CN111089839B - Flexible wireless integrated skin vision sensing system for analyzing body surface liquid - Google Patents
Flexible wireless integrated skin vision sensing system for analyzing body surface liquid Download PDFInfo
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- CN111089839B CN111089839B CN201911369560.3A CN201911369560A CN111089839B CN 111089839 B CN111089839 B CN 111089839B CN 201911369560 A CN201911369560 A CN 201911369560A CN 111089839 B CN111089839 B CN 111089839B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/14517—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for sweat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
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- G—PHYSICS
- G08—SIGNALLING
- G08C—TRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
- G08C17/00—Arrangements for transmitting signals characterised by the use of a wireless electrical link
- G08C17/02—Arrangements for transmitting signals characterised by the use of a wireless electrical link using a radio link
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
Abstract
The invention relates to a flexible wireless integrated skin vision sensing system for analyzing body surface liquid, which comprises: the packaging mechanism is of a multi-layer packaging layer structure and is used for storing the stability of the sensing system, a first cavity is formed in the packaging mechanism, the packaging mechanism is divided into a first packaging layer and a second packaging layer through the first cavity, the thickness of the second packaging layer is larger than that of the first packaging layer, and the second packaging layer is provided with a second cavity; the photosensitive mechanism comprises an irritant photosensitive layer and a flexible photosensitive layer, the irritant photosensitive layer is arranged in the cavity and is attached to the first packaging layer, the flexible photosensitive layer and the electrode mechanism are both arranged in the second cavity, the flexible photosensitive layer is attached to the top end of the second cavity, and the electrode mechanism is attached to the bottom end of the second cavity; the protein viscous substrate is arranged at the bottom of the packaging mechanism and is used for being attached to the surface of a human body; the invention can avoid immunoreaction and frequent battery replacement after contact, and monitor the change of environment and body surface liquid in real time.
Description
Technical Field
The invention relates to the technical field of implantable medical generators, in particular to a flexible wireless integrated skin vision sensing system for analyzing body surface liquid.
Background
Currently, many skin-contact electronic devices are on the market, including: skin electrode, smart watch (monitoring heartbeat) or can wear sweat analysis appearance, the main structure and the principle of this skin contact electron device are: measuring human electrophysiological signals, myoelectricity, electrocardio, etc., but lacking in the measurement of various chemical substances contained in human secretory sweat (such as blood sugar, electrolytes, lactic acid, etc.); among them, a small number of existing wearable devices for measuring sweat are based on electrochemical principles, and do not effectively utilize optical properties of various liquids.
Among them, the existing skin contact electronic devices have certain disadvantages or shortcomings: the analysis based on the electrochemical principle needs energy consumption, and a large amount of electric energy is needed to realize long-term in-vivo measurement; moreover, various key reaction reagents (such as an oxidation-reduction catalyst required for analyzing blood sugar) required by electrochemical analysis are greatly influenced by environmental temperature, body surface pH value and the like, are not suitable for long-term stable measurement and need to be replaced frequently; in addition, the existing skin contact electronic devices are often limited by energy and wireless communication requirements, are large in size, cannot be stably applied to the surface of the skin for a long time, and are fixed by auxiliary means such as wristbands, so that the phenomena of skin allergy and the like of a human body are easily caused.
Disclosure of Invention
In view of the above problems in the prior art, an object of the present invention is to provide a flexible wireless integrated skin vision sensing system for analyzing body surface fluid, which can avoid the problems of immunoreaction and frequent battery replacement after contact, and can monitor the external environment change and the body surface fluid change in real time and with high accuracy.
In order to solve the above problems, the present invention provides a flexible wireless integrated skin vision sensing system for analyzing body surface fluid, comprising: the device comprises a packaging mechanism, a photosensitive mechanism, an electrode mechanism and a protein viscous substrate;
the packaging mechanism adopts a multi-layer packaging layer structure and is used for storing the stability of the sensing system, a first cavity is arranged in the packaging mechanism, the multi-layer packaging layer structure is divided into a first packaging layer and a second packaging layer through the first cavity, the thickness of the second packaging layer is larger than that of the first packaging layer, and the second packaging layer is provided with a second cavity;
the photosensitive mechanism is used for monitoring the change of body surface liquid in real time, and comprises an irritant photosensitive layer and a flexible photosensitive layer, the irritant photosensitive layer is arranged in the cavity and attached to the first packaging layer, the flexible photosensitive layer and the electrode mechanism are both arranged in the second cavity, the flexible photosensitive layer is attached to the top end of the second cavity, and the electrode mechanism is attached to the bottom end of the second cavity;
the protein viscous substrate is arranged at the bottom of the packaging mechanism and is used for being attached to the surface of a human body.
Furthermore, the packaging mechanism is provided with a plurality of holes, and the holes are used for allowing the body surface liquid of the human body to flow in or out.
Further, the packaging mechanism is prepared from silicone oil.
Further, the thickness of the packaging mechanism does not exceed 450 microns.
Further, the thickness of the first cavity is not more than 200 microns
Further, the irritant photosensitive layer is prepared from polydimethylsiloxane.
Further, the flexible photosensitive layer is prepared by 3-hexylthiophene polymer.
Further, the electrode mechanism comprises a wireless reading coil and an interdigital electrode, and the wireless reading coil and the interdigital electrode are integrated integrally.
Further, the wireless reading coil is made of copper and silicon dioxide.
Further, the protein adhesive substrate is an adhesive biocompatible protein substrate, and the adhesive biocompatible protein substrate is prepared by preparing fibroin, spider silk protein, arthritic elastin, glycerol, calcium chloride and deionized water according to a preset proportion.
Due to the technical scheme, the invention has the following beneficial effects:
1) the flexible wireless integrated skin vision sensing system for analyzing the body surface liquid consists of human body biocompatible materials, and does not cause immune reaction after contacting the skin of a human body;
2) the flexible wireless integrated skin vision sensing system for analyzing the body surface liquid comprises a protein viscous substrate, wherein the protein viscous substrate has viscosity, can be firmly attached to the surface of a human body to collect electrophysiological signals on the surface of the human body and monitor the real-time change condition of the physiological state of the human body;
3) according to the flexible wireless integrated skin vision sensing system for analyzing the body surface liquid, disclosed by the invention, the system comprises the integrated wireless communication coil which has the function of wirelessly reading a sensor signal, and energy is provided for the system through wireless transmission, so that the problem of frequent battery replacement is avoided;
4) the flexible wireless integrated skin vision sensing system for analyzing the body surface liquid comprises a flexible photosensitive sensor and a customizable optical element, and the flexible photosensitive sensor and the customizable optical element can realize real-time high-precision monitoring on the external environment change and the body surface liquid change.
Drawings
In order to more clearly illustrate the technical solution of the present invention, the drawings used in the description of the embodiment or the prior art will be briefly described below. It is obvious that the drawings in the following description are only some embodiments of the invention, and that for a person skilled in the art, other drawings can be derived from them without inventive effort.
FIG. 1 is a schematic structural diagram of a flexible wireless integrated skin vision sensing system for analyzing body surface fluid according to an embodiment of the present invention;
FIG. 2 is a cross-sectional view of a flexible wireless integrated skin vision sensing system for analyzing body fluid provided by an embodiment of the present invention;
FIG. 3 is a schematic diagram of a light transmittance experiment result of a flexible wireless integrated skin vision sensing system for analyzing body surface fluid according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of a stability experiment result of a flexible wireless integrated skin vision sensing system for analyzing body surface fluid according to an embodiment of the present invention;
FIG. 5 is a schematic diagram of the experimental results of sodium ion concentration of the flexible wireless integrated skin vision sensing system for analyzing the body surface fluid according to the embodiment of the present invention;
the device comprises a packaging mechanism, a photosensitive mechanism, a 3-electrode mechanism, a 4-protein viscous substrate, a first cavity, a second cavity, a hole 13, a stimulating photosensitive layer 21 and a flexible photosensitive layer 22.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Reference herein to "one embodiment" or "an embodiment" means that a particular feature, mechanism, or characteristic may be included in at least one implementation of the invention. In the description of the present invention, it is to be understood that the terms "upper", "lower", "left", "right", "top", "bottom", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. Moreover, the terms "first," "second," and the like are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the invention described herein are capable of operation in sequences other than those illustrated or described herein.
Example one
In the embodiment, a flexible wireless integrated skin vision sensing system for analyzing body surface liquid is provided, which is shown in fig. 1 and 2, and includes a packaging mechanism 1, a light sensing mechanism 2, an electrode mechanism 3 and a protein viscous substrate 4;
the packaging mechanism 1 adopts a multilayer packaging layer structure and is used for storing the stability of the sensing system, a first cavity 11 is arranged in the packaging mechanism 1, the multilayer packaging layer structure is divided into a first packaging layer and a second packaging layer through the first cavity 11, the thickness of the second packaging layer is larger than that of the first packaging layer, and the second packaging layer is provided with a second cavity 12;
the photosensitive mechanism 2 is used for monitoring the change of body surface liquid in real time, the photosensitive mechanism 2 comprises a stimulation photosensitive layer 21 and a flexible photosensitive layer 22, the stimulation photosensitive layer 21 is arranged in the cavity 11 and is attached to the first packaging layer, the flexible photosensitive layer 22 and the electrode mechanism 3 are both arranged in the second cavity 12, the flexible photosensitive layer 22 is attached to the top end of the second cavity 12, and the electrode mechanism 3 is attached to the bottom end of the second cavity 12;
the protein viscous substrate 4 is arranged at the bottom of the packaging mechanism 1 and is used for being attached to the surface of a human body.
Specifically, the packaging mechanism 1 is provided with a plurality of holes 13, and the holes 13 are used for allowing the body surface liquid of the human body to flow in or out.
Specifically, the packaging mechanism 1 is prepared from silicone oil.
In particular, the thickness of the packaging mechanism 1 is 450 microns.
In particular, the first cavity 11 has a thickness of 200 microns.
Specifically, the stimulating photosensitive layer 21 is a customizable optical member, and the customizable optical member is prepared by polydimethylsiloxane.
In some embodiments, the customizable optic can be made using a variety of flexible transparent materials, such as fibroin, spidroin, polydimethylsiloxane, silica gel, polyethylene terephthalate, or the like.
Specifically, the flexible photosensitive layer 22 is prepared by a 3-hexylthiophene polymer.
In some embodiments, the flexible photosensitive layer 22 can be made of any flexible photosensitive material, for example, organic solutions based on various concentrations of mercuric chloride benzoic acid.
Specifically, the electrode mechanism 3 comprises a wireless reading coil 31 and an interdigital electrode 32, the wireless reading coil 31 and the interdigital electrode 32 are integrated into a whole, and the real-time high-precision monitoring on the external environment change and the body surface liquid change can be realized.
Specifically, the wireless reading coil 31 has a function of wirelessly reading a sensor signal, and provides energy for a system through wireless transmission, so that the problem of frequent battery replacement is avoided, and the wireless reading coil 31 and the interdigital electrode 32 are made of copper and silicon dioxide.
Further, the polydimethylsiloxane was coated at a rotation rate of 1000rpm in 30s, hardening at 80 deg.C for 30min to prepare substrate, depositing transistor-shaped electrode on the polydimethylsiloxane substrate, the electronic electron beam is assisted by a shielding object to evaporate silicon dioxide with the thickness of 50nm and copper with the thickness of 1 mu m, the silicon dioxide enables the copper and the polydimethylsiloxane substrate to form firm connection through covalent bonds, copper coils with preset inductance coefficients are combined into a transistor-shaped electrode for wireless communication, moreover, different copper coils are adopted to realize interference-free multiband cooperative communication, a sensing part is prepared by a transistor-shaped electrode through a 3D printing technology, curing at 120 ℃ for 20min, coating the cured sensing piece on polydimethylsiloxane at a rotation speed of 1000rpm within 30s, and hardening is carried out at 80 ℃ within 30min to prepare the wireless reading coil and the interdigital electrode.
In some embodiments, the wireless reading coil 31 or the interdigital electrode 32 can be replaced by various metals, such as gold, silver, magnesium, iron, zinc, magnesium alloy, iron alloy, etc.; carbon-based conductive materials such as carbon nanotubes, graphene, and the like; or silicon-based conductive materials, such as doped silicon and the like.
Specifically, the protein viscous substrate 2 is a viscous biocompatible protein substrate, and the viscous biocompatible protein substrate is prepared by preparing fibroin, spider silk protein, arthritic elastin, glycerol, calcium chloride and deionized water according to a preset proportion, wherein the glycerol occupies 5% -25% of the mass of the plasticized bioprotein solution, the calcium chloride occupies 0.5% -3% of the mass of the protein solution, the deionized water is used for adjusting the concentration, and the volume of the deionized water occupies 0% -50% of the volume of the protein solution.
Specifically, a light transmission test is carried out on the flexible wireless integrated skin vision sensing system for analyzing the human body surface liquid, the flexible wireless integrated skin vision sensing system for biologically analyzing the human body surface liquid is adhered to the human body surface, and signal response is obtained through wireless reading, so that different skin surface optical intensities can be measured; as shown in fig. 3, experimental results show that the flexible wireless integrated skin vision sensing system for analyzing body surface fluid of the present invention has different outputs at different light intensities, and mainly under the condition that the skin is dry and wet, i.e. sweaty, the customizable optical member on the surface layer of the flexible wireless integrated skin vision sensing system for analyzing body surface fluid of the human body has response, so that the overall output of the flexible wireless integrated skin vision sensing system for analyzing body surface fluid of the human body has obvious difference.
Specifically, a stability experiment is carried out on the flexible wireless integrated skin vision sensing system for analyzing the body surface liquid, and the stability of the flexible wireless integrated skin vision sensing system for analyzing the body surface liquid under multiple sweating cycles is measured by adhering the flexible wireless integrated skin vision sensing system for analyzing the body surface liquid to the body surface of the human body; as shown in FIG. 4, the experimental results show that the flexible wireless integrated skin vision sensing system for analyzing the body surface fluid of the human body has no obvious change after 30 cycles.
Specifically, a sodium ion concentration experiment is carried out on the flexible wireless integrated skin vision sensing system for analyzing the body surface liquid, and by adhering the flexible wireless integrated skin vision sensing system for analyzing the body surface liquid to the body surface of the human body, signals of the flexible wireless integrated skin vision sensing system for analyzing the body surface liquid are changed correspondingly when the concentration of sodium ions in sweat is different under different exercise strengths; as shown in FIG. 5, experimental results show that the flexible wireless integrated skin vision sensing system for analyzing the body surface fluid can obviously measure different sodium ion concentrations, reflect the human body movement intensity, monitor the conditions of water shortage and the like of the human body, and prevent the dangerous conditions of excessive human body movement and the like.
The embodiment provides an integrated skin vision sensing system of flexible wireless of assay human body surface liquid, can avoid the problem that causes immunoreaction and often change the battery after the contact to the real-time high accuracy monitoring of external environment change and body surface liquid change.
The foregoing description has disclosed fully preferred embodiments of the present invention. It should be noted that those skilled in the art can make modifications to the embodiments of the present invention without departing from the scope of the appended claims. Accordingly, the scope of the appended claims is not to be limited to the specific embodiments described above.
Claims (9)
1. A flexible wireless integrated skin vision sensing system for analyzing body surface liquid, comprising: the device comprises a packaging mechanism (1), a photosensitive mechanism (2), an electrode mechanism (3) and a protein viscous substrate (4);
the packaging mechanism (1) adopts a multi-layer packaging layer structure and is used for storing the stability of the sensing system, a first cavity (11) is arranged in the packaging mechanism (1), the multi-layer packaging layer structure is divided into a first packaging layer and a second packaging layer through the first cavity (11), the thickness of the second packaging layer is larger than that of the first packaging layer, and the second packaging layer is provided with a second cavity (12);
the photosensitive mechanism (2) is used for monitoring body surface liquid changes in real time, the photosensitive mechanism (2) comprises a stimulation photosensitive layer (21) and a flexible photosensitive layer (22), the stimulation photosensitive layer (21) is arranged in the first cavity (11) and is attached to the first packaging layer, the flexible photosensitive layer (22) and the electrode mechanism (3) are both arranged in the second cavity (12), the flexible photosensitive layer (22) is attached to the top end of the second cavity (12), the electrode mechanism (3) is attached to the bottom end of the second cavity (12), and the flexible photosensitive layer (22) is prepared from a 3-hexylthiophene polymer;
the protein viscous substrate (4) is arranged at the bottom of the packaging mechanism (1) and is used for being attached to the surface of a human body.
2. A flexible, wireless, integrated skin vision sensing system for analyzing body surface fluids according to claim 1, wherein said packaging mechanism (1) is provided with a plurality of holes (13), said holes (13) being adapted for the inflow or outflow of body surface fluids.
3. A flexible wireless integrated skin vision sensing system for analyzing body surface fluid according to claim 2, characterized in that said encapsulation means (1) is prepared by silicone oil.
4. A flexible, wireless, integrated skin vision sensing system for analyzing body surface fluid according to claim 3, characterized in that said packaging means (1) has a thickness not exceeding 450 microns.
5. A flexible, wireless, integrated skin vision sensing system for analyzing body surface fluid, according to claim 4, characterized in that said first cavity (11) has a thickness not exceeding 200 microns.
6. A flexible wireless integrated skin vision sensing system for analyzing body surface fluid according to claim 1, characterized in that said stimulating photosensitive layer (21) is made of polydimethylsiloxane.
7. A flexible wireless integrated skin vision sensing system for analyzing body surface fluid according to claim 1, characterized in that said electrode means (3) comprises a wireless reading coil (31) and an interdigital electrode (32), said wireless reading coil (31) being integrated with said interdigital electrode (32).
8. A flexible wireless integrated skin vision sensing system for analyzing body surface fluid according to claim 7, characterized in that said wireless reading coil (31) and said interdigital electrode (32) are made of copper and silicon dioxide.
9. A flexible wireless integrated skin vision sensing system for analyzing body surface fluid according to claim 1, characterized in that said protein adhesive substrate (2) is an adhesive biocompatible protein substrate prepared by preparing fibroin, spidroin, arthritic elastin, glycerin, calcium chloride and deionized water in a preset ratio.
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| CN111956218B (en) * | 2020-08-10 | 2024-04-16 | 中国科学院上海微系统与信息技术研究所 | Flexible brain electrode with electrochemical and electrophysiological detection functions and preparation method thereof |
| CN113252081A (en) * | 2021-05-12 | 2021-08-13 | 电子科技大学 | Flexible composite sensor based on fibroin and preparation method thereof |
| CN114235226B (en) * | 2021-12-14 | 2023-02-24 | 西安电子科技大学 | Off-electric wireless passive flexible pressure sensor, preparation and application |
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