CN113188853B - Mask type breath sampler and breath test mask - Google Patents
Mask type breath sampler and breath test mask Download PDFInfo
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- CN113188853B CN113188853B CN202110477662.8A CN202110477662A CN113188853B CN 113188853 B CN113188853 B CN 113188853B CN 202110477662 A CN202110477662 A CN 202110477662A CN 113188853 B CN113188853 B CN 113188853B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
- G01N1/2273—Atmospheric sampling
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
Abstract
The utility model provides a mask type breath sampler and breath test mask, the mask type breath sampler comprises a base, a first sampling device, a second sampling device and a third sampling device, wherein the first sampling device, the second sampling device and the third sampling device are arranged in the base; the inlet of the second sampling device is communicated with the outlet of the first sampling device, the outlet of the second sampling device is communicated with the expiration outlet, and the second sampling device is used for collecting a second expiration sample; the inlet of the third sampling device is communicated with the external environment, the outlet of the third sampling device is communicated with the expiration outlet, and the third sampling device is used for collecting gas samples of the external environment. The sampler has the advantages that synchronous sampling of different samples can be realized, the accuracy of sample analysis is improved, the sampler is simple in structure, sample enrichment in the sampling process of the breath sample can be realized, and the sample pretreatment time is saved.
Description
Technical Field
The disclosure relates to the field of metabolome sampling, in particular to a mask type breath sampler and a breath test mask.
Background
In metabonomic research, the sampling mode of the metabolic samples has certain difference due to different sources. By comparing the sampling modes of samples in different metabolome groups, the expiratory metabonomics research has the advantage of continuous sampling. The qi-blood barrier of an organism has semi-permeability, the gas-liquid exchange area, the water vapor evaporation and the pneumatic atomization of the inner surface liquid film of a lower respiratory tract (bronchioles, respiratory bronchioles, alveolar ducts and the like) in the considerable respiratory process, and the expiratory metabolome not only reflects the metabolism of related tissues mainly comprising the lung, but also can reflect secondary metabolism and systemic metabolism by presenting metabolites in blood.
Currently, the gas collecting bag is the most commonly used off-line expiratory sampling medium, but is limited by the limited volume of the gas collecting bag and the low concentration of the expiratory metabolites, the traditional sampling mode is inconvenient for the subsequent detection of the expiratory metabolites, the time consumption of the sample pretreatment is long, and the actual detection sensitivity is low. Ambient air itself can directly interfere with breath samples and inhalation exposure can also indirectly affect breath metabolism, thus traditional sampling methods can affect the sensitivity and accuracy of breath sample analysis. In addition, techniques for simultaneous sampling of breath samples and ambient air samples are lacking.
Disclosure of Invention
Technical problem to be solved
The present disclosure provides a mask-type breath sampler and breath test mask to at least solve the problems existing in the above prior art.
(II) technical scheme
To achieve the above object, the present disclosure provides a mask-type breath sampler comprising:
a base including an exhalation inlet and an exhalation outlet;
the first sampling device is arranged in the base, the inlet of the first sampling device is communicated with the breath inlet, the breath enters the first sampling device from the inlet of the first sampling device, the breath is output from the outlet of the first sampling device, and the first sampling device is suitable for collecting a first breath sample;
the second sampling device is arranged in the base, the inlet of the second sampling device is communicated with the outlet of the first sampling device, the expired air output by the outlet of the first sampling device enters the second sampling device from the inlet of the second sampling device, the expired air is output by the outlet of the second sampling device, the outlet of the second sampling device is communicated with the expired air outlet, and the second sampling device is suitable for collecting a second expired air sample;
the third sampling device, set up in the base, the entry of third sampling device communicates with each other with external environment, external environment's gas by third sampling device's entry gets into in the third sampling device, external environment's gas by third sampling device's export output, third sampling device's export with exhale the export and communicate with each other, the third sampling device is applicable to the collection external environment's gas sample.
In some embodiments of the present disclosure, the first sampling device comprises:
the first sampling cavity is a channel with three open ends, and a first opening of the first sampling cavity is communicated with the expiration inlet;
a first headspace adsorption extract phase, located within said first sampling chamber, adapted to extract said first breath sample;
first sampling valve, swivelling joint in on the third opening of first sampling chamber, the one end of first sampling valve is sealed, the through-hole has been seted up to the other end of first sampling valve, the side of first sampling valve seted up with first sampling valve the valve that the through-hole link up mutually, through adjusting opening and closing control of the valve of first sampling valve the opening and closing of the second opening of first sampling chamber.
In some embodiments of the present disclosure, the second sampling device comprises:
the second sampling cavity is a channel with three open ends, a first opening of the second sampling cavity is communicated with a second opening of the first sampling cavity, and a second opening of the second sampling cavity is communicated with the expiration outlet;
a second headspace adsorption extract phase, located within said second sampling chamber, adapted to extract said second breath sample;
the second sampling valve is connected to the third opening of the second sampling cavity in a rotating mode, one end of the second sampling valve is sealed, the other end of the second sampling valve is provided with a through hole, the side face of the second sampling valve is provided with a valve which is communicated with the through hole of the first sampling valve, and the opening and closing of the valve of the second sampling valve are controlled to open and close the second opening of the second sampling cavity.
In some embodiments of the present disclosure, the third sampling device comprises:
the third sampling cavity is a channel with three openings, the first opening of the third sampling cavity is communicated with the external environment, and the second opening of the third sampling cavity is communicated with the expiration outlet;
the second headspace adsorption extraction phase is positioned in the third sampling cavity and is suitable for extracting the gas sample in the external environment;
the third sampling valve is rotatably connected to the third end opening of the third sampling cavity, one end of the third sampling valve is sealed, the other end of the third sampling valve is provided with a through hole, the side face of the third sampling valve is provided with an air valve which is communicated with the through hole of the third sampling valve, and the opening and closing of the air valve of the third sampling valve are controlled to open and close the second end opening of the third sampling cavity.
In some embodiments of the present disclosure, the first sampling device further comprises:
the first fence is arranged on the first opening of the first sampling cavity;
one end of the first cylindrical groove is fixedly connected with the through hole of the first sampling valve, and the first cylindrical groove is suitable for placing the first headspace adsorption extraction phase.
In some embodiments of the present disclosure, the second sampling device further comprises:
the second fence is arranged on the first opening of the second sampling cavity;
and one end of the second cylindrical groove is fixedly connected with the through hole of the second sampling valve, and the second cylindrical groove is suitable for placing the second headspace adsorption extraction phase.
In some embodiments of the present disclosure, the third sampling device further comprises:
and one end of the third columnar groove is fixedly connected with the through hole of the third sampling valve, and the third columnar groove is suitable for placing the third headspace adsorption extraction phase.
In some embodiments of the present disclosure, the mask-type breath sampler further comprises a protective cover, the protective cover comprising:
a shutter configured to be detachably connected to the exhalation inlet of the base;
a plug secured to the shutter, the plug configured to be inserted into the exhalation outlet of the base, the plug adapted to prevent foreign objects from entering the mask-type breath sampler during non-sampling periods.
In some embodiments of the present disclosure, the second opening of the third sampling chamber is a thin cylinder configured to drive the ambient air into the third sampling device based on the bernoulli effect.
The present disclosure also provides a breath test mask, including:
the mask-type breath sampler;
the mask is provided with a micro air valve which is fixedly connected to the expiration inlet of the mask type breath sampler.
(III) advantageous effects
According to the technical scheme, the mask type breath sampler disclosed by the invention has at least one or part of the following beneficial effects:
(1) the face guard type respiratory sampler in this disclosure can realize the synchronous sampling to exhale sample and ambient air sample, has improved the accuracy of analysis exhale sample, and this face guard type respiratory sampler simple structure combines the headspace adsorption extraction mode, can realize the sample enrichment in exhale sample sampling process, saves sample pretreatment time.
(2) The sampling chambers of the mask type breath sampler in the disclosure are connected in series, and can hold large-volume and diversified headspace adsorption extraction phases, so that the sensitivity of detection of breath metabolites is improved, the total volume of the large headspace adsorption extraction phases is convenient for selectively putting different types and polarities of headspace adsorption extraction phases, and the diversified detection of metabolic samples is facilitated.
(3) The design of each sampling cavity in the mask type breath sampler in the disclosure can reduce the sample desorption loss rate of the headspace adsorption extraction phase, and is convenient to carry and transport. The sampling process takes the bioenergy of the tested expiratory object as a power source, and can complete the active sampling of the expiratory sample and the ambient air sample only by relying on the natural respiration process, so the use is convenient.
Drawings
FIG. 1 is a schematic exterior view of a mask-type breath sampler in accordance with an embodiment of the disclosure;
FIG. 2 is a top exploded view of a mask-type breath sampler in an embodiment of the present disclosure;
FIG. 3 is an exploded bottom view of a mask-type breath sampler in accordance with an embodiment of the disclosure;
FIG. 4 is a cross-sectional view of a mask-type breath sampler in an embodiment of the disclosure;
FIG. 5 is a short side cut-away cross-sectional view of a mask-type breath sampler in accordance with an embodiment of the disclosure;
FIG. 6 is a longitudinal cross-sectional view of a mask-type breath sampler in accordance with an embodiment of the disclosure.
[ description of main reference numerals in the drawings ] of the embodiments of the present disclosure
1-a base;
11-an expiratory inlet;
12-an expiratory outlet;
2-a first sampling device;
21-a first sampling chamber;
22-a first headspace adsorption extract phase;
23-a first sampling valve;
231 — the gate of the first sample valve;
232-through hole of first sampling valve;
24-a first cylindrical groove;
25-a first fence;
26 — a first opening of a first sampling cavity;
27-a second opening of the first sampling chamber;
28-third opening of the first sampling chamber;
3-a second sampling device;
31-a second sampling chamber;
32-a second headspace adsorption extract phase;
33-a second sampling valve;
331-valve of the second sampling valve;
332-the through hole of the second sampling valve;
34-a second cylindrical groove;
35-a second fence;
36-a first opening of a second sampling chamber;
37-a second opening of a second sampling chamber;
38-the third opening of the second sampling chamber;
4-a third sampling device;
41-a third sampling chamber;
42-a third headspace adsorption extract phase;
43-a third sampling valve;
431-valve of the third sampling valve;
432-the through bore of the third sampling valve;
44-a third cylindrical groove;
45-a first opening of a third sampling chamber;
46-a second opening of the third sampling chamber;
47-a third opening of a third sampling cavity;
5-a protective cover;
51-a shutter;
52-a plug;
53-fixed teeth.
Detailed Description
The utility model provides a mask type breath sampler, which comprises a base, a first sampling device, a second sampling device and a third sampling device, wherein the first sampling device, the second sampling device and the third sampling device are respectively arranged in the base; the inlet of the second sampling device is communicated with the outlet of the first sampling device, the outlet of the second sampling device is communicated with the expiration outlet, and the second sampling device is suitable for collecting a second expiration sample; the inlet of the third sampling device is communicated with the external environment, the outlet of the third sampling device is communicated with the expiration outlet, and the third sampling device is suitable for collecting gas samples of the external environment. The mask type breath sampler can realize synchronous sampling of the breath sample and the ambient air sample, improves the accuracy of analyzing the breath sample, has a simple structure, combines a headspace adsorption extraction mode, can realize sample enrichment in the breath sample sampling process, and saves sample pretreatment time.
Before describing a solution to the problem, it is helpful to define some specific vocabulary.
The research object of metabonomics in the present disclosure is endogenous metabolites, and by analyzing the change rules of these metabolites in body fluids and tissues, the influence of internal and external factors such as gene expression, protein regulation, environmental stress, etc. on the state of the organism can be analyzed from the whole organism level, and the change of any physiological, pathological or other factors in the organism can affect the concentration of metabolites or change the metabolic flux. Therefore, metabolomics is often used to more truly reflect the physical condition of the body.
The "expiratory metabolomics" described in the present disclosure, in terms of the sample source of metabolites, such as: metabolomics of blood, urine, and respiratory metabolome, in which metabolites in exhaled breath of a living body are studied, is called respiratory metabolomics.
The bernoulli effect, also called boundary layer surface effect, is applicable to all ideal fluids including liquid and gas, and is one of the basic phenomena when the fluid flows stably, reflecting the relationship between the pressure and the flow speed of the fluid. The relationship between the flow rate and the pressure is: the greater the flow rate of the fluid, the lower the pressure; the smaller the flow rate of the fluid, the greater the pressure.
Hereinafter, embodiments of the present disclosure will be described with reference to the accompanying drawings. It should be understood that the description is illustrative only and is not intended to limit the scope of the present disclosure. In the following detailed description, for purposes of explanation, numerous specific details are set forth in order to provide a thorough understanding of the embodiments of the disclosure. It may be evident, however, that one or more embodiments may be practiced without these specific details. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present disclosure.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. The terms "comprises," "comprising," and the like, as used herein, specify the presence of stated features, steps, operations, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, or components.
All terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, unless otherwise defined. It is noted that the terms used herein should be interpreted as having a meaning that is consistent with the context of this specification and should not be interpreted in an idealized or overly formal sense.
Where a convention analogous to "at least one of A, B and C, etc." is used, in general such a construction is intended in the sense one having skill in the art would understand the convention (e.g., "a system having at least one of A, B and C" would include but not be limited to systems that have a alone, B alone, C alone, a and B together, a and C together, B and C together, and/or A, B, C together, etc.). Where a convention analogous to "A, B or at least one of C, etc." is used, in general such a construction is intended in the sense one having skill in the art would understand the convention (e.g., "a system having at least one of A, B or C" would include but not be limited to systems that have a alone, B alone, C alone, a and B together, a and C together, B and C together, and/or A, B, C together, etc.).
The present disclosure provides a mask-type breath sampler, as shown in conjunction with fig. 1 to 6, including: a base 1, a first sampling device 2, a second sampling device 3 and a third sampling device 4. The base 1 comprises an exhalation inlet 11 and an exhalation outlet 12.
The first sampling device 2 is arranged in the base 1, the inlet of the first sampling device 2 is communicated with the expiration inlet 11 of the base 1, and the first sampling device 2 is suitable for collecting a first expiration sample; the second sampling device 3 is arranged in the base 1, the inlet of the second sampling device 3 is communicated with the outlet of the first sampling device 2, the outlet of the second sampling device 3 is communicated with the expiration outlet 12, and the second sampling device 3 is suitable for collecting a second expiration sample. The expired air enters the first sampling device 2 from the inlet of the first sampling device 2 and is output to the inlet of the second sampling device 3 from the outlet of the first sampling device 2; the breath enters the second sampling device 3 from the inlet of the second sampling device 3, and is output to the breath outlet 12 of the base 1 from the outlet of the second sampling device 3 and is output to the external environment.
The third sampling device 4 is arranged in the base 1, an inlet of the third sampling device 4 is communicated with the external environment, an outlet of the third sampling device 4 is communicated with the exhalation outlet 12, and the third sampling device 4 is suitable for collecting gas samples of the external environment. The external environment gas enters the third sampling device 4 from the inlet of the third sampling device 4, and the external environment gas is output to the exhalation outlet 12 of the base 1 from the outlet of the third sampling device 4 and is output to the external environment.
Specifically, as shown in fig. 4, the first sampling device 2 includes a first sampling chamber 21, a first headspace adsorption extract phase 22, and a first sampling valve 23. The first sampling chamber 21 is a three-port open channel, and the first opening 26 of the first sampling chamber communicates with the exhalation inlet port 11. A first headspace adsorption extract 22 is located in the first sampling chamber 21 to extract a first breath sample. The first sampling valve 23 is rotatably connected to the third opening 28 of the first sampling cavity, one end of the first sampling valve 23 is sealed, the other end of the first sampling valve 23 is provided with a through hole, the side surface of the first sampling valve 23 is provided with a valve communicated with the through hole 232 of the first sampling valve, and the opening and closing of the second opening 27 of the first sampling cavity are controlled by rotatably adjusting the opening and closing of the valve 231 of the first sampling valve.
The second sampling means 3 comprises a second sampling chamber 31, a second headspace adsorption extract phase 32 and a second sampling valve 33. The second sampling chamber 31 is a three-port open channel, the first opening 36 of the second sampling chamber communicates with the second opening 27 of the first sampling chamber, and the second opening 37 of the second sampling chamber communicates with the exhalation outlet 12. The second headspace extraction phase is located within the second sampling chamber 31 to extract a second breath sample. The second sampling valve 33 is rotatably connected to the third opening 38 of the second sampling cavity, one end of the second sampling valve 33 is closed, the other end of the second sampling valve 33 is provided with a through hole, the side surface of the second sampling valve 33 is provided with a valve communicated with the through hole of the second sampling valve 33, and the opening and closing of the second opening 37 of the second sampling cavity are controlled by rotatably adjusting the opening and closing of the valve of the second sampling valve 33.
The type of the first headspace adsorption extract 22 and the second headspace adsorption extract 32 are selected for sampling purposes, and may be the same type or different types. The arrangement of the first sampling cavity 21 and the second sampling cavity 31 enlarges the sampling area and the sampling types, and enlarges the sampling range.
The third sampling device 4 includes a third sampling chamber 41, a second headspace adsorption extract phase 32, and a third sampling valve 43. The third sampling cavity 41 is a three-opening channel, a first opening 45 of the third sampling cavity is communicated with the external environment, and a second opening 46 of the third sampling cavity is communicated with the expiration outlet 12; the second headspace adsorption extract phase 32 is located in the third sampling chamber 41 and is suitable for extracting a gas sample in the external environment; the third sampling valve 43 is rotatably connected to the third opening 47 of the third sampling cavity, one end of the third sampling valve 43 is closed, the other end of the third sampling valve 43 is provided with a through hole, the side surface of the third sampling valve 43 is provided with a valve communicated with the through hole of the third sampling valve, and the opening and closing of the second opening 46 of the third sampling cavity are controlled by rotatably adjusting the opening and closing of the valve 431 of the third sampling valve.
In the sampling process, the first sampling cavity 21, the second sampling cavity 31 and the third sampling cavity 41 of the mask type breath sampler are communicated with the external environment by adjusting the first sampling valve 23, the second sampling valve 33 and the third sampling valve 43 of the mask type breath sampler, and the first sampling cavity 21 and the second sampling cavity 31 are also communicated with each other, so that an open sampling environment is provided.
The specific steps for realizing the open sampling environment of the mask type breath sampler are as follows:
operation S1: the first sampling valve 23 is rotationally adjusted to make the air gate 231 of the first sampling valve coincide with the second opening 27 of the first sampling cavity, so as to realize the communication between the first sampling device 2 and the second sampling device 3.
Operation S2: the second sampling valve 33 is rotationally adjusted, so that the air gate 331 of the second sampling valve coincides with the second opening 37 of the second sampling cavity, and the second sampling device 3 is communicated with the external environment.
Operation S3: the third sampling valve 43 is rotationally adjusted to make the valve 431 of the third sampling valve coincide with the first opening 45 of the third sampling cavity, so that the third sampling device 4 is communicated with the external environment.
The execution sequence of the operations S1-S3 is not limited in any way, and the steps can be arranged arbitrarily to provide an open sampling environment for the mask-type breath sampler.
In some real-time examples of the present disclosure, the first sampling device 2 further includes a first fence 25 and a first columnar groove 24. A first barrier 25 is provided on the first opening 26 of the first sampling chamber; one end of the first cylindrical groove 24 is fixedly connected with the through hole 232 of the first sampling valve, and the first cylindrical groove 24 is suitable for placing the first headspace adsorption extraction phase 22.
The second sampling means 3 further comprises a second fence 35 and a second cylindrical groove 34. The second barrier 35 is arranged on the first opening 36 of the second sampling chamber; one end of the second cylindrical groove 34 is fixedly connected with the through hole 332 of the second sampling valve, and the second cylindrical groove 34 is suitable for placing the second headspace adsorption extract phase 32.
The third sampling device 4 further comprises a third cylindrical groove 44, one end of the third cylindrical groove 44 is fixedly connected with the through hole 432 of the third sampling valve, and the third cylindrical groove 44 is suitable for placing the third headspace adsorption extract phase 42.
In some embodiments of the present disclosure, the mask-type breath sampler further comprises a protective cover 5, wherein the protective cover 5 comprises a shutter 51 and a plug 52. The shutter 51 is detachably attached to the exhalation inlet 11 of the base 1, for example: the fixed teeth 53 are arranged on the exhalation inlet 11, the shutter 51 is provided with engaging tooth grooves (not shown) matched with the fixed teeth 53, and the shutter 51 is assembled and disassembled on the exhalation inlet 11 of the base 1 by inserting and pulling the fixed teeth 53 and the engaging tooth grooves. Furthermore, a plug 52 is provided on the shutter 51, said plug 52 being configured to be inserted into the exhalation outlet 12 of said base 1, said plug 52 being adapted to prevent foreign matter from entering the mask-type breath sampler during non-sampling periods.
After the sampling is completed, namely during the non-sampling period, the protective cover 5 can be installed on the expiration inlet 11 of the base 1, the first sampling valve 23, the second sampling valve 33 and the third sampling valve 43 are respectively closed, so that each sampling device is mutually independent and closed, the loss rate of each headspace adsorption extraction phase is reduced at normal temperature after the sampling can be realized in a short time, and the mask type respiration sampler is convenient to carry and operate.
The specific steps for realizing the closed sampling environment of the mask type breath sampler are as follows:
operation S4: the protecting cover 5 is mounted on the expiration inlet 11 of the base 1, so that the expiration inlet 11 is closed, and simultaneously the plug 52 on the protecting cover 5 is embedded into the expiration outlet 12, the second opening 37 of the second sampling cavity and the third opening 47 of the third sampling cavity are both closed, so as to prevent foreign matters from entering the mask type breath sampler during non-sampling period.
Operation S5: the first sampling valve 23 is rotationally adjusted such that the damper 231 of the first sampling valve is interleaved with the second opening 27 of the first sampling chamber such that the space between the second opening 27 of the first sampling chamber and the first opening 36 of the second sampling chamber is closed.
Operation S6: the second sampling valve 33 is rotationally adjusted so that the damper 331 of the second sampling valve is interleaved with the second opening 37 of the second sampling chamber, and the second opening 37 of the second sampling chamber is closed from the exhalation outlet 12.
Operation S7: the third sampling valve 43 is rotationally adjusted such that the damper 431 of the third sampling valve intersects the first opening 45 of the third sampling chamber and the first opening 45 of the third sampling chamber is closed.
The execution sequence of the operations S4-S7 is not limited in any way, and the steps can be arranged arbitrarily to achieve the purpose of providing a sealed sampling environment for the mask-type breath sampler.
In some embodiments of the present disclosure, the second opening 46 of the third sampling chamber may be configured as a thin cylinder, and the second opening 46 of the third sampling chamber is configured to drive ambient air into the third sampling device 4 based on the bernoulli effect.
The second opening 46 of the third sampling chamber extends through the exhalation outlet 12 and the second opening 37 of the second sampling chamber, and ambient air can be driven into the third sampling chamber 41 based on the bernoulli effect when the exhalation passes through the first sampling chamber 21 and the second sampling chamber 31 and rapidly flows out of the exhalation outlet 12 with a smaller cross section.
The second opening 46 of the third sampling cavity is designed into a thin-tube-shaped scheme, and the design of each cavity and the gas circuit of the mask type breath sampler is combined, so that the mask type breath sampler can finish active sampling of an expired air sample and an ambient air sample only by means of a natural breathing process, and the mask type breath sampler is more convenient to apply only by means of the biological energy of a tested expired air object.
The present disclosure also provides a breath test mask, including: the mask type breath sampler and the mask are fixedly connected to the exhalation inlet 11 of the mask type breath sampler.
The face guard type respiratory sampler in this disclosure can realize the synchronous sampling to exhale sample and ambient air sample, has improved the accuracy of analysis exhale sample, and this face guard type respiratory sampler simple structure combines the headspace adsorption extraction mode, can realize the sample enrichment in exhale sample sampling process, saves sample pretreatment time. In addition, the sampling cavities of the mask type breath sampler are mutually connected in series, so that the headspace adsorption extraction phases with large volume and diversity can be accommodated, the sensitivity of breath metabolite detection is improved, the total volume of the headspace adsorption extraction phases is large, the headspace adsorption extraction phases with different types and polarities can be conveniently and selectively placed, and the diversified detection of metabolic samples can be favorably realized.
It should also be noted that the directional terms mentioned in the embodiments, such as "upper", "lower", "front", "back", "left", "right", etc., are only directions referring to the drawings, and are not intended to limit the protection scope of the present disclosure. Throughout the drawings, like elements are represented by like or similar reference numerals. In the event of possible confusion for understanding of the present disclosure, conventional structures or configurations will be omitted, and the shapes and sizes of the components in the drawings do not reflect actual sizes and proportions, but merely illustrate the contents of the embodiments of the present disclosure.
Unless otherwise indicated, the numerical parameters set forth in the specification and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by the present disclosure. In particular, all numbers expressing quantities of ingredients, reaction conditions, and so forth used in the specification and claims are to be understood as being modified in all instances by the term "about". Generally, the expression is meant to encompass variations of ± 10% in some embodiments, 5% in some embodiments, 1% in some embodiments, 0.5% in some embodiments by the specified amount.
The use of ordinal numbers such as "first," "second," "third," etc., in the specification and claims to modify a corresponding element does not by itself connote any ordinal number of the element or any ordering of one element from another or the order of manufacture, and the use of the ordinal numbers is only used to distinguish one element having a certain name from another element having a same name.
In addition, unless steps are specifically described or must occur in sequence, the order of the steps is not limited to that listed above and may be changed or rearranged as desired by the desired design. The embodiments described above may be mixed and matched with each other or with other embodiments based on design and reliability considerations, i.e., technical features in different embodiments may be freely combined to form further embodiments.
The above-mentioned embodiments are intended to illustrate the objects, aspects and advantages of the present disclosure in further detail, and it should be understood that the above-mentioned embodiments are only illustrative of the present disclosure and are not intended to limit the present disclosure, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present disclosure should be included in the scope of the present disclosure.
Claims (7)
1. A mask-type breath sampler comprising:
a base including an exhalation inlet and an exhalation outlet;
a first sampling device comprising:
a first sampling chamber;
a first headspace adsorption extract phase, located within the first sampling cavity, adapted to extract a first breath sample;
the first sampling device is arranged in the base, the inlet of the first sampling device is communicated with the breath inlet, the breath enters the first sampling device from the inlet of the first sampling device, the breath is output from the outlet of the first sampling device, and the first sampling device is suitable for collecting a first breath sample;
a second sampling device comprising:
a second sampling chamber;
a second headspace adsorption extract phase, located within said second sampling cavity, adapted to extract a second breath sample;
wherein the breath sampling device is arranged in the base, the inlet of the second sampling device is communicated with the outlet of the first sampling device, the breath output by the outlet of the first sampling device enters the second sampling device from the inlet of the second sampling device, the breath is output by the outlet of the second sampling device, the outlet of the second sampling device is communicated with the breath outlet, and the second sampling device is suitable for collecting a second breath sample;
a third sampling device comprising:
the third sampling cavity is a channel with three openings, a first opening of the third sampling cavity is communicated with the external environment, and a second opening of the third sampling cavity is communicated with the expiration outlet;
a third headspace adsorption extract phase, located within said third sampling cavity, adapted to extract said ambient gas sample;
the third sampling valve is rotatably connected to a third end opening of the third sampling cavity, one end of the third sampling valve is closed, the other end of the third sampling valve is provided with a through hole, the side surface of the third sampling valve is provided with an air valve communicated with the through hole of the third sampling valve, and the opening and closing of a second end opening of the third sampling cavity are controlled by adjusting the opening and closing of the air valve of the third sampling valve;
one end of the third columnar groove is fixedly connected with the through hole of the third sampling valve, and the third columnar groove is suitable for placing the third headspace adsorption extraction phase;
wherein, set up in the base, third sampling device's entry communicates with each other with the external environment, the gaseous by of external environment third sampling device's entry gets into in the third sampling device, the gaseous by of external environment the export output of third sampling device, the export of third sampling device with exhale the export and communicate with each other, third sampling device is applicable to the collection the gaseous sample of external environment, the second opening of third sampling chamber is thin tube-shape, the second opening of third sampling chamber is constructed and is based on bernoulli effect drive ambient air and gets into third sampling device.
2. The mask-type breath sampler of claim 1 wherein the first sampling chamber is a three-port open channel, the first sampling chamber first port communicating with the expiratory inlet, the first sampling device further comprising:
first sampling valve, swivelling joint in on the third opening of first sampling chamber, the one end of first sampling valve is sealed, the through-hole has been seted up to the other end of first sampling valve, the side of first sampling valve seted up with first sampling valve the valve that the through-hole link up mutually, through adjusting opening and closing control of the valve of first sampling valve the opening and closing of the second opening of first sampling chamber.
3. The mask-type breath sampler of claim 2 wherein the second sampling chamber is a three-port open channel, the first opening of the second sampling chamber communicating with the second opening of the first sampling chamber, the second opening of the second sampling chamber communicating with the exhalation outlet, the second sampling device further comprising:
the second sampling valve is rotatably connected to the third opening of the second sampling cavity, one end of the second sampling valve is sealed, the other end of the second sampling valve is provided with a through hole, the side face of the second sampling valve is provided with an air valve which is communicated with the through hole of the first sampling valve, and the opening and closing of the air valve of the second sampling valve are controlled to open and close the second opening of the second sampling cavity.
4. A mask-type breath sampler according to claim 2, wherein said first sampling means further comprises:
the first fence is arranged on the first opening of the first sampling cavity;
one end of the first cylindrical groove is fixedly connected with the through hole of the first sampling valve, and the first cylindrical groove is suitable for placing the first headspace adsorption extraction phase.
5. A mask-type breath sampler according to claim 3 wherein said second sampling means further comprises:
the second fence is arranged on the first opening of the second sampling cavity;
and one end of the second cylindrical groove is fixedly connected with the through hole of the second sampling valve, and the second cylindrical groove is suitable for placing the second headspace adsorption extraction phase.
6. The mask-type breath sampler of claim 1, further comprising a protective cover, the protective cover comprising:
a shutter configured to be detachably connected to the exhalation inlet of the base;
a plug secured to the shutter, the plug configured to be inserted into the exhalation outlet of the base, the plug adapted to prevent foreign objects from entering the mask-type breath sampler during non-sampling periods.
7. A breath test mask comprising:
the mask-type breath sampler of any one of claims 1-6;
the mask is provided with a micro air valve which is fixedly connected to the expiration inlet of the mask type breath sampler.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105122057A (en) * | 2013-03-18 | 2015-12-02 | 西莫内·克里斯托尼 | Apparatus and method for sampling and analyzing breath |
| CN205426592U (en) * | 2015-11-30 | 2016-08-03 | 华中农业大学 | Goat breathes gaseous collection system |
| CN108245757A (en) * | 2017-12-20 | 2018-07-06 | 浙江大学 | Breathed air acquisition device based on breathing circuit |
| CN109938736A (en) * | 2019-04-03 | 2019-06-28 | 浙江大学 | A kind of portable expiratory air acquisition device and method |
| CN212008606U (en) * | 2019-08-19 | 2020-11-24 | 上海摇橹仪器设备有限公司 | Sensor for detecting exhaled gas |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4564406B2 (en) * | 2005-05-25 | 2010-10-20 | 株式会社日立製作所 | Exhalation collection filter, exhalation collection device, exhalation analysis system, and exhalation analysis method |
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2021
- 2021-04-29 CN CN202110477662.8A patent/CN113188853B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105122057A (en) * | 2013-03-18 | 2015-12-02 | 西莫内·克里斯托尼 | Apparatus and method for sampling and analyzing breath |
| CN205426592U (en) * | 2015-11-30 | 2016-08-03 | 华中农业大学 | Goat breathes gaseous collection system |
| CN108245757A (en) * | 2017-12-20 | 2018-07-06 | 浙江大学 | Breathed air acquisition device based on breathing circuit |
| CN109938736A (en) * | 2019-04-03 | 2019-06-28 | 浙江大学 | A kind of portable expiratory air acquisition device and method |
| CN212008606U (en) * | 2019-08-19 | 2020-11-24 | 上海摇橹仪器设备有限公司 | Sensor for detecting exhaled gas |
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