CN113195377A - 紫外光抑制性接触镜片包装件 - Google Patents
紫外光抑制性接触镜片包装件 Download PDFInfo
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Abstract
本发明公开了一种用于接触镜片包装的包装件(10),该包装件具有阻挡紫外线和高能可见光波长的能力。该包装件在介于250nm和475nm之间的波长处具有小于20%的透射率,并且在大于480nm的光波长处具有等于或大于10%的透射率。
Description
背景技术
本发明涉及由接触镜片的消费者使用的包装件。更具体地讲,本发明的包装件有助于抑制紫外光吸收到包装件中以及由于暴露于光而引起的材料疲劳。该属性将可用于包装包含从镜片洗脱的药物的接触镜片。据认为,将紫外光暴露于镜片可导致药物的功效受到损害,这种损害不是对使用者造成危险,而是对其治疗效果。
附图说明
图1为其中放置有接触镜片的接触镜片包装件的下侧视图。根据本文包含的本发明的描述制造包装件;
图2为本发明的未填充镜片包装件的顶视图,该未填充镜片包装件未附接到密封盖或其中放置有接触镜片;
图3为双材料泡罩的另选实施方案的下侧透视图,该另选实施方案包含透光的药物惰性内层(放置成与包含在溶液中的接触镜片接触)和碗状物的外表面上的光保护层;并且
图4为图3的包装件的另选实施方案的透视图。
具体实施方式
已开发出一种光控树脂制剂,用于在镜片储存、处理和分配到最终使用点期间保护光敏接触镜片免于暴露于辐射(即,紫外光)。由该树脂制成的包装件应能提供对波长在200nm至470nm之间的范围内的自然光和人造光的防护。在该波长范围内,树脂提供对高能量剂量的紫外线辐射的有效防护。
该材料的独特属性是对限定波长区域内的光的选择性阻挡或透射。它有效地阻挡200nm至470nm区域内的光,并且允许500nm以上波长的高水平光跃迁。包装件中存在这两种属性很重要,因为这可防止镜片中包含的药物的变质,同时继续允许通过自动视觉机制或通过肉眼看到镜片。当能够在500nm以上看到时,可检查镜片的质量控制以及最终由使用者取出以放置在眼睛上。该选择性透光率与光学透明度相结合,提供了对所选范围内的紫外光的保护性屏蔽,同时允许使用光伏电池单元和相机通过包装件本身使用单色红光进行自动透镜检查。
光控树脂制剂是通过在包装件中使用聚丙烯基体和添加剂实现的,所述添加剂包括紫外线(UV)阻挡剂/反射剂、成核剂/澄清剂和着色染料。
配制工作开始于将均聚物聚丙烯与UV阻挡添加剂共混。对若干添加剂进行了评估,并选择了宽范围的UV酚醛阻挡剂/反射剂:2-(5-氯-2H-苯并三唑-2-基)-6-(1,1-二甲基乙基)-4-甲基苯酚。该添加剂具有通过聚丙烯的低迁移速率的附加有益效果。因此,不太可能从聚丙烯中浸出,从而干扰包装溶液中的药物,该包装溶液位于其中放置有接触镜片的包装件中(以将药物保持在镜片中,同时保持其湿润),或者另一方面,不太可能从聚丙烯中提取。
已确定,为了充分阻挡,所选酚类UV阻挡剂的浓度必须为约0.25重量%。当然,取决于阻挡剂,其他浓度也是可能的。在该浓度处,UV阻挡剂有效地阻挡约200nm至约350nm范围内的辐射波长。然而,将这种阻挡剂/反射剂单独与聚丙烯一起使用会导致所得塑料变得模糊。这使得使用透泡罩摄影难对包装进行质量控制。此外,高能可见光辐射(波长在约350nm至约450nm范围内)仍会穿透初级包装并影响密封产品。
使用两种单独的化学方法解决了上述两个参数。首先,我们添加了澄清剂/成核剂,以减少任何雾度并使泡罩对单色摄影透明。其次,我们添加了黄色/橙色染料。着色染料阻挡波长为约350nm至约450nm的区域的可见光。
在制剂中采用了两种不同的染料。一种制剂包含着色染料GC17 cas#519050-54-5,由DayGlo Corporation[Cleveland,OH]制造。制剂中使用的第二种染料包含ClearTint7364,一种由Milliken Co.[Spartanburg,SC]提供的专有着色剂。当然,可以设想其他染料也可以用于阻挡规定波长的光。
两种树脂制剂(即,具有DayGlo染料或具有Milliken染料)均产生外观呈黄色且透明的聚丙烯树脂,具有上述低染料浸出率以及低药物提取可能性。由此制得的包装碗状物还为密封在包装件内的接触镜片产品提供足够的保护。
如图1和图2所示,包含包装件10,该包装件包含碗状物20和覆盖件30。碗状物根据本发明的描述配制。包装件10具有覆盖件30,该覆盖件由粘附到其上的聚合物和铝箔膜制成。碗状物20具有坐置在其中的接触镜片40。将镜片40置于用于储存的溶液中,并且在储存期间将镜片40保持在湿润状态。该溶液通常为盐水,但在本发明的情况下还包含药物。
与接触镜片一起使用的可用于治疗目的的药物之一是酮替芬药物。溶液的摩尔浓度应使得药物将以治疗上有用的速率洗脱到接触镜片中。
使用常规方法配制与图1的碗状物20结合使用的本发明的光控树脂,该碗状物具有:
a)聚丙烯基体树脂,该聚丙烯基体树脂包括99%聚丙烯均聚物cas#9003-07-0与稳定剂、酸受体和熔融稳定剂
b)至少一种紫外线吸收剂/反射剂,2-(5-氯-2H-苯并三唑-2-基)-6-(1,1-二甲基乙基)-4-甲基苯酚,cas#3896-11-5
c)至少一种着色染料,该至少一种着色染料选自Milliken ClearTint 7364或DayGlo cas#519050-54-5;以及
d)至少一种成核剂/澄清剂。
配制的树脂具有下列特性和下列指定范围内的测试值:
·熔体流动速率范围-根据ASTM测试D 1238,20g/10min至40g/10min
·密度-,根据ASTM D 1505,0.90g/cm3
·熔融温度范围-根据ASTM D 3418,120℃至165℃
·在66psi处的挠曲温度-根据ASTM D 648,105℃至120℃的范围
注:ASTM测试D 1238、D 1505、D 3418、D 648为由美国材料测试协会(ASTM)定义的标准测试
添加剂的浓度针对保护接触镜片30的聚丙烯包装碗状物20的厚度进行优化。碗状物的厚度在约0.5nm至1.0mm的范围内。
本发明的特别优选的实施方案包含按重量计处于以下浓度的碗状物20的各组分:
a)基体聚丙烯树脂:≥99%CAS 9003-07-0
b)紫外线吸收剂/反射剂:<0.3%2-(5-氯-2H-苯并三唑-2-基)-6-(1,1-二甲基乙基)-4-甲基苯酚,CAS 3896-11-5
c)着色染料:<0.3%1,4-环己烷二羧酸与1,4-环己烷二甲醇、2-(3-羟丙基)-6-[(3-羟丙基)氨基]-1H-苯并[de]异喹啉-1,3-(2H)-二酮和1,3-戊二胺、2-羟基-3-苯氧基丙酯的聚合物,CAS 519050-54-5
d)成核剂/澄清剂:介于0.01%-0.3%之间的下列成核剂或澄清剂:
基于山梨醇的澄清剂,诸如:
3,4-甲基亚苄基山梨醇(CAS 135861-56-2);
1-[8-丙基-2,6-双(4-丙基苯基)-4,4a,8,8a-四氢-[1,3]二噁英并[5,4-d][1,3]二噁英-4-基]乙烷-1,2-二醇(CAS 882073-43-0);
N-[3,5-双-(2,2-二甲基-丙酰氨基)-苯基]-2,2-二甲基-丙酰胺,CAS745070-61-5;
顺式-1,2-环己烷二羧酸钙(CAS 491589-22-1);
双(2,2-亚甲基-双(4,6-二叔丁基苯基)磷酸钠)(CAS 85209-91-2);以及
羟基双[2,2'-亚甲基-双(4,6-二叔丁基苯基)磷酸铝](CAS 151841-65-5)
在另一个实施方案中,将组分(c)着色染料CAS 519050-54-5成功地用另一种染料Milliken ClearTint 7364黄MB替换,使用浓度<10%
上述树脂制剂产生表1和表2中所示的透射率特征。
表1:黄色泡罩的典型UV-可见%透射率曲线
表2:透明泡罩的典型UV-可见%透射率曲线
该透射曲线的特性和基本方面为在约450nm至500nm区域范围内的透射率曲线几乎垂直上升至高于80%透光率的水平。这意味着理想情况下,波长低于约450nm或至多470nm,然后高于约450nm的光不透射穿过包装件,光是完全可见的。相反地,在较低波长处,至少200nm和更高波长的光将被阻挡,如表2的曲线图的“左尾”中所见。
也可感知到,本发明的包装件可被制成另选的构型,诸如图3和图4中所见。在那里我们可看到实现相同效果的两部分包装件。包装件100的内部表面或镜片接触表面200由透明聚合物诸如聚丙烯形成。(当然,也可使用另选材料,诸如COP和COC聚合物,只要它们也被配置为阻挡UV光。)这种布置被制成使得光阻挡表面与透镜之间没有接触。此后,将碗状物300放置在框架外部的一点处,以便仍然充分阻挡UV光。
碗状物300和镜片接触框架200彼此(或两者)过盈配合或超声焊接,以确保它们不会因典型处理而分离。
或者,可进行另一种修改,如图4所见。有了该包装件,就不用担心光阻挡碗状物400与接触透镜之间的接触。然后,框架500可以被放置到碗状物400的外部。如图4所示,可以看到清晰的框架500。然而,通过将碗状物放置在内部,框架500的类型可在颜色上变化。例如,“常规”接触镜片可放置在具有透明框架500的包装件中,而复曲面镜片可用于蓝色包装件中,并且老花眼镜片可用于绿色包装件中。
两种包装件的比较展示了本发明的有效性。作为对照,将包含光敏镜片的具有透明泡罩的包装件(如表2所示)置于阳光下。这些包装件中的镜片在包装件中立即变暗。相比之下,具有如表1中的黄色泡罩的包装件即使暴露于阳光下一小时,光敏镜片颜色也不会变深。
可对美容镜片等进行类似的调整。在这样的实施方案中,包装碗状物和附接的凸缘以不同方式解决。碗状物由无菌和保质期所需的任何材料制成,而凸缘被视为识别工具,并且被定制为满足品牌/产品识别或防伪需求。例如,用于染料中以制造凸缘的颜色可被配置为包含在内部的镜片的补充颜色。这种布置将可用于产生使用者的感知虹膜颜色的“美容”型镜片,这对于该产品所针对的年轻人群是有用的。人们可能让每种产品都使用不同颜色的包装件。或者,利用正确的设备,可以在一种产品的同一纸盒内随机放置彩色包装。色轮中的任何颜色凸缘均是可能的,还包括闪光、珠光、大理石花纹或漩涡等。
考虑到所有适当的等同物,应结合所附权利要求书来理解上述发明。
Claims (12)
1.一种用于接触镜片的包装件,所述包装件具有阻挡紫外线和高能可见光波长的能力,所述包装件在介于250nm和475nm之间的波长处具有小于20%的透射率,并且在大于480nm的光波长处具有等于或大于10%的透射率。
2.一种用于接触镜片的包装件,所述包装件包括聚丙烯以及与所述聚丙烯共混的染料。
3.一种用于接触镜片的包装件,所述包装件包括聚丙烯以及与所述聚丙烯共混的染料和紫外线阻挡剂的混合物。
4.根据权利要求3所述的用于接触镜片的包装件,还包括共混在其中的成核剂。
5.根据权利要求2、3或4所述的包装件,其中所述染料为1,4-环己烷二羧酸与1,4-环己烷二甲醇、2-(3-羟丙基)-6-[(3-羟丙基)氨基]-1H-苯并[de]异喹啉-1,3-(2H)-二酮和1,3-戊二胺、2-羟基-3-苯氧基丙酯的聚合物。
6.根据权利要求2、3或4所述的包装件,其中所述染料为Milliken ClearTint 7364黄MB。
7.根据权利要求3所述的包装件,其中所述紫外线阻挡剂为2-(5-氯-2H-苯并三唑-2-基)-6-(1,1-二甲基乙基)-4-甲基苯酚。
8.根据权利要求4所述的包装件,其中所述成核剂为N-[3,5-双-(2,2-二甲基-丙酰氨基)-苯基]-2,2-二甲基-丙酰胺。
9.根据权利要求4所述的包装件,其中所述成核剂为1-[8-丙基-2,6-双(4-丙基苯基)-4,4a,8,8a-四氢-[1,3]二噁英并[5,4-d][1,3]二噁英-4-基]乙烷-1,2-二醇。
10.根据权利要求4所述的包装件,其中所述成核剂为双(2,2-亚甲基-双(4,6-二叔丁基苯基)磷酸钠)。
11.一种用于接触镜片的包装件,所述包装件包含:聚丙烯;1,4-环己烷二羧酸与1,4-环己烷二甲醇、2-(3-羟丙基)-6-[(3-羟丙基)氨基]-1H-苯并[de]异喹啉-1,3-(2H)-二酮和1,3-戊二胺、2-羟基-3-苯氧基丙酯的聚合物;2-(5-氯-2H-苯并三唑-2-基)-6-(1,1-二甲基乙基)-4-甲基苯酚;以及N-[3,5-双-(2,2-二甲基-丙酰氨基)-苯基]-2,2-二甲基-丙酰胺。
12.一种用于接触镜片的包装件,所述包装件包含:聚丙烯;Milliken ClearTint 7364黄MB;2-(5-氯-2H-苯并三唑-2-基)-6-(1,1-二甲基乙基)-4-甲基苯酚;以及N-[3,5-双-(2,2-二甲基-丙酰氨基)-苯基]-2,2-二甲基-丙酰胺。
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