts of keel, 10-120 parts of oyster, 5-50 parts of hypericum perforatum, 5-50 parts of raw liquorice, 5-50 parts of ginger and 5-50 parts of red dates. The traditional Chinese medicine composition can be used for treating phlegm-damp type premature ejaculation and erectile dysfunction, has the characteristics of good curative effect, low recurrence rate, no side effect and the like, is simple, quick and efficient in preparation method, is easy to operate, and is convenient to carry and take.

Description

Traditional Chinese medicine composition for treating premature ejaculation and impotence and preparation method and application thereof

Technical Field

The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for treating premature ejaculation and impotence and a preparation method and application thereof.

Background

Premature Ejaculation (PE) and Erectile Dysfunction (ED) are two most common sexual dysfunction diseases in clinic, and are frequently accompanied by the mutual association of etiology and pathogenesis.

PE is the most common sexual dysfunction in clinic, the onset factors of the PE can include genetic tendency, poor overall health condition, obesity, prostatitis, thyroid hormone imbalance, emotional problems, stress and mental trauma, the PE can be divided into primary premature ejaculation, secondary premature ejaculation, natural variation premature ejaculation, early ejaculation and ejaculation dysfunction and the like, the medicines which are commonly used for treating the PE in clinic comprise 5-hydroxytryptamine reuptake inhibitors (SSRis), local anesthetics, psychology/behavior treatment, alpha receptor antagonists and the like, but the overall curative effect is poor, the PE is discussed earlier in traditional Chinese medicine, namely, refined 'disease', 'chicken essence', 'ejaculation' and the like, and the PE is considered to be related to the dysfunction of the five organs, the kidney is fixed, the liver is free of flow, the heart is mainly lost, the spleen is not normally taken, the lung is released and descended, the PE can be caused, but the PE is complicated in clinic, and the frequency of occurrence varies, and the most commonly effective treatment scheme is still lacking;

ED means that the penis can not achieve or maintain enough erection for more than 3 months to complete satisfactory sexual life, is closely related to the life quality, sex partner relationship and family stability of patients, and is an early warning signal of many body diseases, the clinical symptoms of ED are more, and are often divided into stagnation of liver qi, decline of fire of the gate of life, damp-heat of liver channel, qi stagnation and blood stasis and the like, the traditional Chinese medicine is described as impotence rather than others, but not hard to hold, and is called impotence rather than soon;

through clinical observation, the applicant finds that the phlegm-dampness type is the most common in the traditional Chinese medicine syndrome types of patients with premature ejaculation and erectile dysfunction, and the phlegm-dampness type is probably related to the living habits and manners of the modern society, such as overeating a fat, sweet and thick taste, over-pressure, staying up all night and the like. Therefore, the problem to be solved is to find a medicine or a treatment scheme for treating premature ejaculation and erectile dysfunction, and therefore, the invention provides a traditional Chinese medicine composition for treating premature ejaculation and impotence and a preparation method and application thereof.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides a traditional Chinese medicine composition for treating premature ejaculation and impotence and a preparation method and application thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

a traditional Chinese medicine composition for treating phlegm-damp type premature ejaculation and impotence comprises the following extracts of raw materials in parts by weight:

5-50 parts of pinellia ternate, 5-50 parts of caulis bambusae in taeniam, 5-50 parts of fructus aurantii, 5-60 parts of pericarpium citri reticulatae, 10-50 parts of poria cocos, 5-50 parts of rhizoma acori graminei, 5-50 parts of polygala tenuifolia, 10-120 parts of keel, 10-120 parts of oyster, 5-50 parts of hypericum perforatum, 5-50 parts of raw liquorice, 5-50 parts of ginger and 5-50 parts of red dates.

Further, the raw materials comprise the following components in parts by weight:

5 parts of pinellia ternate, 15-40 parts of caulis bambusae in taeniam, 15-40 parts of fructus aurantii, 15-50 parts of pericarpium citri reticulatae, 15-40 parts of poria cocos, 5-40 parts of rhizoma acori graminei, 15-40 parts of polygala tenuifolia, 30-90 parts of keel, 30-90 parts of oyster, 5-50 parts of hypericum perforatum, 15-40 parts of raw liquorice, 15-40 parts of ginger and 15-40 parts of red dates.

Further, the raw materials comprise the following components in parts by weight: 50 parts of pinellia ternate, 15-40 parts of caulis bambusae in taeniam, 15-40 parts of fructus aurantii, 15-50 parts of pericarpium citri reticulatae, 15-40 parts of poria cocos, 5-40 parts of rhizoma acori graminei, 15-40 parts of polygala tenuifolia, 30-90 parts of dragon bone, 30-90 parts of oyster, 5-50 parts of hypericum perforatum, 15-40 parts of raw liquorice, 15-40 parts of ginger and 15-40 parts of red dates.

Further, the raw materials comprise the following components in parts by weight: 15 parts of pinellia ternate, 15 parts of caulis bambusae in taeniam, 10 parts of fructus aurantii, 20 parts of pericarpium citri reticulatae, 15 parts of poria cocos, 10 parts of rhizoma acori graminei, 10 parts of polygala tenuifolia, 30 parts of keel, 30 parts of oyster, 20 parts of hypericum perforatum, 6 parts of raw liquorice, 15 parts of ginger and 15 parts of red dates.

The preparation method of the Chinese medicinal composition comprises placing the above raw materials in a container, adding an extracting agent, extracting, and concentrating the extractive solution, wherein the extracting agent comprises at least one of water, ethanol, wine, diethyl ether, chloroform and glycerol.

Further, adding water which is 5-15 times of the total weight of the raw materials, soaking for 30-60 minutes, decocting for 1-3 times, each time for 0.5-2 hours, filtering, combining filtrates, concentrating the filtrate to prepare a liquid preparation or adding an auxiliary agent to prepare a solid preparation.

Further, the preparation method of the solid preparation comprises the following steps: concentrating the filtrate under reduced pressure to obtain an extract with the relative density of 1.00-1.20, adding 45-70% ethanol solution, standing for 24 hours, taking supernatant, recovering ethanol in the supernatant, continuing to concentrate to obtain thick paste with the relative density of 1.15-1.35, adding pharmaceutic adjuvant, mixing, and preparing into a solid preparation, wherein the pharmaceutic adjuvant comprises at least one of honey, sucrose or xylitol.

Further, the preparation method of the liquid preparation comprises the following steps: concentrating the filtrate under reduced pressure, centrifuging and diluting to obtain a liquid preparation.

A compound preparation contains the traditional Chinese medicine composition.

The traditional Chinese medicine composition or the traditional Chinese medicine preparation is applied to preparing the medicine for treating the phlegm-damp type premature ejaculation and impotence.

The invention has the beneficial effects that:

the traditional Chinese medicine composition is used for treating phlegm-damp type premature ejaculation and erectile dysfunction, has the characteristics of good curative effect, low recurrence rate, no side effect and the like, is simple, quick and efficient in preparation method, is easy to operate, and is convenient to carry and take.

Detailed Description

Clinical verification shows that the traditional Chinese medicine compound medicine has the effects of eliminating phlegm and dampness, strengthening spleen and promoting qi circulation and harmonizing stomach and soothing nerves, and has the main functions: over-rapid ejaculation, non-hard or firm erection, spermatorrhea, dizziness, dry mouth, bitter taste, nausea, vomiting, palpitation, chest distress, gastric distention, acid regurgitation, loose stool, insomnia, dreaminess, white and greasy tongue coating or wiry and slippery pulse.

In the traditional Chinese medicine composition provided by the invention, the pinellia ternate has the functions of drying dampness and reducing phlegm, harmonizing the stomach and preventing vomiting, the bamboo shavings have the functions of clearing heat and reducing phlegm, relieving restlessness and preventing vomiting, and the pinellia ternate is compatible with the bamboo shavings, so that the traditional Chinese medicine composition has the functions of warming and cooling, resolving phlegm and harmonizing the stomach, preventing vomiting and soothing the nerves;

tangerine peel, pericarpium Citri Reticulatae regulates qi, removes stagnation, eliminates dampness and phlegm, Zhi Qiao, lowers qi, removes stagnation, eliminates phlegm and removes mass, Tangerine peel and Zhi Qiao are combined, so they are also a warm and cool food, and they have increased action of regulating qi and resolving phlegm.

Poria has effects in invigorating spleen, eliminating dampness, calming heart, and tranquilizing mind; cortex et radix Polygalae with tranquilizing and essence controlling effects; the grassleaf sweelflag rhizome, rhizoma acori graminei and the Chinese angelica root are used together to obtain the effect of relieving heart and dissipating phlegm, and can eliminate phlegm, tonify heart and control essence;

os Draconis has effects of tranquilizing mind and astringing to relieve depletion; oyster can subdue yang and induce tranquilization, astringe and arrest discharge, and both of them can induce tranquilization, induce astringency and arrest spontaneous emission;

hypericum perforatum has the functions of clearing away heat, promoting diuresis and tranquilizing;

the ginger and the Chinese date regulate the spleen and the stomach, and the ginger also has the toxicity of pinellia ternata;

the liquorice coordinates the effects of the other drugs in the recipe;

the whole formula has the effects of eliminating phlegm and resolving dampness, strengthening spleen and promoting qi circulation, harmonizing stomach and soothing nerves.

The weight parts of the raw materials are as follows:

The weight parts of the raw materials are as follows: 50 parts of pinellia ternate, 15-40 parts of caulis bambusae in taeniam, 15-40 parts of fructus aurantii, 15-50 parts of pericarpium citri reticulatae, 15-40 parts of poria cocos, 5-40 parts of rhizoma acori graminei, 15-40 parts of polygala tenuifolia, 30-90 parts of dragon bone, 30-90 parts of oyster, 5-50 parts of hypericum perforatum, 15-40 parts of raw liquorice, 15-40 parts of ginger and 15-40 parts of red dates.

The weight parts of the raw materials are as follows: 15 parts of pinellia ternate, 15 parts of caulis bambusae in taeniam, 10 parts of fructus aurantii, 20 parts of pericarpium citri reticulatae, 15 parts of poria cocos, 10 parts of rhizoma acori graminei, 10 parts of polygala tenuifolia, 30 parts of keel, 30 parts of oyster, 20 parts of hypericum perforatum, 6 parts of raw liquorice, 15 parts of ginger and 15 parts of red dates.

The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the steps of putting the raw materials into a container, adding an extracting agent for extraction, and concentrating an extracting solution to obtain the traditional Chinese medicine composition;

for example, water with the weight 5-15 times of the total weight of the raw materials is added, the raw materials are soaked for 30-60 minutes, decocted for 1-3 times, each time lasts for 0.5-2 hours, filtered, the filtrates are combined, and the filtrate is concentrated to prepare a liquid preparation or added with an auxiliary agent to prepare a solid preparation.

The preparation method of the solid preparation comprises the following steps: concentrating the filtrate under reduced pressure to obtain an extract with the relative density of 1.00-1.20, adding 45-70% ethanol solution, standing for 24 hours, taking supernatant, recovering ethanol in the supernatant, continuing to concentrate to obtain thick paste with the relative density of 1.15-1.35, adding pharmaceutic adjuvants, mixing and preparing into a solid preparation, wherein the pharmaceutic adjuvants comprise at least one of starch, dextrin, sucrose, lactose, microcrystalline cellulose, mannitol or hydroxypropyl methylcellulose and the like.

The preparation method of the liquid preparation comprises the following steps: concentrating the filtrate under reduced pressure, centrifuging and diluting to obtain liquid preparation, wherein the liquid preparation comprises solution, emulsion or cream.

The invention also provides a compound preparation, which contains the traditional Chinese medicine composition, namely the compound preparation is the traditional Chinese medicine composition provided by the invention or the traditional Chinese medicine composition and an excipient (used for preparing the traditional Chinese medicine composition into a solid or liquid state) or a preparation prepared by combining the traditional Chinese medicine composition with other auxiliary agents, and the preparation can be a liquid preparation or a solid preparation:

liquid preparations, for example, may be solutions, emulsions or creams;

the solid preparation may be, for example, granules, powder, tablets, pills, mixtures or capsules.

The extraction method of the traditional Chinese medicine composition can be as follows:

the extraction method comprises the following steps: extracting the above raw materials one by one, and mixing the liquid obtained by extraction to obtain filtrate;

extracting any two or more of the above raw materials, and mixing the extracted liquids to obtain filtrate;

example 1

For example, the raw materials can be weighed according to the following mixture ratio:

15 g of pinellia ternate, 15 g of caulis bambusae in taeniam, 10 g of fructus aurantii, 20 g of pericarpium citri reticulatae, 15 g of poria cocos, 10 g of rhizoma acori graminei, 10 g of polygala tenuifolia, 30 g of keel, 30 g of oyster, 20 g of hypericum perforatum, 6 g of raw liquorice, 15 g of ginger and 15 g of red dates;

for example, the raw materials can be mixed completely and placed in a container, water with the weight 5 times of the weight of the mixture, namely 1055g of water, is added into the container, the mixture is soaked for 30-60 minutes, decocted for 3 times, and each time lasts for 1.5 hours, and then filtered to obtain filtrate.

Example 2

5g of pinellia ternate, 15 g of caulis bambusae in taeniam, 15 g of fructus aurantii, 15 g of pericarpium citri reticulatae, 15 g of poria cocos, 5g of rhizoma acori graminei, 15 g of polygala tenuifolia, 30 g of keel, 30 g of oyster, 5g of hypericum perforatum, 15 g of raw liquorice, 15 g of ginger and 15 g of red dates;

for example, the above raw materials can be mixed together and placed in a container, and water with a weight 5 times of the weight of the mixture, that is, 975g of water, is added into the container, and the mixture is soaked for 60 minutes, decocted for 3 times, each time for 0.5h, and filtered to obtain a filtrate.

Example 3

50 g of pinellia ternate, 40 g of caulis bambusae in taeniam, 40 g of fructus aurantii, 50 g of pericarpium citri reticulatae, 40 g of poria cocos, 40 g of rhizoma acori graminei, 40 g of polygala tenuifolia, 90 g of keel, 90 g of oyster, 50 g of hypericum perforatum, 40 g of raw liquorice, 40 g of ginger and 40 g of red dates;

for example, the above raw materials may be mixed together and placed in a container, water in an amount 10 times the weight of the mixture, that is, 6500g of water, is added to the container, the mixture is soaked for 50 minutes, decocted for 3 times, each time for 1 hour, and filtered to obtain a filtrate.

Example 4

50 g of pinellia ternate, 50 g of caulis bambusae in taeniam, 50 g of fructus aurantii, 60 g of pericarpium citri reticulatae, 50 g of poria cocos, 50 g of rhizoma acori graminei, 50 g of polygala tenuifolia, 120 g of keel, 120 g of oyster, 50 g of hypericum perforatum, 50 g of raw liquorice, 50 g of ginger and 50 g of red dates;

for example, the above raw materials may be mixed together and placed in a container, water 10 times the weight of the mixture, i.e., 8000g of water, is added to the container, and the mixture is soaked for 40 minutes, decocted for 3 times, each time for 1 hour, and filtered to obtain a filtrate.

Example 5

Preparing the filtrate extracted from any one of the above embodiments into a solid preparation:

for example, the filtrate is decompressed and concentrated to extract with the relative density of 1.00, then 45% ethanol is added, the mixture is kept stand for 24 hours, supernatant fluid is taken, the ethanol in the supernatant fluid is recovered and then is continuously concentrated to thick paste with the relative density of 1.15, pharmaceutical excipients such as sucrose or starch are added, and the mixture is prepared into granules, powder, tablets, pills, mixture or capsules after mixing.

Example 6

For example, the filtrate is decompressed and concentrated to extract with the relative density of 1.20, then 75% ethanol is added, the mixture is kept stand for 24 hours, supernatant fluid is taken, the ethanol in the supernatant fluid is recovered and then is continuously concentrated to thick paste with the relative density of 1.35, pharmaceutical excipients such as sucrose or starch are added, and the mixture is prepared into granules, powder, tablets, pills, mixture or capsules after mixing.

Example 7

Clinical trial of the Chinese medicinal composition of the invention

1. General data: 100 patients with phlegm-damp type primary premature ejaculation are selected from 6 months in 2018 to 2020 in 6 months in the middle and large hospitals in the university affiliation of southeast east, 80 patients with phlegm-damp type erectile dysfunction (impotence) are selected, the patients are 18-45 years old, and the average age is 29.4 years old.

2. Inclusion standard of phlegm-damp type primary premature ejaculation: (1) age: 18-45 years old; (2) has fixed partner and lives regularly; (3) manual v for diagnosis and statistics of mental disorders diagnostic criteria for primary PE: the following symptoms last at least 6 months and are always or almost always (about 75%) in sexual activity: in sexual activity, the ejaculatory pattern occurs continuously or repeatedly within 2 minutes and earlier than the time expected by the sexual partner; second, premature ejaculation causes significant pain or annoyance; ③ the sexual dysfunction is not caused by some types of mental disorders and is not caused by some factors (such as drug use or drug absorption); (4) according with the phlegm-dampness constitution typing in the Chinese traditional medicine constitution Classification and determination Table established by the Chinese traditional medicine society; (5) similar drug treatment was not used 1 month before treatment; (6) no drug affecting sexual function is taken during the treatment period; (7) the patients informed and agreed to participate in the study. Exclusion criteria: (1) premature ejaculation due to problems (specific circumstances or with specific partners); (2) acute and chronic urogenital infections; (3) patients suffering from a psychiatric disorder in need of treatment or undergoing treatment; (4) those who have a history of drug abuse or drug abuse within 2 years; (5) erectile Dysfunction (ED), retrograde ejaculation, hyposexuality and the like exist; (6) other drug tests for treating PE have been performed within nearly 3 months; (7) diseases of the whole body system, such as diseases of the heart and brain system, diseases of the liver and kidney system, and the like, or other diseases related to the nature; (8) receiving operation during treatment, such as circumcision and the like; (9) those allergic to oral SSRIs drugs; (10) those who do not take the medicine as required, withdraw from the way, lose contact and lose visitors.

The inclusion criteria of phlegm-damp type erectile dysfunction are as follows: (1) age: 18-45 years old; (2) has fixed partner and lives regularly; (3) according with the diagnosis standard of ED, the international erectile function index score (IIEF-5) is less than 22 points; (4) according with the phlegm-dampness constitution typing in the Chinese traditional medicine constitution Classification and determination Table established by the Chinese traditional medicine society; (5) similar drug treatment was not used 1 month before treatment; (6) no drug affecting sexual function is taken during the treatment period; (7) the patients informed and agreed to participate in the study.

Exclusion criteria: (1) congenital malformation of reproductive organs and dysplasia; (2) severe reproductive system infections; (3) ED occurring after urogenital surgery and lower abdominal surgery; (4) severe heart, liver, kidney dysfunction; (5) those with severe hypertension, diabetes, and blood disease left uncontrolled; (6) serious psychological disorders.

3. The treatment scheme comprises the following steps: 100 patients with phlegm-damp type primary premature ejaculation and 80 patients with phlegm-damp type erectile dysfunction take the traditional Chinese medicine composition, and the daily dose is as follows: 15 g of pinellia ternate, 15 g of caulis bambusae in taeniam, 10 g of fructus aurantii, 20 g of pericarpium citri reticulatae, 15 g of poria cocos, 10 g of rhizoma acori graminei, 10 g of polygala tenuifolia, 30 g of dragon bone, 30 g of oyster, 20 g of hypericum perforatum, 6 g of raw liquorice, 15 g of ginger and 15 g of red dates, and the raw materials are decocted with water to obtain 400ml of decoction, and the decoction is taken by 200ml of decoction twice, wherein the treatment period is 4 weeks.

4. Observation indexes are as follows: the latent period of ejaculation (IELT), the diagnostic scale of Premature Ejaculation (PEDT) and adverse reaction in the vagina are respectively recorded before and after observation and treatment of patients with primary premature ejaculation; patients with erectile dysfunction were observed for IIEF-5 scoring and adverse reactions before and after treatment.

5. As a result: after 100 patients with primary premature ejaculation are collected, 7 patients with loss of visit and shedding are finally completed, 93 patients (93%) are tested, after 4 weeks of treatment, the IELT of the patients with premature ejaculation is remarkably improved from [ (1.32 +/-0.46) min ] to [ (5.68 +/-2.53) min ] (P <0.01), the PEDT score is remarkably reduced to (8.56 +/-2.68) (P <0.01) from (14.53 +/-3.64).

80 patients with erectile dysfunction were collected, 6 patients with loss of visit and loss (7.5%) and 74 patients were finally completed (92.5%).

After 4 weeks of treatment, the IIEF-5 score of the erectile dysfunction patient is remarkably improved from (10.26 +/-2.58) to (20.13 +/-3.67) (P <0.01) compared with that before treatment.

And (4) safety observation: the liver and kidney functions, and blood and urine routine tests of two groups of patients before and after treatment show no abnormality;

therefore, the traditional Chinese medicine composition is used for treating the phlegm-damp type premature ejaculation and the erectile dysfunction, has the characteristics of good curative effect, low recurrence rate, no side effect and the like, is simple, quick and efficient in preparation method, is easy to operate, and is convenient to carry and take, and the prepared mixture or granules and the like are convenient to take.

The above description is only a part of the embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can substitute or change the technical solution of the present invention and the inventive concept within the technical scope of the present invention.

Claims

1. The traditional Chinese medicine composition for treating premature ejaculation and impotence is characterized by comprising the following extracts of raw materials in parts by weight:

2. The traditional Chinese medicine composition for treating premature ejaculation and impotence as claimed in claim 1, wherein the raw materials comprise, by weight:

3. The traditional Chinese medicine composition for treating premature ejaculation and impotence as claimed in claim 2, wherein the raw materials comprise, by weight: 50 parts of pinellia ternate, 15-40 parts of caulis bambusae in taeniam, 15-40 parts of fructus aurantii, 15-50 parts of pericarpium citri reticulatae, 15-40 parts of poria cocos, 5-40 parts of rhizoma acori graminei, 15-40 parts of polygala tenuifolia, 30-90 parts of dragon bone, 30-90 parts of oyster, 5-50 parts of hypericum perforatum, 15-40 parts of raw liquorice, 15-40 parts of ginger and 15-40 parts of red dates.

4. The traditional Chinese medicine composition for treating premature ejaculation and impotence as claimed in claim 3, wherein the raw materials comprise, by weight: 15 parts of pinellia ternate, 15 parts of caulis bambusae in taeniam, 10 parts of fructus aurantii, 20 parts of pericarpium citri reticulatae, 15 parts of poria cocos, 10 parts of rhizoma acori graminei, 10 parts of polygala tenuifolia, 30 parts of keel, 30 parts of oyster, 20 parts of hypericum perforatum, 6 parts of raw liquorice, 15 parts of ginger and 15 parts of red dates.

5. The method for preparing a Chinese medicinal composition according to any one of claims 1 to 4, wherein the raw materials are placed in a container, an extracting agent is added for extraction, and the extract is concentrated to obtain the composition.

6. The preparation method of the traditional Chinese medicine composition for treating premature ejaculation and impotence as claimed in claim 5, wherein the water with the weight 5-15 times of the total weight of the raw materials is added, the raw materials are soaked for 30-60 minutes, decocted for 1-3 times with each time of 0.5-2 hours, and filtered to obtain the filtrate.

7. The method for preparing a Chinese medicinal composition for treating premature ejaculation and impotence as claimed in claim 6, wherein the filtrate is prepared into a solid preparation, and the preparation method of the solid preparation comprises: and concentrating the filtrate under reduced pressure to obtain an extract with the relative density of 1.00-1.20, adding 45-70% ethanol solution, standing, taking supernatant, recovering ethanol in the supernatant, and continuing to concentrate to obtain thick paste with the relative density of 1.15-1.35.

8. The preparation method of the traditional Chinese medicine composition for treating premature ejaculation and impotence as claimed in claim 7, wherein the pharmaceutical excipients are added into the thick paste, and the mixture is prepared into a solid preparation after mixing.

9. A compound preparation, which is characterized in that the compound preparation contains the traditional Chinese medicine composition of any one of claims 1 to 4.

10. The use of the Chinese medicinal composition of any one of claims 1 to 4 or the compound preparation of claim 9 in the preparation of a medicament for treating premature ejaculation and impotence.