CN113171094A - Flexible detection circuit for human body emotional state information, preparation method and integrated system - Google Patents
Flexible detection circuit for human body emotional state information, preparation method and integrated system Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
- A61B5/165—Evaluating the state of mind, e.g. depression, anxiety
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1116—Determining posture transitions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1118—Determining activity level
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
- A61B5/6833—Adhesive patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
Abstract
The invention discloses a flexible detection circuit for human body emotional state information, a preparation method and an integrated system, and belongs to the field of medical health monitoring. The method comprises the following steps: the adhesive functional layer is used for being directly attached to the skin of a human body; the top layer flexible packaging layer and the flexible substrate layer jointly form a flexible frame main body, and the chip layer and the top layer flexible lead layer are both positioned in the flexible frame main body; the chip layer comprises a plurality of detection modules which are respectively used for detecting skin electricity, temperature, blood oxygen and acceleration; the flexible substrate layer is provided with a plurality of conductive through holes and is used for conducting interlayer electrical signal conduction on the bottom layer and the top layer flexible lead layers; and the bottom layer and the top layer flexible lead layers are positioned on two sides of the flexible substrate layer and are used for electrically connecting all electronic elements in the chip layer and providing a body signal transmission port. The invention realizes the flexible signal detection and the tight attachment capability by integrating the skin electricity, temperature, blood oxygen and acceleration detection elements and the flexible material.
Description
Technical Field
The invention belongs to the field of medical health monitoring, and particularly relates to a human body emotion state information flexible detection circuit, a preparation method and an integrated system.
Background
Under the fast-paced and stressful environment of modern society, the physical and mental health problems faced by individuals are of concern, and real-time monitoring of the individual health condition is necessary. The physiological signals are the most important and basic vital sign signals of human body, and are skin electrical signals (GSR), blood oxygen signals (SpO2) and temperature signals of human emotion reflection windows, which are main monitoring objects of medical diagnosis and play an important role in judging human emotion states. The monitoring of various human physiological signals including skin electric signals, blood oxygen signals, temperature signals and three-axis acceleration signals is helpful for reminding people to notice the fluctuation of self emotional states and the abnormity of physical conditions as soon as possible, and timely adjustment or treatment is carried out, so that more serious health problems are avoided.
The change of the skin conductivity comes from the skin sweat gland activity controlled by sympathetic nerves, so the change is not influenced by main observation and will be used as an objective index of cognitive state and emotional arousal, and indirect measurement is realized by detecting the voltage and current value between electrodes attached to the skin; the detection principle of the blood oxygen saturation is a photoelectric volume method, and the blood oxygen saturation is measured by mainly utilizing the difference of blood on light absorption quantity when a human blood vessel beats; the temperature signal and the triaxial acceleration signal can reflect real-time body temperature and posture information of a human body, and more dimensionality information is provided for emotional state monitoring.
The flexible electron has the advantages of unique ductility, good wearability, large-scale manufacture, low cost and the like, and is widely applied to the fields of medical treatment, energy, military, education and the like. Flexible electronic products developed at present include printed RFID, flexible displays, organic light emitting diodes OLED, and the like, and are different from conventional hard circuits, and can realize functions of bending, stretching, and the like, so that they are widely used in real life. The traditional micro-nano electron adopts the processes of photoetching, electron beam etching, ion beam etching and the like to realize processing under the micro-nano scale, the process is complex, the manufacturing cost is high, the requirement on the environment is high, and the production requirements of large area, batch production and high adaptability of the flexible electron technology are difficult to meet, so that the stable and efficient process method is developed in the aspects of the flexible electron manufacturing key technology such as structural patterning, high-reliability packaging and the like, and has great application prospect and significance.
At present, most of commercial health monitoring systems for analyzing various physiological signals of a human body are rigid circuit board structures, and do not have flexibility and stretchability. Meanwhile, the traditional health monitoring equipment is generally divided into a front-end sensing circuit and a back-end signal analyzing and processing circuit, the integration level of the whole system is low, and the whole equipment is slightly heavy and not portable. Therefore, the research on a highly integrated flexible skin-attached health monitoring system has great significance to the field of health monitoring.
Disclosure of Invention
Aiming at the defects and improvement requirements of the prior art, the invention provides a flexible detection circuit for human body emotional state information, a preparation method and an integrated system, and aims to realize the capability of tightly attaching the flexible signal detection circuit to human body skin through the application of flexible materials, realize the receiving, processing and sending of front-end sensing data by a signal processing output module through circuit design, and finally realize the real-time transmission and display of human body skin electrical information, blood oxygen saturation information, temperature information and human body state information.
In order to achieve the above object, according to a first aspect of the present invention, there is provided a flexible signal detection circuit for human emotional state information, the flexible signal detection circuit is a double-layer circuit, and includes, from bottom to top: the packaging structure comprises a viscous functional layer, a top layer flexible packaging layer, a chip layer, a top layer flexible lead layer, a flexible substrate layer, a bottom layer flexible lead layer and a bottom layer flexible packaging layer;
the adhesive functional layer is used for being directly attached to human skin;
the top layer flexible packaging layer and the flexible substrate layer jointly form a flexible frame main body, and the chip layer and the top layer flexible lead layer are both positioned in the flexible frame main body;
the chip layer comprises a flexible skin electric detection electrode, a temperature detection module, a blood oxygen detection module and an acceleration detection module, and the flexible skin electric detection electrode, the temperature detection module, the blood oxygen detection module and the acceleration detection module are respectively used for detecting skin electric signals, temperature signals, blood oxygen signals and acceleration signals; wherein, the top layer flexible packaging layer and the viscous functional layer are not arranged below the skin electric detection electrode and are in direct contact with the skin;
the flexible substrate layer is provided with a plurality of conductive through holes and is used for interlayer connection of the bottom layer flexible lead layer and the top layer flexible lead layer and interlayer electric signal conduction of the bottom layer flexible lead layer and the top layer flexible lead layer;
the bottom layer and the top layer flexible lead layers are positioned on two sides of the flexible substrate layer and are used for electrically connecting electronic elements in the chip layer and providing transmission ports for human emotion related signals.
Preferably, the bottom layer and the top layer flexible conductor layer are made of conductive paste formed by mixing gallium-based liquid alloy, silver nano-materials and silane-based high polymer according to a certain proportion, and the mass ratio of the silane-based high polymer is not more than 50%.
Has the advantages that: the flexible signal detection circuit benefits from material characteristics, has good stretchability, adhesion and biocompatibility, and enables the detection process to be more comfortable. The flexible substrate adopts high-elasticity silane-based high polymer as a material, and self-made conductive paste as a wire layer, compared with the traditional hard substrate and the traditional metal conductive material, the circuit has excellent stretchability and ductility, the fluctuation of the conductivity along with the change of the stretching state is small, the conductive stability of the flexible signal detection circuit in the bending and stretching states is facilitated, and the accuracy and the anti-interference capability of signal detection are further improved; the adhesive functional layer is added on the PDMS encapsulation layer, for example, the adhesion layer is prepared by using a silane coupling agent, and the adhesive functional material has flexibility and good biocompatibility, so that the prepared system can keep better conformal contact capability with human skin.
Preferably, the mass ratio of the gallium-based liquid alloy, the silver nano material and the silane-based high molecular polymer is 2:1: 1.
Has the advantages that: the preferable mass ratio of the flexible conductive material is 2:1:1, and experiments prove that the flexible conductive material meeting the proportion has the conductivity higher than 10^6S/m and the tensile strain of 200-500 percent.
Preferably, the gallium-based liquid alloy is submicron particles and the silver nanomaterial is submicron flakes.
Has the advantages that: according to the invention, the gallium-based liquid alloy is preferably submicron particles, the silver nano material is micron-sized sheet-shaped, and the liquid alloy has an anchoring effect on the sheet-shaped silver nano material and can maintain stable conductivity in a stretching state.
Preferably, the silane-based high molecular polymer is polydimethylsiloxane PDMS, Ecoflex or SEBS.
Has the advantages that: according to the invention, the silyl-based high-molecular polymer is polydimethylsiloxane, Ecoflex or SEBS, and due to the low modulus characteristic, the stretchability and the good biocompatibility of the silyl-based high-molecular polymer, the stretchability of the front-end flexible signal detection circuit is improved, so that the detection circuit has better conformal contact capability with skin.
To achieve the above object, according to a second aspect of the present invention, there is provided a method for manufacturing a flexible signal detection circuit according to the first aspect, the method comprising the steps of:
s1, spinning and coating a silane-based high molecular polymer on a sacrificial layer, and dissolving the sacrificial layer in a water bath to obtain a flexible substrate layer;
s2, carrying out laser cutting on the flexible substrate layer to obtain a through hole, wherein the diameter of the through hole is in the range of 0.6-1 mm, and filling conductive slurry in the through hole to obtain a conductive through hole;
s3, preparing a bottom layer flexible lead layer on one surface of the flexible substrate layer by taking the conductive paste as a lead material; spin-coating a silicone-based high molecular polymer on the surface of the bottom layer flexible lead layer away from the flexible substrate layer to prepare a bottom layer flexible packaging layer;
s4, conducting paste is used as a conducting wire material to prepare a top layer flexible conducting wire layer on the surface, far away from the bottom layer flexible conducting wire layer, of the flexible substrate layer; connecting a component on the top layer flexible lead layer to obtain a chip layer; heating and curing to sinter the conductive paste;
s5, covering a layer of film at the position of the skin electric detection electrode, and then pouring silane-based high polymer above the chip layer to obtain a top-layer flexible packaging layer; coating a layer of viscous functional material on the top flexible packaging layer, and standing to obtain a viscous functional layer; finally, the film is removed to expose the skin electrode.
To achieve the above object, according to a third aspect of the present invention, there is provided a flexible integrated system for detecting human emotional state information, comprising a flexible signal detection circuit for human emotional state information as described in the first aspect, and a signal processing output module, wherein,
the flexible signal detection circuit is used for detecting skin electric signals, oxyhemoglobin saturation signals, temperature signals and three-axis acceleration signals of a human body and transmitting the signals to the signal processing output module;
the signal processing output module is connected with the flexible signal detection circuit, processes signals obtained by detection of the flexible signal detection circuit, provides power supply and grounding ports for the flexible signal detection circuit, and finally sends skin electricity data, oxyhemoglobin saturation data, temperature data and triaxial acceleration data obtained through calculation processing to the mobile terminal through the Bluetooth antenna transmitting module, so that data visualization is achieved.
Preferably, the flexible signal detection circuit is connected with the signal processing output module through an FPC flexible flat cable.
Has the advantages that: the invention connects the emotion-related signal flexible integrated acquisition circuit with the signal processing module through the FPC flexible flat cable, and the flexible integrated acquisition circuit is stably connected with the flexible signal detection circuit and the signal processing output module due to the flexible characteristic of the FPC flexible flat cable, so that the universality and wearing comfort of the flexible integrated system and the skin of a human body are improved.
Preferably, the flexible integrated system is a skin-attached flexible signal detection patch.
Generally, by the above technical solution conceived by the present invention, the following beneficial effects can be obtained:
(1) the invention provides a flexible signal detection circuit for human body emotional state information, wherein a substrate layer, a lead layer and a packaging layer are all flexible, a flexible polymer material Polydimethylsiloxane (PDMS) is used as the packaging layer and a viscous polymer material is used as an auxiliary viscous functional layer, and used electronic elements and conductive materials are all packaged by being coated by the flexible material. The flexible material is used as the packaging material of the circuit, so that the whole circuit can bear the capability of a certain range of deformation, the circuit can deform synchronously with the skin of a human body, and the viscous polymer material can be more closely attached to the skin. The sensor is flexibly integrated, a double-layer circuit is adopted, the top layer circuit and the bottom layer circuit are connected by adopting a process of cutting conductive through holes on a flexible substrate and filling conductive slurry, the function of interlayer circuit communication is realized, the area of a detection circuit is greatly reduced while the thickness of the detection circuit is not increased, the integration level of the whole detection system is improved, and various signals of a human body can be measured simultaneously. The chip layer comprises a flexible skin electric detection electrode, a temperature detection module, a blood oxygen detection module and an acceleration detection module which are respectively used for detecting skin electric signals, temperature signals, blood oxygen signals and acceleration signals; the top layer flexible packaging layer and the viscous functional layer are not arranged below the skin electric detection electrode, and the skin electric detection electrode is in direct contact with the skin and can quickly and directly measure signals related to human emotion.
(2) The invention provides a preparation method of a flexible signal detection circuit, which adopts laser cutting and coating processes to realize the preparation of a flexible conductive through hole and adopts a screen printing process to realize the preparation of a flexible circuit patterned conductor layer.
(3) The invention provides a flexible integrated system for detecting human body emotion state information, which detects skin electrical data, oxyhemoglobin saturation data, temperature data and triaxial acceleration data through different modules; the signal processing output module receives the data of sensor simultaneously and sends to mobile terminals such as cell-phones through the bluetooth, and this detecting system can realize wearable, and human skin signal of real-time detection, oxyhemoglobin saturation signal, temperature signal and triaxial acceleration signal to transmit to mobile terminal through wireless bluetooth, the real-time skin electricity of feeding back human body in real time, the blood oxygen, temperature and attitude information, real-time supervision promptly. The whole system is small and portable, and has good stability and high measurement precision. Because the detection circuit is better in skin adhesion, the motion artifact influence in the signal detection process is effectively reduced, and the emotion related signal detection accuracy and wearing comfort are improved.
Drawings
Fig. 1 is a schematic circuit diagram of a flexible integrated system including detection based on human emotion related signals provided by the present invention.
Fig. 2 is a schematic structural diagram of a flexible signal detection circuit provided by the present invention.
Fig. 3 is a flowchart of a method for manufacturing a flexible signal detection circuit according to the present invention.
Throughout the drawings, the same reference numerals are used to designate the same elements or structures. Wherein the content of the first and second substances,
1-a lithium battery power supply module, 2-LP5907MFX voltage stabilizing module, 3-CC2640R2F core processor module, 4-a clock crystal oscillator module, 5-a program downloading module, 6-a Bluetooth antenna transmitting module, 7-a mobile phone APP communication module, 8-LM4041, LMP2231 skin electricity detection module, 9-I2C communication port, 10-FPC soft flat cable connecting end, 11-a flexible skin electricity detection electrode, 12-TMP6131 temperature detection module, 13-MAX30102 blood oxygen detection module, 14-LIS2DS12 acceleration detection module, 201-a top layer packaging layer, 202-a top layer circuit layer, 203-a flexible substrate layer with a conductive through hole, 204-a bottom layer circuit layer, 205-a bottom layer packaging layer, 206-LIS2DS12 triaxial acceleration sensing chip, 207-MAX30102 blood oxygen saturation sensing chip, 208-blood oxygen chip decoupling capacitor, 209-acceleration chip decoupling capacitor, 210-skin electric detection electrode, 211-TMP6131 temperature-sensitive resistor, 301-flexible substrate layer, 302-sacrificial layer, 303-glass slide, 304-conductive through hole, 305-conductive paste, 306-bottom packaging layer, 307-chip layer, 308-top packaging layer and 309-viscous functional layer.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
The invention provides a flexible integrated system based on human emotion related signal detection, which can detect skin electric signals, oxyhemoglobin saturation signals, temperature signals and acceleration signals through a flexible signal detection circuit at the front end, and finally process and transmit through a signal processing and analyzing module at the rear end, and finally realize data visualization through a mobile end.
The technical scheme of the invention is as follows: a flexible integrated system for detecting emotion related signals of a human body is shown in figure 1 and comprises a flexible signal detection circuit and a signal processing output module.
The flexible signal detection circuit takes a flexible material as a flexible substrate layer, a top layer lead layer, a chip layer and a top layer packaging layer on one side of the flexible substrate layer are arranged from bottom to top, and the other side of the flexible substrate layer comprises a bottom layer lead layer and a bottom layer packaging layer. The flexible substrate layer and the top packaging layer jointly form a flexible frame main body of the detection circuit, and the lead layer and the chip layer are both located in the flexible frame main body. The surface of the flexible signal detection circuit is provided with a viscous functional layer which can be directly attached to the skin of a human body; the flexible signal detection circuit is used for detecting skin electric signals, oxyhemoglobin saturation signals, temperature signals and three-axis acceleration signals of a human body and transmitting the signals to the signal processing output module.
The signal processing output module is connected with the flexible signal detection circuit, processes signals obtained by detection of the flexible signal detection circuit, provides power supply and grounding ports for the flexible signal detection circuit, and finally sends skin electric data, oxyhemoglobin saturation data, temperature data and triaxial acceleration data obtained through calculation processing to the mobile terminal through the Bluetooth antenna transmitting module, so that data visualization is achieved.
Preferably, the flexible signal detection circuit comprises a flexible substrate layer, a bottom layer wire layer, a top layer wire layer, a chip layer, an encapsulation layer and an adhesive functional layer. The flexible material is a silane-based polymer material, and the adhesive functional layer is an adhesive polymer material. The viscous high polymer material has flexibility and good biocompatibility, so that the prepared system can keep better conformal contact capability with human skin, the flexible signal detection circuit is endowed with the capability of being tightly attached to the skin, and the accuracy and the stability of signal detection are improved. The detection circuit is designed as a double-layer circuit, the top layer and the bottom layer of wires are respectively positioned on two sides of the flexible basal layer, and the chip layer is positioned above the top layer of wires. Preferably, the chip layer is arranged such that the flexible skin electric detection electrode, the temperature detection module, the blood oxygen detection module and the LIS2DS12 acceleration detection module are located on the same side of the chip layer, and the signal transmission port is located on the other side. During detection, the blood oxygen detection module is attached to the radial artery part of the wrist, so that accurate detection of blood oxygen signals can be realized.
The flexible substrate layer of the flexible signal detection circuit is mainly made of polydimethylsiloxane; the bottom layer and the top layer of the flexible signal detection circuit are made of conductive paste formed by mixing gallium-based liquid alloy, silver nano-materials and flexible high polymer according to a certain proportion, the conductive paste is coated into a polyester screen plate printed with circuit patterns in a blade mode, the conductive paste is coated in a blade mode through a flat scraper, and the conductive layer is formed on the flexible substrate layer through the screen plate under the extrusion of the scraper. The flexible substrate layer is provided with a plurality of conductive through holes, and the conductive slurry is filled in the conductive through holes and is used for conducting electric signals between the bottom layer and the top layer flexible lead layer, so that a functional circuit of the flexible signal detection circuit is formed.
The chip layer mainly comprises a flexible skin electric detection electrode, a TMP6131 temperature detection module, a MAX30102 blood oxygen detection module and a LIS2DS12 acceleration detection module. The flexible skin electric detection electrodes are two circular electrodes and can be directly attached to the skin, and signals are transmitted to the signal processing and outputting module by measuring the potential difference and the current between the two electrodes; the TMP6131 temperature detection module comprises a temperature-sensitive resistor of the TMP6131, and the human body temperature is detected through the resistance value change of the resistor; the MAX30102 blood oxygen detection module comprises a MAX30102 blood oxygen detection chip and two decoupling capacitors, and detects the blood oxygen saturation of human tissues by a reflection type optical principle; the LIS2DS12 acceleration detection module comprises an LIS2DS12 triaxial acceleration sensing chip and a decoupling capacitor, and can reflect the change of the human body posture by detecting the change of the acceleration. And the decoupling capacitor is respectively connected with the power supply and grounding ends of the MAX30102 and the LIS2DS12, so that decoupling and noise reduction are realized. The chip layer pins are adhered to the lead layer in a light touch pressing mode; and the pins of the chip layer can be fixedly connected after the conductive paste of the lead layer is solidified.
The packaging layer is formed by pouring polydimethylsiloxane, and the chip is fixed and protected after solidification. The viscous functional layer material is a viscous material prepared by adopting a viscous high polymer material through reaction with an uncured polydimethylsiloxane packaging layer so as to realize adhesion to the skin.
Preferably, the flexible signal detection circuit is connected with the rear end signal processing output circuit through an FPC connection flex cable.
The flexible detection electrode of the front-end flexible signal detection module is connected with the flexible flat cable connecting end through the FPC and the skin electricity detection moduleThe GSR1 is connected with the GSR2 signal transmission end, and transmits the detected skin electrical signal to the signal processing output module; the temperature detection module is connected with the core processor module through the FPC flexible flat cable connecting end; the MAX30102 blood oxygen detection module and the LIS2DS12 acceleration detection module pass through the FPC soft flat cable connecting end and the signal processing output module I2C, connecting communication ports; the LP5907MFX voltage stabilizing module of the signal processing output module supplies power to the front-end flexible signal detection module through the FPC connecting flexible flat cable and provides grounding potential at the same time.
Preferably, the signal processing and output module comprises a battery voltage-stabilizing power supply module, a core controller module, a skin electricity detection module and a bluetooth antenna transmission module. The battery voltage-stabilizing power supply module mainly comprises a 5V lithium battery power supply end module, an LP5907MPX voltage-stabilizing module and a decoupling module; the 5V lithium battery power supply end module comprises a 5V output lithium battery and a fixed bonding layer; the input end of the LP5907MPX voltage stabilizing module is connected with the output end of the 5V lithium battery power supply end module; the output end of the LP5907MPX module is respectively connected with a VCC port of the rear-end signal processing module and a VIN port of the front-end flexible blood oxygen detection circuit; the 3.3V decoupling module is composed of two parallel patch capacitors, and limits the coupling noise of the 3.3V output voltage.
The core controller module comprises a CC2640R2F core processor, 32.768KHz and 24MHz clock crystal oscillator modules, a program downloading module, a reset circuit and an I2A C communication port; the CC2640 core processor module primarily includes X32KQ1, X32KQ2, X24MP, X24MN, TMSC, TCKC, TDI, TDO, RESET, RFN, RFP, SCL, SDA, INT, GSR _ OUT, TEMP _ OUT ports, with the CC2640R2F core processor X32KQ1, X32KQ2, X24MP, X24MN ports connected with the 32.768KHz and 24MHz clock crystal module inputs, respectively; the TMSC, TCKC, TDI and TDO ports of the CC2640R2F core processor are respectively connected with the signal input end of the program downloading module to realize program burning; the RESET port of the CC2640 core processor is connected with the signal input end of the RESET circuit; the CC2640R2F core processor SCL, SDA and INT ports are respectively corresponding to theI2The signal input end of the communication port C is connected; the port of the CC2640R2F core processor GSR _ OUT is connected with the signal output end of the skin electricity detection module; the TEMP _ OUT port of the CC2640R2F core processor is connected with the signal output end of the temperature detection module; the ports of the core processor RFN and RFP of the CC2640R2F are respectively connected to the signal input end of the bluetooth antenna transmitting module.
The rear-end signal processing circuit adopted by the invention is designed according to the characteristics of the output signal of the front-end signal detection circuit, and the wearable performance of the system is improved by adopting the low-power-consumption Bluetooth communication as the communication mode of the system and the mobile terminal. The invention preferably adopts a CC2640R2F core processor, a LP5907MPX voltage stabilizing chip, a MAX30102 blood oxygen saturation sensing chip, a LIS2DS12 triaxial acceleration sensing chip and the like, so that the integration level of the whole detection system is quite high, and the influence of stretching deformation in the detection process on the whole circuit is reduced while the whole detection system has a tiny detection area.
The electrodermal detection module comprises an LMP2231 amplifier and an LM4041 parallel reference voltage source. The LM4041 parallel reference voltage source is connected in parallel with a GSR1 signal transmission end to serve as an input end of the LMP2231 amplifier, and the GSR2 signal transmission end serves as the other input end and is used for signal amplification through the LMP2231 amplifier. The output end of the skin electricity detection module is connected with the port of the CC2640R2F core processor GSR _ OUT.
The wireless transmission module comprises a 2450BM15A Bluetooth balanced filter and a 2.4GHz patch antenna; the Bluetooth balance filter realizes the noise reduction of wireless signals; 2.4GHz patch antenna realizes the transmission of skin electricity, oxyhemoglobin saturation, temperature, acceleration data, realizes wireless bluetooth communication with cell-phone APP terminal simultaneously.
Preferably, the signal display APP interface comprises four options of searching, starting, setting and opening notification, and four waveform display windows of blood oxygen saturation, skin electricity, temperature and triaxial acceleration so as to display the blood oxygen saturation, the skin electricity, the temperature and the triaxial acceleration signals in real time.
Preferably, the flexible signal detection circuit has a volume not exceeding 20mm × 25mm × 3 mm; the area of the signal processing output module is not more than 25mm multiplied by 25 mm. The flexible signal detection circuit is small in size and high in integral integration level, and improves the comfort in the signal detection process.
In another aspect, the invention provides a method for manufacturing a flexible signal detection circuit, which includes the conductive paste and the method for manufacturing the flexible signal detection circuit. The preparation method of the conductive paste comprises the following steps:
(1) adding the eutectic gallium indium alloy into acetone, performing ultrasonic treatment for a period of time, and performing centrifugal precipitation to obtain submicron particles of the eutectic gallium indium alloy;
(2) filtering out acetone, adding NaOH solution, oscillating, centrifuging, filtering out solution, and cleaning for three times;
(3) adding the silver sheet nano material and the polydimethylsiloxane into the cleaned eutectic gallium-indium alloy according to a certain proportion, oscillating and ultrasonically mixing for a period of time to obtain the flexible lead material.
The preparation method of the flexible signal detection circuit comprises the following steps:
(1) spin-coating a sacrificial layer formed by curing a polyvinyl alcohol aqueous solution on a hard substrate, spin-coating polydimethylsiloxane on the sacrificial layer, and dissolving the sacrificial layer in a water bath to obtain a flexible substrate layer;
(2) carrying out laser cutting on the flexible substrate layer to obtain a through hole, and filling conductive slurry in the through hole to obtain a conductive through hole;
(3) preparing a bottom layer wire layer on one surface of the flexible substrate layer by taking the conductive paste as a wire material; spin-coating polydimethylsiloxane on the surface of the bottom layer wire layer away from the flexible substrate layer to prepare a bottom layer packaging layer;
(4) preparing a top layer lead layer on the surface of the flexible substrate layer away from the bottom layer lead layer by taking conductive paste as a lead material; then, connecting a component on the top layer lead layer to obtain a chip layer; simultaneously, one end of the FPC flexible flat cable is fixedly bonded with the corresponding point of the top layer lead layer;
(5) casting polydimethylsiloxane on the chip layer to obtain a top packaging layer; and coating a layer of adhesive functional material on the top packaging layer, and standing to obtain the adhesive functional layer. Thus, the flexible signal detection circuit is prepared.
Further, the conductive through hole is obtained by cutting the flexible substrate layer by laser; and (3) forming the flexible skin electric detection electrode on the top layer lead layer, and in the step (5), covering the skin electric detection electrode by using an LDPE film and then performing packaging operation so as to prevent the skin electric detection electrode from being covered by the top layer packaging layer.
The manufacturing process of the flexible signal detection circuit will be described with reference to fig. 2 and 3, by way of example.
Example 1
Preparing a flexible lead material:
20ml of acetone is taken out by a measuring cylinder and added into a reagent bottle, then 1g of gallium-indium liquid alloy (the mass fraction of gallium is 75.5 percent, and the mass fraction of indium is 24.5 percent) is taken out by an injector and injected into the acetone, and the acetone is placed on a small vortex oscillator to oscillate for 5min, so as to obtain gallium-indium alloy suspension. And then, putting the alloy into an ultrasonic cleaning machine, and carrying out ultrasonic treatment for 45min to obtain a suspension containing the gallium-indium liquid alloy submicron particles. And then, dividing the solution into two parts, respectively transferring the two parts into two centrifuge tubes, putting the centrifuge tubes into a symmetrical centrifuge, and centrifuging the centrifuge tubes for 10min at the rotating speed of 5000rpm to obtain supernatant and gallium-indium liquid alloy submicron particle precipitate.
And pouring out the supernatant, adding 10ml of 0.1mol/L NaOH solution, placing the mixture on a small vortex oscillator for oscillation for 5min, placing the mixture into a symmetrical centrifuge, centrifuging the mixture for 5min at the rotating speed of 5000rpm, pouring out the supernatant to obtain the gallium-indium liquid alloy submicron particle precipitate, and finishing the one-time cleaning operation. This operation was repeated three times to wash away excess gallium oxide generated during the sonication.
And then, adding 0.5g of gallium-indium liquid alloy submicron particles, 0.25g of silver nano sheets and 0.25g of PDMS into a reagent bottle according to the mass ratio of the gallium-indium liquid alloy submicron particles, the silver nano sheets and the Polydimethylsiloxane (PDMS) of 2:1:1, wherein the mass ratio of the PDMS prepolymer to the curing agent is 10: 1. And then placing the reagent bottle on a small vortex oscillator to oscillate for 5min, and then carrying out ultrasonic treatment for 10min to obtain the conductive paste 305.
Preparing a flexible signal detection circuit:
uniformly mixing polyvinyl alcohol powder and deionized water in a beaker according to the mass ratio of 1:9, adding magnetic beads, sealing the opening of the beaker by using a preservative film, placing the beaker on a magnetic stirrer, setting the temperature of the magnetic stirrer to be 60 ℃, and setting the magnetic stirring time to be 8 hours to obtain a polyvinyl alcohol solution with the mass fraction of 10%, then uniformly injecting the polyvinyl alcohol solution with the mass fraction of 10% onto a glass slide 303 with the length of 75mm, the width of 25mm and the thickness of 2mm, placing the glass slide injected with the polyvinyl alcohol solution onto a platform of a spin coater, setting the spin coater to be in a single-step spin coating mode, and selecting the rotation speed of 800rpm and the acceleration of 500rpm2Min and spin coating time of 30s, so that the thickness of the polyvinyl alcohol solution on the glass slide 303 is uniform; after the spin coating is finished, standing the glass slide 303 coated with the polyvinyl alcohol solution in a spin coating mode for 1-2 minutes at normal temperature, then placing the glass slide on a hot plate, adjusting the temperature of the hot plate to 90 ℃, and curing for 20 minutes to obtain the sacrificial layer 302 on the glass slide 303.
Then, using Sylgard 184 polydimethylsiloxane, wherein the mass ratio of the prepolymer to the curing agent is 10:1, uniformly mixing and stirring the prepolymer and the curing agent for 5-8 minutes to obtain PDMS, placing the PDMS in a vacuum box for vacuumizing, standing for 40-60 minutes, and taking out the PDMS after standing after bubbles in the PDMS are completely dispersed into the air; the air pressure of the vacuum box is 0-0.1 atmosphere.
Then, uniformly injecting the settled PDMS on the glass slide 303 coated with the sacrificial layer 302; putting the glass slide injected with PDMS on a platform of a spin coater, setting the spin coater to be in a single-step spin coating mode, and selecting the rotation speed of 600rpm/min and the acceleration of 500rpm2Min and spin coating time of 30s, so that the thickness of PDMS on the glass slide 303 is uniform; after the spin coating is finished, standing the glass slide 303 coated with PDMS at normal temperature for 1-2 minutes, putting the glass slide on the hot plate, adjusting the temperature to 60 ℃, and curing for 40 minutes to obtain the PDMS-containing glass slideA flexible substrate layer 301 is made on a glass slide 303 coated with a sacrificial layer 302. Then, the glass slide 303 with the cured PDMS is placed in a water bath with deionized water and heated, so that the polyvinyl alcohol sacrificial layer 302 is completely dissolved, and the PDMS flexible substrate layer 301 is released from the glass slide 303, thereby obtaining the flexible substrate layer 301 with uniform thickness and smooth and flat surface. Preferably, the temperature of the water bath for dissolving the sacrificial layer 302 is 90 ℃, and the dissolving time is 6-10 h.
And then, attaching polyethylene terephthalate (PET) films with the thickness of 380 mu m to the upper surface and the lower surface of the PDMS flexible substrate layer 301 which are uniform in thickness and smooth and flat in surface respectively, discharging all bubbles, placing the bubbles on a laser cutting machine platform, transmitting a through hole pattern file to be cut to a computer connected with the laser cutting machine, and after focusing is completed, performing patterned cutting and punching on a sample placed on the platform according to the file to obtain the conductive through hole 304. Preferably, when the diameters of the through holes are respectively set to be 0.6mm, 0.8mm and 1mm, the cut through holes have the optimal surface appearance and the optimal electrical performance. Next, a conductive paste 305 is filled into the laser-cut conductive via 304. And then, placing the PET-PDMS-PET flexible substrate filled with the conductive paste 305 in the conductive through hole 304 in an oven at 160 ℃ for curing for 1h, naturally cooling to 80-100 ℃, taking out the PET-PDMS-PET flexible substrate, and tearing off the polyethylene terephthalate (PET) film to obtain the flexible substrate layer 203 with the patterned conductive through hole.
The flexible substrate 203 with the patterned conductive through holes is fully cooled and then is flattened and fixed on a platform of a screen printing machine, conductive paste 305 is uniformly coated on a circuit pattern part of a polyester screen printing plate engraved with a circuit bottom layer conductor layer pattern, and the position of the screen printing plate is adjusted to enable the positions of the conductive through holes on the screen printing plate pattern to correspond to the conductive through holes 304 on the flexible substrate 203 one by one. The screen of the polyester screen printing plate cannot have larger elasticity, the distance between the screen and the surface of the flexible substrate layer is required to be as small as possible, otherwise, the size of a printed pattern is easy to be distorted, and the mesh number can be 300. After debugging, the scraper is inclined by 45 degrees and horizontally and uniformly scrapes the pattern part of the bottom layer wire layer of the polyester screen plate, the speed is kept at 2cm/s, and the conductive paste 305 is ensured to be uniformly adhered to the surface of the flexible substrate layer 203 through the pattern of the bottom layer wire layer. After the quality of the printed pattern is checked, the flexible substrate with the bottom layer lead layer 204 is placed in a 160 ℃ oven to be heated for 1.5h, and then the temperature is naturally reduced to 80-100 ℃ so as to solidify the printed conductive paste pattern. And then, a thin layer of static PDMS is spin-coated on the bottom layer wire layer 204 as the bottom layer packaging layer 205 according to the method, and the rotation speed is 400r/min and the spin-coating time is 90 s.
The sample thus obtained was mounted on the screen printing machine table with the bottom encapsulation layer 205 facing down and the conductive vias facing up, and the top conductor layer 202 was prepared again in the manner described above.
And then coating a layer of conductive paste 305 on the MAX30102 chip, the LIS2DS chip, the decoupling capacitor and the TMP6131 resistor pin, respectively clamping the chips by using sharp-nose tweezers, aligning the chip package pin positions corresponding to the chip package pin positions on the top lead layer 202, lightly placing and lightly pressing the corresponding chip pins to realize the adhesion of the chip layer 307 and the top lead layer 202, placing the sample adhered with the chip layer 307 in an oven for curing at 160 ℃ for 1 hour and 20 minutes, and reducing the temperature to 90 ℃ at normal temperature, so that the top lead layer 202 and the chip layer 307 are fixedly connected and the conductive paste is cured, and a good electrical connection is formed.
Furthermore, welding a port at one end of the FPC flexible flat cable by adopting a 2.54mm male single-row contact pin, coating conductive paste 305 on each port at the other end of the FPC flexible flat cable connected with the flexible signal detection circuit, aligning one end coated with the conductive paste 305 with a corresponding pin port on the top layer lead layer 202, slightly pressing to enable the end to be tightly adhered, placing the glass slide adhered with the FPC flexible flat cable in an oven for curing at 160 ℃ for 1 hour and 20 minutes, and cooling to 90 ℃ at normal temperature, so that the FPC flexible flat cable and the top layer lead layer 202 can be fixedly connected to form good electrical connection.
Further, an acrylic plate square frame mold which is suitable for the size of a circuit and has the thickness of 1mm is placed on the glass slide of the cured FPC flexible flat cable, after the acrylic plate square frame mold is fixed by a PI adhesive tape, a LDPE film is cut to the size of the skin electric detection electrode and tightly covers the surface of the skin electric detection electrode, then the PDMS after standing is slowly injected into the mold, when the PDMS after standing is uniformly covered on the whole circuit, a layer of silane coupling agent is coated on the upper surface of the PDMS, after standing reaction is carried out for 25 minutes, the PDMS is placed in an oven 8 to be cured for 3 hours at 60 ℃, then the PDMS is taken out, a top packaging layer 308 and an adhesive functional layer 309 are formed above the core layer 307, and the LDPE film and the square frame mold are slowly taken out by a blade so as to expose the skin electric detection electrode; the thin layer above the PDMS, which is in contact with the air, is the adhesive functional layer 309, which has good adhesion, and can be tightly attached to the skin, thereby realizing the wearability of the device.
Thus, the flexible signal detection circuit is prepared.
When the lithium battery power supply module works, the lithium battery power supply module 1 serves as a power supply source to supply 5V voltage to the whole circuit; the LP5907MPX voltage stabilizing module 2 converts the 5V voltage supplied by the lithium battery power supply module 1 into 3.3V, and supplies power to the CC2640R2F core processor module 3, the LM4041, the LMP2231 skin electricity detection module 8, the TMP6131 temperature detection module 12, the MAX30102 blood oxygen detection module 13, and the LIS2DS12 acceleration detection module 14. The TMP6131 temperature detection module 12, the MAX30102 blood oxygen detection module 13 and the LIS2DS12 acceleration detection module 14 are located in the flexible signal detection circuit, and power supply thereof is performed through the 3V3 and 1V8 ports of the FPC flexible flat cable connection terminal 10. Furthermore, the MAX30102 blood oxygen detection module 13 and the LIS2DS12 acceleration detection module 14 in the flexible signal detection circuit are in data communication through INT, SCL and SDA ports of the FPC flexible flat cable connection end 10, and are connected with the I2C communication port 9 of the CC2640R2F to complete command sending and data transmission; the TMP6131 temperature detection module 12 is directly communicated with the core processor module 3 through a TEMP port of the FPC flexible flat cable connecting end 10; the flexible skin electricity detection electrode 11 performs signal transmission with the signal transmission ends of the LM4041 and the LMP2231 skin electricity detection module 8, the GSR1 and the GSR2 through the GSR1 and the GSR2 of the FPC flexible flat cable connection end 10, and performs skin electricity data transmission with the core processor module 3 through the GSR _ OUT port of the skin electricity detection module 8.
The flexible integrated system based on human emotion related signal detection can be particularly used in cooperation with a signal display APP in the mobile terminal. Realize wireless bluetooth communication, transmission data through 2.4GHz antenna module and cell-phone signal show APP. Can open a supporting signal show APP, the cell-phone terminal can receive data, APP operating procedure is simple and convenient, and the professional knowledge level requires lowly, and human-computer interaction interface is friendly, can be adapted to the crowd of different age groups. Further, the signal display APP interface may include four options of search, start, set, open notification. For example, the search option can enable the mobile terminal to detect a bluetooth device to be connected; after the Bluetooth device is connected, the notification is turned on to receive Bluetooth transmission data, the starting option is used for drawing the received data, and the setting option can be used for setting the transmission rate of the data and the time interval of adjacent data points in the drawing. The signal show APP interface includes four options of searching, starting, setting and opening notification, and four waveform display windows of blood oxygen saturation, skin electricity, temperature and triaxial acceleration, so as to display the signals of the blood oxygen saturation, the skin electricity, the temperature and the triaxial acceleration in real time.
All the components (including all the functional modules, chips and the like) adopted by the invention can be purchased from the market; the connections of the pins of the functional module, the chip, and the like are not described in detail with reference to the relevant description.
It will be understood by those skilled in the art that the foregoing is only a preferred embodiment of the present invention, and is not intended to limit the invention, and that any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (9)
1. The utility model provides a flexible signal detection circuitry of human emotional state information which characterized in that, flexible signal detection circuitry is double-deck circuit, includes from bottom to top in proper order: the packaging structure comprises a viscous functional layer, a top layer flexible packaging layer, a chip layer, a top layer flexible lead layer, a flexible substrate layer, a bottom layer flexible lead layer and a bottom layer flexible packaging layer;
the adhesive functional layer is used for being directly attached to human skin;
the top layer flexible packaging layer and the flexible substrate layer jointly form a flexible frame main body, and the chip layer and the top layer flexible lead layer are both positioned in the flexible frame main body;
the chip layer comprises a flexible skin electric detection electrode, a temperature detection module, a blood oxygen detection module and an acceleration detection module, and the flexible skin electric detection electrode, the temperature detection module, the blood oxygen detection module and the acceleration detection module are respectively used for detecting skin electric signals, temperature signals, blood oxygen signals and acceleration signals; wherein, the top layer flexible packaging layer and the viscous functional layer are not arranged below the skin electric detection electrode and are in direct contact with the skin;
the flexible substrate layer is provided with a plurality of conductive through holes and is used for interlayer connection of the bottom layer flexible lead layer and the top layer flexible lead layer and interlayer electric signal conduction of the bottom layer flexible lead layer and the top layer flexible lead layer;
the bottom layer and the top layer flexible lead layers are positioned on two sides of the flexible substrate layer and are used for electrically connecting electronic elements in the chip layer and providing transmission ports for human emotion related signals.
2. The flexible signal detection circuit of claim 1, wherein the bottom and top flexible conductive layers are made of conductive paste formed by mixing gallium-based liquid alloy, silver nanomaterial and silane-based high polymer at a certain ratio, and the silane-based high polymer is not more than 50% by mass.
3. The flexible signal detection circuit of claim 2, wherein the mass ratio of the gallium-based liquid alloy, the silver nanomaterial, and the silane-based high molecular polymer is 2:1: 1.
4. The flexible signal detection circuit of claim 2, wherein the gallium-based liquid alloy is a submicron particle and the silver nanomaterial is a submicron flake.
5. The flexible signal detection circuit of claim 2, wherein the silane-based high molecular polymer is Polydimethylsiloxane (PDMS), platinum vulcanized silicone rubber compound (Ecoflex), or styrene-ethylene-butylene-styrene block copolymer (SEBS).
6. A method of manufacturing a flexible signal detection circuit according to any of claims 1 to 5, comprising the steps of:
s1, spinning and coating a silane-based high molecular polymer on a sacrificial layer, and dissolving the sacrificial layer in a water bath to obtain a flexible substrate layer;
s2, carrying out laser cutting on the flexible substrate layer to obtain a through hole, wherein the diameter of the through hole is in the range of 0.6-1 mm, and filling conductive slurry in the through hole to obtain a conductive through hole;
s3, preparing a bottom layer flexible lead layer on one surface of the flexible substrate layer by taking the conductive paste as a lead material; spin-coating a silicone-based high molecular polymer on the surface of the bottom layer flexible lead layer away from the flexible substrate layer to prepare a bottom layer flexible packaging layer;
s4, conducting paste is used as a conducting wire material to prepare a top layer flexible conducting wire layer on the surface, far away from the bottom layer flexible conducting wire layer, of the flexible substrate layer; connecting a component on the top layer flexible lead layer to obtain a chip layer; heating and curing to sinter the conductive paste;
s5, covering a layer of film at the position of the skin electric detection electrode, and then pouring silane-based high polymer above the chip layer to obtain a top-layer flexible packaging layer; coating a layer of viscous functional material on the top flexible packaging layer, and standing to obtain a viscous functional layer; finally, the film is removed to expose the skin electrode.
7. A flexible integrated system for detecting human emotional state information, comprising a flexible signal detection circuit of human emotional state information according to any one of claims 1 to 5, and a signal processing output module, wherein,
the flexible signal detection circuit is used for detecting skin electric signals, oxyhemoglobin saturation signals, temperature signals and three-axis acceleration signals of a human body and transmitting the signals to the signal processing output module;
the signal processing output module is connected with the flexible signal detection circuit, processes signals obtained by detection of the flexible signal detection circuit, provides power supply and grounding ports for the flexible signal detection circuit, and finally sends skin electricity data, oxyhemoglobin saturation data, temperature data and triaxial acceleration data obtained through calculation processing to the mobile terminal through the Bluetooth antenna transmitting module.
8. The flexible integrated system according to claim 7, wherein the flexible signal detection circuit and the signal processing output module are connected by an FPC flex cable.
9. The flexible integrated system of claim 7, wherein the flexible integrated system is a skin-attached flexible signal detection patch.
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