CN113171730A - Raw material mixing device for preparing pregabalin capsules - Google Patents
Raw material mixing device for preparing pregabalin capsules Download PDFInfo
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- CN113171730A CN113171730A CN202110299757.5A CN202110299757A CN113171730A CN 113171730 A CN113171730 A CN 113171730A CN 202110299757 A CN202110299757 A CN 202110299757A CN 113171730 A CN113171730 A CN 113171730A
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- air
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
- B01J4/002—Nozzle-type elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2204/00—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices
- B01J2204/002—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices the feeding side being of particular interest
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- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
Abstract
The invention discloses a raw material mixing device for preparing pregabalin capsules, which comprises: the cover plate is arranged at the top of the granulator, so that the granulator is in a sealed state, a feed hopper used for injecting raw materials into the cover plate is arranged at the top of the cover plate, and the feed hopper is fixedly connected with the cover plate; the air exhaust mechanism is arranged on the cover plate and exhausts air in the granulator through the air exhaust mechanism; the feeding mechanisms are respectively arranged on the cover plate, and air is exhausted through the air exhaust mechanism, so that auxiliary materials are respectively added into the granulator from the feeding mechanisms.
Description
Technical Field
The invention relates to the technical field of pregabalin capsule preparation, in particular to a raw material mixing device for pregabalin capsule preparation.
Background
Pregabalin belongs to non-gamma-aminobutyric acid (GABA) receptor agonists or antagonists, is a novel calcium ion channel regulator, and can block voltage-dependent calcium channels and reduce the release of neurotransmitters. The traditional Chinese medicine composition is mainly used for treating neuralgia related to diabetic peripheral neuropathy, postherpetic neuralgia and adjuvant therapy of adult partial epileptic seizure, generalized anxiety disorder, central neuralgia (including neuralgia accompanied by spinal cord injury, stroke and multiple sclerosis) and fibromyalgia.
In the preparation process of the pregabalin capsule, raw materials and auxiliary materials are required to be crushed and sieved, the crushed powder is added into a granulator, granules which are in accordance with the capsule filling size are formed after adhesive, wetting agent, lactose and other preparations are added, a negative pressure fan on a cover plate of the granulator extracts air in the granulator to ensure that negative pressure is formed in the granulator, and then the adhesive, the wetting agent and other preparations are attracted into the granulator through the negative pressure, however, when the powdery adhesive and lactose are attracted into the granulator through a pipeline, the adhesive and the lactose are required to be sequentially added into the granulator, the pipeline is possibly blocked by the powdery adhesive and the lactose in the pipeline, particularly, the pipeline is inserted into one end of the granulator, the addition of the adhesive and the lactose is inconvenient, the adhesive and the lactose are directly sprayed out, and the adhesive and the lactose are not fully mixed with the materials in the granulator, to this end, we propose a raw material mixing device for the preparation of pregabalin capsules.
Disclosure of Invention
The invention aims to provide a raw material mixing device for preparing pregabalin capsules, so as to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a raw material mixing device for preparing pregabalin capsules, comprising:
the cover plate is arranged at the top of the granulator, so that the granulator is in a sealed state, a feed hopper used for injecting raw materials into the cover plate is arranged at the top of the cover plate, and the feed hopper is fixedly connected with the cover plate;
the air exhaust mechanism is arranged on the cover plate and exhausts air in the granulator through the air exhaust mechanism;
the feeding mechanism is provided with a plurality of feeding mechanisms which are respectively arranged on the cover plate, and air is pumped by the air pumping mechanism, so that the auxiliary materials are respectively fed into the granulator from the feeding mechanism.
Preferably, the air exhaust mechanism comprises an air exhaust shell fixedly connected with the cover plate, the top of the air exhaust shell is rotatably connected with a motor, the free end of the motor output shaft is provided with fan blades, the outer side of the air exhaust shell is provided with a connecting ring, and the surface of the connecting ring is provided with an outlet hole used for guiding air out.
Preferably, the feeding mechanism comprises a feeding pipe fixedly connected with the cover plate, a spraying plate is arranged in the feeding pipe, and a plurality of spraying holes are formed in the surface of the spraying plate.
Preferably, be equipped with coupling mechanism between reinforced mechanism and the mechanism of bleeding, coupling mechanism includes with the mechanism fixed connection of bleeding and the inside connecting pipe of intercommunication one, the inside sliding connection of connecting pipe one has connecting pipe two, the inside of reinforced mechanism is equipped with reinforced shell, the both ends of reinforced shell are equipped with the connecting pipe three that is used for connecting the outside, connecting pipe three is sealed with the external world with reinforced mechanism, the inside rotation of reinforced shell is connected with the connecting axle, the outside fixedly connected with of connecting axle pushes away the movable vane, the bottom fixedly connected with spiral leaf of connecting axle, connecting pipe three inserts the inside of connecting pipe two, connecting pipe three is sealed relatively with connecting pipe two, be equipped with spring one between connecting pipe two and the connecting pipe one, the both ends of spring one respectively with connecting pipe one and connecting pipe two fixed connection.
Preferably, be equipped with stop gear between coupling mechanism and the apron, the go-between of the mechanism of bleeding is rotated with the shell of bleeding and is connected, the shell of bleeding of the mechanism of bleeding is inside to be equipped with the arc wall that is used for the go-between to rotate and with external UNICOM, stop gear include with two fixed connection's of connecting pipe connecting block, the top fixedly connected with track of apron, be equipped with the stopper respectively corresponding to every reinforced mechanism in the track, the stopper contacts with the connecting block.
Preferably, the connecting block comprises an opening and closing part and a closing part, and inclined planes are arranged on two sides of the opening and closing part and two sides of the closing part.
Preferably, the inside of connecting pipe one is equipped with the sealing mechanism who prevents the air refluence, sealing mechanism include with a connecting pipe inner wall fixed connection's sealing ring, the one end of sealing ring is equipped with sealed the pad, it is equipped with spring two to seal between pad and the connecting pipe one, the both ends of spring two respectively with sealed pad and connecting pipe one fixed connection.
Preferably, the bottom of the air exhaust shell is fixedly connected with an air pipeline, the air inlet end of the air pipeline is far away from the feeding mechanism, and the end part of the air pipeline is fixedly connected with a bent pipe.
The invention has at least the following beneficial effects:
air in the granulator is pumped out through the air pumping mechanism, auxiliary materials are added into the granulator from the feeding mechanism by utilizing negative pressure in the granulator, then the air pumped out by the air pumping mechanism is poured into the feeding mechanism through the connecting mechanism and the limiting mechanism to assist feeding of the feeding mechanism, compared with the prior art, when powdery adhesive and lactose are sucked into the granulator through a pipeline, the adhesive and the lactose need to be sequentially added into the granulator, the pipeline can be blocked by the powdery adhesive and the lactose in the pipeline, particularly, the pipeline is inserted into one end of the granulator, the addition of the adhesive and the lactose is inconvenient, the adhesive and the lactose are directly sprayed out, the adhesive and the lactose are inconvenient to be fully mixed with materials in the granulator, the adhesive and the lactose are respectively and independently added into the granulator through the feeding mechanism, and the powder in the feeding mechanism is driven to rotate through the connecting mechanism, reduce the possibility of pipe blockage, make things convenient for the joining of adhesive and lactose, adhesive and lactose are when the blowout in addition, and coupling mechanism's rotation drives the powder and spills, makes things convenient for the abundant contact of powder and granulator, makes things convenient for the use of equipment.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a bottom view of the present invention;
FIG. 3 is a cross-sectional view of the present invention;
FIG. 4 is an enlarged view of area A of FIG. 3;
FIG. 5 is a partial cross-sectional view of the present invention;
FIG. 6 is an enlarged view of area B of FIG. 5;
fig. 7 is a partial structure view of the stopper mechanism of the present invention.
In the figure: 1-cover plate; 2-a feed hopper; 3-an air exhaust mechanism; 4-a feeding mechanism; 5-air-extracting shell; 6, a motor; 7-fan blades; 8-connecting rings; 9-a lead-out hole; 10-a feed pipe; 11-a jet plate; 12-spraying holes; 13-a connection mechanism; 14-connecting pipe I; 15-connecting pipe II; 16-a casing; 17-connecting pipe III; 18-a connecting shaft; 19-pushing the blades; 20-helical leaves; 21-spring one; 22-a limiting mechanism; 23-an arc-shaped groove; 24-connecting blocks; 25-track; 26-a limiting block; 27-an opening and closing part; 28-a closure; 29-a sealing mechanism; 30-a sealing ring; 31-a gasket; 32-a gas conduit; 33-bending the tube; 34-spring two.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-7, the present invention provides a technical solution: a raw material mixing device for preparing pregabalin capsules, comprising:
the cover plate 1 is arranged at the top of the granulator, so that the granulator is in a sealed state, a feed hopper 2 used for injecting raw materials into the cover plate 1 is arranged at the top of the cover plate 1, and the feed hopper 2 is fixedly connected with the cover plate 1;
the air extracting mechanism 3 is arranged on the cover plate 1, and air in the granulator is extracted by air extraction of the air extracting mechanism 3;
the feeding mechanism 4 is provided with a plurality of materials which are respectively arranged on the cover plate 1 and exhaust air through the air exhaust mechanism 3, so that auxiliary materials are respectively added into the granulator from the feeding mechanism 4.
Air exhaust mechanism 3 includes the shell 5 of bleeding with 1 fixed connection of apron, the top of the shell 5 of bleeding is rotated and is connected with motor 6, the free end of the 6 output shafts of motor is equipped with flabellum 7, the outside of the shell 5 of bleeding is equipped with go-between 8, the exit hole 9 that is used for deriving the air is offered on the surface of go-between 8, when needing to add the auxiliary material in the granulator, starter motor 6, motor 6 drive flabellum 7 and rotate, and the air in the 7 granulator of flabellum is taken out, the inside negative pressure that forms of granulator, and the negative pressure is through feeding mechanism 4 with the auxiliary material suction granulator in, and then makes things convenient for the granulator to the mixture of material.
The feeding mechanism 4 comprises a feeding pipe 10 fixedly connected with the cover plate 1, an injection plate 11 is arranged in the feeding pipe 10, a plurality of spray holes 12 are formed in the surface of the injection plate 11, when negative pressure is formed in the granulator, auxiliary materials are sucked into the feeding pipe 10 by the negative pressure in the granulator, and the materials are sprayed out by the injection plate 11, so that the materials are convenient to mix.
The feeding mechanism 4 and the air exhaust mechanism 3 are provided with a connecting mechanism 13 therebetween, the connecting mechanism 13 comprises a first connecting pipe 14 fixedly connected with the air exhaust mechanism 3 and communicated with the inside of the air exhaust mechanism 3, a second connecting pipe 15 is slidably connected to the inside of the first connecting pipe 14, a feeding shell 16 is arranged inside the feeding mechanism 4, three connecting pipes 17 used for connecting the outside are arranged at two ends of the feeding shell 16, the feeding mechanism 4 is sealed with the outside through the third connecting pipes 17, a connecting shaft 18 is rotatably connected to the inside of the feeding shell 16, a pushing blade 19 is fixedly connected to the outside of the connecting shaft 18, a spiral blade 20 is fixedly connected to the bottom of the connecting shaft 18, the third connecting pipe 17 is inserted into the inside of the second connecting pipe 15, the third connecting pipe 17 is sealed with the second connecting pipe 15, a first spring 21 is arranged between the second connecting pipe 15 and the first connecting pipe 14, and two ends of the first spring 21 are, when air exhaust mechanism 3 bleeds, the air of taking out gets into in the connecting pipe 14, the air in the connecting pipe 14 gets into in the connecting pipe two 15, and then get into in the pipeline three, the flow promotion of air impels leaf 19 to rotate, it drives connecting axle 18 rotation to promote leaf 19, connecting axle 18 drives spiral leaf 20 and rotates, when powdered auxiliary material gets into the filling tube 10, powdered material is promoted by spiral leaf 20, connecting axle 18 drives injection plate 11 in step and rotates, make things convenient for the material to rotate when discharging, make connecting pipe two 15 hug closely pipeline three through spring one 21, make things convenient for the interconversion and the sealing between connecting pipe two 15 and the connecting pipe two 15.
A limiting mechanism 22 is arranged between the connecting mechanism 13 and the cover plate 1, the connecting ring 8 of the air pumping mechanism 3 is rotatably connected with the air pumping shell 5, an arc-shaped groove 23 which is used for the connecting ring 8 to rotate and is communicated with the outside is arranged inside the air pumping shell 5 of the air pumping mechanism 3, the limiting mechanism 22 comprises a connecting block 24 fixedly connected with the connecting pipe II 15, a track 25 is fixedly connected with the top of the cover plate 1, a limiting block 26 is respectively arranged in the track 25 corresponding to each feeding mechanism 4, the limiting blocks 26 are in contact with the connecting block 24, when different auxiliary materials are required to be added into the granulator, only the connecting ring 8 needs to be rotated, the connecting pipe III and the connecting pipe II 15 are driven to rotate by the connecting ring 8, meanwhile, the connecting block 24 slides in the track 25, when the limiting blocks 26 rotate relative to the connecting block 24, the connecting pipe II, after rotating the reinforced mechanism 4 position of required feeding, spring one 21 pops out, and the second 15 cover of connecting pipe is in the outside of the pipeline three of the reinforced mechanism 4 of required feeding to make things convenient for reinforced of reinforced mechanism 4, the switching between the reinforced mechanism 4 of different of being convenient for switches comparatively conveniently.
Connecting block 24 includes and opens and shuts portion 27 and closing part 28, the both sides of portion 27 and closing part 28 that open and shut all are equipped with the inclined plane, and when connecting block 24 laminating stopper 26, portion 27 and the closing part 28 that open and shut can directly be promoted under the effect on inclined plane, lead to connecting pipe two 15 directly to be promoted to make things convenient for the automation of connecting pipe two 15 to withdraw, the user only need rotate go-between 8, need not inwards extrude connecting pipe two 15, make things convenient for stop gear 22's use more.
The inside of connecting pipe one 14 is equipped with the sealing mechanism 29 who prevents the air refluence, sealing mechanism 29 includes the sealing ring 30 with connecting pipe one 14 inner wall fixed connection, the one end of sealing ring 30 is equipped with sealed pad 31, be equipped with spring two 3432 between sealed pad 31 and the connecting pipe one 14, the both ends of spring two 3432 respectively with sealed pad 31 and connecting pipe one 14 fixed connection, when connecting pipe two 15 and pipeline three-phase alternate switch-over, sealed pad 31 laminating sealing ring 30 guarantees that the air can not flow backwards and gets into in the granulator, at motor 6 during operation, the sealed pad 31 of air promotion, sealed pad 31 relative sealing ring 30 is opened, spring two 3432 is tensile, and the air is discharged from connecting pipe two 15, makes things convenient for the use of granulator through sealing mechanism 29, reduces the energy consumption of motor 6 work.
The bottom fixedly connected with gas pipeline 32 of shell 5 takes out, reinforced mechanism 4 is kept away from to the inlet end of gas pipeline 32, gas pipeline 32 tip fixedly connected with bend tube 33, when shell 5 takes out air, is full of the powder in the granulator, and one side powder that is close to reinforced mechanism 4 is more, through gas pipeline 32 and the more position of the skew dust of bend tube 33 to the work of mechanism 3 conveniently takes out air.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. A raw material mixing device for preparing pregabalin capsules, characterized by comprising:
the cover plate (1) is arranged at the top of the granulator, so that the granulator is in a sealed state, a feed hopper (2) used for injecting raw materials into the cover plate (1) is arranged at the top of the cover plate (1), and the feed hopper (2) is fixedly connected with the cover plate (1);
the air extraction mechanism (3) is arranged on the cover plate (1), and air in the granulator is extracted through air extraction of the air extraction mechanism (3);
the feeding mechanism (4) is provided with a plurality of feeding mechanisms, the feeding mechanisms are respectively arranged on the cover plate (1), and air is pumped through the air pumping mechanism (3), so that auxiliary materials are respectively added into the granulator from the feeding mechanism (4).
2. The raw material mixing device for pregabalin capsule preparation of claim 1, wherein: air exhaust mechanism (3) include with apron (1) fixed connection's shell (5) of taking out air, the top of shell (5) of taking out air is rotated and is connected with motor (6), the free end of motor (6) output shaft is equipped with flabellum (7), the outside of shell (5) of taking out air is equipped with go-between (8), lead-out hole (9) that are used for exporting the air are offered on the surface of go-between (8).
3. The raw material mixing device for pregabalin capsule preparation of claim 1, wherein: the feeding mechanism (4) comprises a feeding pipe (10) fixedly connected with the cover plate (1), an injection plate (11) is arranged in the feeding pipe (10), and a plurality of spray holes (12) are formed in the surface of the injection plate (11).
4. The raw material mixing device for pregabalin capsule preparation of claim 1, wherein: the feeding mechanism (4) and the air exhaust mechanism (3) are provided with a connecting mechanism (13) therebetween, the connecting mechanism (13) comprises a first connecting pipe (14) fixedly connected with the air exhaust mechanism (3) and communicated with the inside of the air exhaust mechanism (3), a second connecting pipe (15) is slidably connected with the inside of the first connecting pipe (14), a feeding shell (16) is arranged inside the feeding mechanism (4), third connecting pipes (17) used for connecting the outside are arranged at the two ends of the feeding shell (16), the third connecting pipes (17) seal the feeding mechanism (4) with the outside, a connecting shaft (18) is rotatably connected inside the feeding shell (16), a pushing blade (19) is fixedly connected to the outside of the connecting shaft (18), spiral blades (20) are fixedly connected to the bottom of the connecting shaft (18), the third connecting pipes (17) are inserted into the second connecting pipes (15), and the third connecting pipes (17) are sealed relatively with the second connecting pipes (15), and a first spring (21) is arranged between the second connecting pipe (15) and the first connecting pipe (14), and two ends of the first spring (21) are fixedly connected with the first connecting pipe (14) and the second connecting pipe (15) respectively.
5. The raw material mixing device for pregabalin capsule preparation of claim 4, wherein: be equipped with stop gear (22) between coupling mechanism (13) and apron (1), go-between (8) of mechanism (3) of bleeding rotate with shell (5) of bleeding and be connected, the shell (5) of bleeding of mechanism (3) of bleeding is inside to be equipped with arc wall (23) that are used for go-between (8) to rotate and with external UNICOM, stop gear (22) include with connecting pipe two (15) fixed connection's connecting block (24), the top fixedly connected with track (25) of apron (1), be equipped with stopper (26) respectively corresponding to every reinforced mechanism (4) in track (25), stopper (26) and connecting block (24) contact.
6. The raw material mixing device for pregabalin capsule preparation of claim 5, wherein: the connecting block (24) comprises an opening and closing part (27) and a closing part (28), and inclined planes are arranged on two sides of the opening and closing part (27) and the closing part (28).
7. The raw material mixing device for pregabalin capsule preparation of claim 4, wherein: the inside of connecting pipe (14) is equipped with sealing mechanism (29) that prevents the air refluence, sealing mechanism (29) include with connecting pipe (14) inner wall fixed connection's sealing ring (30), the one end of sealing ring (30) is equipped with sealed pad (31), be equipped with spring two (34) (32) between sealed pad (31) and connecting pipe (14), the both ends of spring two (34) (32) respectively with sealed pad (31) and connecting pipe (14) fixed connection.
8. The raw material mixing device for pregabalin capsule preparation of claim 2, wherein: the bottom fixedly connected with gas pipeline (32) of shell (5) takes out gas, feeding mechanism (4) are kept away from to the inlet end of gas pipeline (32), gas pipeline (32) tip fixedly connected with pipe of buckling (33).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110299757.5A CN113171730B (en) | 2021-03-22 | 2021-03-22 | Raw material mixing device for preparing pregabalin capsules |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110299757.5A CN113171730B (en) | 2021-03-22 | 2021-03-22 | Raw material mixing device for preparing pregabalin capsules |
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| CN113171730A true CN113171730A (en) | 2021-07-27 |
| CN113171730B CN113171730B (en) | 2022-10-11 |
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| WO2010032302A1 (en) * | 2008-09-18 | 2010-03-25 | 東洋エンジニアリング株式会社 | Manufacturing apparatus of polymer, polymerization container, and manufacturing method |
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