CN113164615A - 用于治疗和成像的树状聚体 - Google Patents

用于治疗和成像的树状聚体 Download PDF

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Publication number
CN113164615A
CN113164615A CN201980077232.8A CN201980077232A CN113164615A CN 113164615 A CN113164615 A CN 113164615A CN 201980077232 A CN201980077232 A CN 201980077232A CN 113164615 A CN113164615 A CN 113164615A
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Prior art keywords
dendrimer
cancer
group
subject
radionuclide
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CN201980077232.8A
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English (en)
Chinese (zh)
Inventor
D·J·欧文
R·哈夫顿
K·J·舒尔特
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Starpharma Pty Ltd
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Starpharma Pty Ltd
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Priority claimed from AU2018904548A external-priority patent/AU2018904548A0/en
Application filed by Starpharma Pty Ltd filed Critical Starpharma Pty Ltd
Publication of CN113164615A publication Critical patent/CN113164615A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201980077232.8A 2018-11-29 2019-11-29 用于治疗和成像的树状聚体 Pending CN113164615A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2018904548 2018-11-29
AU2018904548A AU2018904548A0 (en) 2018-11-29 Dendrimer for therapy and imaging
PCT/AU2019/051312 WO2020107078A1 (en) 2018-11-29 2019-11-29 Dendrimer for therapy and imaging

Publications (1)

Publication Number Publication Date
CN113164615A true CN113164615A (zh) 2021-07-23

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Application Number Title Priority Date Filing Date
CN201980077232.8A Pending CN113164615A (zh) 2018-11-29 2019-11-29 用于治疗和成像的树状聚体

Country Status (12)

Country Link
US (2) US20220023448A1 (https=)
EP (1) EP3886912A4 (https=)
JP (1) JP7541978B2 (https=)
KR (1) KR102940818B1 (https=)
CN (1) CN113164615A (https=)
AU (1) AU2019390489B2 (https=)
BR (1) BR112021008480A2 (https=)
CA (1) CA3120881A1 (https=)
IL (1) IL283511A (https=)
MX (1) MX2021006073A (https=)
SG (1) SG11202104309RA (https=)
WO (1) WO2020107078A1 (https=)

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CN117088825A (zh) * 2023-10-12 2023-11-21 成都威斯津生物医药科技有限公司 一种可离子化脂质、含该可离子化脂质的药物组合物及其用途

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KR102948775B1 (ko) * 2018-11-20 2026-04-03 스타파마 피티와이 리미티드 치료 덴드리머
EP4034169B1 (en) * 2019-09-26 2026-02-11 Starpharma Pty Limited Therapeutic dendrimer
KR20230065935A (ko) * 2020-06-03 2023-05-12 스타파마 피티와이 리미티드 치료적 접합체
WO2022094327A1 (en) * 2020-10-30 2022-05-05 Ashvattha Therapeutics, Inc. Radiolabeled ether dendrimer conjugates for pet imaging and radiotherapy
WO2024007034A2 (en) * 2022-07-01 2024-01-04 The Johns Hopkins University Dendrimer-delivered alpha-particle radiotherapy for treatment of glioblastoma and other cancers in the brain
WO2025222234A1 (en) * 2024-04-24 2025-10-30 Starpharma Pty Ltd Targeted dendrimer conjugates

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CN117088825A (zh) * 2023-10-12 2023-11-21 成都威斯津生物医药科技有限公司 一种可离子化脂质、含该可离子化脂质的药物组合物及其用途

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