CN113171730B - Raw material mixing device for preparing pregabalin capsules - Google Patents
Raw material mixing device for preparing pregabalin capsules Download PDFInfo
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- CN113171730B CN113171730B CN202110299757.5A CN202110299757A CN113171730B CN 113171730 B CN113171730 B CN 113171730B CN 202110299757 A CN202110299757 A CN 202110299757A CN 113171730 B CN113171730 B CN 113171730B
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- connecting pipe
- air
- cover plate
- feeding
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
- B01J4/002—Nozzle-type elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2204/00—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices
- B01J2204/002—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices the feeding side being of particular interest
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- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
Abstract
The invention discloses a raw material mixing device for preparing pregabalin capsules, which comprises: the cover plate is arranged at the top of the granulator, so that the granulator is in a sealed state, a feed hopper used for injecting raw materials into the cover plate is arranged at the top of the cover plate, and the feed hopper is fixedly connected with the cover plate; the air pumping mechanism is arranged on the cover plate, and air in the granulator is pumped out through air pumping of the air pumping mechanism; the feeding mechanism is provided with a plurality of feeding mechanisms which are respectively arranged on the cover plate, and air is pumped by the air pumping mechanism, so that auxiliary materials are respectively added into the granulator from the feeding mechanism.
Description
Technical Field
The invention relates to the technical field of pregabalin capsule preparation, in particular to a raw material mixing device for pregabalin capsule preparation.
Background
Pregabalin belongs to non-gamma-aminobutyric acid (GABA) receptor agonists or antagonists, is a novel calcium ion channel regulator, and can block voltage-dependent calcium channels and reduce the release of neurotransmitters. The traditional Chinese medicine composition is mainly used for treating neuralgia related to diabetic peripheral neuropathy, postherpetic neuralgia and adjuvant therapy of adult partial epileptic seizure, generalized anxiety disorder, central neuralgia (including neuralgia accompanied by spinal cord injury, stroke and multiple sclerosis) and fibromyalgia.
In the preparation process of the pregabalin capsule, raw materials and auxiliary materials are required to be ground and sieved, ground powder is added into a granulator, after a preparation such as an adhesive, a wetting agent and lactose is added, granules which are in accordance with the capsule filling size are formed, air in the granulator is extracted by a negative pressure fan on a cover plate of the granulator, so that negative pressure is formed in the granulator, and then the preparation such as the adhesive and the wetting agent is sucked into the granulator by the negative pressure.
Disclosure of Invention
The invention aims to provide a raw material mixing device for preparing pregabalin capsules, so as to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a raw material mixing device for preparing pregabalin capsules, comprising:
the cover plate is arranged at the top of the granulator, so that the granulator is in a sealed state, a feed hopper used for injecting raw materials into the cover plate is arranged at the top of the cover plate, and the feed hopper is fixedly connected with the cover plate;
the air exhaust mechanism is arranged on the cover plate and exhausts air in the granulator through the air exhaust mechanism;
the feeding mechanism is provided with a plurality of feeding mechanisms which are respectively arranged on the cover plate, and air is pumped by the air pumping mechanism, so that the auxiliary materials are respectively fed into the granulator from the feeding mechanism.
Preferably, the air exhaust mechanism comprises an air exhaust shell fixedly connected with the cover plate, the top of the air exhaust shell is rotatably connected with a motor, the free end of the motor output shaft is provided with fan blades, the outer side of the air exhaust shell is provided with a connecting ring, and the surface of the connecting ring is provided with an outlet hole used for guiding air out.
Preferably, the feeding mechanism comprises a feeding pipe fixedly connected with the cover plate, a jet plate is arranged in the feeding pipe, and a plurality of jet holes are formed in the surface of the jet plate.
Preferably, be equipped with coupling mechanism between reinforced mechanism and the mechanism of bleeding, coupling mechanism includes with the mechanism fixed connection of bleeding and the inside connecting pipe of intercommunication one, the inside sliding connection of connecting pipe one has connecting pipe two, the inside of reinforced mechanism is equipped with reinforced shell, the both ends of reinforced shell are equipped with the connecting pipe three that is used for connecting the outside, connecting pipe three is sealed with the external world with reinforced mechanism, the inside rotation of reinforced shell is connected with the connecting axle, the outside fixedly connected with of connecting axle pushes away the movable vane, the bottom fixedly connected with spiral leaf of connecting axle, connecting pipe three inserts the inside of connecting pipe two, connecting pipe three is sealed relatively with connecting pipe two, be equipped with spring one between connecting pipe two and the connecting pipe one, the both ends of spring one respectively with connecting pipe one and connecting pipe two fixed connection.
Preferably, be equipped with stop gear between coupling mechanism and the apron, the go-between of the mechanism of bleeding rotates with the shell of bleeding to be connected, the inside arc wall that is used for the go-between to rotate and with external UNICOM that is equipped with of the shell of bleeding of the mechanism of bleeding, stop gear includes the connecting block with two fixed connection of connecting pipe, the top fixedly connected with track of apron, be equipped with the stopper respectively corresponding to every reinforced mechanism in the track, the stopper contacts with the connecting block.
Preferably, the connecting block comprises an opening and closing part and a closing part, and inclined planes are arranged on two sides of the opening and closing part and two sides of the closing part.
Preferably, the inside of connecting pipe one is equipped with the sealing mechanism who prevents the air refluence, sealing mechanism include with a connecting pipe inner wall fixed connection's sealing ring, the one end of sealing ring is equipped with sealed the pad, it is equipped with spring two to seal between pad and the connecting pipe one, the both ends of spring two respectively with sealed pad and connecting pipe one fixed connection.
Preferably, the bottom of the air exhaust shell is fixedly connected with an air pipeline, the air inlet end of the air pipeline is far away from the feeding mechanism, and the end part of the air pipeline is fixedly connected with a bent pipe.
The invention has at least the following beneficial effects:
the air in the granulator is pumped out through the air pumping mechanism, auxiliary materials are added into the granulator from the feeding mechanism by utilizing negative pressure in the granulator, then the air pumped out by the air pumping mechanism is poured into the feeding mechanism through the connecting mechanism and the limiting mechanism to assist feeding of the feeding mechanism.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a bottom view of the present invention;
FIG. 3 is a cross-sectional view of the present invention;
FIG. 4 is an enlarged view of area A of FIG. 3;
FIG. 5 is a partial cross-sectional view of the present invention;
FIG. 6 is an enlarged view of area B of FIG. 5;
fig. 7 is a partial structure view of the stopper mechanism of the present invention.
In the figure: 1-cover plate; 2-a feed hopper; 3-an air exhaust mechanism; 4-a feeding mechanism; 5-air-extracting shell; 6, a motor; 7-fan blades; 8-connecting rings; 9-a lead-out hole; 10-a feed pipe; 11-a jet plate; 12-spraying holes; 13-a connection mechanism; 14-connecting pipe I; 15-connecting pipe II; 16-a casing; 17-connecting pipe III; 18-a connecting shaft; 19-pushing the blades; 20-helical leaves; 21-spring one; 22-a limiting mechanism; 23-an arc-shaped groove; 24-connecting blocks; 25-track; 26-a limiting block; 27-an opening and closing part; 28-a closure; 29-a sealing mechanism; 30-a sealing ring; 31-a gasket; 32-a gas conduit; 33-bending the tube; 34-spring two.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-7, the present invention provides a technical solution: a raw material mixing device for preparing pregabalin capsules, comprising:
the cover plate 1 is arranged at the top of the granulator, so that the granulator is in a sealed state, a feed hopper 2 used for injecting raw materials into the cover plate 1 is arranged at the top of the cover plate 1, and the feed hopper 2 is fixedly connected with the cover plate 1;
the air extracting mechanism 3 is arranged on the cover plate 1, and air in the granulator is extracted by air extraction of the air extracting mechanism 3;
the feeding mechanism 4 is provided with a plurality of materials which are respectively arranged on the cover plate 1 and exhaust air through the air exhaust mechanism 3, so that auxiliary materials are respectively added into the granulator from the feeding mechanism 4.
Air exhaust mechanism 3 includes the shell 5 of bleeding with 1 fixed connection of apron, the top of the shell 5 of bleeding is rotated and is connected with motor 6, the free end of the 6 output shafts of motor is equipped with flabellum 7, the outside of the shell 5 of bleeding is equipped with go-between 8, the exit hole 9 that is used for deriving the air is offered on the surface of go-between 8, when needing to add the auxiliary material in the granulator, starter motor 6, motor 6 drive flabellum 7 and rotate, and the air in the 7 granulator of flabellum is taken out, the inside negative pressure that forms of granulator, and the negative pressure is through feeding mechanism 4 with the auxiliary material suction granulator in, and then makes things convenient for the granulator to the mixture of material.
The feeding mechanism 4 comprises a feeding pipe 10 fixedly connected with the cover plate 1, an injection plate 11 is arranged in the feeding pipe 10, a plurality of spray holes 12 are formed in the surface of the injection plate 11, when negative pressure is formed in the granulator, auxiliary materials are sucked into the feeding pipe 10 by the negative pressure in the granulator, and the materials are sprayed out by the injection plate 11, so that the materials are convenient to mix.
The powder injection device is characterized in that a connecting mechanism 13 is arranged between the feeding mechanism 4 and the air pumping mechanism 3, the connecting mechanism 13 comprises a first connecting pipe 14 which is fixedly connected with the air pumping mechanism 3 and is communicated with the inside, a second connecting pipe 15 is slidably connected to the inside of the first connecting pipe 14, a feeding shell 16 is arranged inside the feeding mechanism 4, three connecting pipes 17 used for being connected with the outside are arranged at two ends of the feeding shell 16, the feeding mechanism 4 is sealed with the outside through the third connecting pipe 17, a connecting shaft 18 is rotatably connected to the inside of the feeding shell 16, a pushing blade 19 is fixedly connected to the outside of the connecting shaft 18, a spiral blade 20 is fixedly connected to the bottom of the connecting shaft 18, the third connecting pipe 17 is inserted into the inside of the second connecting pipe 15, the third connecting pipe 17 and the second connecting pipe 15 are sealed relatively, a first spring 21 is arranged between the second connecting pipe 15 and the first connecting pipe 14, two ends of the first spring 21 are fixedly connected with the first connecting pipe 14 and the second connecting pipe 15 respectively, when the air pumping mechanism 3 pumps air, the air enters the first connecting pipe 14, the first connecting pipe, the air enters the first connecting pipe, the pushing blade 19 rotates, the connecting pipe 18 drives the connecting pipe to drive the connecting pipe 18 to drive the spiral blade 20 to rotate, and the connecting pipe to drive the connecting pipe to discharge auxiliary material to be conveniently discharged through the first connecting pipe, and the connecting pipe 20, and the connecting pipe 15, and the connecting pipe, so that the connecting pipe 15 and the connecting pipe can be conveniently discharge auxiliary material can be discharged when the connecting pipe 10 is discharged.
The utility model discloses a granulator, including connecting mechanism 13, apron 1, stop gear 22, air exhaust mechanism 3, connecting ring 8, air exhaust shell 5 inside be equipped with be used for the connecting ring 8 to rotate and with external UNICOM's arc 23, stop gear 22 includes the connecting block 24 with two 15 fixed connection of connecting pipe, the top fixedly connected with track 25 of apron 1, be equipped with stopper 26 respectively corresponding to every feeding mechanism 4 in the track 25, stopper 26 contacts with connecting block 24, when needing to add different auxiliary materials in the granulator, only need rotate connecting ring 8, and connecting ring 8 drives pipeline three and connecting pipe two 15 and rotates, and connecting block 24 slides in track 25 simultaneously, and when stopper 26 rotated for connecting block 24, connecting pipe two 15 withdraws, and spring one 21 is tensile, and connecting pipe two 15 separates with pipeline three, rotates to required feeding mechanism 4 position after, spring one 21 pops up, and connecting pipe two 15 overlaps the outside at required feeding mechanism 4's pipeline three of feeding mechanism 4 to make things convenient for feeding in raw material, be convenient for the switching between the different feeding mechanism 4, it is comparatively convenient to switch over.
Connecting block 24 includes and opens and shuts portion 27 and closing part 28, the both sides of portion 27 and closing part 28 that open and shut all are equipped with the inclined plane, and when connecting block 24 laminating stopper 26, portion 27 and the closing part 28 that open and shut can directly be promoted under the effect on inclined plane, lead to connecting pipe two 15 directly to be promoted to make things convenient for the automation of connecting pipe two 15 to withdraw, the user only need rotate go-between 8, need not inwards extrude connecting pipe two 15, make things convenient for stop gear 22's use more.
The inside of connecting pipe one 14 is equipped with the sealing mechanism 29 who prevents the air refluence, sealing mechanism 29 includes the sealing ring 30 with connecting pipe one 14 inner wall fixed connection, the one end of sealing ring 30 is equipped with sealed pad 31, be equipped with spring two 34 between sealed pad 31 and the connecting pipe one 14, the both ends of spring two 34 respectively with sealed pad 31 and connecting pipe one 14 fixed connection, when connecting pipe two 15 and pipeline three-phase alternate switching, sealed pad 31 laminating sealing ring 30 guarantees that the air can not flow backwards and gets into the granulator, at motor 6 during operation, air promotes sealed pad 31, sealed pad 31 relative sealing ring 30 is opened, spring two 34 are tensile, and the air is discharged from connecting pipe two 15, makes things convenient for the use of granulator through sealing mechanism 29, reduces the energy consumption of motor 6 work.
The bottom fixedly connected with gas pipeline 32 of shell 5 takes out, reinforced mechanism 4 is kept away from to the inlet end of gas pipeline 32, gas pipeline 32 tip fixedly connected with bend tube 33, when shell 5 takes out air, is full of the powder in the granulator, and one side powder that is close to reinforced mechanism 4 is more, through gas pipeline 32 and the more position of the skew dust of bend tube 33 to the work of mechanism 3 conveniently takes out air.
It should be noted that, in this document, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. A raw material mixing device for preparing pregabalin capsules, characterized by comprising:
the cover plate (1) is arranged at the top of the granulator, so that the granulator is in a sealed state, a feed hopper (2) used for injecting raw materials into the cover plate (1) is arranged at the top of the cover plate (1), and the feed hopper (2) is fixedly connected with the cover plate (1);
the air extraction mechanism (3) is arranged on the cover plate (1), and air in the granulator is extracted through air extraction of the air extraction mechanism (3);
a plurality of feeding mechanisms (4) which are respectively arranged on the cover plate (1) and used for sucking air through the air sucking mechanism (3) so that the auxiliary materials are respectively added into the granulator from the feeding mechanisms (4),
the feeding mechanism (4) comprises a feeding pipe (10) fixedly connected with the cover plate (1), a jet plate (11) is arranged in the feeding pipe (10), a plurality of jet holes (12) are formed in the surface of the jet plate (11),
the feeding mechanism (4) and the air exhaust mechanism (3) are provided with a connecting mechanism (13) therebetween, the connecting mechanism (13) comprises a first connecting pipe (14) fixedly connected with the air exhaust mechanism (3) and communicated with the inside of the first connecting pipe (14), a second connecting pipe (15) is slidably connected with the inside of the first connecting pipe (14), a feeding shell (16) is arranged inside the feeding mechanism (4), three connecting pipes (17) used for connecting the outside are arranged at the two ends of the feeding shell (16), the three connecting pipes (17) seal the feeding mechanism (4) with the outside, the feeding shell (16) is rotatably connected with a connecting shaft (18) inside, a first spring (21) is arranged between the second connecting pipe (15) and the first connecting pipe (14), a first connecting pipe (14) and a second connecting pipe (15) are fixedly connected with the two ends of the first spring (21) respectively,
the air exhaust mechanism (3) comprises an air exhaust shell (5) fixedly connected with the cover plate (1), a connecting ring (8) is arranged on the outer side of the air exhaust shell (5), an outlet hole (9) used for leading out air is formed in the surface of the connecting ring (8), the outlet hole (9) is connected with a first connecting pipe (14), a limiting mechanism (22) is arranged between the connecting mechanism (13) and the cover plate (1), the connecting ring (8) of the air exhaust mechanism (3) is rotatably connected with the air exhaust shell (5), an arc-shaped groove (23) used for enabling the connecting ring (8) to rotate and communicating with the outside is arranged inside the air exhaust shell (5) of the air exhaust mechanism (3), the limiting mechanism (22) comprises a connecting block (24) fixedly connected with a second connecting pipe (15), a track (25) is fixedly connected to the top of the cover plate (1), a limiting block (26) is arranged in the track (25) corresponding to each feeding mechanism (4), and the limiting block (26) is in the track (25) and is in contact with the connecting block (24),
the connecting block (24) comprises an opening and closing part (27) and a closing part (28), and inclined planes are arranged on two sides of the opening and closing part (27) and the closing part (28).
2. The raw material mixing device for pregabalin capsule preparation of claim 1, wherein: the top of the air exhaust shell (5) is rotatably connected with a motor (6), and the free end of an output shaft of the motor (6) is provided with fan blades (7).
3. The raw material mixing device for pregabalin capsule preparation of claim 1, wherein: the inside of connecting pipe (14) is equipped with sealing mechanism (29) that prevents the air refluence, sealing mechanism (29) include with connecting pipe (14) inner wall fixed connection's sealing ring (30), the one end of sealing ring (30) is equipped with sealed pad (31), be equipped with spring two (34) between sealed pad (31) and connecting pipe (14), the both ends of spring two (34) respectively with sealed pad (31) and connecting pipe (14) fixed connection.
4. The raw material mixing device for pregabalin capsule preparation of claim 1, wherein: the bottom fixedly connected with gas pipeline (32) of shell (5) takes out gas, feeding mechanism (4) are kept away from to the inlet end of gas pipeline (32), gas pipeline (32) tip fixedly connected with pipe of buckling (33).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110299757.5A CN113171730B (en) | 2021-03-22 | 2021-03-22 | Raw material mixing device for preparing pregabalin capsules |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110299757.5A CN113171730B (en) | 2021-03-22 | 2021-03-22 | Raw material mixing device for preparing pregabalin capsules |
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| CN113171730A CN113171730A (en) | 2021-07-27 |
| CN113171730B true CN113171730B (en) | 2022-10-11 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20170029295A (en) * | 2015-09-07 | 2017-03-15 | 주식회사 엘지화학 | Fixed-bed reactor for vapor-liquid hydrogenation and method for preparing neopentyl glycol using the same |
| CN211537662U (en) * | 2019-08-23 | 2020-09-22 | 山东信谊制药有限公司 | Prevent mixing granulator discharge mechanism of jam |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5566295B2 (en) * | 2008-09-18 | 2014-08-06 | 東洋エンジニアリング株式会社 | Polymerized resin production apparatus, polymerization container and production method |
| CN210079284U (en) * | 2019-05-07 | 2020-02-18 | 巩义市兴平耐火材料有限公司 | Mixer is used in stemming mixture |
| CN210332445U (en) * | 2019-08-05 | 2020-04-17 | 邯郸市邯钢附企利达激光科技有限公司 | Powder feeder for repairing roller |
| CN211026178U (en) * | 2019-10-23 | 2020-07-17 | 海南林恒制药股份有限公司 | Manufacturing system and quick mixing granulator of calcium dobesilate dispersible tablet |
| CN110758067A (en) * | 2019-10-31 | 2020-02-07 | 李杰松 | Carsickness-preventing automobile air conditioner medicine device |
| CN212440973U (en) * | 2020-05-18 | 2021-02-02 | 青岛红星新能源技术有限公司 | Powder mixing equipment with dust-free feeding device |
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- 2021-03-22 CN CN202110299757.5A patent/CN113171730B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170029295A (en) * | 2015-09-07 | 2017-03-15 | 주식회사 엘지화학 | Fixed-bed reactor for vapor-liquid hydrogenation and method for preparing neopentyl glycol using the same |
| CN211537662U (en) * | 2019-08-23 | 2020-09-22 | 山东信谊制药有限公司 | Prevent mixing granulator discharge mechanism of jam |
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