CN113212867A

CN113212867A - Inhale first device of filling with acetylcysteine solution

Info

Publication number: CN113212867A
Application number: CN202110524427.1A
Authority: CN
Inventors: 杨育平
Original assignee: Shanxi Guorun Pharmaceutical Co ltd
Current assignee: Shanxi Guorun Pharmaceutical Co ltd
Priority date: 2021-05-13
Filing date: 2021-05-13
Publication date: 2021-08-06
Anticipated expiration: 2041-05-13
Also published as: CN113212867B

Abstract

The invention discloses a filling head device for absorbing acetylcysteine solution, which comprises a filling needle and a plurality of baffle pieces; the blocking piece is fixedly arranged on the outer wall of the filling needle and extends to a position close to the liquid outlet of the filling needle along the axial direction of the filling needle; the plurality of barrier pieces are sequentially arranged at intervals along the circumferential direction of the filling needle. According to the invention, the barrier piece is arranged on the outer wall of the filling needle, so that the filling needle and the inner wall of the ampoule bottle can be separated, the direct contact between the filling needle and the inner wall of the bottle opening of the ampoule bottle is avoided, and the liquid medicine at the liquid outlet of the needle head of the filling needle can be prevented from being attached to the bottle opening, therefore, the carbonization black spot at the bottle opening in the subsequent sealing process can be avoided, the rejection rate is reduced, the yield is improved, the working efficiency of the subsequent link is improved, the liquid medicine in the bottle is prevented from being polluted, the safety of acetylcysteine solution medicines is improved, and the production cost is reduced. The filling needle has a simple structure and is easy to implement, popularize and implement.

Description

Inhale first device of filling with acetylcysteine solution

Technical Field

The invention belongs to the technical field of medicine filling, and particularly relates to a filling head device for acetylcysteine solution for inhalation.

Background

Acetylcysteine (Acetylcysteine) as a mucolytic agent has been widely used in clinical treatment of various respiratory diseases as an expectorant since the last 60 th century. The molecular structural formula is as follows:

the mechanism of action is that acetylcysteine contains sulfydryl (-SH), which can break the disulfide bond (-S-S) in polypeptide chain, reduce the viscosity of sputum, thus easily eliminating respiratory tract and promoting the sputum to be cleared by stimulating the motion of airway epithelial villus. In recent years, it has been found that it has a protective effect on liver cells and can be used for treating liver cell damage caused by various reasons, wherein the treatment of acute liver failure caused by acetaminophen by acetylcysteine has been approved by the FDA in the United states. Acetylcysteine also has the effect of treating acute lung injury and pulmonary interstitial fibrosis, which can exert antioxidant effects by direct and indirect routes, protecting lung tissues from oxidative damage, and thereby alleviating clinical symptoms. Preliminary clinical trial results indicate that prolonged treatment with large doses of acetylcysteine contributes to the improvement of lung function in patients with idiopathic pulmonary fibrosis. Therefore, acetylcysteine has pharmacological activities of mucolysis and antioxidation. It has good tolerance and is a medicine with wide prospect for treating acute and chronic respiratory diseases.

In recent years, NAC has been found to have a protective effect on hepatocytes for the treatment of hepatocellular damage due to a variety of causes, with NAC being approved by the U.S. FDA for the treatment of acetaminophen-induced acute liver failure. N-acetylcysteine also has the effect of treating acute lung injury and pulmonary interstitial fibrosis, which can exert antioxidant effects via direct and indirect routes, protecting lung tissue from oxidative damage, and thereby alleviating clinical symptoms. Preliminary clinical trial results indicate that long-term, high-dose NAC treatment contributes to the improvement of lung function in patients with idiopathic pulmonary fibrosis.

The prior acetylcysteine product dosage forms comprise injection, effervescent tablets, effervescent granules, capsules, inhalation preparations and the like. Compared with other preparations, the inhalation preparation can reach respiratory tract and lung more directly and quickly, has the characteristics of quick response, good curative effect and good compliance, is particularly suitable for children, children and the old, and is widely applied. The acetylcysteine solution for inhalation is the only approved aerosol inhalation expectorant for CFDA, and the clinical effect and the safety performance are very excellent.

The preparation process of the acetylcysteine solution for inhalation comprises the following steps: dissolving the acetylcysteine raw material medicine and the auxiliary material in water for injection at a proper temperature, then performing sterile filtration and filling, and finally performing leak detection, lamp inspection and packaging to obtain the acetylcysteine solution for inhalation. Because acetylcysteine has strong reducibility, the filling material is easy to be carbonized when meeting high temperature. This is because, ampoule bottle (91) is usually adopted for filling, and during filling, the needle is easy to contact the inner wall of the bottle mouth, and the liquid medicine at the liquid outlet of the needle is easy to stick at the bottle mouth, resulting in high temperature carbonization of the liquid medicine at the bottle mouth during the sealing process. The acetylcysteine solution for inhalation produced according to the existing filling process can produce a large amount of products containing carbonized black spots, the rejection rate is up to 12%, the yield is lower than the conventional yield, the working strength and difficulty of the subsequent lamp inspection link are increased, and most importantly, the safety risk and the production cost of the medicine are increased.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides a filling head device for sucking acetylcysteine solution. The technical problem to be solved by the invention is realized by the following technical scheme:

a filling head device for inhalation of acetylcysteine solution comprises a filling needle and a plurality of barriers;

the blocking piece is fixedly arranged on the outer wall of the filling needle and extends to a position close to the liquid outlet of the filling needle along the axial direction of the filling needle;

the plurality of barrier pieces are sequentially arranged at intervals along the circumferential direction of the filling needle.

In one embodiment of the present invention, the filling needle includes: a needle cylinder and a core tube;

the core tube is fixedly arranged in the needle cylinder, and the lower end of the core tube extends to the lower part of the lower end of the needle cylinder;

the barrier piece is arranged on the outer wall of the needle cylinder.

In one embodiment of the present invention, further comprising: the first negative pressure liquid suction device and the first liquid suction pipe;

the first liquid suction pipe is arranged in the needle cylinder, one end of the first liquid suction pipe is communicated with the core pipe and is close to the lower end of the core pipe, and the other end of the first liquid suction pipe penetrates out of the upper end of the needle cylinder and is communicated with a liquid inlet of the first negative pressure liquid suction device.

In one embodiment of the invention, a filling head device for inhalation of acetylcysteine solution comprises: the device comprises a fixed frame, a lifting arm, a filling and mounting frame, a telescopic arm and a residual liquid treatment assembly;

the lifting arm is vertically arranged, a fixed end is fixedly connected with the top of the fixing frame, and a telescopic end is fixedly connected with the filling mounting frame;

the filling mounting frame is fixedly connected with the filling needle;

the telescopic arm is horizontally arranged and located below the filling mounting frame, the fixed end of the telescopic arm is connected with the side wall of the fixing frame, and the telescopic end of the telescopic arm is fixedly connected with the residual liquid treatment assembly and faces towards the filling needle.

In one embodiment of the invention, the raffinate processing assembly comprises: the first bearing box, the water absorption membrane cloth and the drying agent;

the top and one side wall of the first bearing box are of opening structures, the two opening structures are communicated, and the opening structures face the filling needle;

the water absorption membrane cloth is positioned in the first bearing box and wraps the drying agent.

In one embodiment of the invention, the raffinate processing assembly comprises: the second bearing box, the second negative pressure liquid suction device and the second liquid suction tube;

the top and one side wall of the second bearing box are provided with openings, and the bottom of the second bearing box is provided with a flow guide hole;

the two openings are communicated and face the filling needle;

one end of the second liquid suction pipe is communicated with the flow guide hole, and the other end of the second liquid suction pipe is communicated with a liquid inlet of the second negative pressure liquid suction device.

In one embodiment of the present invention, a sliding groove is formed on a side wall of the fixing frame;

the long shaft of the sliding chute extends along the vertical direction, and a plurality of concave parts are arranged on the two side walls;

the plurality of concave parts are sequentially arranged along the long axis direction of the sliding chute and connected with each other;

the fixed end of the telescopic arm is provided with an elastic clamping component;

the elastic clamping component is accommodated in the concave part.

In one embodiment of the present invention, the elastic clamping assembly includes: two elastic ball plungers;

the two elastic ball-head plungers are oppositely arranged on the side wall of the telescopic arm, and the ball heads of the elastic ball-head plungers are abutted to the recessed portion.

In one embodiment of the present invention, the recess is a circular arc-shaped recess structure.

The invention has the beneficial effects that:

according to the invention, the barrier piece is arranged on the outer wall of the filling needle, so that the filling needle and the inner wall of the ampoule bottle can be separated, the direct contact between the filling needle and the inner wall of the bottle opening of the ampoule bottle is avoided, and the liquid medicine at the liquid outlet of the needle head of the filling needle can be prevented from being attached to the bottle opening, therefore, the generation of carbonized black spots at the bottle opening in the subsequent sealing process can be avoided, the rejection rate is reduced, the yield is improved, the working efficiency of the subsequent lamp inspection link is improved, the liquid medicine in the bottle is prevented from being polluted, the safety of acetylcysteine solution medicines is improved, and the production cost is reduced. The filling needle has a simple structure and is easy to implement, popularize and implement.

The present invention will be described in further detail with reference to the accompanying drawings and examples.

Drawings

Fig. 1 is a schematic structural diagram of a filling head device for sucking acetylcysteine solution according to an embodiment of the present invention;

fig. 2 is a bottom view of a filling head device for inhalation acetylcysteine solution according to an embodiment of the present invention;

fig. 3 is a schematic diagram illustrating a use state of a filling head for absorbing acetylcysteine solution according to an embodiment of the present invention;

fig. 4 is a schematic view showing a state of use of a conventional needle of the prior art.

Fig. 5 is a schematic structural diagram of another filling head for sucking acetylcysteine solution provided by the embodiment of the invention;

fig. 6 is a schematic structural diagram of a filling head for inhalation acetylcysteine solution according to another embodiment of the present invention;

fig. 7 is a schematic structural diagram of a filling head for inhalation acetylcysteine solution according to another embodiment of the present invention;

FIG. 8 is a schematic diagram of a raffinate processing assembly according to an embodiment of the present invention;

FIG. 9 is a schematic diagram of an alternative raffinate processing assembly according to an embodiment of the present invention;

FIG. 10 is a schematic structural diagram of a fixing frame according to an embodiment of the present invention;

FIG. 11 is a schematic structural diagram of a telescopic arm according to an embodiment of the present invention;

fig. 12 is a schematic structural diagram of a resilient ball plunger according to an embodiment of the present invention;

fig. 13 is a schematic structural diagram of the fixing frame and the telescopic arm provided by the embodiment of the invention.

Description of reference numerals:

10-filling needle; 11-a syringe; 12-a core tube; 20-a barrier; 30-a first negative pressure aspirator; 31-a first pipette; 40-a fixing frame; 41-a chute; 42-a recess; 50-a lifting arm; 60-filling and mounting the rack; 70-a telescopic arm; 71-resilient ball plunger; 72-a base; 73-bulb; 74-a spring; 80-a residual liquid treatment component; 81-a first carrying case; 82-water absorption membrane cloth; 83-a second carrying case; 84-a second negative pressure aspirator; 85-a second pipette; 86-diversion holes; 90-common needle head; 91-ampoule bottle.

Detailed Description

The present invention will be described in further detail with reference to specific examples, but the embodiments of the present invention are not limited thereto.

Example one

Referring to fig. 1, 2 and 3, a filling head device for inhalation of acetylcysteine solution includes a filling needle 10 and a plurality of barriers 20. The blocking member 20 is fixedly disposed on the outer wall of the filling needle 10, and the blocking member 20 extends along the axial direction of the filling needle 10 to a position close to the liquid outlet of the filling needle 10. The plurality of barriers 20 are sequentially disposed at intervals in the circumferential direction of the filling needle 10. In this embodiment, the filling needle 10 is disposed on the filling device, and the filling device can drive the filling needle 10 to move up and down to fill the ampoule bottle 91. The production process of the acetylcysteine solution for inhalation comprises the following steps: (1) dissolving the prepared solution according to the process requirements. (2) The filling needle 10 is inserted into the ampoule 91 at a height of 4-6mm from the liquid level of the product volume. (3) After filling, the ampoule bottle 91 is sealed, sterilized, inspected by a lamp, and packaged.

In this embodiment, set up on the outer wall of filling needle 10 and separate fender piece 20, separate fender piece 20 protrusion in the outer wall of filling needle 10, separate and keep off between the inner wall that separates filling needle 10 and ampoule 91 with blocking piece 20, increased the distance between filling needle 10 and the ampoule 91 inner wall, avoid filling needle 10 and ampoule 91's bottleneck inner wall direct contact in the filling process, can avoid the liquid medicine of filling needle 10 syringe needle liquid outlet to glue in bottleneck department, therefore, can avoid producing the carbomorphism black spot in follow-up melt-sealing in-process bottleneck department, not only reduced the rejection rate, the yield is improved, the work efficiency of follow-up environment has been improved, still avoid the liquid medicine in the bottle to be polluted, the security of acetylcysteine solution medicine has been improved, and production cost is reduced. The filling needle 10 of the present invention has a simple structure and is easy to implement, popularize and implement.

In one possible embodiment, the filling device is equipped with a plurality of filling needles 10, and a plurality of ampoules 91 are filled simultaneously. The number of the barriers 20 is two or three or four.

The effectiveness of the filling head device of the invention is analyzed in detail below:

firstly, (1) dissolving the prepared liquid according to the process requirements, and dividing the liquid medicine into two parts.

(2) After passing through the sterilizing filter, the liquid medicine is filled by using a common needle 90 (as shown in fig. 4, the common needle 90 is not provided with the barrier member 20) and the filling needle 10 of the embodiment according to a conventional filling process.

(3) And (3) inserting a common needle 90 and a filling needle 10 into the ampoule bottle 91, wherein the inserting heights of the needle are that the liquid outlet is 2-3mm away from the liquid level of the product capacity, and continuously filling 3 batches.

(4) After filling, the ampoule bottle 91 is sealed, sterilized, inspected by a lamp, and packaged.

The carbonization rate and the yield of the two needles are compared and shown in table 1.

Calculating the formula: the carbonization rate is the number of products with carbonized black spots/the total filling quantity;

the yield is the number of qualified products/the total number of filling products;

TABLE 1

As can be seen from Table 1, the carbonization rate of 3 batches after the special needle head is adopted for filling is obviously reduced and is superior to that of a common needle head 90; and the yield of 3 batches of the needle is obviously improved and is superior to that of the common needle 90.

Secondly, (1) dissolving the prepared liquid according to the process requirements, and dividing the liquid medicine into two parts.

(2) After the liquid medicine passes through the sterilizing filter, the filling needle 10 of the embodiment is used for filling according to a conventional filling process.

(3) The filling needle 10 is inserted into the ampoule bottle 91, and the needle insertion height is 3mm, 4mm, 5mm, 6mm and 7mm from the liquid outlet to the liquid level of the product capacity for continuous filling of 5 batches.

The 5 batches were examined for carbonation and yield, respectively, and are shown in table 2.

batch number	Carbonization ratio (%)	Yield (%)
			01(3mm)	2.5	97.5
02(4mm)	0.7	98.8
			03(5mm)	0.6	98.8
04(6mm)	0.8	98.7
			05(7mm)	2.1	97.8

TABLE 2

As can be seen from the data in table 2, the carbonization rate of the product produced by the filling process of this embodiment (the needle insertion height is 4-6mm from the liquid outlet to the liquid level of the product volume) is significantly better than that of the filling process of the ordinary needle 90, and the yield is significantly higher than that of the filling process of the ordinary needle 90.

Example two

As shown in fig. 5, the present embodiment is based on the first embodiment, and further defines a filling needle 10, including: a cylinder 11 and a barrel 12. The core tube 12 is fixedly disposed in the cylinder 11, and a lower end of the core tube 12 extends below a lower end of the cylinder 11. The barrier 20 is provided on the outer wall of the cylinder 11. In this embodiment, filling needle 10 is bilayer structure, and outside cylinder 11 can further avoid the inner wall contact of core pipe 12 and ampoule 91, consequently, has further increased the distance between the inner wall of core pipe 12 and ampoule 91, makes bottleneck department comparatively clean, has further avoided the liquid medicine that core pipe 12 liquid outlet goes out to glue in bottleneck department, avoids follow-up melt-sealing in-process bottleneck department to produce the carbomorphism black spot.

Wherein, the liquid medicine of the filling equipment enters the ampoule bottle 91 through the core tube 12.

Further, as shown in fig. 6, a filling head device for inhalation acetylcysteine solution further includes: a first negative pressure pipette 30 and a first pipette 31. The first liquid suction tube 31 is arranged in the syringe 11, one end of the first liquid suction tube 31 is communicated with the core tube 12, one end of the first liquid suction tube 31 is close to the lower end of the core tube 12, and the other end of the first liquid suction tube 31 penetrates through the upper end of the syringe 11 and is communicated with a liquid inlet of the first negative pressure liquid suction device 30. In this embodiment, when filling needle 10 every accomplished the filling, close the inlet channel who connects core pipe 12, open first negative pressure aspirator 30 simultaneously and absorb the recovery to remaining liquid medicine in core pipe 12, the liquid medicine gets into first negative pressure aspirator 30 through first aspirator 31, therefore, can avoid remaining liquid medicine outflow core pipe 12 to flow to ampoule 91's bottleneck department, make bottleneck department comparatively clean, avoid follow-up melt to seal in-process bottleneck department to produce the carbomorphism black spot, the rejection rate has further been reduced, and simultaneously, can also carry out recovery processing to remaining liquid medicine, avoid extravagant.

In this embodiment, after the first negative pressure pipette 30 works for a certain time, the first negative pressure pipette 30 is turned off, and the filling equipment continues to work to perform the next filling and pipetting. The operation of the first negative pressure pipette 30 is controlled by the controller, the controller controls the first negative pressure pipette 30 to be opened when the controller closes the valve connected to the liquid inlet channel of the core tube 12, and the controller controls the first negative pressure pipette 30 to be closed after the first negative pressure pipette 30 operates for a certain time.

EXAMPLE III

As shown in fig. 7, the present embodiment further defines a filling head device for inhalation acetylcysteine solution based on the first embodiment, which includes: a mounting bracket 40, a lifting arm 50, a filling mount 60, a telescopic arm 70 and a residual liquid treatment assembly 80. The lifting arm 50 is vertically arranged, the fixed end of the lifting arm 50 is fixedly connected with the top of the fixing frame 40, and the telescopic end of the lifting arm 50 is fixedly connected with the filling installation frame 60. The filling mount 60 is fixedly connected to the filling needle 10. The filling mount 60 serves to mount the filling needle 10. The telescopic arm 70 is horizontally arranged, the telescopic arm 70 is positioned below the filling mounting frame 60, the fixed end of the telescopic arm 70 is connected with the side wall of the fixing frame 40, and the telescopic end of the telescopic arm 70 is fixedly connected with the residual liquid treatment assembly 80 and faces towards the filling needle 10.

In this embodiment, the lifting arm 50 can drive the filling mounting frame 60 to move up and down, and further drive the filling needle 10 to move, so as to fill the ampoule bottles 91 in multiple batches continuously. Specifically, the lift arm 50 descends to perform the filling, and after the filling is completed, the lift arm 50 ascends. The lifting arm 50 reciprocates to carry out filling. The telescopic arm 70 is horizontally disposed, and the telescopic movement of the telescopic arm 70 drives the residual liquid processing assembly 80 to approach or depart from the filling needle 10. Specifically, when filling needle 10 accomplishes a filling, lift arm 50 drives filling needle 10 and rises, filling needle 10 leaves the back from ampoule 91's bottleneck, remaining liquid processing subassembly 80 is close to filling needle 10, can hold the lower part of filling needle 10 in remaining liquid processing subassembly 80's bears the weight of the box, thereby, remaining liquid medicine gets into under the action of gravity among the filling needle 10 and is absorbed in remaining liquid processing subassembly 80, so, after accomplishing a filling, when carrying out the next filling, avoid filling needle 10 to get into filling needle 10 before ampoule 91 in remaining liquid medicine outflow, the environment of pollution ampoule 91 bottleneck or filling needle 10 below that leads to. After the telescopic arm 70 is extended for a certain time and before the next filling, the telescopic arm 70 is retracted to drive the residual liquid treatment assembly 80 to be retracted, and then the lifting arm 50 is lowered to perform the next filling operation.

In this embodiment, the remaining liquid medicine in the filling needle 10 is absorbed by the remaining liquid processing assembly 80 after filling is completed each time, so that the remaining liquid medicine can be prevented from flowing to the bottleneck of the ampoule bottle 91, waste products caused by charring black spots at the bottleneck in the subsequent sealing process can be avoided, and the yield is improved.

In one possible implementation, the lifting arm 50 and the telescoping arm 70 may be electric or hydraulic telescoping rods or cylinders.

Example four

As shown in fig. 8, based on the third embodiment, it is further defined that the raffinate processing assembly 80 comprises: a first carrying case 81, a water absorbing membrane cloth 82, and a desiccant. The top and a side wall of the first carrying case 81 are open structures, and the two open structures are through and face the filling needle 10. The water absorption membrane cloth 82 is positioned in the first bearing box 81, and the water absorption membrane cloth 82 wraps the drying agent. In this embodiment, when the telescopic arm 70 extends, the first carrying box 81 moves towards the filling needle 10, the filling needle 10 enters the carrying box from the opening structure and contacts with the water-absorbing membrane cloth 82, and the residual liquid medicine can be absorbed by the water-absorbing membrane cloth 82 and the drying agent. The residual liquid treatment assembly 80 of the present embodiment has a simple structure and a low cost. The water absorption membrane cloth 82 can prevent the filling needle 10 from directly contacting with the desiccant, and prevent the filling needle 10 from being polluted by the desiccant.

EXAMPLE five

As shown in fig. 9, based on the third embodiment, it is further defined that the raffinate processing assembly 80 comprises: a second carrying cassette 83, a second negative pressure pipette 84, and a second pipette 85. The top and a lateral wall of the second bearing box 83 are both provided with openings, and the bottom of the second bearing box 83 is provided with a diversion hole 86. The two openings are through and face the filling needle 10. One end of the second pipette 85 is communicated with the diversion hole 86, and the other end of the second pipette 85 is communicated with the liquid inlet of the second negative pressure pipette 84.

In this embodiment, when the telescopic arm 70 extends, the second bearing box 83 moves towards the filling needle 10, the filling needle 10 enters the bearing box from the opening, the lower end of the filling needle 10 is located above the diversion hole 86 and close to the diversion hole 86, the second negative-pressure liquid suction device 84 is opened to suck and recover the residual liquid medicine in the filling needle 10, and the liquid medicine enters the second negative-pressure liquid suction device through the diversion hole 86 and the second liquid suction tube 85.

In this embodiment, after the second negative pressure liquid sucker 84 works for a certain time, the second negative pressure liquid sucker 84 is closed, the telescopic arm 70 is retracted, and the lifting arm 50 continues to work for the next filling and liquid sucking.

Further, as shown in fig. 10 and 11, a sliding groove 41 is formed on a side wall of the fixing frame 40. The long axis of the slide groove 41 extends in the vertical direction, and a plurality of recesses 42 are provided on both side walls of the slide groove 41. The plurality of recessed portions 42 are provided in order along the longitudinal direction of the chute 41 and are connected to each other. The fixed end of the telescopic arm 70 is provided with an elastic clamping component. The resilient snap-fit component is received in the recess 42. In this embodiment, the elastic clamping component can slide in or out between two adjacent concave parts 42 under the action of an upward or downward external force. After the elastic engaging member slides into the recess 42, it can engage with the recess 42 to position the position of the telescopic arm 70. The embodiment can adjust the position of the telescopic arm 70 to be suitable for different use scenes, and the universality is expanded. In particular, the height of the telescopic arm 70 may be adjusted according to the height of the filling needle 10 to accommodate the remaining liquid treatment of filling needles 10 of different heights.

Further, as shown in fig. 11 and 12, the elastic snap-fit assembly includes: two resilient ball plungers 71. Two resilient ball plungers 71 are oppositely arranged on the side walls of the telescopic arm 70. The ball 73 of the resilient ball plunger 71 abuts the recess 42. In this embodiment, the elastic ball plunger 71 includes a base 72, a ball 73 and a spring 74, the base 72 is cylindrical, the spring 74 is located in the base 72, one end of the spring 74 abuts against the ball 73, the ball 73 is located at the end of the base 72, the ball 73 protrudes out of the end of the base 72 but does not detach from the base 72, and the ball 73 can extend out or retract in the base 72 under the action of the spring 74. When the telescopic arm 70 is pushed, a part of the ball head 73 retracts into the base 72 and compresses the spring 74, the telescopic arm 70 enters the adjacent concave part 42 from one concave part 42, when the external force pushing the telescopic arm 70 is removed, the spring 74 is reset, the ball head 73 extends and is clamped on the concave part 42, and the telescopic arm 70 can be fixed at a certain height position.

In a possible implementation, as shown in fig. 13, the base 72 of the elastic ball plunger 71 can be embedded in the telescopic arm 70, so that the structure is more compact and the space is saved.

Further, the recess 42 has a circular arc-shaped recess structure. The circular arc-shaped concave structure enables the ball head 73 to move more smoothly, and saves more labor when the telescopic arm 70 is pushed.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples described in this specification can be combined and combined by those skilled in the art.

The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several simple deductions or substitutions can be made without departing from the spirit of the invention, and all shall be considered as belonging to the protection scope of the invention.

Claims

1. A filling head device for inhalation acetylcysteine solution, comprising a filling needle (10) and a plurality of barriers (20);

the blocking piece (20) is fixedly arranged on the outer wall of the filling needle (10) and extends to a position close to a liquid outlet of the filling needle (10) along the axial direction of the filling needle (10);

the plurality of the blocking pieces (20) are sequentially arranged at intervals along the circumferential direction of the filling needle (10).

2. A filling head device for inhalation acetylcysteine solution as claimed in claim 1, wherein said filling needle (10) comprises: a cylinder (11) and a core tube (12);

the core tube (12) is fixedly arranged in the needle cylinder (11), and the lower end of the core tube extends to the lower part of the lower end of the needle cylinder (11);

the barrier piece (20) is arranged on the outer wall of the needle cylinder (11).

3. A filling head device for an inhalation acetylcysteine solution as claimed in claim 2, further comprising: a first negative pressure liquid suction device (30) and a first liquid suction pipe (31);

the first liquid suction pipe (31) is arranged in the needle cylinder (11), one end of the first liquid suction pipe is communicated with the core pipe (12) and is close to the lower end of the core pipe (12), and the other end of the first liquid suction pipe penetrates out of the upper end of the needle cylinder (11) and is communicated with a liquid inlet of the first negative pressure liquid suction device (30).

4. A filling head device for an inhalation acetylcysteine solution as claimed in claim 1, comprising: a fixed mount (40), a lifting arm (50), a filling mounting rack (60), a telescopic arm (70) and a residual liquid treatment assembly (80);

the lifting arm (50) is vertically arranged, a fixed end is fixedly connected with the top of the fixed frame (40), and a telescopic end is fixedly connected with the filling mounting frame (60);

the filling mounting frame (60) is fixedly connected with the filling needle (10);

the telescopic arm (70) is horizontally arranged and located below the filling mounting frame (60), a fixed end of the telescopic arm is connected with the side wall of the fixing frame (40), and a telescopic end of the telescopic arm is fixedly connected with the residual liquid treatment assembly (80) and faces towards the filling needle (10).

5. Filling head device for inhalation acetylcysteine solution according to claim 4, wherein said residual liquid treatment unit (80) comprises: a first carrying box (81), a water absorption membrane cloth (82) and a drying agent;

the top and one side wall of the first bearing box (81) are of an opening structure, the two opening structures are communicated, and the opening structures face the filling needle (10);

the water absorption membrane cloth (82) is positioned in the first bearing box (81) and wraps the desiccant.

6. Filling head device for inhalation acetylcysteine solution according to claim 4, wherein said residual liquid treatment unit (80) comprises: a second carrying box (83), a second negative pressure pipette (84) and a second pipette (85);

the top and one side wall of the second bearing box (83) are provided with openings, and the bottom of the second bearing box is provided with a flow guide hole (86);

the two openings are through and face the filling needle (10);

one end of the second liquid suction pipe (85) is communicated with the flow guide hole (86), and the other end of the second liquid suction pipe is communicated with a liquid inlet of the second negative pressure liquid suction device (84).

7. The filling head device for acetylcysteine solution for inhalation as claimed in claim 4, wherein the side wall of said fixed frame (40) is equipped with a sliding groove (41);

the long shaft of the sliding groove (41) extends along the vertical direction, and a plurality of concave parts (42) are arranged on two side walls;

the plurality of concave parts (42) are sequentially arranged along the long axis direction of the sliding chute (41) and are connected with each other;

the fixed end of the telescopic arm (70) is provided with an elastic clamping component;

the elastic clamping component is accommodated in the concave part (42).

8. The filling head device for acetylcysteine solution for inhalation according to claim 7, wherein said resilient snap-fit assembly comprises: two resilient ball plungers (71);

the two elastic ball plunger pistons (71) are oppositely arranged on the side walls of the telescopic arm (70), and a ball head (73) of the elastic ball plunger piston (71) is abutted against the recessed portion (42).

9. The filling head device for acetylcysteine inhalation according to claim 7, wherein said depression (42) is a circular arc depression.