CN113166761B - 用于抑制pnpla3表达的rnai构建体 - Google Patents

用于抑制pnpla3表达的rnai构建体

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Publication number
CN113166761B
CN113166761B CN201980081364.8A CN201980081364A CN113166761B CN 113166761 B CN113166761 B CN 113166761B CN 201980081364 A CN201980081364 A CN 201980081364A CN 113166761 B CN113166761 B CN 113166761B
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Prior art keywords
pnpla
rnai
pnpla3
expression
cells
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CN201980081364.8A
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Chinese (zh)
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CN113166761A (zh
Inventor
I·拉利夫森
J·K·默里
M·奥尔曼
O·霍曼
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Amgen Inc
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Amgen Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980081364.8A 2018-12-10 2019-12-10 用于抑制pnpla3表达的rnai构建体 Active CN113166761B (zh)

Priority Applications (1)

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CN202511224281.3A CN121320339A (zh) 2018-12-10 2019-12-10 用于抑制pnpla3表达的rnai构建体

Applications Claiming Priority (3)

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US201862777714P 2018-12-10 2018-12-10
US62/777714 2018-12-10
PCT/US2019/065481 WO2020123508A2 (en) 2018-12-10 2019-12-10 Rnai constructs for inhibiting pnpla3 expression and methods of use thereof

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CN113166761A CN113166761A (zh) 2021-07-23
CN113166761B true CN113166761B (zh) 2025-09-09

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US (2) US20220017906A1 (https=)
EP (1) EP3894555A2 (https=)
JP (2) JP2022511550A (https=)
KR (1) KR20210102932A (https=)
CN (2) CN113166761B (https=)
AR (1) AR117297A1 (https=)
AU (1) AU2019396419B2 (https=)
BR (1) BR112021011061A2 (https=)
CA (1) CA3121510A1 (https=)
CL (1) CL2021001489A1 (https=)
CO (1) CO2021008997A2 (https=)
CR (1) CR20210371A (https=)
EA (1) EA202191629A1 (https=)
IL (1) IL283473A (https=)
JO (1) JOP20210142A1 (https=)
MX (2) MX2021006784A (https=)
PE (1) PE20211225A1 (https=)
PH (1) PH12021551326A1 (https=)
SG (1) SG11202105711SA (https=)
TW (1) TW202039843A (https=)
UY (1) UY38503A (https=)
WO (1) WO2020123508A2 (https=)

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EA201792263A1 (ru) 2015-04-13 2018-08-31 Элнилэм Фармасьютикалз, Инк. КОМПОЗИЦИИ НА ОСНОВЕ iRNA ПРОТИВ АНГИОПОЭТИН-ПОДОБНОГО БЕЛКА 3 (ANGPTL3) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
AR113490A1 (es) * 2017-12-12 2020-05-06 Amgen Inc CONSTRUCCIONES DE ARNi PARA INHIBIR LA EXPRESIÓN DE PNPLA3 Y MÉTODOS DE USO DE LAS MISMAS
EP4096396A1 (en) 2020-01-28 2022-12-07 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
US12084662B2 (en) * 2021-04-14 2024-09-10 Dicerna Pharmaceuticals, Inc. Compositions and methods for modulating PNPLA3 expression
EP4347823A1 (en) * 2021-06-02 2024-04-10 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
AU2022339846A1 (en) * 2021-09-01 2024-03-14 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof
JP2025524135A (ja) * 2022-07-27 2025-07-25 イー－セラピューティクス・ピーエルシー 核酸化合物
JP2025542119A (ja) * 2022-12-07 2025-12-25 シャンハイ アルゴ バイオファーマシューティカル カンパニー，リミテッド パタチン様ホスホリパーゼドメイン含有３（ｐｎｐｌａ３）の発現を阻害するための組成物及び方法
AU2023408479A1 (en) * 2022-12-19 2025-05-01 Arnatar Therapeutics, Inc Advanced rna targeting (arnatar)
CN121152879A (zh) * 2023-02-14 2025-12-16 基愈治疗公司 经修饰的双链rna药剂
WO2024182446A2 (en) * 2023-02-28 2024-09-06 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof
IL324720A (en) * 2023-05-26 2026-01-01 Adarx Pharmaceuticals Inc SOD1 modulators and methods of using them

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